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Article ; Online: Frontline clinical diagnosis-FTIR on pancreatic cancer.

Duckworth, Edward / Mortimer, Matthew / Al-Sarireh, Bilal / Kanamarlapudi, Venkateswarlu / Roy, Debdulal

2023 Volume 12, Issue 16, Page(s) 17340–17345

Abstract: Objective: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer.: Methods: A novel, affordable, non-invasive diagnostic method has been developed by ... ...

Abstract	Objective: Accurate, easily accessible and economically viable cancer diagnostic tools are pivotal in improving the abysmal 5% survival rate of pancreatic cancer. Methods: A novel, affordable, non-invasive diagnostic method has been developed by combining measurement precision of infrared spectroscopy with classification using machine learning tools. Results: Diagnosis accuracy as high as 90% has been achieved. The study investigated urine and blood from pancreas cancer patients and healthy volunteers, and significantly improved accuracy by focusing on sweet-spots within blood plasma fractions containing molecules within a narrow range of molecular weights.
MeSH term(s)	Humans ; Spectroscopy, Fourier Transform Infrared/methods ; Pancreatic Neoplasms/diagnosis ; Machine Learning ; Pancreatic Neoplasms
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6346
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Article ; Online: Measuring blood cell DNA damage using the PIG-A mutation and CBMN assay in pancreatic cancer patients: a pilot study.

Nichols, Lucy / Lawrence, Rachel / Haboubi, Hasan / Al-Sarireh, Bilal / Doak, Shareen / Jenkins, Gareth

Mutagenesis

2023 Volume 38, Issue 2, Page(s) 93–99

Abstract: Pancreatic cancer still has one of the worst prognoses of all solid malignancies, despite developments in cancer knowledge and care. Research into pancreatic cancer has not fully translated into clinical improvements and as a result, fewer than 1% of ... ...

Abstract	Pancreatic cancer still has one of the worst prognoses of all solid malignancies, despite developments in cancer knowledge and care. Research into pancreatic cancer has not fully translated into clinical improvements and as a result, fewer than 1% of patients survive 10 years post-diagnosis. This bleak outlook for patients could be improved by earlier diagnosis. The human erythrocyte phosphatidylinositol glycan class A (PIG-A) assay monitors the mutation status of the X-linked PIG-A gene by measuring glycosyl phosphatidylinositol (GPI)-anchored proteins on the extracellular surface. We have previously identified an elevated PIG-A mutant frequency in oesophageal adenocarcinoma patients and here investigate whether this could be seen in a pancreatic cancer cohort, given the urgent need for novel pancreatic cancer biomarkers. In our pilot study, an elevated PIG-A mutant frequency (5.775 × 10-6 (95% CI 4.777-10) mutants per million) was seen in pancreatic cancer patients (n = 30) when compared to the non-cancer control group (n = 14) who had an erythrocyte mutant frequency of 4.211 × 10-6 (95% CI 1.39-5.16) mutants per million (p = 0.0052). A cut-off value of 4.7 mutants per million provided an AUROC of 0.7595 with a sensitivity of 70% and specificity of 78.57%. A secondary measure of DNA damage in an alternative blood cell population also showed an increase in peripheral lymphocytes using the cytokinesis-block micronucleus assay (p = 0.0164) (AUROC = 0.77, sensitivity = 72.22%, specificity = 72.73%). The micronucleus frequency and PIG-A status show some potential as blood-based biomarkers of pancreatic cancer, but further investigations of these DNA damage tests are required to assess their utility in pancreatic cancer diagnosis.
MeSH term(s)	Humans ; Glycosylphosphatidylinositols ; Pilot Projects ; Mutation ; DNA Damage/genetics ; Lymphocytes ; Micronucleus Tests ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics
Chemical Substances	Glycosylphosphatidylinositols
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632903-2
ISSN	1464-3804 ; 0267-8357
ISSN (online)	1464-3804
ISSN	0267-8357
DOI	10.1093/mutage/gead006
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Zs.A 2189: Show issues

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Article ; Online: The Impact of a Centralised Pancreatic Cancer Service: a Case Study of Wales, UK.

Mowbray, Nicholas G / Griffiths, Rowena / Akbari, Ashley / Hutchings, Hayley / Jenkins, Gareth / Al-Sarireh, Bilal

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2021 Volume 26, Issue 2, Page(s) 367–375

Abstract: Introduction: The centralisation of pancreatic cancer (PC) services still varies worldwide. This study aimed to assess the impact that a centralisation has had on patients in South Wales, UK.: Methods: A retrospective cohort analysis of patients in ... ...

Abstract	Introduction: The centralisation of pancreatic cancer (PC) services still varies worldwide. This study aimed to assess the impact that a centralisation has had on patients in South Wales, UK. Methods: A retrospective cohort analysis of patients in South Wales, UK, with PC prior to (2004-2009), and after (2010-2014) the formation of a specialist centre. Patients were identified using record linkage of electronic health records. Results: The overall survival (OS) of all 3413 patients with PC increased from a median (IQR) 10 weeks (3-31) to 11 weeks (4-35), p = 0.038, after centralisation. The OS of patients undergoing surgical resection or chemotherapy alone did not improve (93 weeks (39-203) vs. 90 weeks (50-95), p = 0.764 and 33 weeks (20-57) vs. 33 weeks (19-58), p = 0.793). Surgical resection and chemotherapy rates increased (6.1% vs. 9.2%, p < 0.001 and 19.7% vs. 27.0%, p < 0.001). The 30-day mortality rate trended downwards (7.2% vs. 3.6%, p = 0.186). The percentage of patients who received no treatment reduced (75.2% vs. 69.6%, p < 0.001). Conclusion: The centralisation of PC services in South Wales is associated with a small increase in OS and a larger increase in PC treatment utilisation. It is concerning that many patients still fail to receive any treatments.
MeSH term(s)	Cohort Studies ; Humans ; Pancreatic Neoplasms/surgery ; Retrospective Studies ; United Kingdom/epidemiology
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-020-04612-8
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Ruptured pseudoaneurysm of an unnamed vessel as complication of chronic pancreatitis.

Karsan, Rickesh B / Al-Sarireh, Bilal

Journal of surgical case reports

2018 Volume 2018, Issue 8, Page(s) rjy194

Abstract: Pseudoaneurysms in the celiac territory are mostly managed conservatively. Endovascular thromboembolisation with or without stenting is currently the standard treatment with good outcome. We present a case of a patient with chronic pancreatitis who ... ...

Abstract	Pseudoaneurysms in the celiac territory are mostly managed conservatively. Endovascular thromboembolisation with or without stenting is currently the standard treatment with good outcome. We present a case of a patient with chronic pancreatitis who initially underwent endovascular treatment for presumed splenic artery pseudoaneurysm and subsequently required surgical intervention for complicated unnamed artery pseudoaneurysm. Radiological diagnosis was instrumental in guiding the ensuing surgical procedure and the patient made a good postoperative recovery.
Language	English
Publishing date	2018-08-17
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjy194
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Article ; Online: Oncological outcomes after pancreatoduodenectomy for pancreatic ductal adenocarcinoma in octogenarians: case-control study.

Pande, Rupaly / Attard, Joseph A / Al-Sarireh, Bilal / Bhogal, Ricky Harminder / Farrugia, Alexia / Fusai, Giuseppe / Harper, Simon / Hidalgo-Salinas, Camila / Jah, Asif / Marangoni, Gabriele / Mortimer, Matthew / Pizanias, Michail / Prachialias, Andreas / Roberts, Keith J / Hee, Chloe Sew / Soggiu, Fiammetta / Srinivasan, Parthi / Chatzizacharias, Nikolaos A

BJS open

2023 Volume 7, Issue 4

Abstract: Background: By the end of this decade, 70 per cent of all diagnosed pancreatic ductal adenocarcinomas will be in the elderly. Surgical resection is the only curative option. In the elderly perioperative mortality is higher, while controversy still ... ...

Abstract	Background: By the end of this decade, 70 per cent of all diagnosed pancreatic ductal adenocarcinomas will be in the elderly. Surgical resection is the only curative option. In the elderly perioperative mortality is higher, while controversy still exists as to whether aggressive treatment offers any survival benefit. This study aimed to assess the oncological benefit of pancreatoduodenectomy in octogenarians with pancreatic ductal adenocarcinoma. Method: Retrospective multicentre case-control study of octogenarians and younger controls who underwent pancreatoduodenectomy for pancreatic ductal adenocarcinoma between 2008 and 2017. The primary endpoint was overall survival and the secondary endpoint was disease-free survival. Results: Overall, 220 patients were included. Although the Charlson co-morbidity index was higher in octogenerians, Eastern Cooperative Oncology Group performance status, ASA and pathological parameters were comparable. Adjuvant therapy was more frequently delivered in the younger group (n = 80, 73 per cent versus n = 58, 53 per cent, P = 0.006). There was no significant difference between octogenarians and controls in overall survival (20 versus 29 months, P = 0.095) or disease-free survival (19 versus 22 months, P = 0.742). On multivariable analysis, age was not an independent predictor of either oncological outcome measured. Conclusion: Octogenarians with pancreatic ductal adenocarcinoma of the head and uncinate process may benefit from comparable oncological outcomes to younger patients with surgical treatment. Due to the age- and disease-related frailty and co-morbidities, careful preoperative assessment and patient selection is of paramount importance.
MeSH term(s)	Aged ; Aged, 80 and over ; Humans ; Case-Control Studies ; Pancreaticoduodenectomy ; Octogenarians ; Pancreatic Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Pancreatic Neoplasms
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Multicenter Study ; Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrad053
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Article ; Online: A meta-analysis of the utility of the neutrophil-to-lymphocyte ratio in predicting survival after pancreatic cancer resection.

Mowbray, Nicholas G / Griffith, David / Hammoda, Mohammed / Shingler, Guy / Kambal, Amir / Al-Sarireh, Bilal

HPB : the official journal of the International Hepato Pancreato Biliary Association

2018 Volume 20, Issue 5, Page(s) 379–384

Abstract: Background: The neutrophil-to-lymphocyte ratio (NLR) is thought to reflect cancer disease burden. To assess the prognostic ability of the NLR on overall survival in patients with resectable, pancreatic cancer a meta-analysis of published literature was ... ...

Abstract	Background: The neutrophil-to-lymphocyte ratio (NLR) is thought to reflect cancer disease burden. To assess the prognostic ability of the NLR on overall survival in patients with resectable, pancreatic cancer a meta-analysis of published literature was undertaken. Method: A systematic review was performed independently by two authors using PubMed, Ovid MEDLINE and Embase databases. Included studies detailed the pre-operative NLR and overall survival of pancreatic cancer patients. Results: Of the 214 studies retrieved using the search strategy, 8 studies involving 1519 patients were included in the meta-analysis. Only one study did not find a statistically significant association between a high NLR and OS. The pooled Hazard Ratio was 1.77 (95% CI [1.45-2.15]; p < 0.01). The NLR cut-off values ranged from 2 to 5. There was low to moderate inter-study heterogeneity (I Conclusions: A high pre-operative NLR indicates a worse prognosis than in patients with a low NLR. There is potential to use the NLR to direct therapies. A specific cut-off value has not been established from this study and so further research is required.
MeSH term(s)	Aged ; Female ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Pancreatectomy/adverse effects ; Pancreatectomy/mortality ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Predictive Value of Tests ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2018-01-11
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2017.12.009
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Zs.A 6326: Show issues

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Article: The microbiology of infected pancreatic necrosis.

Mowbray, Nicholas G / Ben-Ismaeil, Bassam / Hammoda, Mohammed / Shingler, Guy / Al-Sarireh, Bilal

Hepatobiliary & pancreatic diseases international : HBPD INT

2018 Volume 17, Issue 5, Page(s) 456–460

Abstract: Background: Acute pancreatitis (AP) continues to cause significant morbidity and mortality, especially when it leads to infected pancreatic necrosis (IPN). Modern treatment of IPN frequently involves prolonged courses of antibiotics in combination with ... ...

Abstract	Background: Acute pancreatitis (AP) continues to cause significant morbidity and mortality, especially when it leads to infected pancreatic necrosis (IPN). Modern treatment of IPN frequently involves prolonged courses of antibiotics in combination with minimally invasive therapies. This study aimed to update the existing evidence base by identifying the pathogens causing IPN and therefore aid future selection of empirical antibiotics. Methods: Clinical data, including microbiology results, of consecutive patients with IPN undergoing minimally invasive necrosectomy at our institution between January 2009 and July 2016 were retrospectively reviewed. Results: The results of 40 patients (22 males and 18 females, median age 60 years) with IPN were reviewed. The etiology of AP was gallstones, alcohol, dyslipidemia and unknown in 31, 2, 2 and 5 patients, respectively. The most frequently identified microbes in microbiology cultures were Enterococcus faecalis and faecium (22.5% and 20.0%) and Escherichia coli (20.0%). In 19 cases the cultures grew multiple organisms. The antibiotics with the least resistance amongst the microbiota were teicoplanin (5.0%), linezolid (5.6%), ertapenem (6.5%), and meropenem (7.4%). Conclusion: The carbapenem antibiotics, ertapenem and meropenem provide good antimicrobial cover against the common, mainly enteral, microorganisms causing IPN. Culture and sensitivity results of acquired samples should be regularly reviewed to adjust prescribing and monitor for emergence of resistance.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Databases, Factual ; Drainage/methods ; Drug Therapy, Combination ; Female ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/isolation & purification ; Humans ; Infusions, Intravenous ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Pancreatitis, Acute Necrotizing/drug therapy ; Pancreatitis, Acute Necrotizing/microbiology ; Pancreatitis, Acute Necrotizing/mortality ; Pancreatitis, Acute Necrotizing/surgery ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Survival Rate ; Tertiary Care Centers ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-08-29
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2018.08.007
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Zs.A 6313: Show issues

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Article ; Online: Laparoscopic Left Pancreatectomy in the United Kingdom: Analysis of a Six-Year Experience in a Single Tertiary Center.

Mowbray, Nicholas George / Al-Sarira, Ali / Al-Sarireh, Bilal

Pancreas

2016 Volume 45, Issue 8, Page(s) 1204–1207

Abstract: Objectives: Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to ... ...

Abstract	Objectives: Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. Methods: Patients undergoing LLP for lesions in the body and tail of the pancreas between April 2009 and April 2015 were identified. Patient records were reviewed retrospectively. Results: Laparoscopic left pancreatectomy was performed on 46 patients, median age, 62 years (range, 19-84). The spleen was preserved in 27 patients (93% of planned), and 6 (13%) operations were converted to open. The overall morbidity rate was 39%; 28 patients had no complications. Significant complications were seen in 7 (15%) patients; this included 3 pancreatic fistula (6.5%) and 1 mortality (2%). Median length of stay was 6 days (range, 3-28). Histology revealed 15 neuroendocrine tumors, 8 adenocarcinomas, 4 mucinous cystadenomas, 1 intraductal papillary mucinous neoplasm, 2 metastases, and 16 other benign pathologies. Conclusions: Laparoscopic pancreatic surgery has a low risk of significant complications. Our results offer encouragement to identify LLP as the gold standard approach for premalignant lesions. Further work should clarify the outcomes for malignant lesions.
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000000605
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Zs.A 2160: Show issues

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Article ; Online: Reduced kinase D‑interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression.

Cai, Shuo / Sun, Zhiwei / Sun, Ping-Hui / Gao, Xiangyu / Ji, Ke / Tian, Xiuyun / Ji, Jiafu / Hao, Chunyi / Soliman, Faris / Liu, Chang / Al-Sarireh, Bilal / Griffiths, Paul / Hiscox, Stephen / Jiang, Wen G / Ye, Lin

International journal of oncology

2021 Volume 58, Issue 6

Abstract: Kidins220 is a transmembrane scaffold protein involved in several types of cancer. The aim of the present study was to examine the role of Kidins220 in tumorigenesis and disease progression of pancreatic cancer. The relevant signalling pathways including ...

Abstract	Kidins220 is a transmembrane scaffold protein involved in several types of cancer. The aim of the present study was to examine the role of Kidins220 in tumorigenesis and disease progression of pancreatic cancer. The relevant signalling pathways including EGFR, EMT, and MMP were also investigated. The expression of Kidins220 was examined at the transcript and protein level. The Kidins220 knockdown cell model was established and its influence on cellular functions was determined. Involvement of Kidins220 in tumorigenesis and metastasis was examined in CD1 mice, respectively. The results showed that, reduced Kidin220 expression was associated with tumorigenesis, metastasis, and overall survival of pancreatic cancer. Knockdown of Kidins220 promoted proliferation, colony formation and tumorigenic capacity of pancreatic cancer cells
MeSH term(s)	Animals ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cohort Studies ; Disease Progression ; ErbB Receptors/metabolism ; Female ; Gene Knockdown Techniques ; Humans ; Kaplan-Meier Estimate ; MAP Kinase Signaling System ; Matrix Metalloproteinase 1/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Neoplasm Invasiveness/pathology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Pancreas/pathology ; Pancreas/surgery ; Pancreatectomy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Xenograft Model Antitumor Assays
Chemical Substances	KIDINS220 protein, human ; Membrane Proteins ; Nerve Tissue Proteins ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2021-05-06
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2021.5214
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Zs.A 3690: Show issues

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Article ; Online: PIGA mutations and glycosylphosphatidylinositol anchor dysregulation in polyposis-associated duodenal tumorigenesis.

Meuser, Elena / Chang, Kyle / Walters, Angharad / Hurley, Joanna J / West, Hannah D / Perry, Iain / Mort, Matthew / Reyes-Uribe, Laura / Truscott, Rebekah / Jones, Nicholas / Lawrence, Rachel / Jenkins, Gareth / Giles, Peter / Dolwani, Sunil / Al-Sarireh, Bilal / Hawkes, Neil / Short, Emma / Williams, Geraint T / Taggart, Melissa W /

Luetchford, Kim / Lynch, Patrick M / Terlouw, Diantha / Nielsen, Maartje / Walton, Sarah-Jane / Latchford, Andrew / Clark, Susan K / Sampson, Julian R / Vilar, Eduardo / Thomas, Laura E

Molecular cancer research : MCR

2024

Abstract: The pathogenesis of duodenal tumours in the inherited tumour syndromes Familial Adenomatous Polyposis (FAP) and MUTYH-associated Polyposis (MAP) is poorly understood. This study aimed to identify genes that are significantly mutated in these tumours and ... ...

Abstract	The pathogenesis of duodenal tumours in the inherited tumour syndromes Familial Adenomatous Polyposis (FAP) and MUTYH-associated Polyposis (MAP) is poorly understood. This study aimed to identify genes that are significantly mutated in these tumours and to explore the effects of these mutations. Whole exome and whole transcriptome sequencing identified recurrent somatic coding variants of PIGA in 19/70 (27%) FAP and MAP duodenal adenomas, and further confirmed the established driver roles for APC and KRAS. PIGA catalyses the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. Flow cytometry of PIGA-mutant adenoma-derived and CRISPR-edited duodenal organoids confirmed loss of GPI anchors in duodenal epithelial cells and transcriptional profiling of duodenal adenomas revealed transcriptional signatures associated with loss of PIGA. Implications: PIGA somatic mutation in duodenal tumours from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-23-0810
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