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Article: Exploring the Advantages of a Hydrolyzed Rice Formula in the Dietary Management of Infants with Cow’s Milk Allergy in the Middle East, North Africa, and Pakistan Region

Vandenplas, Yvan / Dupont, Christophe / Al-Dekhail, Wajeeh / Hashmi, Hani A. Al / Khalil, Ahmed Fouad / El-Hodhod, Mostafa Abdel-Aziz / Husain, Khaled / Singh, Avantika

Nutrients. 2021 Sept. 28, v. 13, no. 10

2021

Abstract: Cow’s milk allergy (CMA) is the most common food allergy in early childhood, and its prevalence continues to rise. Exclusive breastfeeding is recommended for infants in the first 6 months of life, but this recommendation is poorly adhered to in many ... ...

Abstract	Cow’s milk allergy (CMA) is the most common food allergy in early childhood, and its prevalence continues to rise. Exclusive breastfeeding is recommended for infants in the first 6 months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle East, North Africa, and Pakistan (MENAP) region. If the infant is affected by CMA, current guidelines recommend extensively hydrolyzed formulas (eHFs) or amino acid-based formulas (AAFs) in the case of severe symptoms, and hydrolyzed rice formulas (HRFs) where available. In recent years, HRFs have been proposed as a plant-based alternative to cow’s milk protein-based eHFs, and updates to current guidelines have been recommended. In 2014, a consensus statement and guidelines were published for the Middle East region on the prevention, diagnosis, and management of CMA. As new advances have been made in the extensively hydrolyzed hypoallergenic infant formula space, along with updated scientific evidence, a workshop of experts from the MENAP region focused on HRF was convened in 2021. This publication summarizes the insights from this meeting. During the consensus part of the meeting, a new approach was discussed and approved by all participants, and agreement was reached that HRF can be recommended as a first-line alternative to cow’s milk-based eHF in the dietary management of CMA.
Keywords	breast feeding ; childhood ; cows ; hydrolysis ; infant formulas ; milk ; milk allergy ; rice ; Middle East ; Northern Africa ; Pakistan
Language	English
Dates of publication	2021-0928
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103429
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incidental finding of a needle in the root of the mesentery of an 11-month-old boy: A case report.

Dana, Kalagi / Lama, AlFakhri / Mays, AlTahhan / Ayman, AlKhamisy / Zakaria, Habib / AlDekhail, Wajeeh

International journal of pediatrics & adolescent medicine

2020 Volume 8, Issue 2, Page(s) 117–120

Abstract: Foreign body (FB) ingestion is very common in the pediatric population. Children will have different presentations based on their age, size, type, and site of the ingested FB. Some children can present with serious complications, others can be completely ...

Abstract	Foreign body (FB) ingestion is very common in the pediatric population. Children will have different presentations based on their age, size, type, and site of the ingested FB. Some children can present with serious complications, others can be completely asymptomatic. An eleven-month-old male child, previously healthy, was following up with the family medicine department for a routine visit. A pelvic x-ray was done to rule out developmental dysplasia of the hip, and a needle was found incidentally in the small bowel loops. The child was completely asymptomatic. Daily radiographs were taken three days in a row and showed that the needle was still in place. The patient was then referred to the pediatric surgery department for laparoscopic exploration and removal of the needle before complications occur. During exploration, the needle was found at the root of the mesentery. The needle was taken out uneventfully without the evidence of perforation. It is unusual to find a sharp FB located at the root of the mesentery in a completely asymptomatic infant as an incidental finding. Serial radiographic images after the initial presentation of foreign body ingestion is important to guide us through surgical intervention.
Language	English
Publishing date	2020-04-07
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2832064-5
ISSN	2352-6467 ; 2352-6467
ISSN (online)	2352-6467
ISSN	2352-6467
DOI	10.1016/j.ijpam.2020.03.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Intramural esophageal foreign body in a child.

Skaff, Chahdah / Al Awadhi, Haifa / Habib, Zakaria / Al-Dekhail, Wajeeh

International journal of pediatrics & adolescent medicine

2015 Volume 3, Issue 1, Page(s) 34–37

Abstract: Foreign body ingestion is a common problem in the pediatric population. The majority of cases occur between 6 months and 3 years of age. Major complications, including bowel perforation and obstruction, have been reported. Forty percent of ingested ... ...

Abstract	Foreign body ingestion is a common problem in the pediatric population. The majority of cases occur between 6 months and 3 years of age. Major complications, including bowel perforation and obstruction, have been reported. Forty percent of ingested foreign bodies are unwitnessed, and in fact, many are asymptomatic. We report the case of a 2-year-old girl who was referred to King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia (KFSH&RC) with suspected congenital esophageal stenosis. Upon investigation, she was diagnosed with intramural esophageal foreign body.
Language	English
Publishing date	2015-12-24
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2832064-5
ISSN	2352-6467
ISSN	2352-6467
DOI	10.1016/j.ijpam.2015.11.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the Advantages of a Hydrolyzed Rice Formula in the Dietary Management of Infants with Cow's Milk Allergy in the Middle East, North Africa, and Pakistan Region.

Vandenplas, Yvan / Dupont, Christophe / Al-Dekhail, Wajeeh / Hashmi, Hani A Al / Khalil, Ahmed Fouad / El-Hodhod, Mostafa Abdel-Aziz / Husain, Khaled / Singh, Avantika

Nutrients

2021 Volume 13, Issue 10

Abstract: Cow's milk allergy (CMA) is the most common food allergy in early childhood, and its prevalence continues to rise. Exclusive breastfeeding is recommended for infants in the first 6 months of life, but this recommendation is poorly adhered to in many ... ...

Abstract	Cow's milk allergy (CMA) is the most common food allergy in early childhood, and its prevalence continues to rise. Exclusive breastfeeding is recommended for infants in the first 6 months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle East, North Africa, and Pakistan (MENAP) region. If the infant is affected by CMA, current guidelines recommend extensively hydrolyzed formulas (eHFs) or amino acid-based formulas (AAFs) in the case of severe symptoms, and hydrolyzed rice formulas (HRFs) where available. In recent years, HRFs have been proposed as a plant-based alternative to cow's milk protein-based eHFs, and updates to current guidelines have been recommended. In 2014, a consensus statement and guidelines were published for the Middle East region on the prevention, diagnosis, and management of CMA. As new advances have been made in the extensively hydrolyzed hypoallergenic infant formula space, along with updated scientific evidence, a workshop of experts from the MENAP region focused on HRF was convened in 2021. This publication summarizes the insights from this meeting. During the consensus part of the meeting, a new approach was discussed and approved by all participants, and agreement was reached that HRF can be recommended as a first-line alternative to cow's milk-based eHF in the dietary management of CMA.
MeSH term(s)	Africa, Northern/epidemiology ; Animals ; Disease Management ; Disease Susceptibility ; Humans ; Infant Formula ; Middle East/epidemiology ; Milk Hypersensitivity/diagnosis ; Milk Hypersensitivity/epidemiology ; Milk Hypersensitivity/etiology ; Milk Hypersensitivity/therapy ; Oryza ; Pakistan/epidemiology ; Public Health Surveillance
Language	English
Publishing date	2021-09-28
Publishing country	Switzerland
Document type	Congress
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence of celiac disease in Saudi children with Down syndrome: A retrospective study.

AlRuwaily, Fawzah / Kattan, Hoda A / AlMehaidib, Ali M / AlDekhail, Wajeeh

International journal of pediatrics & adolescent medicine

2017 Volume 4, Issue 2, Page(s) 51–53

Abstract: Celiac disease (CD) is an immune-mediated disease affecting the small intestine secondary to gluten exposure. The currently available treatment is lifelong adherence to a gluten-free diet (GFD). Several disorders are known to be associated with celiac ... ...

Abstract	Celiac disease (CD) is an immune-mediated disease affecting the small intestine secondary to gluten exposure. The currently available treatment is lifelong adherence to a gluten-free diet (GFD). Several disorders are known to be associated with celiac disease, including Down syndrome (DS). In several studies, the prevalence of CD in DS ranged between 4 and 17%. CD is prevalent in Arabs; however, few studies have been performed to determine the prevalence of CD in DS patients. Our study aimed to determine the prevalence of CD in Saudi Down syndrome patients using serological markers and small bowel biopsy. This is a retrospective study in which files relating to Down syndrome patients who were followed up in a general pediatric clinic at King Faisal Specialist Hospital and Research Center were reviewed regarding demographic data, serological markers and biopsy results. Of the total number of patients reviewed (91), 7 were excluded because data were missing; the remaining 84 patients included 35 females and 49 males. The age range of the patients at the time of screening was from 1 to 18 years. Patient demographic data are shown in Table 1. Among the studied patients, antigliadin antibody (AGA) IgA was high in 27 patients (32.14%), and AGA IgG was high in 44 patients (52.38%). Twelve patients (14.28%) tested positive and 58 (69.04%) tested negative for anti-endomysial antibodies. Anti-tissue glutaminase antibody IgA was found to be high in 13 patients (15.5%) and normal in 54 patients (64.28%). Serum IgA levels were normal in 36 patients (43%) and low in 1 patient (1.2%). Biopsy was performed in 22 patients who tested positive for anti-endomysial or anti-tissue transglutaminase antibodies. The biopsies provided positive results in 9 patients (10.7%). Our study showed a confirmed prevalence of 10.7% for celiac disease in Saudi patients with Down syndrome based on serology and biopsy; together with previous cases reported in the literature, this result indicates a need to screen these patients for celiac disease.
Language	English
Publishing date	2017-02-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2832064-5
ISSN	2352-6467
ISSN	2352-6467
DOI	10.1016/j.ijpam.2016.12.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surgical consequences in infants with delayed diagnosis of congenital chloride diarrhea.

Al Awadhi, Haifa / Al Mehaidib, Ali / AlSaleem, Khalid / Banemai, Mohammed / Al Dekhail, Wajeeh

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2017 Volume 28, Issue 6, Page(s) 510–513

Abstract: Despite the usual typical presentation, congenital chloride diarrhea (CCD) poses multiple diagnostic challenges. It has an incidence of 1/5000 in Saudi Arabia. CCD can mimic intestinal obstruction and result in avoidable surgical interventions. ... ...

Abstract	Despite the usual typical presentation, congenital chloride diarrhea (CCD) poses multiple diagnostic challenges. It has an incidence of 1/5000 in Saudi Arabia. CCD can mimic intestinal obstruction and result in avoidable surgical interventions. Contributing factors are abdominal distension and the watery (urine-like) diarrhea that is often interpreted as delayed passage of meconium. Surgical interventions would unnecessarily increase the morbidity. Therefore, a high index of suspicion and educating neonatologists, general pediatricians, and pediatric surgeons regarding this diagnostic entity is essential. Here we describe five such cases.
MeSH term(s)	Delayed Diagnosis/adverse effects ; Diagnosis, Differential ; Diarrhea/congenital ; Diarrhea/diagnosis ; Diarrhea/surgery ; Female ; Humans ; Infant ; Infant, Newborn ; Intestinal Obstruction/diagnosis ; Male ; Metabolism, Inborn Errors/diagnosis ; Metabolism, Inborn Errors/surgery ; Unnecessary Procedures/adverse effects
Language	English
Publishing date	2017-11
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2017.17061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Use of bone densitometry to assess bone disease in aluminum toxicity complicating parentral nutrition: A case report.

Al Awadhi, Haifa / Al Mehaidib, Ali / Al Dekhail, Wajeeh / Mulia, Hamdy / Al Saleem, Khalid / Abanemai, Mohammed

International journal of pediatrics & adolescent medicine

2018 Volume 5, Issue 1, Page(s) 31–33

Abstract: Aluminum toxicity affecting bone mineral density is a known complication of long-term parentral nutrition. In this report, we describe a similar patient who suffered from bone disease and had a favorable response to chelation therapy using deferoxamine. ... ...

Abstract	Aluminum toxicity affecting bone mineral density is a known complication of long-term parentral nutrition. In this report, we describe a similar patient who suffered from bone disease and had a favorable response to chelation therapy using deferoxamine. We believe this may be a possible agent improving the life quality for the above mentioned group of patients.
Language	English
Publishing date	2018-02-27
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2832064-5
ISSN	2352-6467
ISSN	2352-6467
DOI	10.1016/j.ijpam.2018.01.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spontaneous recovery of propylthiouracil-induced fulminant hepatic failure in an 8-year old child.

Bin-Abbas, Bassam S / Shabib, Souheil M / Al-Dekhail, Wajeeh M / Al-Shanafey, Saud N / Al-Mehaideb, Ali I / Al-Ashwal, Abdullah A

Saudi medical journal

2007 Volume 28, Issue 5, Page(s) 804–806

MeSH term(s)	Antithyroid Agents/adverse effects ; Child ; Female ; Humans ; Hyperthyroidism/drug therapy ; Liver Failure, Acute/chemically induced ; Propylthiouracil/adverse effects
Chemical Substances	Antithyroid Agents ; Propylthiouracil (721M9407IY)
Language	English
Publishing date	2007-05
Publishing country	Saudi Arabia
Document type	Case Reports ; Journal Article
ZDB-ID	392302-2
ISSN	1658-3175 ; 0379-5284
ISSN (online)	1658-3175
ISSN	0379-5284
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MB 6: Show issues

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Article ; Online: The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.

Monies, Dorota / Abouelhoda, Mohamed / AlSayed, Moeenaldeen / Alhassnan, Zuhair / Alotaibi, Maha / Kayyali, Husam / Al-Owain, Mohammed / Shah, Ayaz / Rahbeeni, Zuhair / Al-Muhaizea, Mohammad A / Alzaidan, Hamad I / Cupler, Edward / Bohlega, Saeed / Faqeih, Eissa / Faden, Maha / Alyounes, Banan / Jaroudi, Dyala / Goljan, Ewa / Elbardisy, Hadeel /

Akilan, Asma / Albar, Renad / Aldhalaan, Hesham / Gulab, Shamshad / Chedrawi, Aziza / Al Saud, Bandar K / Kurdi, Wesam / Makhseed, Nawal / Alqasim, Tahani / El Khashab, Heba Y / Al-Mousa, Hamoud / Alhashem, Amal / Kanaan, Imaduddin / Algoufi, Talal / Alsaleem, Khalid / Basha, Talal A / Al-Murshedi, Fathiya / Khan, Sameena / Al-Kindy, Adila / Alnemer, Maha / Al-Hajjar, Sami / Alyamani, Suad / Aldhekri, Hasan / Al-Mehaidib, Ali / Arnaout, Rand / Dabbagh, Omar / Shagrani, Mohammad / Broering, Dieter / Tulbah, Maha / Alqassmi, Amal / Almugbel, Maisoon / AlQuaiz, Mohammed / Alsaman, Abdulaziz / Al-Thihli, Khalid / Sulaiman, Raashda A / Al-Dekhail, Wajeeh / Alsaegh, Abeer / Bashiri, Fahad A / Qari, Alya / Alhomadi, Suzan / Alkuraya, Hisham / Alsebayel, Mohammed / Hamad, Muddathir H / Szonyi, Laszlo / Abaalkhail, Faisal / Al-Mayouf, Sulaiman M / Almojalli, Hamad / Alqadi, Khalid S / Elsiesy, Hussien / Shuaib, Taghreed M / Seidahmed, Mohammed Zain / Abosoudah, Ibraheem / Akleh, Hana / AlGhonaium, Abdulaziz / Alkharfy, Turki M / Al Mutairi, Fuad / Eyaid, Wafa / Alshanbary, Abdullah / Sheikh, Farrukh R / Alsohaibani, Fahad I / Alsonbul, Abdullah / Al Tala, Saeed / Balkhy, Soher / Bassiouni, Randa / Alenizi, Ahmed S / Hussein, Maged H / Hassan, Saeed / Khalil, Mohamed / Tabarki, Brahim / Alshahwan, Saad / Oshi, Amira / Sabr, Yasser / Alsaadoun, Saad / Salih, Mustafa A / Mohamed, Sarar / Sultana, Habiba / Tamim, Abdullah / El-Haj, Moayad / Alshahrani, Saif / Bubshait, Dalal K / Alfadhel, Majid / Faquih, Tariq / El-Kalioby, Mohamed / Subhani, Shazia / Shah, Zeeshan / Moghrabi, Nabil / Meyer, Brian F / Alkuraya, Fowzan S

Human genetics

2017 Volume 136, Issue 8, Page(s) 921–939

Abstract: In this study, we report the experience of the only reference clinical next-generation sequencing lab in Saudi Arabia with the first 1000 families who span a wide-range of suspected Mendelian phenotypes. A total of 1019 tests were performed in the period ...

Abstract	In this study, we report the experience of the only reference clinical next-generation sequencing lab in Saudi Arabia with the first 1000 families who span a wide-range of suspected Mendelian phenotypes. A total of 1019 tests were performed in the period of March 2016-December 2016 comprising 972 solo (index only), 14 duo (parents or affected siblings only), and 33 trio (index and parents). Multigene panels accounted for 672 tests, while whole exome sequencing (WES) represented the remaining 347 tests. Pathogenic or likely pathogenic variants that explain the clinical indications were identified in 34% (27% in panels and 43% in exomes), spanning 279 genes and including 165 novel variants. While recessive mutations dominated the landscape of solved cases (71% of mutations, and 97% of which are homozygous), a substantial minority (27%) were solved on the basis of dominant mutations. The highly consanguineous nature of the study population also facilitated homozygosity for many private mutations (only 32.5% of the recessive mutations are founder), as well as the first instances of recessive inheritance of previously assumed strictly dominant disorders (involving ITPR1, VAMP1, MCTP2, and TBP). Surprisingly, however, dual molecular diagnosis was only observed in 1.5% of cases. Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CABP1, CCDC186, CCP110, CLSTN2, CNTN3, CNTN5, CTNNA2, CWC22, DMAP1, DMKN, DMXL1, DSCAM, DVL2, ECI1, EP400, EPB41L5, FBXL22, GAP43, GEMIN7, GIT1, GRIK4, GRSF1, GTRP1, HID1, IFNL1, KCNC4, LRRC52, MAP7D3, MCTP2, MED26, MPP7, MRPS35, MTDH, MTMR9, NECAP2, NPAT, NRAP, PAX7, PCNX, PLCH2, PLEKHF1, PTPN12, QKI, RILPL2, RIMKLA, RIMS2, RNF213, ROBO1, SEC16A, SIAH1, SIRT2, SLAIN2, SLC22A20, SMDT1, SRRT, SSTR1, ST20, SYT9, TSPAN6, UBR4, VAMP4, VPS36, WDR59, WDYHV1, and WHSC1) not previously linked to human phenotypes and these are presented to accelerate post-publication matchmaking. Two of these genes were independently mutated in more than one family with similar phenotypes, which substantiates their link to human disease (AKAP6 in intellectual disability and UBR4 in early dementia). If the novel candidate disease genes in this cohort are independently confirmed, the yield of WES will have increased to 83%, which suggests that most "negative" clinical exome tests are unsolved due to interpretation rather than technical limitations.
MeSH term(s)	Consanguinity ; Exome ; Female ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/epidemiology ; Genetic Testing ; Genome, Human ; High-Throughput Nucleotide Sequencing ; Homozygote ; Humans ; Male ; Molecular Sequence Annotation ; Morbidity ; Mutation ; Phenotype ; Reproducibility of Results ; Saudi Arabia/epidemiology ; Sequence Analysis, DNA
Language	English
Publishing date	2017-06-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	223009-4
ISSN	1432-1203 ; 0340-6717
ISSN (online)	1432-1203
ISSN	0340-6717
DOI	10.1007/s00439-017-1821-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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