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Article ; Online: Colchicine for the prevention of ischemic stroke: An updated meta-analysis of randomized clinical trials.

Al-Atta, Ayman / Kuzemczak, Michał / Alkhalil, Mohammad

2021 Volume 7, Issue 3, Page(s) 187–193

Abstract: Background: Inflammation is increasingly recognized as a target to reduce residual cardiovascular risk. Colchicine is an anti-inflammatory drug that was associated with improved cardiovascular outcomes. However, its effect on stroke reduction was not ... ...

Abstract	Background: Inflammation is increasingly recognized as a target to reduce residual cardiovascular risk. Colchicine is an anti-inflammatory drug that was associated with improved cardiovascular outcomes. However, its effect on stroke reduction was not consistent across studies. Therefore, the aim of this study-level meta-analysis was to evaluate the influence of colchicine on stroke in patients with coronary artery disease (CAD). Methods: Electronic databases were searched through October 2020, to identify randomized controlled trials using colchicine in patients with CAD. The incidence of clinical endpoints such as stroke, death, myocardial infarction (MI), study-defined major adverse cardiovascular events (MACE), and atrial fibrillation (AF) was compared between colchicine and placebo groups. Results: A total number of 11,594 (5,806 in the colchicine arm) patients from 4 eligible studies were included in the final analysis. Stroke incidence was lower in the colchicine arm compared to placebo (rate ratio [RR] 0.48 [95% confidence interval [CI], 0.29-0.78], Conclusions: This meta-analysis confirms a significant influence of colchicine on stroke in CAD patients. Despite its neutral effect on AF occurrence, other mechanisms related to plaque stabilization are plausible. The concept seems to be supported by contemporaneous MI reduction and posits that anti-inflammatory properties of colchicine may translate into a reduction of stroke risk.
Language	English
Publishing date	2021-08-27
Publishing country	India
Document type	Journal Article
ZDB-ID	2950273-1
ISSN	2455-4626 ; 2394-8108
ISSN (online)	2455-4626
ISSN	2394-8108
DOI	10.4103/bc.bc_24_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Meta-analysis Comparing Long-Term Clinical Outcomes of Percutaneous Coronary Intervention versus no Intervention in Patients with Chronic Total Occlusion.

Ibrahem, Abdalazeem / Farag, Mohamed / Gue, Ying X / Spinthakis, Nikolaos / Al-Atta, Ayman / Egred, Mohaned

Heart views : the official journal of the Gulf Heart Association

2023 Volume 24, Issue 2, Page(s) 104–108

Abstract: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has substantially improved due to increasing operator experience and advancements in equipment, techniques, and management algorithms. However, the overall benefit of CTO PCI remains ... ...

Abstract	Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has substantially improved due to increasing operator experience and advancements in equipment, techniques, and management algorithms. However, the overall benefit of CTO PCI remains controversial, particularly since only a few randomized trials have been reported to date. Methods: We performed a meta-analysis to evaluate the efficacy of CTO PCI. The study outcomes were the occurrence of all-cause mortality, myocardial infarction, repeat revascularization, stroke, or freedom from angina at the longest documented follow-up period. Results: In five trials including 1790 patients, the mean age was 63 ± 10 years, 17% were female, with a median follow-up of 2.9 years. The procedural success rate ranged from 73% to 97% and the right coronary artery was the most involved artery (52%). There was no significant difference between CTO PCI and no intervention regarding all-cause mortality (odds ratio [OR]: 1.10, 95% confidence interval [CI]: 0.49-2.47, Conclusions: CTO PCI appears to have a similar efficacy profile compared to no intervention at long-term follow-up, but with a significant improvement of angina favoring PCI-treated patients. Further adequately powered and long-term trials are required to identify the best management strategy for patients with coronary CTO.
Language	English
Publishing date	2023-03-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2575257-1
ISSN	0976-5123 ; 1995-705X
ISSN (online)	0976-5123
ISSN	1995-705X
DOI	10.4103/heartviews.heartviews_82_22
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Article ; Online: Arginine Vasopressin Plays a Role in Microvascular Dysfunction After ST-Elevation Myocardial Infarction.

Al-Atta, Ayman / Spray, Luke / Mohammed, Ashfaq / Shmeleva, Evgeniya / Spyridopoulos, Ioakim

Journal of the American Heart Association

2023 Volume 12, Issue 18, Page(s) e030473

Abstract: Background Coronary microvascular dysfunction (CMD) predicts mortality after ST-elevation-myocardial infarction (STEMI). Arginine vasopressin (AVP) may be implicated, but data in humans are lacking, and no study has investigated the link between arginine ...

Abstract	Background Coronary microvascular dysfunction (CMD) predicts mortality after ST-elevation-myocardial infarction (STEMI). Arginine vasopressin (AVP) may be implicated, but data in humans are lacking, and no study has investigated the link between arginine vasopressin and invasive measures of CMD. Methods and Results We invasively assessed CMD in 55 patients with STEMI treated with primary percutaneous coronary intervention (PPCI), by measuring the index of microcirculatory resistance after PPCI. In a separate group of 45 patients with STEMI/PPCI, recruited for a clinical trial, we measured infarct size and microvascular obstruction with cardiac magnetic resonance (CMR) imaging at 1 week and 12 weeks post-STEMI. Serum copeptin was measured at 4 time points before and after PPCI in all patients with STEMI. Plasma copeptin levels fell from 92.5 pmol/L before reperfusion to 6.4 pmol/L at 24 hours. Copeptin inversely correlated with diastolic, but not systolic, blood pressure (r=-0.431,
MeSH term(s)	Humans ; Arginine Vasopressin ; ST Elevation Myocardial Infarction/therapy ; Microcirculation ; Myocardial Ischemia ; Coronary Artery Disease
Chemical Substances	Arginine Vasopressin (113-79-1)
Language	English
Publishing date	2023-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.030473
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Article: Intensive lipid-lowering therapy, time to think beyond low-density lipoprotein cholesterol.

Abdalwahab, Ahmed / Al-Atta, Ayman / Zaman, Azfar / Alkhalil, Mohammad

World journal of cardiology

2021 Volume 13, Issue 9, Page(s) 472–482

Abstract: Statins have been shown to be effective in reducing cardiovascular events. Their magnitude of benefits has been proportionate to the reduction in low-density lipoprotein cholesterol (LDL-c). Intensive lipid-lowering therapies using ezetimibe and more ... ...

Abstract	Statins have been shown to be effective in reducing cardiovascular events. Their magnitude of benefits has been proportionate to the reduction in low-density lipoprotein cholesterol (LDL-c). Intensive lipid-lowering therapies using ezetimibe and more recently proprotein convertase subtilisin kexin 9 inhibitors have further improved clinical outcomes. Unselective application of these treatments is undesirable and unaffordable and, therefore, has been guided by LDL-c level. Nonetheless, the residual risk in the post-statin era is markedly heterogeneous, including thrombosis and inflammation risks. Moreover, the lipo-protein related risk is increasingly recognised to be related to other non-LDL-c markers such as Lp(a). Emerging data show that intensive lipid-lowering therapy produce larger absolute risk reduction in patients with polyvascular disease, post coronary artery bypass graft and diabetes. Notably, these clinical entities share similar phenotype of large burden of atherosclerotic plaques. Novel plaque imaging may aid decision making by identifying patients with propensity to develop lipid rich plagues at multi-vascular sites. Those patients may be suitable candidates for intensive lipid lowering treatment.
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573665-6
ISSN	1949-8462
ISSN	1949-8462
DOI	10.4330/wjc.v13.i9.472
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Article ; Online: Clinical outcomes of percutaneous coronary intervention in high-risk patients turned down for surgical revascularization.

Farag, Mohamed / Al-Atta, Ayman / Abdalazeem, Ibrahem / Salim, Tarik / Alkhalil, Mohammad / Egred, Mohaned

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2022 Volume 100, Issue 3, Page(s) 360–366

Abstract: Aims: There are limited data on outcomes of PCI in surgical turndown patientsespecially in those presenting with ACS.: Methods and results: A retrospective analysis of prospectively collected data of patients who were turned down for CABG and had PCI ...

Abstract	Aims: There are limited data on outcomes of PCI in surgical turndown patientsespecially in those presenting with ACS. Methods and results: A retrospective analysis of prospectively collected data of patients who were turned down for CABG and had PCI between 2013 and 2020. All consecutive patients (449), ACS (n = 245) and no-ACS (n = 204) were included. In-hospital complications occurred in 28 patients (6.2%). At 30 days, 27 patients (6.0%) died (18 patients in the ACS group [7.3%] vs. 9 patients in the no-ACS group [4.4%], p = 0.23). Following multivariate analysis, no significant difference in long-term mortality was observed between the two groups (median follow-up of 4 [2-6] years, hazard ratio [HR]: 1.08, 95% confidence interval [CI]: 0.75-1.58, p = 0.667). In propensity score-matched analysis, the adjusted mortality risk was also not different between the groups (HR: 0.74, 95% CI: 0.25-1.26, p = 0.374). Independent predictors of mortality included chronic kidney disease stage ≥ 3 (HR: 1.64, 95% CI: 1.13-2.39, p = 0.009), high European System for Cardiac Operative Risk Evaluation II (HR: 1.02, 95% CI: 1.00-1.05, p = 0.035), and laser atherectomy use (HR: 3.35, 95% CI: 1.32-8.54, p = 0.011). Conclusions: PCI in surgical patients turndown patients appears safe. ACSpresentation was associated with more comorbid illnesses; however, afteradjustment, ACS did not independently confer additional risk of mortality.
MeSH term(s)	Coronary Artery Bypass ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Humans ; Percutaneous Coronary Intervention ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30318
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Article: Coronary revascularization in patients with left ventricle systolic dysfunction, current challenges and clinical outcomes.

Abdalwahab, Ahmed / Al-Atta, Ayman / Egred, Mohaned / Alkhalil, Mohammad / Zaman, Azfar

Reviews in cardiovascular medicine

2022 Volume 23, Issue 1, Page(s) 33

Abstract: The effects of coronary revascularization in patients with left ventricle systolic dysfunction (LVSD) are not well studied. The decision about revascularization and its timing remain challenging, not only related to procedural risk, but also linked to ... ...

Abstract	The effects of coronary revascularization in patients with left ventricle systolic dysfunction (LVSD) are not well studied. The decision about revascularization and its timing remain challenging, not only related to procedural risk, but also linked to other several limitations including assessment of ischemia, viability, and ability to predict LV recovery. The role of viability as a prognostic marker for patients with LVSD and its use as a therapeutic target remains debatable. In this article, we will review the role of LVSD in patients undergoing coronary revascularization alongside the role of ischemia and viability assessment. We will provide a review of the literature on the outcomes of coronary revascularization, both surgically and percutaneously, in patients with LVSD.
MeSH term(s)	Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Heart Ventricles ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology
Language	English
Publishing date	2022-01-29
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2108910-3
ISSN	1530-6550
ISSN	1530-6550
DOI	10.31083/j.rcm2301033
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Zs.A 6410: Show issues

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Article ; Online: Accessory Mitral Valve Tissue Causing Features Of Left Ventricular Outflow Tract Obstruction-A Case Report And Updated Literature Review.

Al-Atta, Ayman / Khan, Habib / Sosin, Michael

Journal of Ayub Medical College, Abbottabad : JAMC

2019 Volume 31, Issue 2, Page(s) 276–278

Abstract: Accessory mitral valve tissue is a rare congenital anomaly that is commonly incidentally diagnosed. When symptomatic, it tends to present with features of left ventricular outflow (LVOT) obstruction in about two thirds of cases. It is also commonly ... ...

Abstract	Accessory mitral valve tissue is a rare congenital anomaly that is commonly incidentally diagnosed. When symptomatic, it tends to present with features of left ventricular outflow (LVOT) obstruction in about two thirds of cases. It is also commonly associated with other congenital anomalies, notably ventricular septal defects. Transthoracic echocardiography is a very useful diagnostic test to make a diagnosis and its widespread use will increase detection of this condition. We are presenting a case of a 29-year-old lady who presented with breathlessness in the third trimester of pregnancy and was subsequently found to have evidence of accessory mitral valve tissue on echocardiography.
MeSH term(s)	Adult ; Dyspnea/etiology ; Echocardiography ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/physiopathology ; Humans ; Mitral Valve/abnormalities ; Mitral Valve/diagnostic imaging ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnostic imaging ; Pregnancy Complications, Cardiovascular/physiopathology
Language	English
Publishing date	2019-05-15
Publishing country	Pakistan
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6109: Show issues

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Article ; Online: Prognostic Role of Sex-Specific Flow Threshold in Patients UndergoingTranscatheter Aortic Valve Replacement.

Jeyalan, Visvesh / Al-Atta, Ayman / Das, Rajiv / Edwards, Richard / Zaman, Azfar / Alkhalil, Mohammad

Cardiovascular revascularization medicine : including molecular interventions

2021 Volume 36, Page(s) 164–165

MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Female ; Heart Valve Prosthesis ; Humans ; Male ; Prognosis ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Letter
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2021.05.002
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Zs.A 5562: Show issues

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Article: Mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock.

Al-Atta, Ayman / Zaidan, Mohammad / Abdalwahab, Ahmed / Asswad, Amjad Ghazal / Egred, Mohaned / Zaman, Azfar / Alkhalil, Mohammad

Reviews in cardiovascular medicine

2022 Volume 23, Issue 2, Page(s) 71

Abstract: Patients with acute myocardial infarction (MI) complicated by cardiogenic shock (CS) have poor prognosis. Over the last two decades, there has been some improvement in mortality rates associated with CS. Initial measures to stabilise patients should ... ...

Abstract	Patients with acute myocardial infarction (MI) complicated by cardiogenic shock (CS) have poor prognosis. Over the last two decades, there has been some improvement in mortality rates associated with CS. Initial measures to stabilise patients should follow a shock protocol, including therapies such as volume expansion, inotropes/vasopressors, and early coronary revascularisation. The use of mechanical circulatory support (MCS) devices demonstrated better haemodynamic and metabolic profiles for patients with CS. However, these benefits have not been consistently translated into significant reductions in cardiovascular adverse events. This review aims to discuss emerging concepts related to CS including an update on its classification and pathophysiology. The focus is on recent evidence regarding the use of MCS and the timing of initiating in patients with CS.
MeSH term(s)	Heart-Assist Devices/adverse effects ; Humans ; Intra-Aortic Balloon Pumping ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Treatment Outcome
Language	English
Publishing date	2022-02-28
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2108910-3
ISSN	1530-6550
ISSN	1530-6550
DOI	10.31083/j.rcm2302071
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Zs.A 6410: Show issues

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Article ; Online: Magnetic Resonance Left Ventricle Mass-Index/Fibrosis: Long-Term Predictors for Ventricular Arrhythmia in Hypertrophic Cardiomyopathy-A Retrospective Registry.

Khan, Habib Rehman / Rodwell, Philip / Taha, Ahmed Hasan / Goha, Ahmed / Ahmed, Mobeen / Thain, Andrew Peter / Somarakis, Konstantinos / Al-Atta, Ayman / Erhayiem, Bara / Uddin, Akhlaque / Mathew, Thomas

Journal of cardiovascular development and disease

2023 Volume 10, Issue 3

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10030120
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