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  1. Article: Retraction Note to: A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation.

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder / Bolla, Srinivasa Rao

    3 Biotech

    2022  Volume 12, Issue 4, Page(s) 94

    Abstract: This retracts the article DOI: 10.1007/s13205-019-1885-3.]. ...

    Abstract [This retracts the article DOI: 10.1007/s13205-019-1885-3.].
    Language English
    Publishing date 2022-03-16
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03161-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  2. Article ; Online: Correction: Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation.

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder

    RSC advances

    2020  Volume 10, Issue 46, Page(s) 27322

    Abstract: This corrects the article DOI: 10.1039/C9RA03102B.]. ...

    Abstract [This corrects the article DOI: 10.1039/C9RA03102B.].
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra90079f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Correction: Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder

    RSC advances. 2020 July 22, v. 10, no. 46

    2020  

    Abstract: Correction for ‘Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation’ by Niyaz Ahmad et al., RSC Adv., 2019, 9, 20192–20206, DOI: 10.1039/C9RA03102B. ...

    Abstract Correction for ‘Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation’ by Niyaz Ahmad et al., RSC Adv., 2019, 9, 20192–20206, DOI: 10.1039/C9RA03102B.
    Keywords curcumin ; inflammation ; nanoemulsions ; tissue repair ; ultrasonic treatment
    Language English
    Dates of publication 2020-0722
    Size p. 27322.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d0ra90079f
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation.

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder

    RSC advances

    2019  Volume 9, Issue 35, Page(s) 20192–20206

    Abstract: The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery. The comparative effects of Cur-NE were evaluated in terms of wound healing and anti-inflammatory action. Clove oil (oil), Tween-80 ...

    Abstract The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery. The comparative effects of Cur-NE were evaluated in terms of wound healing and anti-inflammatory action. Clove oil (oil), Tween-80 (surfactant), and PEG-400 (co-surfactant) were selected on the basis of their solubility and maximum nanoemulsion region. An aqueous micro-titration method with high-energy ultrasonication was used for the preparation of Cur-NE. This method was optimized to find the best NE, followed by a five-factor, three-level, central composite design. % oil, %
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra03102b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation.

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder / Bolla, Srinivasa Rao

    publication RETRACTED

    3 Biotech

    2019  Volume 9, Issue 10, Page(s) 360

    Abstract: The main objective of this study was to develop and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of curcumin (Cur) to enhance their solubility as well as improve skin permeation; and evaluate wound healing potential of Cur via SNEDDS in ... ...

    Abstract The main objective of this study was to develop and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of curcumin (Cur) to enhance their solubility as well as improve skin permeation; and evaluate wound healing potential of Cur via SNEDDS in comparison with standards pure eucalyptus oil-SNEDDS (Euc-SNEDDS), pure curcumin suspension (Cur-S), and standard fusidic acid followed by their anti-inflammatory action. Curcumin-loaded different SNEDDS formulations were formulated through aqueous phase titration method and the zones of SNEDDS were recognized by the construction of phase diagrams. Eucalyptus oil, Tween 80 (surfactant), and Transcutol HP (co-surfactant) were selected on the basis of their solubility and highest nanoemulsion region. Characterization of thermodynamic stability for Cur-loaded SNEDDS was evaluated by its globule size, zeta potential, polydispersity index, viscosity, % transmittance, refractive index, and surface morphology. Cur-SNEDDS (Cur-SN4) was optimized and selected on the basis of their excellent physicochemical parameters for in vivo activity. The particle size (59.56 ± 0.94 nm), % transmittance (99.08 ± 0.07%), and PDI (0.207 ± 0.011 were observed for optimized Cur-SNEDDS. TEM and SEM showed their smooth and spherical shape of the morphological characterization with zeta potential (- 21.41 ± 0.89), refractive index (1.341 ± 0.06), and viscosity (11.64 ± 1.26 cp) for optimized Cur-SNEDDS. Finally, optimized Cur-SNEDDS was used to enhance skin permeation with improvement in the solubility of Cur. However, optimized Cur-SNEDDS showed significant wound healing activity as compared with pure eucalyptus oil and Cur-S on topical application. Optimized Cur-SNEDDS showed healing of wound as compared to standard fusidic acid. Optimized Cur-SNEDDS exhibited no signs of inflammatory cells on the histopathological studies of treated rats which were recommended the safety and non-toxicity of Cur-SNEDDS. Newly developed Cur-SNEDDS could be successfully used to enhance Cur-solubility and skin permeation, as well as suggested a potential role of Cur-SNEDDS for better improvement of wound healing activity followed by anti-inflammatory action of Cur via topical application.
    Language English
    Publishing date 2019-09-09
    Publishing country Germany
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-019-1885-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article: A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder / Bolla, Srinivasa Rao

    3 Biotech. 2019 Oct., v. 9, no. 10

    2019  

    Abstract: The main objective of this study was to develop and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of curcumin (Cur) to enhance their solubility as well as improve skin permeation; and evaluate wound healing potential of Cur via SNEDDS in ... ...

    Abstract The main objective of this study was to develop and evaluate self-nanoemulsifying drug delivery system (SNEDDS) of curcumin (Cur) to enhance their solubility as well as improve skin permeation; and evaluate wound healing potential of Cur via SNEDDS in comparison with standards pure eucalyptus oil-SNEDDS (Euc-SNEDDS), pure curcumin suspension (Cur-S), and standard fusidic acid followed by their anti-inflammatory action. Curcumin-loaded different SNEDDS formulations were formulated through aqueous phase titration method and the zones of SNEDDS were recognized by the construction of phase diagrams. Eucalyptus oil, Tween 80 (surfactant), and Transcutol HP (co-surfactant) were selected on the basis of their solubility and highest nanoemulsion region. Characterization of thermodynamic stability for Cur-loaded SNEDDS was evaluated by its globule size, zeta potential, polydispersity index, viscosity, % transmittance, refractive index, and surface morphology. Cur-SNEDDS (Cur-SN4) was optimized and selected on the basis of their excellent physicochemical parameters for in vivo activity. The particle size (59.56 ± 0.94 nm), % transmittance (99.08 ± 0.07%), and PDI (0.207 ± 0.011 were observed for optimized Cur-SNEDDS. TEM and SEM showed their smooth and spherical shape of the morphological characterization with zeta potential (− 21.41 ± 0.89), refractive index (1.341 ± 0.06), and viscosity (11.64 ± 1.26 cp) for optimized Cur-SNEDDS. Finally, optimized Cur-SNEDDS was used to enhance skin permeation with improvement in the solubility of Cur. However, optimized Cur-SNEDDS showed significant wound healing activity as compared with pure eucalyptus oil and Cur-S on topical application. Optimized Cur-SNEDDS showed healing of wound as compared to standard fusidic acid. Optimized Cur-SNEDDS exhibited no signs of inflammatory cells on the histopathological studies of treated rats which were recommended the safety and non-toxicity of Cur-SNEDDS. Newly developed Cur-SNEDDS could be successfully used to enhance Cur-solubility and skin permeation, as well as suggested a potential role of Cur-SNEDDS for better improvement of wound healing activity followed by anti-inflammatory action of Cur via topical application.
    Keywords Eucalyptus ; anti-inflammatory activity ; curcumin ; drug delivery systems ; histopathology ; inflammation ; nanoemulsions ; oils ; particle size ; permeability ; polysorbates ; rats ; refractive index ; scanning electron microscopy ; solubility ; surfactants ; thermodynamics ; tissue repair ; titration ; topical application ; transmission electron microscopy ; transmittance ; viscosity ; zeta potential
    Language English
    Dates of publication 2019-10
    Size p. 360.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-019-1885-3
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder

    RSC advances. 2019 June 28, v. 9, no. 35

    2019  

    Abstract: The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery. The comparative effects of Cur-NE were evaluated in terms of wound healing and anti-inflammatory action. Clove oil (oil), Tween-80 ...

    Abstract The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery. The comparative effects of Cur-NE were evaluated in terms of wound healing and anti-inflammatory action. Clove oil (oil), Tween-80 (surfactant), and PEG-400 (co-surfactant) were selected on the basis of their solubility and maximum nanoemulsion region. An aqueous micro-titration method with high-energy ultrasonication was used for the preparation of Cur-NE. This method was optimized to find the best NE, followed by a five-factor, three-level, central composite design. % oil, % Smix, ultrasonication time (min), ultrasonication intensity (%), and temperature (°C) were selected and optimized as independent variables. The optimized NE had parameters of 5.0% oil, 10% Smix, ultrasonication time (10 min), 40% ultrasonication intensity and 50 °C temperature, which were applied as independent and dependent variables. On the basis of experimental data of the dependent variables, we calculated a hydrodynamic diameter of 93.64 ± 6.48 nm, transmittance of 98.64 ± 0.37%, and PDI of 0.263 ± 0.021. TEM and SEM results revealed the smooth and spherical shape of the particles in the NE, with a zeta potential of −11.67 ± 0.11, refractive index of 1.71 ± 0.034, viscosity of 37 ± 7 cp, pH of 7.4 ± 0.07, and drug content of 98.11 ± 0.16% for the optimized Cur-NE. Cur-NE optimization with clove oil, Tween-80, and PEG-400 might be useful for enhancing the skin permeation of Cur. In conclusion, Cur-NE played a significant role in wound healing and exhibited anti-inflammatory effects, demonstrating its potential as a nanoformulation for safe and nontoxic transdermal delivery.
    Keywords anti-inflammatory activity ; clove oil ; curcumin ; drugs ; hydrodynamics ; inflammation ; lipid content ; nanoemulsions ; oils ; pH ; permeability ; polysorbates ; refractive index ; scanning electron microscopy ; solubility ; surfactants ; temperature ; tissue repair ; transdermal application ; transmission electron microscopy ; transmittance ; ultrasonic treatment ; viscosity ; zeta potential
    Language English
    Dates of publication 2019-0628
    Size p. 20192-20206.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c9ra03102b
    Database NAL-Catalogue (AGRICOLA)

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