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  1. Article ; Online: Importance of Fluorine in Benzazole Compounds.

    Al-Harthy, Thuraya / Zoghaib, Wajdi / Abdel-Jalil, Raid

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 20

    Abstract: Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to ...

    Abstract Fluorine-containing heterocycles continue to receive considerable attention due to their unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules imparts a significant enhancement their biological activities compared to non-fluorinated molecules. In this short review, we will highlight the importance of incorporating fluorine as a basic appendage in benzothiazole and benzimidazole skeletons. The chemistry and pharmacological activities of heterocycles containing fluorine during the past years are compiled and discussed.
    MeSH term(s) Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Benzimidazoles/chemistry ; Benzimidazoles/pharmacology ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacology ; Chemistry, Pharmaceutical/methods ; Drug Design ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Fluorine/chemistry ; Heterocyclic Compounds, 2-Ring/chemistry ; Heterocyclic Compounds, 2-Ring/pharmacology ; Humans ; Structure-Activity Relationship
    Chemical Substances Benzimidazoles ; Benzothiazoles ; Enzyme Inhibitors ; Heterocyclic Compounds, 2-Ring ; Fluorine (284SYP0193) ; benzimidazole (E24GX49LD8) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; BTK protein, human (EC 2.7.10.2) ; benzothiazole (G5BW2593EP)
    Language English
    Publishing date 2020-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25204677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Unlocking the Anticancer Potential of Frankincense Essential Oils (FEOs) Through Nanotechnology: A Review.

    Al-Balushi, Rayya A / Haque, Ashanul / Saeed, Mohd / Al-Harthy, Thuraya / Al-Hinaai, Mohammed / Al-Hashmi, Salim

    Molecular biotechnology

    2023  

    Abstract: Cancer is a group of heterogeneous diseases that occur when cells in the body proliferate and divide uncontrollably. As the current treatment modalities have pros and cons, the discovery of new chemotherapeutic agents with the least side effects is one ... ...

    Abstract Cancer is a group of heterogeneous diseases that occur when cells in the body proliferate and divide uncontrollably. As the current treatment modalities have pros and cons, the discovery of new chemotherapeutic agents with the least side effects is one of the most investigated research areas. In this context, plant-based natural products are a rich source of drugs and have served humanity for ages. Frankincense essential oils (FEOs) are among the most promising plant-based oils in Gulf countries. In addition to their high cultural value, FEOs are also famous for their engaging biological activities, including anti-cancerous. However, the practical application of FEOs is often hindered/by their low water solubility, limited bioavailability, high volatility, and sensitivity toward heat, humidity, light, or oxygen. Thus, a significant demand for technological advancement would improve their ability to target particular cells and tissues. Nanotechnology emerged as an exciting approach in this context. Through suitable nano-formulation (functionalization or encapsulation into a nanostructure), issues arising due to solubility, targeting capability, and delivery can be controlled.
    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1193057-3
    ISSN 1559-0305 ; 1073-6085
    ISSN (online) 1559-0305
    ISSN 1073-6085
    DOI 10.1007/s12033-023-00918-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4031: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.

    Schöpel, Miriam / Potheraveedu, Veena Nambiar / Al-Harthy, Thuraya / Abdel-Jalil, Raid / Heumann, Rolf / Stoll, Raphael

    Biological chemistry

    2017  Volume 398, Issue 5-6, Page(s) 577–588

    Abstract: Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDP-loaded) form. The hydrolysis and replenishing of GTP is controlled by two ... ...

    Abstract Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDP-loaded) form. The hydrolysis and replenishing of GTP is controlled by two additional protein classes: GAP (GTPase-activating)- and GEF (Guanine nucleotide exchange factors)-proteins. The complex interplay of the proteins is known as the GTPase-cycle. Several point mutations of the Ras protein deregulate this cycle. Mutations in Ras are associated with up to one-third of human cancers. The three isoforms of Ras (H, N, K) exhibit high sequence similarity and mainly differ in a region called HVR (hypervariable region). The HVR governs the differential action and cellular distribution of the three isoforms. Rheb is a Ras-like GTPase that is conserved from yeast to mammals. Rheb is mainly involved in activation of cell growth through stimulation of mTORC1 activity. In this review, we summarise multidimensional NMR studies on Rheb and Ras carried out to characterise their structure-function relationship and explain how the activity of these small GTPases can be modulated by low molecular weight compounds. These might help to design GTPase-selective antagonists for treatment of cancer and brain disease.
    MeSH term(s) Animals ; GTPase-Activating Proteins/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Magnetic Resonance Spectroscopy/methods ; Small Molecule Libraries/pharmacology ; ras Proteins/chemistry ; ras Proteins/metabolism
    Chemical Substances GTPase-Activating Proteins ; Guanine Nucleotide Exchange Factors ; Small Molecule Libraries ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2017-05-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2016-0276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
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  4. Article ; Online: The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.

    Schöpel, Miriam / Potheraveedu, Veena Nambiar / Al-Harthy, Thuraya / Abdel-Jalil, Raid / Heumann, Rolf / Stoll, Raphael

    Biological chemistry

    2017  

    Abstract: Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDPloaded) form. The hydrolysis and replenishing of GTP is controlled by two ... ...

    Abstract Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDPloaded) form. The hydrolysis and replenishing of GTP is controlled by two additional protein classes: GAP (GTPase-activating)- and GEF (Guanine nucleotide exchange factors)-proteins. The complex interplay of the proteins is known as the GTPase-cycle. Several point mutations of the Ras protein deregulate this cycle. Mutations in Ras are associated with up to one third of human cancers. The three isoforms of Ras (H, N, K) exhibit high sequence similarity and mainly differ in a region called HVR (hypervariable region). The HVR governs the differential action and cellular distribution of the three isoforms. Rheb is a Ras-like GTPase that is conserved from yeast to mammals. Rheb is mainly involved in activation of cell growth through stimulation of mTORC1 activity. In this review, we summarise multidimensional NMR studies on Rheb and Ras carried out to characterise their structure-function relationship and explain how the activity of these small GTPases can be modulated by low molecular weight compounds. These might help to design of GTPase-selective antagonists for treatment of cancer and brain disease.
    Language English
    Publishing date 2017-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2016-0276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.50: Show issues Location:
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  5. Article ; Online: Stereoselective synthesis and molecular modeling of chiral cyclopentanes.

    Abdel-Jalil, Raid J / Steinbrecher, Thomas / Al-Harthy, Thuraya / Mahal, Ahmed / Abou-Zied, Osama K / Voelter, Wolfgang

    Carbohydrate research

    2015  Volume 415, Page(s) 12–16

    Abstract: The reaction of 3-methyseleno-2-methylselenomethyl-propene with benzyl 2,3-anhydro-4-O-triflyl-β-L-ribopyranoside provides a major convenient enantiomeric product of 1-methylene-(benzyl3,4-dideoxy-α-D-arabinopyranoso)-[3,4-c]-cyclopentane, with benzyl-2, ... ...

    Abstract The reaction of 3-methyseleno-2-methylselenomethyl-propene with benzyl 2,3-anhydro-4-O-triflyl-β-L-ribopyranoside provides a major convenient enantiomeric product of 1-methylene-(benzyl3,4-dideoxy-α-D-arabinopyranoso)-[3,4-c]-cyclopentane, with benzyl-2,3-anhydro-4-deoxy-4-C-(2-methyl- propen-3-yl)-α-D-lyxopyranoside as a minor product. While the reaction of 3-methyseleno-2-[methylselenomethyl]-propene with benzyl 2,3-anhydro-4-O-triflyl-α-D-ribopyranoside produces a good yield of benzyl-2,3-anhydro-4-deoxy-4-C-(2-methylpropen-3-yl)-α-D-lyxo-pyranoside. Molecular modeling and molecular dynamics simulations indicate that the intermediate in the reaction of the β-L sugar frequently occupies an optimal conformation that leads to the formation of cyclopentane, while the intermediate in the reaction of the α-D sugar has a very small probability. The results point to the dominant role of the β-L sugar intermediate in controlling the cyclopentane formation.
    MeSH term(s) Carbon/chemistry ; Cyclopentanes/chemical synthesis ; Models, Molecular ; Organoselenium Compounds/chemical synthesis ; Organoselenium Compounds/chemistry ; Stereoisomerism
    Chemical Substances 3-methyseleno-2-methylselenomethyl-propene ; Cyclopentanes ; Organoselenium Compounds ; Carbon (7440-44-0)
    Language English
    Publishing date 2015-10-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2015.07.012
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    Z 2002/704: Show issues
    Z 4.3: Show issues

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  6. Article ; Online: Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles.

    Al-Harthy, Thuraya / Zoghaib, Wajdi Michel / Pflüger, Maren / Schöpel, Miriam / Önder, Kamil / Reitsammer, Maria / Hundsberger, Harald / Stoll, Raphael / Abdel-Jalil, Raid

    Molecules (Basel, Switzerland)

    2016  Volume 21, Issue 10

    Abstract: To design new compounds suitable as starting points for anticancer drug development, we have synthesized a novel series of benzoxazoles with pharmaceutically advantageous piperazine and fluorine moieties attached to them. The newly synthesized ... ...

    Abstract To design new compounds suitable as starting points for anticancer drug development, we have synthesized a novel series of benzoxazoles with pharmaceutically advantageous piperazine and fluorine moieties attached to them. The newly synthesized benzoxazoles and their corresponding precursors were evaluated for cytotoxicity on human A-549 lung carcinoma cells and non-cancer HepaRG hepatocyes. Some of these new benzoxazoles show potential anticancer activity, while two of the intermediates show lung cancer selective properties at low concentrations where healthy cells are unaffected, indicating a selectivity window for anticancer compounds.
    Language English
    Publishing date 2016-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules21101290
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    Zs.MO 81: Show issues

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