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  1. Article ; Online: Maternal Dietary Patterns During Pregnancy Are Linked to Hypertensive Disorders of Pregnancy Among a Predominantly Low-Income US Hispanic/Latina Pregnancy Cohort.

    Maldonado, Luis E / Bastain, Theresa M / Toledo-Corral, Claudia M / Dunton, Genevieve F / Habre, Rima / Eckel, Sandrah P / Yang, Tingyu / Grubbs, Brendan H / Chavez, Thomas / Al-Marayati, Laila A / Breton, Carrie V / Farzan, Shohreh F

    Journal of the American Heart Association

    2024  Volume 13, Issue 5, Page(s) e029848

    Abstract: Background: Diet during pregnancy may be a potential intervention for preventing hypertensive disorders of pregnancy that disproportionally burdens Hispanic/Latina women.: Methods and results: The MADRES (Maternal And Developmental Risks from ... ...

    Abstract Background: Diet during pregnancy may be a potential intervention for preventing hypertensive disorders of pregnancy that disproportionally burdens Hispanic/Latina women.
    Methods and results: The MADRES (Maternal And Developmental Risks from Environmental and Social stressors) study (n=451) is a prospective pregnancy cohort of predominantly low-income Hispanic/Latina women in Los Angeles, California, who completed up to 2 staff-administered 24-hour dietary recalls in the third trimester of pregnancy. Hypertensive disorders of pregnancy were abstracted from medical records and based on a physician's diagnosis or systolic or diastolic blood pressure (≥140 or ≥90 mm Hg, respectively) at ≥2 consecutive prenatal visits. Using multivariable logistic regression, we evaluated associations of 2 previously derived dietary patterns in this population (solid fats, refined grains, and cheese and vegetables, oils, and fruit) and the Healthy Eating Index 2015 with (1) gestational hypertension, (2) preeclampsia, and (3) any hypertensive disorder of pregnancy (either gestational hypertension or preeclampsia). In separate models, we additionally tested interactions with prepregnancy body mass index. Comparing highest-to-lowest quartiles, the solid fats, refined grains, and cheese dietary pattern was associated with an increased odds of any hypertensive disorder of pregnancy (odds ratio [OR], 3.99 [95% CI, 1.44-11.0];
    Conclusions: While the solid fats, refined grains, and cheese diet was strongly associated with preeclampsia during pregnancy, findings suggest the vegetables, oils, and fruit diet may be more relevant than Healthy Eating Index 2015 for preventing preeclampsia among low-income Hispanic/Latina women.
    MeSH term(s) Pregnancy ; Female ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/prevention & control ; Risk Factors ; Prospective Studies ; Dietary Patterns ; Vegetables ; Hispanic or Latino ; Oils
    Chemical Substances Oils
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.029848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hematometrocolpos following Low Transverse Cesarean Delivery Complicated by Uterine Dehiscence.

    Gabby, Lauryn C / McDaniel, Katherine E / Gordon, Brian J / Al-Marayati, Laila A

    Case reports in obstetrics and gynecology

    2021  Volume 2021, Page(s) 5591893

    Abstract: Background: Hematometrocolpos is a rare complication following procedures performed on the female genital tract. While usually seen in adolescents with congenital anomalies including imperforate hymen and vaginal stenosis, it has also been described ... ...

    Abstract Background: Hematometrocolpos is a rare complication following procedures performed on the female genital tract. While usually seen in adolescents with congenital anomalies including imperforate hymen and vaginal stenosis, it has also been described following obstetric vaginal lacerations. The incidence following cesarean delivery is unknown.
    Case: This is a 43-year-old multigravida who underwent a low transverse cesarean delivery complicated by uterine dehiscence, as well as cervical and vaginal lacerations. The repair resulted in lower genital tract obstruction. She presented seven months afterwards with severe abdominopelvic pain and secondary amenorrhea, which resolved after vaginal dilation and excision of the vaginal scar.
    Conclusion: Systematic inspection of the upper vagina should be undertaken following complicated cesarean delivery with vaginal extension. Hematometrocolpos after cesarean delivery should be managed similar to a transverse vaginal septum.
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2021/5591893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detected prenatal perfluorooctanoic acid (PFOA) exposure is associated with decreased fetal head biometric parameters in participants experiencing higher perceived stress during pregnancy in the MADRES cohort.

    Peterson, Alicia K / Eckel, Sandrah P / Habre, Rima / Yang, Tingyu / Faham, Dema / Amin, Monica / Grubbs, Brendan H / Farzan, Shohreh F / Kannan, Kurunthachalam / Robinson, Morgan / Lerner, Deborah / Al-Marayati, Laila A / Walker, Daphne K / Grant, Edward G / Breton, Carrie V / Bastain, Theresa M

    Environmental advances

    2022  Volume 9

    Abstract: Background: Perfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals with long half-lives and are known to cross the placenta during pregnancy. We examined the influence of maternal PFAS levels on : Methods: Blood serum concentrations of ... ...

    Abstract Background: Perfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals with long half-lives and are known to cross the placenta during pregnancy. We examined the influence of maternal PFAS levels on
    Methods: Blood serum concentrations of five PFAS (PFOS, PFHxS, PFNA, PFOA, PFDA) were measured in 335 prenatal specimens (mean gestational age (GA): 21±9 weeks) in the MADRES cohort. Fetal growth outcomes (head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and estimated fetal weight (EFW)) were abstracted from ultrasound medical records and measured at the 3rd trimester study visit (
    Results: Participants were on average 29±6 years old and predominately Hispanic (76%). Median serum concentrations of PFOS, PFHxS, PFNA, PFOA and PFDA were 1.34, 1.10, 0.07, 0.12, and 0.04 ng/mL, respectively. Participants with detected PFOA concentrations had fetuses with -2.5 mm (95% CI -4.2, -0.8) smaller HC and-0.7 mm (95% CI -1.3, -0.2) smaller BPD on average for a fixed GA than those without detected PFOA concentrations. In models stratified by PSS level, the effects of PFOA on fetal growth parameters were stronger and only significant in participants with higher stress levels (HC:
    Conclusions: Prenatal PFOA exposure adversely impacted fetal head biometric parameters in participants experiencing higher stress during pregnancy.
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article
    ISSN 2666-7657
    ISSN (online) 2666-7657
    DOI 10.1016/j.envadv.2022.100286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort.

    Peterson, Alicia K / Habre, Rima / Niu, Zhongzheng / Amin, Monica / Yang, Tingyu / Eckel, Sandrah P / Farzan, Shohreh F / Lurmann, Fred / Pavlovic, Nathan / Grubbs, Brendan H / Walker, Daphne / Al-Marayati, Laila A / Grant, Edward / Lerner, Deborah / Bastain, Theresa M / Breton, Carrie V

    Environmental health : a global access science source

    2022  Volume 21, Issue 1, Page(s) 115

    Abstract: Background: It is well documented that persons of color experience disproportionate exposure to environmental contaminants, including air pollution, and have poorer pregnancy outcomes. This study assessed the critical windows of exposure to ambient air ... ...

    Abstract Background: It is well documented that persons of color experience disproportionate exposure to environmental contaminants, including air pollution, and have poorer pregnancy outcomes. This study assessed the critical windows of exposure to ambient air pollution on in utero fetal growth among structurally marginalized populations in urban Los Angeles.
    Methods: Participants (N = 281) from the larger ongoing MADRES pregnancy cohort study were included in this analysis. Fetal growth outcomes were measured on average at 32 [Formula: see text] 2 weeks of gestation by a certified sonographer and included estimated fetal weight, abdominal circumference, head circumference, biparietal diameter and femur length. Daily ambient air pollutant concentrations were estimated for four pollutants (particulate matter less than 2.5 µm (PM
    Results: Participants were on average 29 years [Formula: see text] 6 old and predominately Hispanic (82%). We identified a significant sensitive window of PM
    Discussion: These results suggest that exposure to particulate matter in early to mid-pregnancy, but not preconception or late pregnancy, may have critical implications on fetal growth.
    MeSH term(s) Female ; Humans ; Pregnancy ; Cohort Studies ; Fetal Weight ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Fetal Development ; Hispanic or Latino
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2022-11-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-022-00925-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prenatal Perfluorooctanoic Acid (PFOA) Exposure Is Associated With Lower Infant Birthweight Within the MADRES Pregnancy Cohort.

    Peterson, Alicia K / Eckel, Sandrah P / Habre, Rima / Yang, Tingyu / Faham, Dema / Farzan, Shohreh F / Grubbs, Brendan H / Kannan, Kurunthachalam / Robinson, Morgan / Lerner, Deborah / Al-Marayati, Laila A / Walker, Daphne K / Grant, Edward G / Bastain, Theresa M / Breton, Carrie V

    Frontiers in epidemiology

    2022  Volume 2, Page(s) 934715

    Abstract: Introduction: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals found in household products that can cross the placenta during pregnancy. We investigated whether PFAS exposure during pregnancy was associated with ... ...

    Abstract Introduction: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals found in household products that can cross the placenta during pregnancy. We investigated whether PFAS exposure during pregnancy was associated with infant birth outcomes in a predominantly urban Hispanic population.
    Methods: Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 342 prenatal biospecimens (mean gestational age: 21 ± 9 weeks) from participants in the ongoing Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) cohort. PFAS compounds were modeled continuously or categorically, depending on the percentage of samples detected. The birth outcomes assessed were birthweight, gestational age at birth, and birthweight for gestational age (BW-for-GA) z-scores that accounted for parity or infant sex. Single pollutant and multipollutant linear regression models were performed to evaluate associations between PFAS exposures and birth outcomes, adjusting for sociodemographic, perinatal, and study design covariates.
    Results: Maternal participants (n = 342) were on average 29 ± 6 years old at study entry and were predominantly Hispanic (76%). Infants were born at a mean of 39 ± 2 weeks of gestation and weighed on average 3,278 ± 522 g. PFOS and PFHxS were detected in 100% of the samples while PFNA, PFOA, and PFDA were detected in 70%, 65%, and 57% of the samples, respectively. PFAS levels were generally lower in this cohort than in comparable cohorts. Women with detected levels of PFOA during pregnancy had infants weighing on average 119.7 g less (95% CI -216.7, -22.7) than women with undetected levels of PFOA in adjusted single pollutant models. PFOA results were also statistically significant in BW-for-GA z-score models that were specific for sex or parity. In models that were mutually adjusted for five detected PFAS compounds, PFOA results remained comparable; however, the association was only significant in BW-for-GA z-scores that were specific for parity (β = -0.3; 95% CI -0.6, -0.01). We found no significant adjusted associations with the remaining PFAS concentrations and the birth outcomes assessed.
    Conclusion: Prenatal exposure to PFOA was associated with lower birthweight in infants, suggesting that exposure to these chemicals during critical periods of development might have important implications for children's health.
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-1199
    ISSN (online) 2674-1199
    DOI 10.3389/fepid.2022.934715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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