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  1. Article ; Online: Management of poor-grade subarachnoid haemorrhage: a self-fulfilling prophecy of good outcome?

    Al-Tamimi, Y Z

    European journal of neurology

    2017  Volume 24, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.13192
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  2. Article: Human Rights and the Excess of Identity: A Legal and Theoretical Inquiry into the Notion of Identity in Strasbourg Case Law.

    Al Tamimi, Yussef

    Social & legal studies

    2017  Volume 27, Issue 3, Page(s) 283–298

    Abstract: Identity is a central theme in contemporary politics, but legal academia lacks a rigorous analysis of this concept. The aim of this article is twofold: (i) firstly, it aims to reveal presumptions on identity in human rights law by mapping how the ... ...

    Abstract Identity is a central theme in contemporary politics, but legal academia lacks a rigorous analysis of this concept. The aim of this article is twofold: (i) firstly, it aims to reveal presumptions on identity in human rights law by mapping how the European Court of Human Rights approaches identity and (ii) secondly, it seeks to analyse these presumptions using theoretical insights on identity. By merging legal and theoretical analysis, this article contributes a reading of the Court's case law which suggests that the tension between the political and apolitical is visible as a common thread in the Court's use of identity. In case law concerning paternity, the Court appears to hold a specific view of what is presented as an unquestionable part of identity. This ostensibly pre-political notion of identity becomes untenable in cases where the nature of an identity feature, such as the headscarf, is contended or a minority has adopted a national identity that conflicts with the majoritarian national identity. The Court's approach to identity in such cases reflects a paradox that is inherent to identity; identity is personal while simultaneously constituted and shaped by overarching power mechanisms.
    Language English
    Publishing date 2017-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2024212-8
    ISSN 1461-7390 ; 0964-6639
    ISSN (online) 1461-7390
    ISSN 0964-6639
    DOI 10.1177/0964663917722598
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  3. Article ; Online: Target controlled infusion of opioids for bariatric surgery and morphine loading dose.

    Al-Tamimi, Y

    British journal of anaesthesia

    2009  Volume 102, Issue 3, Page(s) 432–3; author reply 433

    MeSH term(s) Analgesics, Opioid/administration & dosage ; Drug Administration Schedule ; Gastroplasty ; Humans ; Morphine/administration & dosage ; Pain, Postoperative/prevention & control ; Research Design
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2009-03
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/aen396
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  4. Article: The 'Ins and Outs' of Early Preclinical Models for Brain Tumor Research: Are They Valuable and Have We Been Doing It Wrong?

    Rominiyi, Ola / Al-Tamimi, Yahia / Collis, Spencer J

    Cancers

    2019  Volume 11, Issue 3

    Abstract: In this perspective, we congratulate the international efforts to highlight critical challenges in brain tumor research through a recent Consensus Statement. We also illustrate the importance of developing more accurate and clinically relevant early ... ...

    Abstract In this perspective, we congratulate the international efforts to highlight critical challenges in brain tumor research through a recent Consensus Statement. We also illustrate the importance of developing more accurate and clinically relevant early translational in vitro brain tumor models-a perspective given limited emphasis in the Consensus Statement, despite in vitro models being widely used to prioritize candidate therapeutic strategies prior to in vivo studies and subsequent clinical trials. We argue that successful translation of effective novel treatments into the clinic will require investment into the development of more predictive early pre-clinical models. It is in the interest of researchers, clinicians, and ultimately, patients that the most promising therapeutic candidates are identified and translated toward use in the clinic. Highlighting the value of early pre-clinical brain tumor models and debating how such models can be improved is of the utmost importance to the neuro-oncology research community and cancer research more broadly.
    Language English
    Publishing date 2019-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11030426
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  5. Article ; Online: Correction: Tumour treating fields therapy for glioblastoma: current advances and future directions.

    Rominiyi, Ola / Vanderlinden, Aurelie / Clenton, Susan Jane / Bridgewater, Caroline / Al-Tamimi, Yahia / Collis, Spencer James

    British journal of cancer

    2021  Volume 125, Issue 4, Page(s) 623

    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01451-5
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  6. Article ; Online: Tumour treating fields therapy for glioblastoma: current advances and future directions.

    Rominiyi, Ola / Vanderlinden, Aurelie / Clenton, Susan Jane / Bridgewater, Caroline / Al-Tamimi, Yahia / Collis, Spencer James

    British journal of cancer

    2020  Volume 124, Issue 4, Page(s) 697–709

    Abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)-an approach in ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)-an approach in which alternating electrical fields exert biophysical force on charged and polarisable molecules known as dipoles-to standard therapy, has been shown to extend survival for patients with newly diagnosed GBM, recurrent GBM and mesothelioma, leading to the clinical approval of this approach by the FDA. TTFields represent a non-invasive anticancer modality consisting of low-intensity (1-3 V/cm), intermediate-frequency (100-300 kHz), alternating electric fields delivered via cutaneous transducer arrays configured to provide optimal tumour-site coverage. Although TTFields were initially demonstrated to inhibit cancer cell proliferation by interfering with mitotic apparatus, it is becoming increasingly clear that TTFields show a broad mechanism of action by disrupting a multitude of biological processes, including DNA repair, cell permeability and immunological responses, to elicit therapeutic effects. This review describes advances in our current understanding of the mechanisms by which TTFields mediate anticancer effects. Additionally, we summarise the landscape of TTFields clinical trials across various cancers and consider how emerging preclinical data might inform future clinical applications for TTFields.
    MeSH term(s) Animals ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Clinical Trials, Phase III as Topic ; Electric Stimulation Therapy/methods ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01136-5
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  7. Article ; Online: A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic Chronic Subdural Haematoma (Dex-CSDH trial).

    Hutchinson, Peter J / Edlmann, Ellie / Hanrahan, John G / Bulters, Diederik / Zolnourian, Ardalan / Holton, Patrick / Suttner, Nigel / Agyemang, Kevin / Thomson, Simon / Anderson, Ian A / Al-Tamimi, Yahia / Henderson, Duncan / Whitfield, Peter / Gherle, Monica / Brennan, Paul M / Allison, Annabel / Thelin, Eric P / Tarantino, Silvia / Pantaleo, Beatrice /
    Caldwell, Karen / Davis-Wilkie, Carol / Mee, Harry / Warburton, Elizabeth A / Barton, Garry / Chari, Aswin / Marcus, Hani J / Pyne, Sarah / King, Andrew T / Belli, Antonio / Myint, Phyo K / Wilkinson, Ian / Santarius, Thomas / Turner, Carole / Bond, Simon / Kolias, Angelos G

    Health technology assessment (Winchester, England)

    2024  Volume 28, Issue 12, Page(s) 1–122

    Abstract: Background: Chronic subdural haematoma is a collection of 'old blood' and its breakdown products in the subdural space and predominantly affects older people. Surgical evacuation remains the mainstay in the management of symptomatic cases.: Objective!# ...

    Abstract Background: Chronic subdural haematoma is a collection of 'old blood' and its breakdown products in the subdural space and predominantly affects older people. Surgical evacuation remains the mainstay in the management of symptomatic cases.
    Objective: The Dex-CSDH (DEXamethasone in Chronic SubDural Haematoma) randomised trial investigated the clinical effectiveness and cost-effectiveness of dexamethasone in patients with a symptomatic chronic subdural haematoma.
    Design: This was a parallel, superiority, multicentre, pragmatic, randomised controlled trial. Assigned treatment was administered in a double-blind fashion. Outcome assessors were also blinded to treatment allocation.
    Setting: Neurosurgical units in the UK.
    Participants: Eligible participants included adults (aged ≥ 18 years) admitted to a neurosurgical unit with a symptomatic chronic subdural haematoma confirmed on cranial imaging.
    Interventions: Participants were randomly assigned in a 1 : 1 allocation to a 2-week tapering course of dexamethasone or placebo alongside standard care.
    Main outcome measures: The primary outcome was the Modified Rankin Scale score at 6 months dichotomised to a favourable (score of 0-3) or an unfavourable (score of 4-6) outcome. Secondary outcomes included the Modified Rankin Scale score at discharge and 3 months; number of chronic subdural haematoma-related surgical interventions undertaken during the index and subsequent admissions; Barthel Index and EuroQol 5-Dimension 5-Level utility index score reported at discharge, 3 months and 6 months; Glasgow Coma Scale score reported at discharge and 6 months; mortality at 30 days and 6 months; length of stay; discharge destination; and adverse events. An economic evaluation was also undertaken, during which the net monetary benefit was estimated at a willingness-to-pay threshold of £20,000 per quality-adjusted life-year.
    Results: A total of 748 patients were included after randomisation: 375 were assigned to dexamethasone and 373 were assigned to placebo. The mean age of the patients was 74 years and 94% underwent evacuation of their chronic subdural haematoma during the trial period. A total of 680 patients (91%) had 6-month primary outcome data available for analysis: 339 in the placebo arm and 341 in the dexamethasone arm. On a modified intention-to-treat analysis of the full study population, there was an absolute reduction in the proportion of favourable outcomes of 6.4% (95% confidence interval 11.4% to 1.4%;
    Conclusions: This trial reports a higher rate of unfavourable outcomes at 6 months, and a higher rate of serious adverse events, in the dexamethasone arm than in the placebo arm. Dexamethasone was also not estimated to be cost-effective. Therefore, dexamethasone cannot be recommended for the treatment of chronic subdural haematoma in this population group.
    Future work and limitations: A total of 94% of individuals underwent surgery, meaning that this trial does not fully define the role of dexamethasone in conservatively managed haematomas, which is a potential area for future study.
    Trial registration: This trial is registered as ISRCTN80782810.
    Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 13/15/02) and is published in full in
    MeSH term(s) Adult ; Humans ; Aged ; Hematoma, Subdural, Chronic/drug therapy ; Hospitalization ; Cost-Benefit Analysis ; Double-Blind Method ; Dexamethasone/therapeutic use
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2006765-3
    ISSN 2046-4924 ; 1366-5278
    ISSN (online) 2046-4924
    ISSN 1366-5278
    DOI 10.3310/XWZN4832
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  8. Article ; Online: Posterior cervical foraminotomy versus anterior cervical discectomy for Cervical Brachialgia: the FORVAD RCT.

    Thomson, Simon / Ainsworth, Gemma / Selvanathan, Senthil / Kelly, Rachel / Collier, Howard / Mujica-Mota, Ruben / Talbot, Rebecca / Brown, Sarah Tess / Croft, Julie / Rousseau, Nikki / Higham, Ruchi / Al-Tamimi, Yahia / Buxton, Neil / Carleton-Bland, Nicholas / Gledhill, Martin / Halstead, Victoria / Hutchinson, Peter / Meacock, James / Mukerji, Nitin /
    Pal, Debasish / Vargas-Palacios, Armando / Prasad, Anantharaju / Wilby, Martin / Stocken, Deborah

    Health technology assessment (Winchester, England)

    2023  Volume 27, Issue 21, Page(s) 1–228

    Abstract: Background: Posterior cervical foraminotomy and anterior cervical discectomy are routinely used operations to treat cervical brachialgia, although definitive evidence supporting superiority of either is lacking.: Objective: The primary objective was ... ...

    Abstract Background: Posterior cervical foraminotomy and anterior cervical discectomy are routinely used operations to treat cervical brachialgia, although definitive evidence supporting superiority of either is lacking.
    Objective: The primary objective was to investigate whether or not posterior cervical foraminotomy is superior to anterior cervical discectomy in improving clinical outcome.
    Design: This was a Phase III, unblinded, prospective, United Kingdom multicentre, parallel-group, individually randomised controlled superiority trial comparing posterior cervical foraminotomy with anterior cervical discectomy. A rapid qualitative study was conducted during the close-down phase, involving remote semistructured interviews with trial participants and health-care professionals.
    Setting: National Health Service trusts.
    Participants: Patients with symptomatic unilateral cervical brachialgia for at least 6 weeks.
    Interventions: Participants were randomised to receive posterior cervical foraminotomy or anterior cervical discectomy. Allocation was not blinded to participants, medical staff or trial staff. Health-care use from providing the initial surgical intervention to hospital discharge was measured and valued using national cost data.
    Main outcome measures: The primary outcome measure was clinical outcome, as measured by patient-reported Neck Disability Index score 52 weeks post operation. Secondary outcome measures included complications, reoperations and restricted American Spinal Injury Association score over 6 weeks post operation, and patient-reported Eating Assessment Tool-10 items, Glasgow-Edinburgh Throat Scale, Voice Handicap Index-10 items, PainDETECT and Numerical Rating Scales for neck and upper-limb pain over 52 weeks post operation.
    Results: The target recruitment was 252 participants. Owing to slow accrual, the trial closed after randomising 23 participants from 11 hospitals. The qualitative substudy found that there was support and enthusiasm for the posterior cervical FORaminotomy Versus Anterior cervical Discectomy in the treatment of cervical brachialgia trial and randomised clinical trials in this area. However, clinical equipoise appears to have been an issue for sites and individual surgeons. Randomisation on the day of surgery and processes for screening and approaching participants were also crucial factors in some centres. The median Neck Disability Index scores at baseline (pre surgery) and at 52 weeks was 44.0 (interquartile range 36.0-62.0 weeks) and 25.3 weeks (interquartile range 20.0-42.0 weeks), respectively, in the posterior cervical foraminotomy group (
    Conclusions: The data suggest that posterior cervical foraminotomy is associated with better outcomes, fewer complications and lower costs, but the trial recruited slowly and closed early. Consequently, the trial is underpowered and definitive conclusions cannot be drawn. Recruitment was impaired by lack of individual equipoise and by concern about randomising on the day of surgery. A large prospective multicentre trial comparing anterior cervical discectomy and posterior cervical foraminotomy in the treatment of cervical brachialgia is still required.
    Trial registration: This trial is registered as ISRCTN10133661.
    Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme and will be published in full in
    MeSH term(s) Humans ; Foraminotomy ; State Medicine ; Neck Pain ; Prospective Studies ; Diskectomy ; Cost-Benefit Analysis ; Quality of Life
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 2006765-3
    ISSN 2046-4924 ; 1366-5278
    ISSN (online) 2046-4924
    ISSN 1366-5278
    DOI 10.3310/OTOH7720
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  9. Article ; Online: Estimation of infant dose and exposure to pethidine and norpethidine via breast milk following patient-controlled epidural pethidine for analgesia post caesarean delivery.

    Al-Tamimi, Y / Ilett, K F / Paech, M J / O'Halloran, S J / Hartmann, P E

    International journal of obstetric anesthesia

    2011  Volume 20, Issue 2, Page(s) 128–134

    Abstract: Background: There is no information about the distribution of pethidine into breast milk and/or exposure of the breastfed infant during pethidine patient-controlled epidural analgesia after caesarean delivery.: Methods: We conducted an observational ... ...

    Abstract Background: There is no information about the distribution of pethidine into breast milk and/or exposure of the breastfed infant during pethidine patient-controlled epidural analgesia after caesarean delivery.
    Methods: We conducted an observational study among 20 women. The mean (95% confidence interval) pethidine dose administered was 670 (346-818) mg over 41 (35-46) h. Maternal plasma and milk and neonatal plasma were collected near the time of pethidine cessation and 6h later. Absolute and relative infant doses via milk and infant exposure were calculated. Infant behaviour was assessed using the Neurologic and Adaptive Capacity Score.
    Results: At first and second sampling times, mean absolute infant doses for pethidine were 20 (14-27) μg/kg/day and 10 (7-13) μg/kg/day, while mean relative infant doses were 0.7 (0.1-1.4)% and 0.3 (0.1-0.5)% respectively. Similar values for norpethidine (expressed as pethidine equivalents) were 21 (16-26) μg/kg/day and 22 (12-32) μg/kg/day; and 0.7 (0.3-1)% and 0.6 (0.2-1)% respectively. Mean pethidine and norpethidine concentrations in neonatal plasma were 3 (0-6.1) μg/L and 0.6 (0.2-1) μg/L. Compared with a time-matched maternal sample, the infant's exposure was 1.4 (0.2-2.8)% for pethidine and 0.4 (0.2-0.6)% for norpethidine. The mean (95% confidence interval) neurologic and adaptive capacity score was 33.6 (32.2-34.9).
    Conclusion: The combined absolute infant dose of pethidine and norpethidine received via milk was 1.8% of the neonatal therapeutic dose and the combined relative infant dose was below the 10% recommended safety level. Breastfed infants are at low risk of drug exposure when mothers self-administer epidural pethidine after caesarean delivery.
    MeSH term(s) Analgesia, Epidural ; Analgesia, Obstetrical ; Analgesia, Patient-Controlled ; Analgesics, Opioid/pharmacokinetics ; Breast Feeding ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Meperidine/analogs & derivatives ; Meperidine/pharmacokinetics ; Milk, Human/metabolism ; Pain, Postoperative/drug therapy ; Pregnancy
    Chemical Substances Analgesics, Opioid ; Meperidine (9E338QE28F) ; normeperidine (JG096PMW2N)
    Language English
    Publishing date 2011-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1086024-1
    ISSN 1532-3374 ; 0959-289X
    ISSN (online) 1532-3374
    ISSN 0959-289X
    DOI 10.1016/j.ijoa.2010.12.004
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  10. Article ; Online: Measurement of long-term outcome in patients with cervical spondylotic myelopathy treated surgically.

    Al-Tamimi, Y Z / Guilfoyle, M / Seeley, H / Laing, R J

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2013  Volume 22, Issue 11, Page(s) 2552–2557

    Abstract: Purpose: The Myelopathy Disability Index and the Neck Disability Index are widely used to assess outcome in cervical spine surgery. Short Form (SF) 36 is a generic measure of health which can be used to measure health gains across a wide variety of ... ...

    Abstract Purpose: The Myelopathy Disability Index and the Neck Disability Index are widely used to assess outcome in cervical spine surgery. Short Form (SF) 36 is a generic measure of health which can be used to measure health gains across a wide variety of conditions. The aim of the current study is to assess long-term outcomes using these measures in a cohort of patients with cervical spondylotic myelopathy (CSM).
    Methods: Cohort study with prospective data collection. Patients with CSM being offered decompressive surgery were asked to complete a set of generic and condition-specific outcome measures. This was repeated post-operatively at 3, 12, 24 and 60 months. SF-36 was used as a generic outcome measure and the Myelopathy Index, Neck Disability Score and visual analogue scores for arm, neck and hand pain, paraesthesia and dysthaesia were used as condition-specific outcome measures.
    Results: Significant improvements in all outcome measures were seen in 70% of the cohort. For SF-36, pre-operative scores were lower than age-matched controls in all domains and significant improvements were seen 3 months following surgery. This improvement in outcome was maintained at 5 years follow-up in approximately two-thirds of those with initial improvement.
    Conclusion: We have used generic and condition-specific outcome measures of health and shown that in patients with CSM treated surgically, up to 70% can expect improvement in their quality of life. These outcome measures are easy to collect and provide objective evidence of changes in quality of life and disability and can help quantify the potential health gains that can be achieved.
    MeSH term(s) Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Spinal Cord Diseases/etiology ; Spinal Cord Diseases/surgery ; Spondylosis/complications ; Spondylosis/surgery ; Treatment Outcome
    Language English
    Publishing date 2013-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-013-2965-4
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