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Article ; Online: Genetics of Cardiac Tumours: A Narrative Review.

AlRasheed, Maha M

2023

Abstract: Cardiac tumours can occur in association with genetic syndromes. Rhabdomyomas have been reported in association with tuberous sclerosis, myxomas with Carney's complex, cardiac fibromas with Gorlin syndrome, and paragangliomas with multiple endocrine ... ...

Abstract	Cardiac tumours can occur in association with genetic syndromes. Rhabdomyomas have been reported in association with tuberous sclerosis, myxomas with Carney's complex, cardiac fibromas with Gorlin syndrome, and paragangliomas with multiple endocrine neoplasm syndrome. The presentation and prognosis of cardiac tumours associated with genetic syndromes differ compared with sporadic cases. Knowledge about the associated syndromes' genetic features and extracardiac manifestations is essential for the diagnosis, prognosis, and management of cardiac neoplasms. Moreover, identifying genetic mutations in benign and malignant cardiac tumours is needed to personalise management and improve treatment outcomes. Thus, this review discusses the genetic abnormalities associated with cardiac tumours, the current genetic screening recommendations, and the effect of those genetic mutations on the outcomes.
Language	English
Publishing date	2023-12-30
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2023.11.005
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Article: TSH-β gene polymorphism in Saudi patients with thyroid cancer: A case-control study.

AlRasheed, Maha M

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2022 Volume 30, Issue 11, Page(s) 1538–1542

Abstract: Background: The role of thyroid-stimulating hormone in the pathogenesis of thyroid cancer is not yet fully explored. This study aimed to evaluate the role of the TSH-β polymorphism in thyroid cancer in a Saudi cohort.: Methods: A prospective case- ... ...

Abstract	Background: The role of thyroid-stimulating hormone in the pathogenesis of thyroid cancer is not yet fully explored. This study aimed to evaluate the role of the TSH-β polymorphism in thyroid cancer in a Saudi cohort. Methods: A prospective case-control study was conducted on 507 patients with differentiated thyroid carcinoma and compared them with 560 controls of Saudi origin. The association of two variants, the rs201857310, and rs7530810, in the TSH-β gene with thyroid cancer risk as well as thyroxine dose, were evaluated. Results: The rs201857310_A > G [OR: 0.50 (95 % CI: 0.35-0.71); Conclusions: Our findings indicate that the TSH-β gene could have a role in the pathogenesis of differentiated thyroid carcinoma in the Saudi population.
Language	English
Publishing date	2022-07-29
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2022.07.015
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Article: Evaluation of the role of

AlRasheed, Maha Meshal

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2018 Volume 26, Issue 8, Page(s) 1199–1203

Abstract: Background: Coronary heart disease (CAD) is a multiple with several contributory risk traits, including type 2 diabetes and hypertension, which may share common genetic risk variants with the disease. Genome-wide association studies (GWASs) have yielded ...

Abstract	Background: Coronary heart disease (CAD) is a multiple with several contributory risk traits, including type 2 diabetes and hypertension, which may share common genetic risk variants with the disease. Genome-wide association studies (GWASs) have yielded a wealth of information suggesting that CAD, the extent of contributory variants may differ according to genetic locus. The present study aimed at verifying whether the cyclin-dependent kinase 4 inhibitor B ( Methodology: We genotyped eight Results: Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension. Conclusions: Our finding does not support the notion of a critical role for the
Language	English
Publishing date	2018-07-20
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2018.07.009
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Article: Safety of prolonged use of metoclopramide and domperidone as treatment for chronic gastrointestinal dysmotility disorders in patients with systemic sclerosis.

Alkhowaiter, Saad / Al Rasheed, Maha M / Alammar, Nuha / Alotaibi, Ammar / Altuwaijri, Mansour / Alshankiti, Suliman / Omair, Mohammed A / Alsahafi, Majid

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2024 Volume 32, Issue 5, Page(s) 102039

Abstract: Background: Metoclopramide and domperidone are prokinetic agents commonly used to treat gastrointestinal dysmotility disorders. This study aimed to evaluate the safety and associated side effects of prolonged-use metoclopramide and domperidone as ... ...

Abstract	Background: Metoclopramide and domperidone are prokinetic agents commonly used to treat gastrointestinal dysmotility disorders. This study aimed to evaluate the safety and associated side effects of prolonged-use metoclopramide and domperidone as treatment for chronic gastrointestinal dysmotility disorders in patients with systemic sclerosis (SSc). Methods: A quantitative observational survey was conducted by interview questionnaire in rheumatology outpatients at a tertiary teaching hospital in Riyadh, Saudi Arabia. The study included all patients aged 25-80 years diagnosed with SSc. All patients were on metoclopramide or domperidone for the treatment of chronic gastrointestinal dysmotility symptoms over at least 12 weeks. Results: Eighteen eligible patients were included. Most study participants were diagnosed with SSc complicated by interstitial lung disease (n = 13; 72.2 %). The most frequently reported side effect that occurred while taking prokinetic drugs was shortness of breath (n = 12; 66.7 %). None of the participants reported experiencing depression, galactorrhea, or syncope. CNS side effects were reported in 5.6 %. There were no differences in side effects based on the type and dosage of prokinetic drug used. Conclusions: Use of metoclopramide and domperidone for the treatment of chronic gastrointestinal dysmotility in SSc patients for 12 weeks or longer was not associated with any troublesome side effects. Further studies with more participants are needed to confirm our findings.
Language	English
Publishing date	2024-03-16
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2024.102039
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Article: Genetic Insights into the Middle East Respiratory Syndrome Coronavirus Infection among Saudi People.

Abuelizz, Hatem A / AlRasheed, Maha M / Alhoshani, Ali / Alhawassi, Tariq

Vaccines

2021 Volume 9, Issue 10

Abstract: Background: The Middle East respiratory syndrome coronavirus (MERS-CoV) was isolated for the first time in Saudi Arabia from a patient suffering from atypical pneumonia. The Saudi Genome database was built by King Abdulaziz Medical City via the next- ... ...

Abstract	Background: The Middle East respiratory syndrome coronavirus (MERS-CoV) was isolated for the first time in Saudi Arabia from a patient suffering from atypical pneumonia. The Saudi Genome database was built by King Abdulaziz Medical City via the next-generation sequencing of 7000 candidates. Method: A large list of point mutations were reported in the region of the dipeptidyl peptidase 4 (DPP4) gene. The DPP4 amino acid residues correlated to MERS-CoV entry and the site of activity of DPP4 inhibitors was investigated. We retrieved the SNPs (Single-Nucleotide Polymorphism) with a variation frequency of >0.05. Results: SNP 2:162,890,175 and SNP 2:162,891,848 in the intronic region were located within 50 bp of amino acid residues responsible for MERS-CoV entry, amino acids 259-296 and 205-258, respectively. The variation frequency of SNP 2:162,890,175 was 2321 out of 2379 screened individuals. Moreover, mutation of SNP 2:162,891,848, which is located near amino acid residues E205 and E206 (crucial for the activity of DPP4 inhibitors), occurred in 76 out of 2379 screened individuals. Conclusions: Our study shows high variation frequency in the DPP4 region reported in the Saudi Genome database. The identified SNPs are of high significance for MERS-CoV infection in better understanding disease pathogenesis.
Language	English
Publishing date	2021-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines9101193
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Article: Feasibility, and barriers to use escitalopram in functional gastrointestinal disorders.

Alkhowaiter, Saad S / Alshahrani, Amani H / Almarzouqi, Hala F / Alonazi, Gadah K / Alhawassi, Tariq M / AlRasheed, Maha M

Frontiers in pharmacology

2023 Volume 14, Page(s) 1131354

Abstract: Background and study aims: ...

Abstract	Background and study aims:
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1131354
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Article: The Psychometric Properties of the Arabic Version of the Anxiety and Preoccupation About Sleep Questionnaire (APSQ).

Alghamdi, Abdulmajeed Abdullah / Abanumai, Abdulmalik Abdulrahman / Althobaiti, Meshal Fawaz / Alzahrani, Meshari Salem / Abu-Saleh, Salma Yasser / Ammar, Achraf / Ghazzawi, Hadeel / Trabelsi, Khaled / Bragazzi, Nicola / BaHammam, Ahmed S / Jahrami, Haitham / AlRasheed, Maha M

Nature and science of sleep

2024 Volume 16, Page(s) 75–83

Abstract: Background: Insomnia disorder is a common health condition; it has a role in increasing the possibility of developing other psychological disorders, including anxiety and depression. Anxiety and preoccupation with sleep are two examples of common ... ...

Abstract	Background: Insomnia disorder is a common health condition; it has a role in increasing the possibility of developing other psychological disorders, including anxiety and depression. Anxiety and preoccupation with sleep are two examples of common cognitive factors that contribute to the development of chronic insomnia; thus, it is important to have a tool that assesses worry in insomnia. There is no comprehensive psychiatric measure to assess anxiety and preoccupation with sleep in Arabic. We conducted this study to translate, adapt, and validate the Arabic version of the Anxiety and Preoccupation about Sleep Questionnaire (APSQ), providing a reliable psychometric tool to assess concerns regarding sleep within Arabic-speaking communities. Methods: The translation process of the scale involved several steps, including forward and backward translation. A cross-sectional study was conducted using an online survey completed by 523 participants from various Arabic-speaking countries. Psychometric analysis was performed utilizing the R software, including internal consistency, test-retest reliability, and confirmatory factor analysis. In addition, convergent and divergent against the Athens insomnia scale (AIS) and general anxiety disorder (GAD) were conducted. Results: The Arabic-translated form of the APSQ expresses excellent internal consistency with a value of 0.91 for both Cronbach's α and McDonald's ω. The test-retest reliability of a subsample showed an excellent coefficient of 0.93 (p<0.01). A good fit of the APSQ was observed by CFI = 0.93, TLI = 0.91, SRMR = 0.05, and RMSEA = 0.1. Convergent and divergent against AIS and GAD showed statistically significant correlations of 0.85 (p<0.01) and 0.69 (p<0.01), respectively. Our sample showed a mean APSQ score of 31.28 ± 8.31, and the mean age was 23.62 ± 7.5. Conclusion: The Arabic APSQ is reliable and valid for measuring anxiety and preoccupation with sleep in Arabic countries. Using translated APSQ for clinical diagnosis and research is currently trustworthy.
Language	English
Publishing date	2024-02-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2587468-8
ISSN	1179-1608
ISSN	1179-1608
DOI	10.2147/NSS.S449354
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Article ; Online: Branched-Chain Amino Acids Supplementation and Post-Exercise Recovery: An Overview of Systematic Reviews.

Salem, Atef / Trabelsi, Khaled / Jahrami, Haitham / AlRasheed, Maha M / Boukhris, Omar / Puce, Luca / Bragazzi, Nicola Luigi / Ammar, Achraf / Glenn, Jordan M / Chtourou, Hamdi

Journal of the American Nutrition Association

2024 Volume 43, Issue 4, Page(s) 384–396

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Amino Acids, Branched-Chain/administration & dosage ; Humans ; Dietary Supplements ; Myalgia ; Exercise/physiology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Muscle, Skeletal/metabolism ; Biomarkers/blood ; Creatine Kinase/blood ; Post-Exercise Recovery
Chemical Substances	Amino Acids, Branched-Chain ; Biomarkers ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2769-707X
ISSN (online)	2769-707X
DOI	10.1080/27697061.2023.2297899
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Article ; Online: Predicting factors and clinical outcome of biochemical incomplete response in middle eastern differentiated thyroid carcinoma.

Parvathareddy, Sandeep Kumar / Siraj, Abdul K / Ahmed, Saeeda O / Annaiyappanaidu, Padmanaban / Al-Rasheed, Maha / Al-Haqawi, Wael / Qadri, Zeeshan / Al-Sobhi, Saif S / Al-Dayel, Fouad / Al-Kuraya, Khawla S

Endocrine

2024

Abstract: Purpose: The aim of this study was evaluate biochemical incomplete response (BIR) in Middle Eastern differentiated thyroid cancer (DTC), identify factors that could predict BIR before radioactive iodine (RAI) ablation and to investigate the long-term ... ...

Abstract	Purpose: The aim of this study was evaluate biochemical incomplete response (BIR) in Middle Eastern differentiated thyroid cancer (DTC), identify factors that could predict BIR before radioactive iodine (RAI) ablation and to investigate the long-term clinical outcome of DTC patient exhibiting BIR to initial therapy. Methods: We retrospectively evaluated 1286 DTCs from Middle Eastern ethnicity who underwent total thyroidectomy and RAI therapy. Demograpic and clinico-pathological factors predicting BIR were evaluated. The outcome of these patients was analyzed using primary outcome of structural disease and disease-free survival (DFS). Results: With a median follow-up of 10 years, 266 (20.7%) patients had BIR. High pre-ablation stimulated thyroglobulin (presTg), presence of lymph node metastasis, male gender and delayed initial RAI therapy (≥3 months) after thyroidectomy were significant independent predictors of BIR. Upon evaluating long-term clinical outcomes in 266 patients with BIR, we found 36.8% of patients developed structural disease. Male sex (OR = 1.56; 95% CI = 1.05-2.30; p = 0.0272) and increasing Tg after initial therapy (OR = 4.25; 95% CI = 1.93-10.82; p = 0.0001) were independent risk factors for structural disease in patients with BIR. DFS was significantly worse if both these risk factors existed concomitantly (p < 0.0001). Conclusion: To achieve the fair efficacy of RAI therapy, early prediction of BIR before RAI ablation is desirable. Our finding of the clinico-pathological factors (high presTg level, LNM, delayed RAI therapy and male gender) could serve as easy and robust early predictors of BIR. In addition, DTC patients exhibiting BIR had a high risk of structural disease and hence personalized management approach would be preferable for BIR patients to ensure best clinical outcome.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-024-03844-x
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Article: Appraisal survey of the knowledge, attitudes, and behaviors of Jordanian society toward diet and nutrition during COVID-19 era.

Alhaj, Omar / Al-Sayyed, Hiba F / AlRasheed, Maha M / Jahrami, Haitham

Journal of public health research

2021 Volume 10, Issue 4

Abstract: Introduction: This study aimed to evaluate the knowledge, attitudes, and behavior (KAB) of the Jordanian society toward nutrition and diet during the COVID-19 era.: Design and methods: This study is an observational, cross-sectional study using a ... ...

Abstract	Introduction: This study aimed to evaluate the knowledge, attitudes, and behavior (KAB) of the Jordanian society toward nutrition and diet during the COVID-19 era. Design and methods: This study is an observational, cross-sectional study using a structured, validated, reproducible, self-administered online Arabic questionnaire. KAB of the study participants was assessed via a web-based, structured, validated, reproducible Arabic questionnaire. The tool for the assessment of the KAB was composed of 33-closed-ended multi-answer questions. Results: A total of 672 people were surveyed, 70.2% were between 18 and 34, and 69.5% were females. Participants have paid little attention to the healthfulness of their diet in the last year. The majority of participant's attitudes towards using different approaches to manage weight in the next year were: eating smaller portions for weight management, tracking to maximize the amount of time of physical activity, and substituting lower-calorie foods for full-calorie alternatives. Only tenth of participants utilize the time to perform physical activity. The majority made changes to their diet and exercise, and strictly follow commitment in connection with planning for the following year. Conclusions: Educators, legislative, food manufacturers, household heads, and policymakers are called upon to improve Jordanians' KAB on nutrition and diet. Furthermore, Jordanian nutrition and diet behavior can be invested to improve the dietary interventions designed by nutrition and dietetics professionals.
Language	English
Publishing date	2021-07-16
Publishing country	Italy
Document type	Journal Article
ISSN	2279-9028
ISSN	2279-9028
DOI	10.4081/jphr.2021.2381
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