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  1. Article: Long-Term Effects of Pediatric Acute Lymphoblastic Leukemia Chemotherapy: Can Recent Findings Inform Old Strategies?

    Al-Mahayri, Zeina N / AlAhmad, Mohammad M / Ali, Bassam R

    Frontiers in oncology

    2021  Volume 11, Page(s) 710163

    Abstract: During the last few decades, pediatric acute lymphoblastic leukemia (ALL) cure rates have improved significantly with rates exceeding 90%. Parallel to this remarkable improvement, there has been mounting interest in the long-term health of the survivors. ...

    Abstract During the last few decades, pediatric acute lymphoblastic leukemia (ALL) cure rates have improved significantly with rates exceeding 90%. Parallel to this remarkable improvement, there has been mounting interest in the long-term health of the survivors. Consequently, modified treatment protocols have been developed and resulted in the reduction of many adverse long-term consequences. Nevertheless, these are still substantial concerns that warrant further mitigation efforts. In the current review, pediatric-ALL survivors' late adverse events, including secondary malignant neoplasms (SMNs), cardiac toxicity, neurotoxicity, bone toxicity, hepatic dysfunction, visual changes, obesity, impact on fertility, and neurocognitive effects have been evaluated. Throughout this review, we attempted to answer a fundamental question: can the recent molecular findings mitigate pediatric-ALL chemotherapy's long-term sequelae on adult survivors? For SMNs, few genetic predisposition factors have been identified including
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.710163
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  2. Article ; Online: Current opinion on the pharmacogenomics of paclitaxel-induced toxicity.

    Al-Mahayri, Zeina N / AlAhmad, Mohammad M / Ali, Bassam R

    Expert opinion on drug metabolism & toxicology

    2021  Volume 17, Issue 7, Page(s) 785–801

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Biomarkers/metabolism ; Genome-Wide Association Study ; Humans ; Neoplasms/drug therapy ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/genetics ; Paclitaxel/administration & dosage ; Paclitaxel/adverse effects ; Paclitaxel/pharmacokinetics ; Pharmacogenetics
    Chemical Substances Antineoplastic Agents, Phytogenic ; Biomarkers ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2021.1943358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6264: Show issues Location:
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  3. Article ; Online: Value of the clinical pharmacist interventions in the application of the American College of Cardiology (ACC/AHA) 2018 guideline for cholesterol management.

    AlAhmad, Mohammad M / ZainAlAbdin, Sham / AlAhmad, Khozama / AlAhmad, Iqbal / AbuRuz, Salah

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283369

    Abstract: Objectives: The study aims to examine the extent to which the updated ACC/AHA management of blood cholesterol guideline (2018) is implemented in practice and to assess the value of the clinical pharmacist interventions in improving physicians' adherence ...

    Abstract Objectives: The study aims to examine the extent to which the updated ACC/AHA management of blood cholesterol guideline (2018) is implemented in practice and to assess the value of the clinical pharmacist interventions in improving physicians' adherence the guidelines recommendations.
    Methods: We utilized in this study an interventional before-after design. The study was conducted on 272 adult patients who visited the study site internal medicine clinics and were candidates for statin therapy based on the 2018 ACC/AHA guidelines for cholesterol management. Adherence to guideline recommendations was measured before and after clinical pharmacists' interventions by calculating the percentage of patients receiving statin therapy as per guideline recommendation, the type and intensity (moderate or high intensity) of statin therapy used, and the need for additional non-statin therapy.
    Results: Adherence with guideline recommendations was significantly improved from 60.3% to 92.6% (X2 = 79.1, p = 0.0001) after clinical pharmacist interventions. Among patients who were on statin therapy, the percentage of those who were on proper statin intensity increased significantly from 47.6% to 94.4% (X2 = 72.5, p = 0.0001). The combination of statins with non-statin therapies such as ezetimibe and PCSK9 inhibitors increased from 8.5% to 30.6% (X2 = 95, p<0.0001) and from 0.0% to 1.6% (X2 = 6, p = 0.014), respectively. The use of other lipid-lowering agents was diminished from 14.6% to 3.2% (X2 = 19.2, p<0.0001).
    Conclusion: Collaboration between physicians and clinical pharmacists is a crucial strategy to improve patients' treatment and hence, achieve better health outcomes among patients suffering from dyslipidemia.
    MeSH term(s) Adult ; Humans ; United States ; Proprotein Convertase 9 ; Pharmacists ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/chemically induced ; Cardiovascular Diseases ; Cholesterol ; Cardiology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Guideline Adherence
    Chemical Substances PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol (97C5T2UQ7J) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283369
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  4. Article: Antimicrobial Stewardship Practices of Community Pharmacists in United Arab Emirates.

    AlAhmad, Mohammad M / Rabbani, Syed Arman / Al-Salman, Remah / Alameri, Hiba / Al Namer, Yamama / Jaber, Ammar Ali Saleh

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: Background: The purpose of this paper is to assess the implementation of antimicrobial stewardship (AMS) activities in community pharmacies in the United Arab Emirates (UAE).: Methods: A descriptive cross-sectional study in the Emirate of Abu Dhabi, ... ...

    Abstract Background: The purpose of this paper is to assess the implementation of antimicrobial stewardship (AMS) activities in community pharmacies in the United Arab Emirates (UAE).
    Methods: A descriptive cross-sectional study in the Emirate of Abu Dhabi, UAE, was conducted using a validated questionnaire. The questionnaire consisted of four AMS outpatient core elements, namely, commitment, action, tracking and reporting, and education and expertise, with each element containing different associated items. Pharmacy teams' responses were categorized into three levels: low, satisfactory, or high.
    Results: Fifty-five pharmacy teams participated. Respondents confirmed implementation of at least one item of each AMS outpatient core element: commitment (94.5%), action (94.5%), tracking and reporting (67.3%), and education and expertise (81.8%). In supporting AMS implementation, surveyed teams scored high (81.8%) for action, satisfactory (65.5%) for education and expertise, low (43.6%) for tracking and reporting, and satisfactory (76.4%) for commitment. Attending antimicrobial stewardship programs was found to be a statistically significant predictor of implementation of antimicrobial stewardship activities (
    Conclusions: The majority of community pharmacies met the core elements of outpatient antimicrobial stewardship to some degree. There is a significant association between participation in antimicrobial stewardship programs and implementation of antimicrobial stewardship activities by pharmacists in practice.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081238
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  5. Article: Are we ready yet for digital transformation? Virtual versus on-campus OSCE as assessment tools in pharmacy education. A randomized controlled head-to-head comparative assessment.

    Kharaba, Zelal / AlAhmad, Mohammad M / Ahmed Elnour, Asim / Abou Hajal, Abdallah / Abumweis, Suhad / Ghattas, Mohammad A

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2023  Volume 31, Issue 3, Page(s) 359–369

    Abstract: Background: The global COVID-19 pandemic has influenced pharmacy education including learning, assessment, and exams. In the UAE, pharmacy instructors have adapted several innovative teaching methods to strive for quality learning outcomes. The current ... ...

    Abstract Background: The global COVID-19 pandemic has influenced pharmacy education including learning, assessment, and exams. In the UAE, pharmacy instructors have adapted several innovative teaching methods to strive for quality learning outcomes. The current trial presented a head-to-head comparative assessment between on-campus versus virtual Objective Structured Clinical Examination (OSCE) with examiners' and students' perspectives.
    Aim: The main aim was to compare fourth-year students' and examiners' perceptions of the feasibility (time and logistics), stress, performance, and satisfaction between on-campus versus virtual OSCE.
    Method: A randomized controlled head-to-head comparative assessment between the On-campus and virtual OSCE was conducted to explore performance and satisfaction of pharmacy students and examiners towards the two OSCE settings. The virtual OSCE was carried out directly after the on-campus -OSCE and the setting was designed in a way that aligned with the on-campus OSCE but in a virtual way. Microsoft Teams® breakout room was used as a virtual stations. Respondus-lockdown-browse and Google Meet® were used for proctoring purposes.
    Results: Students who sat for the on-campus assessment were more satisfied with the instructions, the orientation session, the time management, and the overall exam setting, the ability of the exam to assess their communication and clinical skills, professionalism and attitude, and the interactivity of the exam compared to the students who sat for the virtual assessment. Examiners' perceptions for both settings were the same with the exception of interaction with students (p less than 0.05) as the on-campus OSCE was more interactive.
    Conclusion: Students still prefer the on-campus OSCE to the virtual OSCE format in many aspects. Nevertheless, virtual OSCE is still a feasible and satisfactory method of assessment when on-campus OSCE is not possible. There is a need of a specialized platform to conduct the virtual OSCE from A to Z rather than maximizing the use of options in the current digital platforms.
    Language English
    Publishing date 2023-01-25
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2023.01.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4758: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The impact of community-pharmacist-led medication reconciliation process: Pharmacist-patient-centered medication reconciliation.

    AlAhmad, Mohammad M / Majed, Iqbal / Sikh, Nour / AlAhmad, Khozama

    Journal of pharmacy & bioallied sciences

    2020  Volume 12, Issue 2, Page(s) 177–182

    Abstract: Background and purpose: Patients and their healthcare providers' are in need to access a correct and complete list of all patients' active bills for safe and effective clinical care. Currently, Healthcare Information Systems are not providing a proper ... ...

    Abstract Background and purpose: Patients and their healthcare providers' are in need to access a correct and complete list of all patients' active bills for safe and effective clinical care. Currently, Healthcare Information Systems are not providing a proper access to the patients' medications lists. Thus, this study aimed to evaluate the impact of community pharmacist-led medication reconciliation process in community pharmacies in the UAE through applying a pharmacist-patient-centered medication reconciliation (PPCMR).
    Materials and methods: This was an interventional study of medication reconciliation process in 25 pharmacies in the UAE during July 1, 2019 till September 1, 2019. The participant pharmacists were surveyed and interviewed to gather more information about the barriers and enablers of the process before and after the implementation of PPCMR.
    Results: After the implementation of PPCMR, medication reconciliation service was available in 84% of the pharmacies compared to 40% before the PPCMR (
    Conclusion: Community pharmacists are not always accessible or well placed to provide a medication reconciliation service. The implementation of PPCMR in each community pharmacy will raise the expectations regarding the appropriateness of medication management and use.
    Language English
    Publishing date 2020-04-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.JPBS_55_20
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  7. Article: A Comparison of 3D Conformal and Deep Inspiratory Breath Holding vs. 4D-CT Intensity-Modulated Radiation Therapy for Patients with Left Breast Cancer.

    Aldaly, Moustafa / Hussien, Azza / El-Nadi, Inas Mohsen / Laz, Nabila Ibrahim / Said, Amira S A / Al-Ahmad, Mohammad M / Hussein, Raghda R S / Rabie, Al Shaimaa Ibrahim / Shaaban, Ahmed Hassan

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Background: Multimodality is required for the treatment of breast cancer. Surgery, radiation (RT), and systemic therapy were traditionally used. Pharmacotherapy includes different drug mechanisms, such as chemotherapy, hormone therapy, and targeted ... ...

    Abstract Background: Multimodality is required for the treatment of breast cancer. Surgery, radiation (RT), and systemic therapy were traditionally used. Pharmacotherapy includes different drug mechanisms, such as chemotherapy, hormone therapy, and targeted therapies, alone or in combination with radiotherapy. While radiation offers numerous benefits, it also has certain harmful risks. such as cardiac and pulmonary toxicity, lymphedema, and secondary cancer. Modern radiation techniques have been developed to reduce organs at risk (OAR) doses.
    Materials and methods: This study is a prospective feasibility trial conducted at the Fayium Oncology Center on patients with left breast cancer receiving adjuvant locoregional radiotherapy after either breast conservative surgery (BCS) or modified radical mastectomy (MRM). This study aimed to assess the proportion of patients who are fit both physically and intellectually to undergo breast radiotherapy using the deep inspiratory breath-holding (DIBH) technique, comparing different dosimetric outcomes between the 3D dimensional conformal with DIBH and 4D-CT IMRT plans of the same patient.
    Results: D95 of the clinical target volume (CTV) of the target is significantly higher in the 3D DIBH plan than in the IMRT plan, with an average of 90.812% vs. 86.944%. The dosimetry of the mean heart dose (MHD) in the 4D-CT IMRT plan was significantly lower than in the 3D conformal with the DIBH plan (2.6224 vs. 4.056 Gy,
    Conclusions: Radiotherapy of the breast and chest wall with the 4D-CT IMRT technique appears not to be inferior to the 3D conformal with the DIBH technique and can be used as an alternative to the 3D conformal with the DIBH technique in patients meeting the exclusion criteria for performing the DIBH maneuver concerning coverage to target volumes or unacceptably high doses to OAR.
    Language English
    Publishing date 2023-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245799
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  8. Article: COVID-19's Psychological Impact on Chronic Disease Patients Seeking Medical Care.

    Salah, Hager / Ibrahim Rabie, A L Shaimaa / Said, Amira S A / AlAhmad, Mohammad M / Shaaban, Ahmed Hassan / Khalil, Doaa Mahmoud / Hussein, Raghda R S / Khodary, Azza

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 6

    Abstract: Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. The pandemic's psychological impact is thought to change their routine of seeking medical care. Research Question or Hypothesis: During COVID-19, patients ... ...

    Abstract Background: The outbreak has harmed patients with multiple comorbidities and chronic conditions. The pandemic's psychological impact is thought to change their routine of seeking medical care. Research Question or Hypothesis: During COVID-19, patients with chronic conditions may experience anxiety, depression, and stress, and their pattern of seeking medical care may change.
    Materials and methods: In May 2021, a cross-sectional, web-based study of patients with chronic diseases was conducted. Eligible patients (1036) were assessed for psychological disorders, primarily depression, stress, and anxiety, using the DASS-21 scale, and their pattern of receiving medical care during COVID-19.
    Results: During the pandemic, 52.5% of the patients with chronic diseases were depressed, 57.9% were anxious, and 35.6% were stressed. Patients with chronic diseases who had moderate to severe depression (34.9% versus 45.1%,
    Conclusions: Patients with chronic conditions experienced significant anxiety, depression, and stress during COVID-19, which changed their pattern of seeking medical care, and the majority of them did not receive follow-up for their chronic conditions.
    Language English
    Publishing date 2023-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11060888
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  9. Article ; Online: Assessment of Prescribing Practices and Factors Related to Antibiotic Prescribing in Community Pharmacies.

    Rabbani, Syed Arman / Sridhar, Sathvik B / Safdar, Maryam / Rao, Padma G M / Jaber, Ammar Ali Saleh / AlAhmad, Mohammad M / Shaar, Khaled / Emad, Israa / Azim, Muhammad Abdul

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 5

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Child ; Adolescent ; Humans ; Anti-Bacterial Agents/therapeutic use ; Pharmacies ; Cross-Sectional Studies ; Drug Prescriptions ; World Health Organization
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050843
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  10. Article: COVID-19 Booster Doses: A Multi-Center Study Reflecting Healthcare Providers' Perceptions.

    Salah, Hager / Sinan, Israa / Alsamani, Omar / Abdelghani, Lamyaa Samir / ElLithy, May Hassan / Bukamal, Nazar / Jawad, Huda / Hussein, Raghda R S / Elgendy, Marwa O / Rabie, Al Shaimaa Ibrahim / Khalil, Doaa Mahmoud / Said, Amira S A / AlAhmad, Mohammad M / Khodary, Azza

    Vaccines

    2023  Volume 11, Issue 6

    Abstract: 1) Background: During 2019, the COVID-19 pandemic was threatening healthcare services and workers, and acquiring immunity was an option to stop or limit the burden of this pandemic. Herd immunity was a top priority worldwide as the virus was spreading ... ...

    Abstract (1) Background: During 2019, the COVID-19 pandemic was threatening healthcare services and workers, and acquiring immunity was an option to stop or limit the burden of this pandemic. Herd immunity was a top priority worldwide as the virus was spreading rapidly. It was estimated that 67% of the total global population should be immunized against COVID-19 to achieve herd immunity. The aim of the current study is to investigate different perceptions of healthcare workers in the Kingdom of Bahrain and Egypt using an online survey in an attempt to evaluate their awareness and concerns regarding new variants and booster doses. (2) Methods: This study conducted a survey on healthcare workers in the Kingdom of Bahrain and Egypt about their perception and concerns on the COVID-19 vaccines. (3) Results: The study found that out of 389 healthcare workers 46.1% of the physicians were not willing to take the booster doses (
    Language English
    Publishing date 2023-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11061061
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