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  1. Article ; Online: Magnesium Bismuth Ferrite Nitrogen-Doped Carbon Nanomagnetic Perovskite: Synthesis and Characterization as a High-Performance Electrode in a Supercapacitor for Energy Storage.

    Al-Maswari, Basheer Mohammed / Al-Zaqri, Nabil / Alkanad, Khaled / AlOstoot, Fares Hezam / Boshaala, Ahmed / Radhika, Rayapura Thimmegowda / Venkatesha, Bellale Marigowda

    ACS omega

    2023  Volume 8, Issue 18, Page(s) 16145–16157

    Abstract: Bismuth ferrite ( ... ...

    Abstract Bismuth ferrite (BiFeO
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tumor angiogenesis: Current challenges and therapeutic opportunities.

    Al-Ostoot, Fares Hezam / Salah, Salma / Khamees, Hussien Ahmed / Khanum, Shaukath Ara

    Cancer treatment and research communications

    2021  Volume 28, Page(s) 100422

    Abstract: Angiogenesis plays an important role in the development of cancer since it allows for the delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant organs. Inhibition of angiogenesis is an important strategy for the ... ...

    Abstract Angiogenesis plays an important role in the development of cancer since it allows for the delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant organs. Inhibition of angiogenesis is an important strategy for the prevention of multiple solid tumors that depend on cutting or at least reducing the blood supply to tumor micro-regions, resulting in pan-hypoxia and pan-necrosis within solid tumor tissues. These drugs are an important part of treatment for some types of cancer. As a stand-alone therapy, inhibition of tumor angiogenesis can arrest or halt tumor growth, but will not eliminate the tumor. Therefore, anti-angiogenic drugs in combinations with another anti-cancer treatment method, like chemotherapy, lead to being critical for optimum cancer patient outcomes. Over the last two decades, investigations have been made to improve the efficacy of anti-angiogenic drugs, recognize their potential in drug interactions, and come up with plausible explanations for possible treatment resistance. This review will offer an overview of the varying concepts of tumor angiogenesis, several important angiogenic factors; focus on the role of anti-angiogenesis strategies in cancer treatment.
    MeSH term(s) Humans ; Immunotherapy/methods ; Neoplasms/pathology ; Neovascularization, Pathologic/metabolism
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2021.100422
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  3. Article ; Online: Enhancing photovoltaic efficiency with SQI-Br and SQI-I sensitizers

    Al-horaibi Sultan A. / Al-Odayni Abdel-Basit / ALSaeedy Mohammed / Al-Ostoot Fares Hezam / Al-Salihy Adel / Ghaleb Jawaher Q. / Al-Adhreai Arwa / Saif Faizaa A. / Yaseen Salama A. / Saeed Waseem Sharf

    Open Chemistry, Vol 21, Iss 1, Pp 135943-

    A comparative analysis

    2023  Volume 99

    Keywords dsscs ; unsymmetrical squaraine dyes ; cdca ; photovoltaic efficiency ; dft methods ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Exploring DSSC Efficiency Enhancement: SQI-F and SQI-Cl Dyes with Iodolyte Electrolytes and CDCA Optimization.

    Al-Horaibi, Sultan A / Al-Odayni, Abdel-Basit / ALSaeedy, Mohammed / Al-Ostoot, Fares Hezam / Al-Salihy, Adel / Alezzy, Abdulmajeed / Al-Adhreai, Arwa / Saif, Faizaa A / Yaseen, Salama A / Saeed, Waseem Sharaf

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 20

    Abstract: This investigation delves into the potential use of halogen bonding to enhance both the short-circuit current ( ...

    Abstract This investigation delves into the potential use of halogen bonding to enhance both the short-circuit current (
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28207129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer.

    Abad, Nadeem / Al-Ostoot, Fares Hezam / Ashraf, Sajda / Chkirate, Karim / Aljohani, Majed S / Alharbi, Hussam Y / Buhlak, Shafeek / El Hafi, Mohamed / Van Meervelt, Luc / Al-Maswari, Basheer M / Essassi, El Mokhtar / Ramli, Youssef

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21312

    Abstract: Overall, drug design is a dynamic and evolving field, with researchers constantly working to improve their understanding of molecular interactions, develop new computational methods, and explore innovative techniques for creating effective and safe ... ...

    Abstract Overall, drug design is a dynamic and evolving field, with researchers constantly working to improve their understanding of molecular interactions, develop new computational methods, and explore innovative techniques for creating effective and safe medications. The process can involve steps such as the identification of targets, the discovery of lead compounds, lead optimization, preliminary testing, human trials, regulatory approval and finally post-marketing surveillance, all aimed at bringing a new drug from concept to market. In this article, the synthesis of the novel triazolequinoxalin (
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Crystal structure, Hirshfeld surface analysis and density functional theory study of benzyl 2-oxo-1-(prop-2-yn-1-yl)-1,2-di-hydro-quinoline-4-carboxyl-ate.

    Bouzian, Younos / Chkirate, Karim / Mague, Joel T / Al-Ostoot, Fares Hezam / Hammou Ahabchane, Noureddine / Essassi, El Mokhtar

    Acta crystallographica. Section E, Crystallographic communications

    2021  Volume 77, Issue Pt 8, Page(s) 824–828

    Abstract: The title mol-ecule, ... ...

    Abstract The title mol-ecule, C
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989021007416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Crystal structure, Hirshfeld surface analysis and density functional theory study of 1-nonyl-3-phenyl-quinoxalin-2-one.

    Abad, Nadeem / Chkirate, Karim / Al-Ostoot, Fares Hezam / Van Meervelt, Luc / Lahmidi, Sanae / Ferfra, Souad / Ramli, Youssef / Essassi, El Mokhtar

    Acta crystallographica. Section E, Crystallographic communications

    2021  Volume 77, Issue Pt 10, Page(s) 1037–1042

    Abstract: In the title mol-ecule, ... ...

    Abstract In the title mol-ecule, C
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989021009737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression.

    Al-Ostoot, Fares Hezam / Sherapura, Ankith / V, Vigneshwaran / Basappa, Giridhara / H K, Vivek / B T, Prabhakar / Khanum, Shaukath Ara

    Pharmacological reports : PR

    2021  Volume 73, Issue 5, Page(s) 1328–1343

    Abstract: Background: Hypoxic microenvironment is a common feature of solid tumors, which leads to the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic conditions stimulates tumor angiogenesis, favoring HIF-1α as a promising ... ...

    Abstract Background: Hypoxic microenvironment is a common feature of solid tumors, which leads to the promotion of cancer. The transcription factor, HIF-1α, expressed under hypoxic conditions stimulates tumor angiogenesis, favoring HIF-1α as a promising anticancer agent. On the other hand, synthetic Indolephenoxyacetamide derivatives are known for their pharmacological potentiality. With this background here, we have synthesized, characterized, and validated the new IPA (8a-n) analogs for anti-tumor activity.
    Methods: The new series of IPA (8a-n) were synthesized through a multi-step reaction sequence and characterized based on the different spectroscopic analysis FT-IR,
    Results: Screening for anti-proliferative studies inferred, IPA (8k) is a lead molecule with an IC
    Conclusion: The IPA (8k) is a potent anti-proliferative molecule with anti-angiogenic activity and specifically targets HIF1α, thereby modulates its downstream regulatory genes both in vitro and in vivo. The study provides scope for new target-specific drug development against HIF-1α for the treatment of solid tumors.
    MeSH term(s) Acetamides/chemical synthesis ; Acetamides/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Lymphoma/drug therapy ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/drug therapy ; Rats ; Rats, Wistar ; Signal Transduction ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
    Chemical Substances Acetamides ; Antineoplastic Agents ; Hif1a protein, rat ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-021-00266-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia.

    Al-Ostoot, Fares Hezam / Sherapura, Ankith / Malojirao, Vikas H / Thirusangu, Prabhu / Al-Muhimeed, Tahani I / Khanum, Shaukath Ara / Prabhakar, B T

    Pharmacological reports : PR

    2021  Volume 73, Issue 5, Page(s) 1344–1360

    Abstract: Background: Imbalance and instability in the structure of the DNA have become major characteristics of cancer. In response to DNA damage, DNA damage response (DDR) protein, ataxia telangiectasia mutated (ATM), plays a pivotal role in the modulation of ... ...

    Abstract Background: Imbalance and instability in the structure of the DNA have become major characteristics of cancer. In response to DNA damage, DNA damage response (DDR) protein, ataxia telangiectasia mutated (ATM), plays a pivotal role in the modulation of regulatory regions responsible for inhibition of apoptosis, thereby neoplastic progression.
    Methods: A new series of DPA (7a-t) were synthesized, characterized. Anti-proliferative studies to identify the lead compound were carried out by LDH and MTT assay. Apoptosis/DNA damage was measured through FACS, Annexin-v staining, TUNEL and Comet assay. Elucidation of molecular mechanism through immunoblot and further validation of the drug effect through in vivo approaches.
    Results: Initial in vitro anti-proliferative screening of Compounds DPA (7a-t) against multiple cancer cell lines identified Compound DPA (7n) as a potent cytotoxic molecule with IC
    Conclusions: Compound DPA (7n) emerged as a potent proapoptotic and anti-neoplastic agent by inhibiting ATM kinase activity both in vitro and in vivo. The conferring results ascertain that the drug could be developed as a new ATM kinase inhibitor with anti-cancer capacity.
    MeSH term(s) Acetamides/chemical synthesis ; Acetamides/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Line, Tumor ; DNA Damage ; DNA Repair ; Drug Delivery Systems ; Humans ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Xenograft Model Antitumor Assays
    Chemical Substances Acetamides ; Antineoplastic Agents
    Language English
    Publishing date 2021-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1007/s43440-021-00292-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Flaxseed oil ameliorates mercuric chloride-induced liver damage in rats.

    AlRamadneh, Tareq Nayef / AlQurashi, Naif / Khan, Mohd Sajjad Ahmad / Hashimi, Saeed Mujahid / Javaraiah, Rajesh / Al-Ostoot, Fares Hezam / Alhaija, Abed Alkarem Abu

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2022  Volume 71, Page(s) 126965

    Abstract: Background: Mercury is a relentless pollutant, and its toxicity contributes to significant health problems due to exposure to the environment. The present study has determined the impact of flaxseed oil on mercuric chloride (HgCl: Methods: Twenty- ... ...

    Abstract Background: Mercury is a relentless pollutant, and its toxicity contributes to significant health problems due to exposure to the environment. The present study has determined the impact of flaxseed oil on mercuric chloride (HgCl
    Methods: Twenty-four healthy male Wistar rats were divided into four groups with six animals in each group. Group-A was the Control group treated with saline; Group-B received 1.0 ml oral dosage of flaxseed oil; Group-C was given 200 µl intraperitoneal injection of HgCl
    Results: Mercuric chloride (HgCl
    Conclusions: The findings of this study concluded that flaxseed oil had an outstanding remedial effect on mercuric chloride-mediated hepatic cytotoxicity.
    MeSH term(s) Rats ; Male ; Animals ; Antioxidants/metabolism ; Linseed Oil/pharmacology ; Linseed Oil/therapeutic use ; Linseed Oil/metabolism ; Mercuric Chloride/toxicity ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Oxidative Stress ; Lipid Peroxidation ; Liver Diseases/metabolism ; Liver/metabolism ; Glutathione/metabolism
    Chemical Substances Antioxidants ; Linseed Oil (8001-26-1) ; Mercuric Chloride (53GH7MZT1R) ; Reactive Oxygen Species ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-02-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2022.126965
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    Zs.A 2279: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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