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  1. AU="Al-Asady, Abdulridha Mohammed"
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  1. Article: Differential effects of antiseizure medications on neurogenesis: Evidence from cells to animals.

    Alavi, Mohaddeseh Sadat / Al-Asady, Abdulridha Mohammed / Fanoudi, Sahar / Sadeghnia, Hamid R

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26650

    Abstract: Neurogenesis, the process of generating functionally integrated neurons from neural stem and progenitor cells, is involved in brain development during embryonic stages but continues throughout life. Adult neurogenesis plays essential roles in many brain ... ...

    Abstract Neurogenesis, the process of generating functionally integrated neurons from neural stem and progenitor cells, is involved in brain development during embryonic stages but continues throughout life. Adult neurogenesis plays essential roles in many brain functions such as cognition, brain plasticity, and repair. Abnormalities in neurogenesis have been described in many neuropsychiatric and neurological disorders, including epilepsy. While sharing a common property of suppressing seizures, accumulating evidence has shown that some antiseizure medications (ASM) exhibit neuroprotective potential in the non-epileptic models including Parkinson's disease, Alzheimer's disease, cerebral ischemia, or traumatic brain injury. ASM are a heterogeneous group of medications with different mechanisms of actions. Therefore, it remains to be revealed whether neurogenesis is a class effect or related to them all. In this comprehensive literature study, we reviewed the literature data on the influence of ASM on the neurogenesis process during brain development and also in the adult brain under physiological or pathological conditions. Meanwhile, we discussed the underlying mechanisms associated with the neurogenic effects of ASM by linking the reported
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Niosomes as a Promising Therapeutic Approach against Colorectal Cancer: A Focus on the Delivery of Chemotherapeutics and Natural Products.

    Mollazadeh, Samaneh / Al-Asady, Abdulridha Mohammed / Barjasteh, Amirhosein / Latifi, Hanieh / Avan, Amir / Khazaei, Majid / Ryzhikov, Mikhail / Hassanian, Seyed Mahdi

    Current pharmaceutical design

    2024  

    Abstract: Nanotechnology has emerged as an effective approach to cancer treatment, including Colorectal Cancer (CRC). While conventional treatments, such as chemotherapeutic agents, are used to manage CRC, their efficacy can be improved using drug delivery systems ...

    Abstract Nanotechnology has emerged as an effective approach to cancer treatment, including Colorectal Cancer (CRC). While conventional treatments, such as chemotherapeutic agents, are used to manage CRC, their efficacy can be improved using drug delivery systems that enhance their bioavailability and reduce side effects. Niosomes, polymeric nanoparticles, have shown promise as biocompatible vehicles that can transport hydrophilic and lipophilic molecules. This can result in reduced drug dosage and increased efficacy. This review examines the use of niosomal formulations as a delivery platform for treating CRC and provides practical insights into their clinical applications.
    Language English
    Publishing date 2024-05-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128303645240429052835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights.

    Soleimani, Atena / Saeedi, Nikoo / Al-Asady, Abdulridha Mohammed / Nazari, Elnaz / Hanaie, Reyhane / Khazaei, Majid / Ghorbani, Elnaz / Akbarzade, Hamed / Ryzhikov, Mikhail / Avan, Amir / Mehr, Seyed Mahdi Hasanian

    Current pharmaceutical design

    2024  

    Abstract: Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface ...

    Abstract Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.
    Language English
    Publishing date 2024-04-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128291321240329050945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Advancing Novel Strategies against Post-surgical Tendon Adhesion Bands, Exploring New Frontiers.

    Alaei, Maryam / Abdulhasan, Doaa Jawad-Kadhim / Barjasteh, Amir Hossein / Al-Asady, Abdulridha Mohammed / Latifi, Hanieh / Vahedi, Ehsan / Avan, Amir / Khazaei, Majid / Ryzhikov, Mikhail / Hassanian, Seyed Mahdi

    Current pharmaceutical design

    2024  

    Abstract: Current interest in adhesion formation stems from its global impact on the function and quality of life, spanning a spectrum of subtle impairments to significant disabilities, based on the affected area and the extent of adhesion. Yet therapeutic agents ... ...

    Abstract Current interest in adhesion formation stems from its global impact on the function and quality of life, spanning a spectrum of subtle impairments to significant disabilities, based on the affected area and the extent of adhesion. Yet therapeutic agents are restricted to prophylactic anti-inflammatories, revision surgeries, and biological and physical techniques, none of which grant a decent outcome. Recent advancements in tissue- engineered biomaterials, drug delivery systems, and fabricating technologies such as nanoparticles, hydrogels, and weaving or braiding demonstrate potential for improved outcomes. However, none of the mentioned methods have reliable outcomes, thus this study aims to elucidate the mechanisms involved in the pathophysiology of tendon adhesion and post-surgical adhesion band formation (PSAB), with a closer look at inflammatory pathways stimulating the process. This article consolidates information on diverse therapeutic and prophylactic methods and cutting-edge technologies, aiming to provide a comprehensive update on this topic, and providing researchers an avenue for new and innovative ideas for further investigations.
    Language English
    Publishing date 2024-05-06
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128299091240423121840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Therapeutic potency of A1 adenosine receptor antagonists in the treatment of cardiovascular diseases, current status and perspectives.

    Bahreyni, Amirhossein / Saeedi, Nikoo / Al-Asady, Abdulridha Mohammed / Soleimani, Atena / Ghorbani, Elnaz / Khazaei, Majid / Alaei, Maryam / Hanaei, Reyhane / Ryzhikov, Mikhail / Avan, Amir / Hassanian, Seyed Mahdi

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 358

    Abstract: Background: Cardiomyocytes form, transport, and metabolize the omnipresent metabolite adenosine. Depending upon the adenosine concentrations and the pharmacological properties of receptor subtypes, adenosine exerts (patho)physiological responses in the ... ...

    Abstract Background: Cardiomyocytes form, transport, and metabolize the omnipresent metabolite adenosine. Depending upon the adenosine concentrations and the pharmacological properties of receptor subtypes, adenosine exerts (patho)physiological responses in the cardiovascular system. The objective of this review is to present different protective mechanisms of A1-adenosine receptor inhibitors in cardiovascular diseases.
    Methods and results: Literature references were collected and sorted using relevant keywords and key phrases as search terms in scientific databases such as Web of Science, PubMed and Google Scholar. A1 adenosine receptor regulates free fatty acid metabolism, lipolysis, heart rate, blood pressure, and cardiovascular toxicity. The evidence clearly supporting the therapeutic potency of pharmacological A1 adenosine receptors agonists and antagonists in modulating cardiovascular risk factor parameters and treatment of cardiovascular diseases.
    Conclusion: This review summarizes the protective role of pharmacological A1-adenosine receptor regulators in the pathogenesis of cardiovascular diseases for a better management of cardiovascular diseases.
    MeSH term(s) Humans ; Purinergic P1 Receptor Antagonists/pharmacology ; Cardiovascular Diseases/drug therapy ; Blood Pressure ; Adenosine ; Receptors, Purinergic P1
    Chemical Substances Purinergic P1 Receptor Antagonists ; Adenosine (K72T3FS567) ; Receptors, Purinergic P1
    Language English
    Publishing date 2024-02-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09246-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer.

    Binabaj, Maryam Moradi / Asgharzadeh, Fereshteh / Rahmani, Farzad / Al-Asady, Abdulridha Mohammed / Hashemzehi, Milad / Soleimani, Atena / Avan, Amir / Mehraban, Saeedeh / Ghorbani, Elnaz / Ryzhikov, Mikhail / Khazaei, Majid / Hassanian, Seyed Mahdi

    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

    2023  Volume 31, Issue 2, Page(s) 193–203

    Abstract: Background: Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogenesis. The aim of the current study is to investigate the therapeutic potential of Vactosertib (EW-7197), a selective ... ...

    Abstract Background: Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogenesis. The aim of the current study is to investigate the therapeutic potential of Vactosertib (EW-7197), a selective inhibitor of TGF-β receptor type I, either alone or in combination with the standard first-line chemotherapeutic treatment, 5-Fluorouracil (5-FU), in CRC progression in both cellular and animal models.
    Methods: Real-Time PCR, Zymography, enzyme-linked immunosorbent assay (ELISA), Hematoxylin and Eosin (H&E) tissue staining, and Flow cytometry techniques were applied to determine the anti-tumor properties of this novel TGF-β inhibitor in in vitro (CT-26 cell line) and in vivo (inbred BALB/C mice) samples.
    Results: Our findings showed that Vactosertib decreased cell proliferation and induced spheroid shrinkage. Moreover, this inhibitor suppressed the cell cycle and its administration either alone or in combination with 5-FU induced apoptosis by regulating the expression of p53 and BAX proteins. It also improved 5-FU anti-cancer effects by decreasing the tumor volume and weight, increasing tumor necrosis, and regulating tumor fibrosis and inflammation in an animal model. Vactosertib also enhanced the inhibitory effect of 5-FU on invasive behavior of CRC cells by upregulating the expression of E-cadherin and inhibiting MMP-9 enzymatic activity.
    Conclusion: This study demonstrating the potent anti-tumor effects of Vactosertib against CRC progression. Our results clearly suggest that this inhibitor could be a promising agent reducing CRC tumor progression when administered either alone or in combination with standard treatment in CRC patients.
    MeSH term(s) Mice ; Animals ; Humans ; Colorectal Neoplasms/drug therapy ; Mice, Inbred BALB C ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Colonic Neoplasms/drug therapy ; Apoptosis ; Cell Proliferation ; Transforming Growth Factor beta/pharmacology ; Transforming Growth Factor beta/therapeutic use ; Cell Line, Tumor
    Chemical Substances vactosertib (6T4O391P5Y) ; Fluorouracil (U3P01618RT) ; Transforming Growth Factor beta
    Language English
    Publishing date 2023-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2129183-4
    ISSN 2008-2231 ; 1560-8115
    ISSN (online) 2008-2231
    ISSN 1560-8115
    DOI 10.1007/s40199-023-00474-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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