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  1. Article ; Online: Preventing neurodegenerative disease.

    Al-Chalabi, Ammar

    Brain : a journal of neurology

    2021  Volume 144, Issue 5, Page(s) 1279–1280

    MeSH term(s) Humans ; Neurodegenerative Diseases/prevention & control
    Language English
    Publishing date 2021-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awab151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What is the extent of reliability and validity evidence for screening tools for cognitive and behavioral change in people with ALS? A systematic review.

    Didcote, Lyndsay / Vitoratou, Silia / Al-Chalabi, Ammar / Goldstein, Laura H

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2024  , Page(s) 1–15

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2024.2314063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5874: Show issues Location:
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  3. Article ; Online: Non-motor symptoms in amyotrophic lateral sclerosis.

    Shojaie, Ali / Al Khleifat, Ahmad / Opie-Martin, Sarah / Sarraf, Payam / Al-Chalabi, Ammar

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2024  Volume 25, Issue 1-2, Page(s) 61–66

    Abstract: Objective: While motor symptoms are well-known in ALS, non-motor symptoms are often under-reported and may have a significant impact on quality of life. In this study, we aimed to examine the nature and extent of non-motor symptoms in ALS.: Methods: ... ...

    Abstract Objective: While motor symptoms are well-known in ALS, non-motor symptoms are often under-reported and may have a significant impact on quality of life. In this study, we aimed to examine the nature and extent of non-motor symptoms in ALS.
    Methods: A 20-item questionnaire was developed covering the domains of autonomic function, sleep, pain, gastrointestinal disturbance, and emotional lability, posted online and shared on social media platforms to target people with ALS and controls.
    Results: A total of 1018 responses were received, of which 927 were complete from 506 people with ALS and 421 unaffected individuals. Cold limbs (p 1.66 × 10
    Conclusions: Non-motor symptoms in ALS are common. The identification and management of non-motor symptoms should be integrated into routine clinical care for people with ALS. Further research is warranted to investigate the relationship between non-motor symptoms and disease progression, as well as to develop targeted interventions to improve the quality of life for people with ALS.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnosis ; Quality of Life ; Pain/etiology ; Disease Progression
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2263868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5874: Show issues Location:
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  4. Article ; Online: Analysis of non-motor symptoms in amyotrophic lateral sclerosis.

    Shojaie, Ali / Al Khleifat, Ahmad / Sarraf, Payam / Al-Chalabi, Ammar

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2023  Volume 25, Issue 3-4, Page(s) 237–241

    Abstract: Objective: We investigated non-motor symptoms in ALS using sequential questionnaires; here we report the findings of the second questionnaire.: Methods: A social media platform (Twitter, now known as X) was used to publicize the questionnaires. Data ... ...

    Abstract Objective: We investigated non-motor symptoms in ALS using sequential questionnaires; here we report the findings of the second questionnaire.
    Methods: A social media platform (Twitter, now known as X) was used to publicize the questionnaires. Data were downloaded from SurveyMonkey and analyzed by descriptive statistics, comparison of means, and regression models.
    Results: There were 182 people with ALS and 57 controls. The most important non-motor symptoms were cold limbs (60.4% cases, 14% controls,
    Conclusions: Non-motor symptoms are an important feature of ALS. Further investigation is needed to understand their physiological basis and whether they represent phenotypic differences useful for subtyping ALS.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/epidemiology ; Surveys and Questionnaires ; Pain/epidemiology ; Pain/etiology
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2280618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Reply: A new diagnostic entity must enable earlier treatment in gene carriers.

    Benatar, Michael / Al-Chalabi, Ammar / Crawley, Anita / Wuu, Joanne

    Brain : a journal of neurology

    2023  Volume 146, Issue 10, Page(s) e80–e82

    MeSH term(s) Humans ; Heterozygote ; Genetic Diseases, Inborn/diagnosis
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Neurogenetics Collection: emerging themes and future considerations for the field in Brain.

    Traynor, Bryan J / Al-Chalabi, Ammar

    Brain : a journal of neurology

    2022  Volume 145, Issue 5, Page(s) e31–e35

    MeSH term(s) Brain ; Head ; Humans ; Neurosciences
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The genetic architecture of ALS.

    Shatunov, Aleksey / Al-Chalabi, Ammar

    Neurobiology of disease

    2020  Volume 147, Page(s) 105156

    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Genetic Predisposition to Disease/genetics ; Humans
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2020.105156
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    Zs.A 4444: Show issues Location:
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  8. Article ; Online: Amyotrophic lateral sclerosis and cerebellum.

    Kabiljo, Renata / Iacoangeli, Alfredo / Al-Chalabi, Ammar / Rosenzweig, Ivana

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 12586

    Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating, heterogeneous neurodegenerative neuromuscular disease that leads to a fatal outcome within 2-5 years, and yet, a precise nature of the association between its major phenotypes and the cerebellar role ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a devastating, heterogeneous neurodegenerative neuromuscular disease that leads to a fatal outcome within 2-5 years, and yet, a precise nature of the association between its major phenotypes and the cerebellar role in ALS pathology remains unknown. Recently, repeat expansions in several genes in which variants appreciably contribute to cerebellar pathology, including C9orf72, NIPA1, ATXN2 and ATXN1, have been found to confer a significant risk for ALS. To better define this relationship, we performed MAGMA gene-based analysis and tissue enrichment analysis using genome-wide association study summary statistics based on a study of 27,205 people with ALS and 110,881 controls. Our preliminary results imply a striking cerebellar tissue specificity and further support increasing calls for re-evaluation of the cerebellar role in the ALS pathology.
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; C9orf72 Protein/genetics ; Cerebellum/pathology ; DNA Repeat Expansion ; Genome-Wide Association Study ; Humans
    Chemical Substances C9orf72 Protein
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-16772-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Non-motor symptoms in amyotrophic lateral sclerosis: lessons from Parkinson's disease.

    Shojaie, Ali / Rota, Silvia / Al Khleifat, Ahmad / Ray Chaudhuri, K / Al-Chalabi, Ammar

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2023  , Page(s) 1–10

    Abstract: Amyotrophic lateral sclerosis and Parkinson's disease are neurodegenerative diseases of the motor system which are now recognized also to affect non-motor pathways. Non-motor symptoms have been acknowledged as important determinants of quality of life in ...

    Abstract Amyotrophic lateral sclerosis and Parkinson's disease are neurodegenerative diseases of the motor system which are now recognized also to affect non-motor pathways. Non-motor symptoms have been acknowledged as important determinants of quality of life in Parkinson's disease, and there is increasing interest in understanding the extent and role of non-motor symptoms in amyotrophic lateral sclerosis. We therefore reviewed what is known about non-motor symptoms in amyotrophic lateral sclerosis, using lessons from Parkinson's disease.
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2220748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Perspective: Don't keep it in the family.

    Al-Chalabi, Ammar

    Nature

    2017  Volume 550, Issue 7676, Page(s) S112

    MeSH term(s) Amyotrophic Lateral Sclerosis/classification ; Amyotrophic Lateral Sclerosis/etiology ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/therapy ; Biomedical Research ; C9orf72 Protein/genetics ; Family Health ; Female ; Humans ; Male ; Risk Factors ; Terminology as Topic
    Chemical Substances C9orf72 Protein ; C9orf72 protein, human
    Language English
    Publishing date 2017-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/550S112a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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