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Article ; Online: Evaluation of Metal-Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development.

Al-Ansari, Dana E / Al-Badr, Mashael / Zakaria, Zain Z / Mohamed, Nura Adam / Nasrallah, Gheyath K / Yalcin, Huseyin C / Abou-Saleh, Haissam

Toxicology reports

2022 Volume 9, Page(s) 951–960

Abstract: Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the ... ...

Abstract	Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 - 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24-72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1-10 µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30 µM
Language	English
Publishing date	2022-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.04.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development

Al-Ansari, Dana E. / Al-Badr, Mashael / Zakaria, Zain Z. / Mohamed, Nura Adam / Nasrallah, Gheyath K. / Yalcin, Huseyin C. / Abou-Saleh, Haissam

Toxicology Reports. 2022, v. 9 p.951-960

2022

Abstract	Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 - 300 µM) at 4 h post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24-72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1-10 µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30 µM). Our findings add novel information into the available data about the in vivo toxicity of nanoMIL-89 and demonstrate its innocuity and safe use in biological, environmental, and medical applications.
Keywords	Danio rerio ; cardiac output ; coordination polymers ; developmental toxicity ; environmental health ; fatty liver ; heart ; humans ; nanoparticles ; neurodevelopment ; risk ; toxicology ; viability ; Larvae ; Development ; Organ toxicity ; Nanotechnology
Language	English
Size	p. 951-960.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.04.016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy.

Benslimane, Fatiha M / Zakaria, Zain Z / Shurbaji, Samar / Abdelrasool, Mahmoud Khatib Ali / Al-Badr, Mashael Ali H I / Al Absi, Enas Said Khalil / Yalcin, Huseyin C

Micron (Oxford, England : 1993)

2020 Volume 136, Page(s) 102876

Abstract: Background: In the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function and blood flow ... ...

Abstract	Background: In the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function and blood flow hemodynamics need to be assessed to study the effects of the interference on the cardiovascular system. For heart function assessment, most important parameters include heart rate, cardiac output, ejection fraction, fractional area change, and fractional shortening. Methods: A 10 s high-speed video of beating heart and flowing blood within major vessels of zebrafish that are less than 5 days post fertilization (dpf) were recorded via a stereo microscope equipped with a high speed camera. The videos were analyzed using MicroZebraLab and image J software for the assessment of cardiac function. Results: Using the technique described here, we were able to simply yet effectively assess cardiac function and blood flow dynamics of normal zebrafish embryos. We believe that the practical method presented here will help cardiac researchers using the zebrafish as a model to examine cardiac function by using tools that could be available in their laboratory.
MeSH term(s)	Animals ; Blood Circulation ; Cardiovascular Diseases ; Cardiovascular System ; Disease Models, Animal ; Heart Rate/physiology ; Hemodynamics ; Microscopy, Video/methods ; Zebrafish/physiology
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207808-9
ISSN	1878-4291 ; 0047-7206 ; 0968-4328
ISSN (online)	1878-4291
ISSN	0047-7206 ; 0968-4328
DOI	10.1016/j.micron.2020.102876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar.

Bansal, Devendra / Atia, Hassan / Al Badr, Mashael / Nour, Mohamed / Abdulmajeed, Jazeel / Hasan, Amal / Al-Hajri, Noora / Ahmed, Lina / Ibrahim, Rumissa / Zamel, Reham / Mohamed, Almuthana / Pattalaparambil, Hamad / Daraan, Faisal / Chaudhry, Adil / Oraby, Sahar / El-Saleh, Sahar / El-Shafie, Sittana S / Al-Farsi, Affra Faiz / Paul, Jiji /

Ismail, Ahmed / Al-Romaihi, Hamad Eid / Al-Thani, Mohammed Hamad / Doi, Suhail A R / Zughaier, Susu M / Cyprian, Farhan / Farag, Elmobashar / Farooqui, Habib Hasan

Vaccines

2023 Volume 11, Issue 3

Abstract: There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term anti-S IgG antibody titers and ... ...

Abstract	There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term anti-S IgG antibody titers and their dynamics in individuals who have completed a primary COVID-19 vaccination schedule. A total of 300 male participants who received any of the following vaccines BNT162b2/Comirnaty, mRNA-1273, ChAdOx1-S/Covishield, COVID-19 Vaccine Janssen/Johnson, or BBIBP-CorV or Covaxin were enrolled in our study. All sera samples were tested by chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of IgG antibodies to SARS-CoV-2, receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2. Antibodies against SARS-CoV-2 nucleocapsid (SARS-CoV-2 N-protein IgG) were also determined. Kaplan-Meier survival curves were used to compare the time from the last dose of the primary vaccination schedule to the time by which anti-S IgG antibody titers fell into the lowest quartile (range of values collected) for the mRNA and non-mRNA vaccines. Participants vaccinated with mRNA vaccines had higher median anti-S IgG antibody titers. Participants vaccinated with the mRNA-1273 vaccine had the highest median anti-S-antibody level of 13,720.9 AU/mL (IQR 6426.5 to 30,185.6 AU/mL) followed by BNT162b2 (median, 7570.9 AU/mL; IQR, 3757.9 to 16,577.4 AU/mL); while the median anti-S antibody titer for non-mRNA vaccinated participants was 3759.7 AU/mL (IQR, 2059.7-5693.5 AU/mL). The median time to reach the lowest quartile was 3.53 months (IQR, 2.2-4.5 months) and 7.63 months (IQR, 6.3-8.4 months) for the non-mRNA vaccine recipients and Pfizer vaccine recipients, respectively. However, more than 50% of the Moderna vaccine recipients did not reach the lowest quartile by the end of the follow-up period. This evidence on anti-S IgG antibody titers should be considered for informing decisions on the durability of the neutralizing activity and thus protection against infection after the full course of primary vaccination in individuals receiving different type (mRNA verus non-mRNA) vaccines and those with natural infection.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11030496
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamics of anti-S IgG antibodies titers after the second dose of COVID 19 mRNA and non-mRNA vaccines in the manual and craft worker population of Qatar

Ismail, Ahmed / Al-Romaihi, Hamad E. / Al-Thani, Mohammed H / Doi, Suhail A.R. / Zughaier, Susu M / Cyprian, Farhan / Farag, Elmobashar / Farooqui, Habib Hasan

medRxiv

Abstract: Background: There is limited sero epidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term anti-S IgG ... ...

Abstract	Background: There is limited sero epidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term anti-S IgG antibodies titers and their dynamics in individuals who have completed a primary COVID-19 vaccination schedule. Methods: A total of 300 participants who received any of the following vaccines BNT162b2/Comirnaty or mRNA-1273 or ChAdOx1-S/Covishield or COVID-19 Vaccine Janssen/Johnson or BBIBP-CorV or Covaxin were enrolled in our study. All sera samples were tested by chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of IgG antibodies to SARS-CoV-2, receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2. Antibodies against SARS-CoV-2 nucleocapsid (SARS-CoV-2 N-protein IgG) were also determined. Kaplan-Meier survival curves were used to compare the time from the last dose of the primary vaccination schedule to the time by which anti-S IgG antibodies titers fell into the lowest quartile (range of values collected) for the mRNA and non-mRNA vaccines. Results: Participants vaccinated with mRNA vaccines had higher median anti-S IgG antibody titers. Participants vaccinated with the mRNA-1273 vaccine had the highest median anti-S-antibody level of 13720.9 AU/mL (IQR 6426.5 to 30185.6 AU/mL) followed by BNT162b2 (median, 7570.9 AU/ml; IQR, 3757.9 to 16577.4 AU/mL); while the median anti-S antibody titer for non-mRNA vaccinated participants was 3759.7 AU/mL (IQR, 2059.7-5693.5 AU/mL). The median time to reach the lowest quartile was 3.53 months (IQR, 2.2-4.5 months) and 7.63 months (IQR, 6.3-8.4 months) for the non-mRNA vaccine recipients and Pfizer vaccine recipients, respectively. However, more than 50% of the Moderna vaccine recipients did not reach the lowest quartile by the end of the follow-up period. Conclusions: This evidence on anti-S IgG antibody titers, their durability and decay over time should be considered for the utility of these assays in transmission dynamics after the full course of primary vaccination.
Keywords	covid19
Language	English
Publishing date	2022-08-25
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.08.24.22279159
Database	COVID19

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Article ; Online: One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar.

Benslimane, Fatiha M / Al Khatib, Hebah A / Al-Jamal, Ola / Albatesh, Dana / Boughattas, Sonia / Ahmed, Ayeda A / Bensaad, Meryem / Younuskunju, Shameem / Mohamoud, Yasmin A / Al Badr, Mashael / Mohamed, Abdalla A / El-Kahlout, Reham A / Al-Hamad, Tasneem / Elgakhlab, Dina / Al-Kuwari, Fatima H / Saad, Chadi / Jeremijenko, Andrew / Al-Khal, Abdullatif / Al-Maslamani, Muna A /

Bertollini, Roberto / Al-Kuwari, Einas A / Al-Romaihi, Hamad E / Al-Marri, Salih / Al-Thani, Mohammed / Badji, Radja M / Mbarek, Hamdi / Al-Sarraj, Yasser / Malek, Joel A / Ismail, Said I / Abu-Raddad, Laith J / Coyle, Peter V / Thani, Asmaa A Al / Yassine, Hadi M

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 768883

Abstract: Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected ... ...

Abstract	Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March-2021, representing 1.5% of all positive cases in this period. Despite the restrictions on international travel, the viruses sampled from the populace of Qatar mirrored nearly the entire global population's genomic diversity with nine predominant viral lineages that were sustained by local transmission chains and the emergence of mutations that are likely to have originated in Qatar. We reported an increased number of mutations and deletions in B.1.1.7 and B.1.351 lineages in a short period. These findings raise the imperative need to continue the ongoing genomic surveillance that has been an integral part of the national response to monitor the SARS-CoV-2 profile and re-emergence in Qatar.
MeSH term(s)	COVID-19 ; Disease Outbreaks ; Genomics ; Humans ; Qatar/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.768883
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One year of SARS-CoV-2: Genomic characterization of COVID-19 outbreak in Qatar

Benslimane, Fatiha M. / AlKhatib, Hebah A. / Al-Jamal, Ola / Albatesh, Dana / Boughattas, Sonia / Ahmed, Ayeda A. / Bensaad, Meryem / Younuskunju, Shameem / Mohamoud, Yasmin A. / Al Badr, Mashael / Mohamed, Abdalla A. / El Kahlout, Reham A. / Al Hamad, Tasneem / Elgakhlab, Dina / Al-Kuwari, Fatima H. / Saad, Chadi / Jeremijenko, Andrew / Al-Khal, Abdullatif / Al-Maslamani, Muna A. /

Bertollini, Roberto / Al-Kuwari, Einas A. / Al-Romaihi, Hamad E. / Al-Marri, Salih / Al-Thani, Mohammed / Badji, Radja M. / Mbarek, Hamdi / Al-Sarraj, Yasser / Malek, Joel A / Ismail, Said I. / Abu-Raddad, Laith J / Coyle, Peter / Althani, Asmaa A. / YASSINE, HADI M.

medRxiv

Abstract: Qatar, a state that has a diverse population consisting mainly of foreign residents, has experienced a large COVID19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March- ...

Abstract	Qatar, a state that has a diverse population consisting mainly of foreign residents, has experienced a large COVID19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March-2021, representing 1.5% of all positive cases in this period. Despite the restrictions on international travel, the viruses sampled from the populace of Qatar mirrored nearly the entire global population9s genomic diversity with nine predominant viral lineages that were sustained by local transmission chains and the emergence of mutations that are likely to have originated in Qatar. We reported an increased number of mutations and deletions in B.1.1.7 and B.1.351 lineages in a short period. These findings raise the imperative need to continue the ongoing genomic surveillance that has been an integral part of the national response to monitor the SARS-CoV-2 profile and re-emergence in Qatar.
Keywords	covid19
Language	English
Publishing date	2021-05-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.05.19.21257433
Database	COVID19

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Article ; Online: Evaluation of Metal-Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development.

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Article ; Online: Evaluation of Metal‐Organic Framework MIL-89 nanoparticles toxicity on embryonic zebrafish development

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Article ; Online: Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy.

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In stock of ZB MED Cologne/Königswinter

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Article: Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar.

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Article ; Online: Dynamics of anti-S IgG antibodies titers after the second dose of COVID 19 mRNA and non-mRNA vaccines in the manual and craft worker population of Qatar

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Inter-library loan at ZB MED

Article ; Online: One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar.

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Order via subito

Article ; Online: One year of SARS-CoV-2: Genomic characterization of COVID-19 outbreak in Qatar

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Kategorien

Inter-library loan at ZB MED