Article ; Online: Demographic, clinical, and outcomes of confirmed cases of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in Najran, Kingdom of Saudi Arabia (KSA); A retrospective record based study.
Journal of infection and public health
2020 Volume 13, Issue 9, Page(s) 1342–1346
Abstract: Introduction: MERS is caused by a viral infection, which was first identified in KSA, 2012. MERS-CoV infection consequences with either hospitalization or death.: Methods: All positive MERS-CoV cases that diagnosed in and reported to a referral ... ...
| Abstract | Introduction: MERS is caused by a viral infection, which was first identified in KSA, 2012. MERS-CoV infection consequences with either hospitalization or death. Methods: All positive MERS-CoV cases that diagnosed in and reported to a referral hospital in Najran, KSA from March/2014 to December/2018 were revised retrospectively. We identified patients from infection control department and medical records. Demographic, clinical, and outcome data were collected. Results: Of the 54 positive MERS-CoV cases, 3 cases were excluded because no available data. Therefore, the final number of the included cases in the study was 51 cases (94.4). Most of the patients were Saudi 36 (70.6%), and majority of cases were reported in the winter 18 (35.3) season. Fever 47 (92.2%), cough 44 (86.3%), and shortness of breath 37 (72.5%) were reported as most common symptoms. Most patients had diabetes mellitus and hypertension. Overall mortality rate was 37.3%, and interestingly the mortality rate dropped sharply over 5 years. In logistic regression analysis, Season and Chronic Kidney disease patients were the only two variables statistically significantly associated with death. The odds of death the patients infected by MERS-CoV during Autumn and Winter season were 4.09 times higher than those patients who infected during Spring and Summer season (OR = 4.09, CI 1.18-14.15, P < 0.026). Compared with MERS-CoV patients who had Non-Chronic kidney diseases, the odds of death the MERS-CoV patients who had chronic kidney diseases were 18.08 times higher (OR = 18.08, CI -2.01-162.99, P < 0.01). Conclusion: The case fatality rate of MERS-CoV infection was high. Further studies with large sample sizes are needed to explore the reasons behind the decrease in the mortality rate over the time period. |
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| MeSH term(s) | Aged ; Comorbidity ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Middle East Respiratory Syndrome Coronavirus ; Retrospective Studies ; Saudi Arabia/epidemiology ; Seasons |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-24 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2467587-8 |
| ISSN | 1876-035X ; 1876-0341 |
| ISSN (online) | 1876-035X |
| ISSN | 1876-0341 |
| DOI | 10.1016/j.jiph.2020.04.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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