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Article: Primary Squamous Cell Biliary Carcinoma With Liver Metastasis Is Rare but Malicious.

Almujarkesh, Mohamad Khaled / Damughatla, Anirudh R / Bathla, Jasdeep / Sugg, Kyle / LaBuda, Dana / Alkassis, Samer / Al Hallak, Mohammed Najeeb

Gastroenterology research

2023 Volume 16, Issue 5, Page(s) 276–279

Abstract: Primary squamous cell carcinoma (SCC) of the liver is quite rare, and to our knowledge, very few cases have been reported in the literature. The exact pathogenesis of the disease is unestablished; however, it is mostly reported to be associated with ... ...

Abstract	Primary squamous cell carcinoma (SCC) of the liver is quite rare, and to our knowledge, very few cases have been reported in the literature. The exact pathogenesis of the disease is unestablished; however, it is mostly reported to be associated with hepatic cyst, Caroli's disease, hepatolithiasis, hepatic cirrhosis, and hepatic teratoma. We report a case of a 50-year-old woman with no prior medical history initially, who presented with postprandial epigastric and right upper quadrant pain that continued to worsen and was associated with early satiety, nausea, and weight loss of 25 pounds over 2 months, which prompted further evaluation by her primary care physician. Magnetic resonance imaging (MRI) examination a month later revealed a large heterogeneous area measuring 8.5 × 2.4 × 7.4 cm in the inferior right hepatic lobe with heterogeneous enhancement and involvement of the gallbladder, concerning for cholangiocarcinoma. Given radiographic findings, she underwent a computed tomography (CT)-guided core biopsy of the liver, which showed a necrotic malignant tumor favoring adenocarcinoma and was also found to have germline
Language	English
Publishing date	2023-10-21
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2475913-2
ISSN	1918-2813 ; 1918-2805
ISSN (online)	1918-2813
ISSN	1918-2805
DOI	10.14740/gr1637
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Article ; Online: Gastric Cancer Survivorship: Multidisciplinary Management, Best Practices and Opportunities.

Cobani, Era / Al Hallak, Mohammed Najeeb / Shields, Anthony F / Maier, Jordan / Kelly, Thomas E / Naidoo, Niren / Tobon, Miguel / Kim, Steve / Beal, Eliza W

Journal of gastrointestinal cancer

2024

Abstract: Purpose: Gastric cancer is the 5th most common malignancy worldwide. As early detection increases and treatments for gastric cancer improve, the number of gastric cancer survivors grows.: Methods: Here, we review the diagnosis and management of ... ...

Abstract	Purpose: Gastric cancer is the 5th most common malignancy worldwide. As early detection increases and treatments for gastric cancer improve, the number of gastric cancer survivors grows. Methods: Here, we review the diagnosis and management of gastric cancer and discuss important considerations for gastric cancer survivorship including cancer surveillance, weight loss, malnutrition, fatigue, specific complications related to surgery and radiation, quality of life in gastric cancer survivorship, health behavior, and models of survivorship. Results: Multimodality therapy with chemotherapy and surgery can result in chronic toxicities in multiple organ systems. This emphasizes the need for a multidisciplinary survivorship care model including cancer surveillance, management of chronic toxicities, and optimization of modifiable risk factors with long-term involvement of appropriate providers. Conclusion: Adequately caring for gastric cancer survivors requires a coordinated, multidisciplinary approach.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-023-01001-7
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Article: Non-Coding RNAs in Pancreatic Cancer Diagnostics and Therapy: Focus on lncRNAs, circRNAs, and piRNAs.

Li, Yiwei / Al Hallak, Mohammed Najeeb / Philip, Philip A / Azmi, Asfar S / Mohammad, Ramzi M

Cancers

2021 Volume 13, Issue 16

Abstract: Pancreatic cancer is an aggressive malignance with high mortality. The lack of early diagnosis and effective therapy contributes to the high mortality of this deadly disease. For a long time being, the alterations in coding RNAs have been considered as ... ...

Abstract	Pancreatic cancer is an aggressive malignance with high mortality. The lack of early diagnosis and effective therapy contributes to the high mortality of this deadly disease. For a long time being, the alterations in coding RNAs have been considered as major targets for diagnosis and treatment of pancreatic cancer. However, with the advances in high-throughput next generation of sequencing more alterations in non-coding RNAs (ncRNAs) have been discovered in different cancers. Further mechanistic studies have demonstrated that ncRNAs such as long noncoding RNAs (lncRNA), circular RNAs (circRNA) and piwi-interacting RNA (piRNA) play vital roles in the regulation of tumorigenesis, tumor progression and prognosis. In recent years, increasing studies have focused on the roles of ncRNAs in the development and progression of pancreatic cancer. Novel findings have demonstrated that lncRNA, circRNA, and piRNA are critically involved in the regulation of gene expression and cellular signal transduction in pancreatic cancer. In this review, we summarize the current knowledge of roles of lncRNA, circRNA, and piRNA in the diagnosis and prognosis of pancreatic cancer, and molecular mechanisms underlying the regulation of these ncRNAs and related signaling in pancreatic cancer therapy. The information provided here will help to find new strategies for better treatment of pancreatic cancer.
Language	English
Publishing date	2021-08-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13164161
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Article ; Online: The phase I/II eNRGy trial: Zenocutuzumab in patients with cancers harboring

Kim, Dong-Wan / Schram, Alison M / Hollebecque, Antoine / Nishino, Kazumi / Macarulla, Teresa / Rha, Sun Young / Duruisseaux, Michaël / Liu, Stephen V / Al Hallak, Mohammed Najeeb / Umemoto, Kumiko / Wesseler, Claas / Cleary, James M / Springfeld, Christoph / Neuzillet, Cindy / Joe, Andrew / Jauhari, Shekeab / Ford, Jim / Goto, Koichi

Future oncology (London, England)

2024

Abstract: Neuregulin 1 ( ...

Abstract	Neuregulin 1 (
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2023-0824
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Article: Regulator of Chromosome Condensation (RCC1) a novel therapeutic target in pancreatic ductal adenocarcinoma drives tumor progression via the c-Myc-RCC1-Ran axis.

Bannoura, Sahar F / Aboukameel, Amro / Khan, Husain Yar / Uddin, Md Hafiz / Jang, Hyejeong / Beal, Eliza / Thangasamy, Amalraj / Kim, Seongho / Wagner, Kay Uwe / Mohammad, Ramzi / Al-Hallak, Mohammed Najeeb / Pasche, Boris C / Azmi, Asfar S

bioRxiv : the preprint server for biology

2023

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited therapeutic options. Here we for the first time evaluated the role of regulator of chromosome condensation 1 (RCC1) in PDAC subsistence and drug resistance. RCC1 ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited therapeutic options. Here we for the first time evaluated the role of regulator of chromosome condensation 1 (RCC1) in PDAC subsistence and drug resistance. RCC1 expression was found to be elevated in PDAC tissues in comparison with normal pancreatic tissues and was linked to poor prognosis. RCC1 silencing in a panel of PDAC cells by RNA interference and CRISPR-Cas9 resulted in reduced cellular proliferation in 2D and 3D cultures. RCC1 KD reduced migratory and clonogenic ability, enhanced apoptosis, and altered cell cycle distribution in human PDAC cells as well as cells isolated from the LSL-Kras
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.18.572102
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Article ; Online: Gastric cancer: a comprehensive review of current and future treatment strategies.

Sexton, Rachel E / Al Hallak, Mohammed Najeeb / Diab, Maria / Azmi, Asfar S

Cancer metastasis reviews

2020 Volume 39, Issue 4, Page(s) 1179–1203

Abstract: Gastric cancer remains a major unmet clinical problem with over 1 million new cases worldwide. It is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women. A major fraction of gastric cancer has been ... ...

Abstract	Gastric cancer remains a major unmet clinical problem with over 1 million new cases worldwide. It is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women. A major fraction of gastric cancer has been linked to variety of pathogenic infections including but not limited to Helicobacter pylori (H. pylori) or Epstein Barr virus (EBV). Strategies are being pursued to prevent gastric cancer development such as H. pylori eradication, which has helped to prevent significant proportion of gastric cancer. Today, treatments have helped to manage this disease and the 5-year survival for stage IA and IB tumors treated with surgery are between 60 and 80%. However, patients with stage III tumors undergoing surgery have a dismal 5-year survival rate between 18 and 50% depending on the dataset. These figures indicate the need for more effective molecularly driven treatment strategies. This review discusses the molecular profile of gastric tumors, the success, and challenges with available therapeutic targets along with newer biomarkers and emerging targets.
MeSH term(s)	Animals ; Biomarkers, Tumor/metabolism ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Combined Modality Therapy ; Epstein-Barr Virus Infections/pathology ; Helicobacter Infections/pathology ; Helicobacter pylori/isolation & purification ; Herpesvirus 4, Human/isolation & purification ; Humans ; Molecular Targeted Therapy ; Neoplasm Staging ; Randomized Controlled Trials as Topic ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-09-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-020-09925-3
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Zs.A 1812: Show issues

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Article: Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside.

Uddin, Md Hafiz / Al-Hallak, Mohammed Najeeb / Philip, Philip A / Mohammad, Ramzi M / Viola, Nerissa / Wagner, Kay-Uwe / Azmi, Asfar S

Cancers

2021 Volume 13, Issue 11

Abstract: Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal ... ...

Abstract	Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.
Language	English
Publishing date	2021-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13112777
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Article: Spotlight on Trastuzumab Deruxtecan (DS-8201,T-DXd) for

Azar, Ibrahim / Alkassis, Samer / Fukui, Jami / Alsawah, Fares / Fedak, Kalub / Al Hallak, Mohammed Najeeb / Sukari, Ammar / Nagasaka, Misako

Lung Cancer (Auckland, N.Z.)

2021 Volume 12, Page(s) 103–114

Abstract: Human epidermal growth factor receptor 2 ( ...

Abstract	Human epidermal growth factor receptor 2 (
Language	English
Publishing date	2021-10-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2587467-6
ISSN	1179-2728
ISSN	1179-2728
DOI	10.2147/LCTT.S307324
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Article ; Online: Liquid biopsy for therapy monitoring in early-stage non-small cell lung cancer.

Nagasaka, Misako / Uddin, Mohammed Hafiz / Al-Hallak, Mohammed Najeeb / Rahman, Sarah / Balasubramanian, Suresh / Sukari, Ammar / Azmi, Asfar S

Molecular cancer

2021 Volume 20, Issue 1, Page(s) 82

Abstract: Liquid biopsy is now considered a valuable diagnostic tool for advanced metastatic non-small cell lung cancer (NSCLC). In NSCLC, circulating tumor DNA (ctDNA) analysis has been shown to increase the chances of identifying the presence of targetable ... ...

Abstract	Liquid biopsy is now considered a valuable diagnostic tool for advanced metastatic non-small cell lung cancer (NSCLC). In NSCLC, circulating tumor DNA (ctDNA) analysis has been shown to increase the chances of identifying the presence of targetable mutations and has been adopted by many clinicians owing to its low risk. Serial monitoring of ctDNA may also help assess the treatment response or for monitoring relapse. As the presence of detectable plasma ctDNA post-surgery likely indicates residual tumor burden, studies have been performed to quantify plasma ctDNA to assess minimal residual disease (MRD) in early-stage resected NSCLC. Most data on utilizing liquid biopsy for monitoring MRD in early-stage NSCLC are from small-scale studies using ctDNA. Here, we review the recent research on liquid biopsy in NSCLC, not limited to ctDNA, and focus on novel methods such as micro RNAs (miRNA) and long non-coding (lncRNA).
MeSH term(s)	Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell-Free Nucleic Acids/blood ; Humans ; Liquid Biopsy/methods ; Lung Neoplasms/blood ; Lung Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; Cell-Free Nucleic Acids
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2091373-4
ISSN	1476-4598 ; 1476-4598
ISSN (online)	1476-4598
ISSN	1476-4598
DOI	10.1186/s12943-021-01371-1
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Article: Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset.

Nagasaka, Misako / Brazel, Danielle / Baca, Yasmine / Xiu, Joanne / Al-Hallak, Mohammed Najeeb / Kim, Chul / Nieva, Jorge / Swensen, Jeffrey J / Spetzler, David / Korn, Wolfgang Michael / Socinski, Mark A / Raez, Luis E / Halmos, Balazs / Ou, Sai-Hong Ignatius

Translational oncology

2023 Volume 36, Page(s) 101744

Abstract: Background: RET fusions are driver alterations in cancer and are most commonly found in non-small cell lung cancer and well-differentiated thyroid cancer. However, RET fusion have been reported in other solid tumors.: Material and methods: A ... ...

Abstract	Background: RET fusions are driver alterations in cancer and are most commonly found in non-small cell lung cancer and well-differentiated thyroid cancer. However, RET fusion have been reported in other solid tumors. Material and methods: A retrospective analysis of RET+ solid malignancies identified by targeted RNA sequencing and whole transcriptome sequencing of clinical tumor samples performed at Caris Life Science (Phoenix, AZ). Results: As of March 22, 2022, a total of 378 RET+ solid malignancies were identified in 15 different tumor types and carcinoma of unknown primary (CUP) that underwent next-generation RNA sequencing. RET+ NSCLC and RET+ thyroid cancer constituted 66.9% and 11.1% of the RET+ solid malignancies, respectively. RET+ colorectal adenocarcinoma and RET+ breast adenocarcinoma constituted 10.1% and 2.6%, respectively. The estimated frequency of RET fusions within specific tumor types were NSCLC 0.7%, thyroid cancer 3.1%, colorectal cancer 0.2% and breast cancer 0.1%. KIF5B (46.8%) was the most common fusion partner followed by CCDC6 (28.3%) and NCOA4 (13.8%) in RET+ solid tumors. KIF5B-RET was the dominant fusion variant in RET+ NSCLC, NCOA4-RET was the dominant variant in RET+ colorectal carcinoma, and CCDC6-RET was the dominant variant in thyroid cancer. The most common single gene alterations in RET+ tumors were TP53 (34.8%), RASA1 (14.3%) and ARIAD1A (11.6%). RET+ CRC had a high median TMB of 20.0 and were commonly MSI-H. Conclusions: RET fusions were identified in multiple tumor types. With a higher median TMB and commonly MSI-H, RET fusion positive CRC may be a unique molecular subset of CRC.
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2023.101744
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