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  1. Book ; Online ; E-Book: Recent advances in natural products science

    Al-Harrasi, Ahmed

    2023  

    Abstract: Advances in Natural Product science provides the summarized information related to global herbal drug market and its regulations, ethnopharmacology of traditional crude drugs, isolation of phytopharmaceuticals, phytochemistry, standardization and ... ...

    Author's details Ahmed Al-Harrasi [and five others]
    Abstract "Advances in Natural Product science provides the summarized information related to global herbal drug market and its regulations, ethnopharmacology of traditional crude drugs, isolation of phytopharmaceuticals, phytochemistry, standardization and quality assessment of the crude drugs. Natural product science has constantly been developing with comprehensive data contemplating different parts of the natural drugs such as global trade, quality control and regulatory concerns, traditional medicine systems, production and utilization of drugs and utilization of medicinal and aromatic plants. This broad information about the crude drug gives rise to a subject that is now recognized as advance natural product science. Contemplating all this thorough knowledge of the areas, a textbook is intended to provide considerably to the natural products science. Area of natural product science involves a broad range of topics such as pharmacognostical, phytochemical, ethno-pharmacological aspects of the crude drugs. The book is intended to have six chapters whereas each chapter is written with the aim to give a sufficient understanding to academician and researchers in the respective topic. This book includes 40 illustrations and descriptions of roughly 80 medicinal plants which are used for herbal medicine. Also, the current book is an imperative source for all researchers, academician, students, and those interested in the natural products science. KEY FEATURES Include advance knowledge and detailed developments in natural product science Discusses about the most important phytopharmaceuticals used in pharmaceutical industries Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, global trade of natural products Gives a deep understanding related to recent advances in the herbal medicines to treat various ailments Discusses about national and WHO regulations and policies related to herbal medicine Covers the complete profile of some important traditional medicinal plants especially their historical background, biology and chemistry"--
    Keywords Materia medica, Vegetable ; Herbs/Therapeutic use.
    Subject code 615.321
    Language English
    Size 1 online resource (255 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida
    Document type Book ; Online ; E-Book
    Note Description based upon print version of record.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-327412-9 ; 1-003-27412-9 ; 1-000-62210-X ; 1-03-222776-1 ; 978-1-00-327412-4 ; 978-1-003-27412-4 ; 978-1-000-62210-2 ; 978-1-03-222776-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Synthesis and Fluorescence Properties of Imidazopyridine-Linked Coumarins via Tandem C(sp

    Hooshmand, Seyyed Emad / Amini, Zahra / Shiri, Morteza / Al-Harrasi, Ahmed

    Journal of fluorescence

    2023  Volume 34, Issue 3, Page(s) 1131–1137

    Abstract: A catalyst-, oxidant-free and green synthetic route for direct access to a series of novel imidazopyridine-linked coumarins has been devised through tandem C( ... ...

    Abstract A catalyst-, oxidant-free and green synthetic route for direct access to a series of novel imidazopyridine-linked coumarins has been devised through tandem C(sp
    Language English
    Publishing date 2023-07-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-023-03345-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Decoding the Virtual 2D Map of the Chloroplast Proteomes.

    Mohanta, Tapan Kumar / Mohanta, Yugal Kishore / Al-Harrasi, Ahmed

    Biological procedures online

    2022  Volume 24, Issue 1, Page(s) 23

    Abstract: Background: The chloroplast is a semi-autonomous organelle having its own genome and corresponding proteome. Although chloroplast genomes have been reported, no reports exist on their corresponding proteomes. Therefore, a proteome-wide analysis of the ... ...

    Abstract Background: The chloroplast is a semi-autonomous organelle having its own genome and corresponding proteome. Although chloroplast genomes have been reported, no reports exist on their corresponding proteomes. Therefore, a proteome-wide analysis of the chloroplast proteomes of 2893 species was conducted, and a virtual 2D map was constructed.
    Results: The resulting virtual 2D map of the chloroplast proteome exhibited a bimodal distribution. The molecular mass of the chloroplast proteome ranged from 0.448 to 616.334 kDa, and the isoelectric point (pI) ranged from 2.854 to 12.954. Chloroplast proteomes were dominated by basic pI proteins with an average pI of 7.852. The molecular weight and isoelectric point of chloroplast proteome were found to show bimodal distribution. Leu was the most abundant and Cys the least abundant amino acid in the chloroplast proteome. Notably, Trp amino acid was absent in the chloroplast protein sequences of Pilostyles aethiopica. In addition, Selenocysteine (Sec) and Pyrrolysine (Pyl) amino acids were also found to be lacking in the chloroplast proteomes.
    Conclusion: The virtual 2D map and amino acid composition of chloroplast proteome will enable the researchers to understand the biochemistry of chloroplast protein in detail. Further, the amino acid composition of the chloroplast proteome will also allow us to understand the codon usage bias. The codon usage bias and amino acid usage bias of chloroplast will be crucial to understanding their relationship.
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2027823-8
    ISSN 1480-9222
    ISSN 1480-9222
    DOI 10.1186/s12575-022-00186-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial for the special issue on frankincense.

    Csuk, René / Al-Harrasi, Ahmed

    Phytochemistry

    2020  Volume 173, Page(s) 112299

    MeSH term(s) Boswellia ; Frankincense ; Resins, Plant
    Chemical Substances Resins, Plant ; Frankincense (R9XLF1R1WM)
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Editorial
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2020.112299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The 3D Genome: From Structure to Function.

    Mohanta, Tapan Kumar / Mishra, Awdhesh Kumar / Al-Harrasi, Ahmed

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and ...

    Abstract The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in
    MeSH term(s) Animals ; CCCTC-Binding Factor/genetics ; Cell Cycle Proteins/genetics ; Chromatin/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomes/genetics ; Genome/genetics ; Genomics/methods ; Humans ; Lamins/genetics ; Plants/genetics ; Cohesins
    Chemical Substances CCCTC-Binding Factor ; Cell Cycle Proteins ; Chromatin ; Chromosomal Proteins, Non-Histone ; Lamins
    Language English
    Publishing date 2021-10-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Structures, properties and applications of Cu(II) complexes with tridentate donor ligands.

    Anwar, Muhammad Usman / Al-Harrasi, Ahmed / Rawson, Jeremy M

    Dalton transactions (Cambridge, England : 2003)

    2021  Volume 50, Issue 15, Page(s) 5099–5108

    Abstract: Tridentate ligands offer theree donor atoms to coordinate to metal ions. The remaining vacant coordination sites on the metal ions provided opportunities to implement additional co-ligands to generate complexes with desired properties. Herein we discuss ... ...

    Abstract Tridentate ligands offer theree donor atoms to coordinate to metal ions. The remaining vacant coordination sites on the metal ions provided opportunities to implement additional co-ligands to generate complexes with desired properties. Herein we discuss selected examples of Cu(ii) complexes with tridentate ligands utilizing combinations of N, O, S, and Se donors, focusing on effects of ligand flexibility/rigidity on their coordination modes, properties and applications.
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d1dt00483b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Uncovering the first complete plastome genomics, comparative analyses, and phylogenetic dispositions of endemic medicinal plant Ziziphus hajarensis (Rhamnaceae).

    Asaf, Sajjad / Ahmad, Waqar / Al-Harrasi, Ahmed / Khan, Abdul Latif

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 83

    Abstract: Background: Ziziphus hajarensis is an endemic plant species well-distributed in the Western Hajar mountains of Oman. Despite its potential medicinal uses, little is known regarding its genomic architecture, phylogenetic position, or evolution. Here we ... ...

    Abstract Background: Ziziphus hajarensis is an endemic plant species well-distributed in the Western Hajar mountains of Oman. Despite its potential medicinal uses, little is known regarding its genomic architecture, phylogenetic position, or evolution. Here we sequenced and analyzed the entire chloroplast (cp) genome of Z. hajarensis to understand its genetic organization, structure, and phylogenomic disposition among Rhamnaceae species.
    Results: The results revealed the genome of Z. hajarensis cp comprised 162,162 bp and exhibited a typical quadripartite structure, with a large single copy (LSC) region of 895,67 bp, a small single copy (SSC) region of 19,597 bp and an inverted repeat (IR) regions of 26,499 bp. In addition, the cp genome of Z. hajarensis comprises 126 genes, including 82 protein-coding genes, eight rRNA genes, and 36 tRNA genes. Furthermore, the analysis revealed 208 microsatellites, 96.6% of which were mononucleotides. Similarly, a total of 140 repeats were identified, including 11 palindromic, 24 forward, 14 reverse, and 104 tandem repeats. The whole cp genome comparison of Z. hajarensis and nine other species from family Rhamnaceae showed an overall high degree of sequence similarity, with divergence among some intergenic spacers. Comparative phylogenetic analysis based on the complete cp genome, 66 shared genes and matK gene revealed that Z. hajarensis shares a clade with Z. jujuba and that the family Rhamnaceae is the closest family to Barbeyaceae and Elaeagnaceae.
    Conclusion: All the genome features such as genome size, GC content, genome organization and gene order were highly conserved compared to the other related genomes. The whole cp genome of Z. hajarensis gives fascinating insights and valuable data that may be used to identify related species and reconstruct the phylogeny of the species.
    MeSH term(s) Genome, Chloroplast ; Genomics ; Microsatellite Repeats ; Phylogeny ; Plants, Medicinal/genetics ; Rhamnaceae ; Ziziphus/genetics
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08320-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Fungal genomes: suffering with functional annotation errors.

    Mohanta, Tapan Kumar / Al-Harrasi, Ahmed

    IMA fungus

    2021  Volume 12, Issue 1, Page(s) 32

    Abstract: Background: The genome sequence data of more than 65985 species are publicly available as of October 2021 within the National Center for Biotechnology Information (NCBI) database alone and additional genome sequences are available in other databases and ...

    Abstract Background: The genome sequence data of more than 65985 species are publicly available as of October 2021 within the National Center for Biotechnology Information (NCBI) database alone and additional genome sequences are available in other databases and also continue to accumulate at a rapid pace. However, an error-free functional annotation of these genome is essential for the research communities to fully utilize these data in an optimum and efficient manner.
    Results: An analysis of proteome sequence data of 689 fungal species (7.15 million protein sequences) was conducted to identify the presence of functional annotation errors. Proteins associated with calcium signaling events, including calcium dependent protein kinases (CDPKs), calmodulins (CaM), calmodulin-like (CML) proteins, WRKY transcription factors, selenoproteins, and proteins associated with the terpene biosynthesis pathway, were targeted in the analysis. Gene associated with CDPKs and selenoproteins are known to be absent in fungal genomes. Our analysis, however, revealed the presence of proteins that were functionally annotated as CDPK proteins. However, InterproScan analysis indicated that none of the protein sequences annotated as "calcium dependent protein kinase" were found to encode calcium binding EF-hands at the regulatory domain. Similarly, none of a protein sequences annotated as a "selenocysteine" were found to contain a Sec (U) amino acid. Proteins annotated as CaM and CMLs also had significant discrepancies. CaM proteins should contain four calcium binding EF-hands, however, a range of 2-4 calcium binding EF-hands were present in the fungal proteins that were annotated as CaM proteins. Similarly, CMLs should possess four calcium binding EF-hands, but some of the CML annotated fungal proteins possessed either three or four calcium binding EF-hands. WRKY transcription factors are characterized by the presence of a WRKY domain and are confined to the plant kingdom. Several fungal proteins, however, were annotated as WRKY transcription factors, even though they did not contain a WRKY domain.
    Conclusion: The presence of functional annotation errors in fungal genome and proteome databases is of considerable concern and needs to be addressed in a timely manner.
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2666116-0
    ISSN 2210-6359 ; 2210-6340
    ISSN (online) 2210-6359
    ISSN 2210-6340
    DOI 10.1186/s43008-021-00083-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative Evaluation of Reversed Stationary Phase Geometries and Greener Systems on HPLC and UHPLC Using Five Recent Hepatitis-C Antivirals.

    Ibrahim, Adel Ehab / Abd Elmonem, Hadeel Mohamed / Al-Harrasi, Ahmed / El Deeb, Sami

    Journal of AOAC International

    2023  Volume 106, Issue 3, Page(s) 580–587

    Abstract: Background: Being the most widely used LC mode, reversed-phase (RP)-HPLC accounts for the highest percentage of HPLC separations. The main aim of the green analytical chromatographer is to enhance the efficiency of separations in short analysis times, ... ...

    Abstract Background: Being the most widely used LC mode, reversed-phase (RP)-HPLC accounts for the highest percentage of HPLC separations. The main aim of the green analytical chromatographer is to enhance the efficiency of separations in short analysis times, using the ecologically safest materials and lowest energy consumption.
    Objective: Being the heart of any chromatography where the actual separations take place, LC columns have diverse varieties which include different stationary phase geometries as well as different particles sizes. The rationale for column choice is quite complicated. Totally porous, core-shell particles, and monolithic rods are stationary phase types manufactured in RP-mode. The main objective of this research study is to aid in the selection of HPLC or ultra-high performance lquid chromatography (UHPLC) instrumentation.
    Methods: In this research article, three different column packing phases were evaluated and compared by both HPLC and UHPLC techniques. The purpose was to explore the best rational choice of column packing as well as LC instrumentation, when using greener chromatographic conditions.
    Results: The study showed core-shell particles were superior in both HPLC and UHPLC techniques.
    Conclusion: Core-shell particles enabled the utilization of greener mobile phase compositions. Monolithic columns showed better tolerance of greener mobile phase flow rates, without considerable loss of performance.
    Highlights: The use of greener organic solvents was assessed on different stationary phase geometries. The separation efficiency for five recent antiviral drugs was evaluated, in order to give better understanding of the way for column choice according to the underlying experimental conditions. UHPLC and HPLC were compared comprehensively for applicability and cost-effectiveness.
    MeSH term(s) Humans ; Antiviral Agents ; Chromatography, High Pressure Liquid/methods ; Hepatitis ; Porosity
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    DOI 10.1093/jaoacint/qsad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of Boswellic acids on T cell proliferation and activation.

    Meyiah, Abdo / Shawkat, Murtada Y / Ur Rehman, Najeeb / Al-Harrasi, Ahmed / Elkord, Eyad

    International immunopharmacology

    2023  Volume 122, Page(s) 110668

    Abstract: Boswellic acids have been recognized as anti-inflammatory and immunomodulatory agents with potentials to control autoimmune and inflammatory diseases. However, their effects on T cell proliferation and activation are not fully elucidated. In this study, ... ...

    Abstract Boswellic acids have been recognized as anti-inflammatory and immunomodulatory agents with potentials to control autoimmune and inflammatory diseases. However, their effects on T cell proliferation and activation are not fully elucidated. In this study, we investigated effects of individual compounds including β-Boswellic acids (β-BA), 11-keto-β-Boswellic acid (β-KBA), 3-O-acetyl β-Boswellic acids (β-ABA), and 3-O-acetyl-11-keto-β-Boswellic acid (β-AKBA) on human peripheral blood mononuclear cells (PBMCs) and their potential role in modulating immune responses. We showed that β-BA, KBA, and AKBA at a 0.025 µM concentration significantly reduced T cell proliferation without inducing cytotoxicity, however, ABA showed cytotoxic effects at this concentration. β-BA and KBA showed significantly reduced T cell proliferation at 0.05 µM concentration without cytotoxic effects. Interestingly, we found that AKBA at 0.025 µM concentration significantly reduced CD25 expression on both CD4
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Cell Proliferation
    Chemical Substances acetyl-11-ketoboswellic acid ; boswellic acid (631-69-6)
    Language English
    Publishing date 2023-07-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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