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Article ; Online: Should Calcineurin Inhibitors/Sirolimus Be Ceased Completely In Posterior Reversible Encephalopathy Syndrome?

Karataş, Cihan / Akyollu, Başak / Arpalı, Emre / Kocak, Burak

2024 Volume 56, Issue 1, Page(s) 93–96

Abstract: Background: To investigate the relationship between immunosuppressive treatments and posterior reversible encephalopathy syndrome (PRES) in transplant patients.: Methods: We presented a retrospective study of 4 cases of PRES in transplant patients. ... ...

Abstract	Background: To investigate the relationship between immunosuppressive treatments and posterior reversible encephalopathy syndrome (PRES) in transplant patients. Methods: We presented a retrospective study of 4 cases of PRES in transplant patients. Patient records were reviewed to identify potential risk factors, clinical presentations, radiological findings, and immunosuppressive treatments used. Results: Our analysis revealed a potential association between immunosuppressive treatments and the development of PRES in transplant patients. Specifically, we found that adjusting or switching immunosuppressive treatments can improve outcomes and prevent the recurrence of PRES. Conclusion: Our findings highlight the importance of recognizing PRES as a potential complication of immunosuppressive treatments in transplant patients. Early detection and management, including a review of immunosuppressive treatments, may improve patient outcomes and prevent further complications.
MeSH term(s)	Humans ; Calcineurin Inhibitors/adverse effects ; Immunosuppressive Agents/adverse effects ; Posterior Leukoencephalopathy Syndrome/chemically induced ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Retrospective Studies ; Sirolimus
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.11.012
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Zs.A 835: Show issues

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Article: Experience of kidney transplantation to a patient with Bernard Soulier syndrome: A case report.

Karataş, Cihan / Akyollu, Başak / Arpalı, Emre / Yelken, Berna / Türkmen, Aydın / Koçak, Burak

Turkish journal of surgery

2023 Volume 39, Issue 1, Page(s) 86–88

Abstract: Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a ...

Abstract	Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a rare hereditary disease associated with defects of the platelet glycoprotein complex glycoprotein Ib/V/IX and characterized by large platelets, thrombocytopenia, and severe bleeding symptoms. Here, we present a challenging renal transplantation in BSS.
Language	English
Publishing date	2023-03-03
Publishing country	Turkey
Document type	Case Reports
ISSN	2564-6850
ISSN	2564-6850
DOI	10.47717/turkjsurg.2022.4567
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Article ; Online: Effects of erector spinae plane block on opioid consumption in patients undergoing hand-assisted laparoscopic donor nephrectomy: a randomized controlled trial.

Özkalayci, Özlem / Karakaya, Muhammet A / Yenigün, Yılmaz / Çetin, Seçil / Darçin, Kamil / Akyollu, Başak / Arpali, Emre / Koçak, Burak / Gürkan, Yavuz

Minerva anestesiologica

2024 Volume 90, Issue 3, Page(s) 154–161

Abstract: Background: The erector spinae plane block is a relatively new regional anesthesia technique that is expected to provide some benefits for postoperative analgesia. This study investigated the effects of erector spinae plane block on postoperative opioid ...

Abstract	Background: The erector spinae plane block is a relatively new regional anesthesia technique that is expected to provide some benefits for postoperative analgesia. This study investigated the effects of erector spinae plane block on postoperative opioid consumption in kidney donors undergoing hand-assisted laparoscopic donor nephrectomy for renal transplantation. Methods: Fifty-two donors scheduled for elective hand-assisted laparoscopic donor nephrectomy were randomly divided into the block (25 donors) and control (27 donors) groups. Donors in the block group received 30 mL of 0.25% bupivacaine under ultrasound guidance, whereas the control group received no block treatment. The primary outcome measure was the amount of fentanyl administered via patient-controlled analgesia at 24 h. Secondary outcomes included the duration of stay, opioid consumption in the post-anesthesia care unit, and pain scores during the recording hours. Results: No significant differences were observed between the groups regarding total opioid consumption converted to intravenous morphine equivalent administered via patient-controlled analgesia (33.3±21.4 mg vs. 37.5±18.5 mg; P=0.27) and in the postanesthesia care unit (1.5±0.9 mg vs. 1.4±0.8 mg; P=0.55). The duration of stay in the postanesthesia care unit (86.3±32.6 min vs. 85.7±33.6 min; P=0.87) was similar between the groups. There was no significant difference between the groups in the postoperative donor-reported NRS pain scores (P>0.05 for all the time points). Conclusions: Preoperative erector spinae plane block is not an effective strategy for reducing postoperative pain or opioid consumption in patients undergoing hand-assisted laparoscopic donor nephrectomy. Different block combinations are needed for optimal pain management in hand-assisted laparoscopic donor nephrectomy.
MeSH term(s)	Humans ; Analgesics, Opioid ; Anesthetics, Local ; Hand-Assisted Laparoscopy ; Nerve Block/methods ; Pain, Postoperative ; Nephrectomy ; Ultrasonography, Interventional/methods
Chemical Substances	Analgesics, Opioid ; Anesthetics, Local
Language	English
Publishing date	2024-02-02
Publishing country	Italy
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.23.17706-6
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Zs.A 516: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 192: Show issues

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Article ; Online: Effects of 5-fluorouracil released from different prosthetic meshes on post-operative adhesion formation in rats.

Balas, Sener / Dora, Devrim Demir / Erol, Timucin / Akyollu, Basak / Korkusuz, Petek / Hamaloglu, Erhan

Northern clinics of Istanbul

2022 Volume 9, Issue 6, Page(s) 565–575

Abstract: Objective: Post-operative adhesion is a common problem in abdominal surgery. Especially, foreign materials are strong stimulus for the development of adhesions. The aim of this study was to investigate whether drug release material coated prosthetic ... ...

Abstract	Objective: Post-operative adhesion is a common problem in abdominal surgery. Especially, foreign materials are strong stimulus for the development of adhesions. The aim of this study was to investigate whether drug release material coated prosthetic mesh decreases intra-abdominal adhesion formation or not. Methods: 5-Fluorouracil (5-FU) releasing "chitosan gels" were loaded to polypropylene and polyglactin-910 grafts. Polypropylene, polyglactin-910 grafts, chitosan gel, and 5-FU-loaded polyglactin 910, polypropylene grafts were used to cover abdominal defects of rats which were created under sterile conditions (n=84). Each group was divided into two subgroups (n=6). Subgroups were sacrificed on the 7 Results: The 7 Conclusion: This study showed that 5-FU decreases the adhesions but the dosage and release kinetics need further investigations.
Language	English
Publishing date	2022-12-05
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2021.45548
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Article ; Online: Hand-assisted laparoscopic donor nephrectomy: 1864 cases in 15 years of experience.

Günaydın, Bilal / Uçar, Taha / Arpalı, Emre / Akyollu, Başak / Akıncı, Serkan / Karataş, Cihan / Öztorun, Kenan / Koçak, Burak

Turkish journal of medical sciences

2022 Volume 52, Issue 4, Page(s) 1322–1328

Abstract: Background: To evaluate hand-assisted laparoscopic donor nephrectomy (HALDN) in terms of intraoperative and postoperative results.: Methods: After institutional review board approval was obtained, a total of 1864 HALDN operations performed between ... ...

Abstract	Background: To evaluate hand-assisted laparoscopic donor nephrectomy (HALDN) in terms of intraoperative and postoperative results. Methods: After institutional review board approval was obtained, a total of 1864 HALDN operations performed between March 2007 and January 2022 were retrospectively analyzed. Age, sex, body mass index (BMI), status of smoking and presence of previous abdominal surgery, laterality, operative time, transfusion requirement, port counts, length of extraction incision, time until mobilization, time until oral intake, donor serum creatinine levels before and one week after the surgery, length of postoperative hospital stay, intraoperative complications, and postoperative recovery and complications were recorded and statistically analyzed. Multiple renal arteries, BMI, right nephrectomy and male sex were also separately evaluated as risk factors for complications and operative time. Results: A total of 825 (44.26%) male and 1039 (55.74%) female patients were enrolled in the study. The mean age of the patients was 45.79 ± 12.88 years. There were a total of 143 complications (7.67% of the total 1864 cases) consisting of 68 (3.65%) intraoperative and 75 (4.02%) postoperative complications. Open conversion was necessary for 10 patients (0.53%) to manage intraoperative complications. Reoperation was needed for 1 patient due to bleeding 6 h after the operation. Multiple renal arteries were a risk factor for intraoperative complications and prolonged operative time. Right nephrectomy and male sex were also related with longer operative times. Discussion: HALDN is a safe procedure associated with low complication rates.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Hand-Assisted Laparoscopy/adverse effects ; Hand-Assisted Laparoscopy/methods ; Living Donors ; Retrospective Studies ; Kidney Transplantation ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Intraoperative Complications/etiology
Language	English
Publishing date	2022-08-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.55730/1300-0144.5438
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3242: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Case report: A kidney transplant patient with mild COVID-19.

Arpali, Emre / Akyollu, Basak / Yelken, Berna / Tekin, Suda / Turkmen, Aydin / Kocak, Burak

Transplant infectious disease : an official journal of the Transplantation Society

2020 Volume 22, Issue 4, Page(s) e13296

Abstract: Coronavirus Disease 2019 (COVID-19) is currently a pandemic with a mortality rate of 1%-6% in the general population. However, the mortality rate seems to be significantly higher in elderly patients, especially those hospitalized with comorbidities, such ...

Abstract	Coronavirus Disease 2019 (COVID-19) is currently a pandemic with a mortality rate of 1%-6% in the general population. However, the mortality rate seems to be significantly higher in elderly patients, especially those hospitalized with comorbidities, such as hypertension, diabetes, or coronary artery diseases. Because viral diseases may have atypical presentations in immunosuppressed patients, the course of the disease in the transplant patient population is unknown. Hence, the management of these patients with COVID-19 is an area of interest, and a unique approach is warranted. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. We believe that screening protocols for SARS-Cov-2 should be re-evaluated in patients with solid-organ transplants.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Cough/etiology ; Disease Management ; Female ; Fever/etiology ; Glucocorticoids ; Graft Rejection/prevention & control ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Lupus Nephritis/surgery ; Oseltamivir/therapeutic use ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Prednisone/therapeutic use ; SARS-CoV-2 ; Severity of Illness Index ; Tacrolimus/therapeutic use
Chemical Substances	Antiviral Agents ; Glucocorticoids ; Immunosuppressive Agents ; Oseltamivir (20O93L6F9H) ; Prednisone (VB0R961HZT) ; Tacrolimus (WM0HAQ4WNM)
Keywords	covid19
Language	English
Publishing date	2020-05-04
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13296
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Zs.A 5100: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Hand-assisted laparoscopic donor nephrectomy in kidneys with multiple renal arteries versus a single renal artery: An analysis of vascular complications from 1,350 cases.

Arpalı, Emre / Karataş, Cihan / Akyollu, Başak / Yaprak, Doğukan / Günaydın, Bilal / Koçak, Burak

Turkish journal of urology

2020

Abstract: Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship ... ...

Abstract	Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship between the donors with MRAs and risk of perioperative vascular complications related to donor nephrectomy was investigated. Material and methods: Patients who underwent hand-assisted LDNs between January 2007 and February 2018 were reviewed retrospectively. Patient age, sex, body mass index (BMI), waist circumference, side of donor nephrectomies, donors with MRAs, intraoperative vascular complications, conversion rates, hospitalization durations, and operative times were extracted. Risk factors for perioperative vascular complications were defined. Results: There were MRAs in 288 kidney donors (21.3%). The number of patients who underwent a right donor nephrectomy was 113 (8.4%). BMI, waist circumference, and postoperative hospital stay were not significantly different between donors with one artery and those with MRAs (p>0.05). The renovascular complication rate and overall conversion rate to open surgery were significantly higher in donors with MRAs (p<0.05). Conclusion: Perioperative safety of the kidney donors is of crucial importance. Surgeons performing LDNs must be aware of the potential risks. Our analysis suggests that procurement of kidneys from donors with MRAs is a risk factor for renovascular complications.
Language	English
Publishing date	2020-03-27
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2020.19280
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Article ; Online: Oligosymptomatic Kidney Transplant Patients With COVID-19: Do They Pose a Risk to Other Recipients?

Kocak, Burak / Arpali, Emre / Akyollu, Basak / Yelken, Berna / Tekin, Suda / Kanbay, Mehmet / Turkmen, Aydin / Kalayoglu, Munci

Transplantation proceedings

2020 Volume 52, Issue 9, Page(s) 2663–2666

Abstract: The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general ... ...

Abstract	The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general opinion, transplant patients may be asymptomatic or oligosymptomatic, which could be a risk factor for underdiagnosis and the dissemination of this viral disease. This study presents the clinical features of 2 oligosymptomatic kidney transplant patients diagnosed with COVID-19. We suggest that new screening algorithms for COVID-19 should be reconsidered for the transplant patient population.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/immunology ; Female ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients
Chemical Substances	Immunosuppressive Agents
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2020.05.028
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Zs.A 835: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article: Case report: A kidney transplant patient with mild COVID-19

Arpali, Emre / Akyollu, Basak / Yelken, Berna / Tekin, Suda / Turkmen, Aydin / Kocak, Burak

Transpl Infect Dis

Abstract	Coronavirus Disease 2019 (COVID-19) is currently a pandemic with a mortality rate of 1%-6% in the general population. However, the mortality rate seems to be significantly higher in elderly patients, especially those hospitalized with comorbidities, such as hypertension, diabetes, or coronary artery diseases. Because viral diseases may have atypical presentations in immunosuppressed patients, the course of the disease in the transplant patient population is unknown. Hence, the management of these patients with COVID-19 is an area of interest, and a unique approach is warranted. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. We believe that screening protocols for SARS-Cov-2 should be re-evaluated in patients with solid-organ transplants.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #73020
Database	COVID19

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Book ; Online: Oligosymptomatic kidney transplant patients with COVID-19

Arpalı, Emre / Akyollu, Başak / Koçak, Burak / Yelken, Berna / Kalayoğlu, Münci / Türkmen, Aydın / Koruk, Süda Tekin / Kanbay, Mehmet (ORCID 0000-0002-1297-0675 & YÖK ID 110580)

Transplantation Proceedings

do they pose a risk to other recipients?

2020

Abstract	The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general opinion, transplant patients may be asymptomatic or oligosymptomatic, which could be a risk factor for underdiagnosis and the dissemination of this viral disease. This study presents the clinical features of 2 oligosymptomatic kidney transplant patients diagnosed with COVID-19. We suggest that new screening algorithms for COVID-19 should be reconsidered for the transplant patient population.
Keywords	Medicine ; Middle East respiratory syndrome coronavirus ; Coronavirus infections ; covid19
Language	English
Publisher	Elsevier
Publishing country	tr
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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