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  1. Article ; Online: PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide.

    Al-Zuhairy, Saeed A S / Teaima, Mahmoud H / Shoman, Nabil A / Elasaly, Mohamed / El-Nabarawi, Mohamed A / El-Sawy, Hossam S

    Drug delivery

    2023  Volume 30, Issue 1, Page(s) 2189112

    Abstract: A PEGylated Tween 80-functionalized chitosan-lipidic (PEG-T-Chito-Lip) nano-vesicular hybrid was developed for intranasal administration as an alternative delivery route to help improve the poor oral bioavailability of BCS class-III model/antiemetic ( ... ...

    Abstract A PEGylated Tween 80-functionalized chitosan-lipidic (PEG-T-Chito-Lip) nano-vesicular hybrid was developed for intranasal administration as an alternative delivery route to help improve the poor oral bioavailability of BCS class-III model/antiemetic (metoclopramide hydrochloride; MTC). The influence of varying levels of chitosan, cholesterol, PEG 600, and Tween 80 on the stability/release parameters of the formulated nanovesicles was optimized using Draper-Lin Design. Two optimized formulations (Opti-Max and Opti-Min) with both maximized and minimized MTC-release goals, were predicted, characterized, and proved their vesicular outline
    MeSH term(s) Rats ; Animals ; Metoclopramide/metabolism ; Polysorbates ; Chitosan/metabolism ; Biological Availability ; Rats, Sprague-Dawley ; Drug Delivery Systems ; Administration, Intranasal ; Brain/metabolism ; Lipids ; Drug Carriers/metabolism
    Chemical Substances Metoclopramide (L4YEB44I46) ; Polysorbates ; Chitosan (9012-76-4) ; Lipids ; Drug Carriers
    Language English
    Publishing date 2023-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2023.2189112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Revolutionizing Psoriasis Topical Treatment: Enhanced Efficacy Through Ceramide/Phospholipid Composite Cerosomes Co-Delivery of Cyclosporine and Dithranol: In-Vitro, Ex-Vivo, and in-Vivo Studies.

    Elhabal, Sammar Fathy / Abdelaal, Nashwa / Al-Zuhairy, Saeed A S / Mohamed Elrefai, Mohamed Fathi / Khalifa, Mohamed Mansour / Khasawneh, Mohammad Ahmad / Elsaid Hamdan, Ahmed Mohsen / Mohie, Passant M / Gad, Rania A / Kabil, Soad L / El-Ashery, Mohamed Kandeel / Jasti, Bhaskara R / Elzohairy, Nahla A / Elfar, Nehal / Elnawawy, Tayseer / Hassan, Fatma E / El-Nabarawi, Mohamed Ahmed

    International journal of nanomedicine

    2024  Volume 19, Page(s) 1163–1187

    Abstract: Purpose: Improving the treatment of psoriasis is a serious challenge today. Psoriasis is an immune-mediated skin condition affecting 125 million people worldwide. It is commonly treated with cyclosporine-A (CsA) and dithranol (DTH). CsA suppresses the ... ...

    Abstract Purpose: Improving the treatment of psoriasis is a serious challenge today. Psoriasis is an immune-mediated skin condition affecting 125 million people worldwide. It is commonly treated with cyclosporine-A (CsA) and dithranol (DTH). CsA suppresses the activation of T-cells, immune cells involved in forming psoriatic lesions. Meanwhile, DTH is a potent anti-inflammatory and anti-proliferative drug that effectively reduces the severity of psoriasis symptoms such as redness, scaling, and skin thickness. CsA and DTH belong to BCS class II with limited oral bioavailability. We aim to develop a drug delivery system for topical co-delivery of CsA and DTH, exploring its therapeutic potential.
    Methods: Firstly, we developed a niosomal drug delivery system based on ceramide IIIB to form Cerosomes. Cerosomes were prepared from a mixture of Ceramide, hyaluronic acid, and edge activator using a thin-film hydration technique. To co-deliver CsA and DTH topically for the treatment of psoriasis. These two hydrophobic drugs encapsulated into our synthesized positively charged particle cerosomes.
    Results:  Cerosomes had an average particle size of (222.36 nm± 0.36), polydispersity index of (0.415±0.04), Entrapment Efficiency of (96.91%± 0.56), and zeta potential of (29.36±0.38mV) for selected formula. In vitro, In silico, in vivo, permeation, and histopathology experiments have shown that cerosomes enhanced the skin penetration of both hydrophobic drugs by 66.7% compared to the CsA/DTH solution. Imiquimod (IMQ) induced psoriatic mice model was topically treated with our CsA/DTH cerosomes. We found that our formulation enhances the skin penetration of both drugs and reduces psoriasis area and severity index (PASI score) by 2.73 times and 42.85%, respectively, compared to the CsA/DTH solution. Moreover, it reduces the levels of proinflammatory cytokines, TNF-α, IL-10, and IL-6 compared to CsA/DTH solution administration.
    Conclusion: The Cerosomes nano-vesicle-containing CsA/DTH represents a more promising topical treatment for psoriasis, giving new hope to individuals with psoriasis, compared to commercial and other conventional alternatives.
    MeSH term(s) Humans ; Animals ; Mice ; Anthralin/pharmacology ; Anthralin/therapeutic use ; Cyclosporine/pharmacology ; Phospholipids ; Ceramides/pharmacology ; Administration, Cutaneous ; Psoriasis/drug therapy ; Psoriasis/pathology ; Skin ; Disease Models, Animal
    Chemical Substances Anthralin (U8CJK0JH5M) ; Cyclosporine (83HN0GTJ6D) ; Phospholipids ; Ceramides
    Language English
    Publishing date 2024-02-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S443812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Development and Evaluation of Biocompatible Topical Petrolatum-liquid Crystal Formulations with Enhanced Skin Permeation Properties.

    Al-Zuhairy, Saeed A S / Kadhum, Wesam R / Alhijjaj, Muqdad / Kadhim, Mustafa M / Al-Janabi, Ahmed S / Salman, Abbas Washeel / Al-Sharifi, Haitham K R / Khadom, Anees A

    Journal of oleo science

    2022  Volume 71, Issue 3, Page(s) 459–468

    Abstract: Transdermal administration represents a major advancement over traditional pharmaceutical dosing methods. However, a frequent issue is inadequate penetration of the active medicinal component through the skin. As a result, in the current research, we ... ...

    Abstract Transdermal administration represents a major advancement over traditional pharmaceutical dosing methods. However, a frequent issue is inadequate penetration of the active medicinal component through the skin. As a result, in the current research, we assessed the utility of newly developed petrolatum-liquid crystal (LC) ointment formulations and characterized their biocompatibility and function in the transdermal drug delivery system. To begin, we made petrolatum-LC formulations using p-aminobenzoic acid (PABA) as a hydrophilic model molecule. The viscosity, small-angle X-ray scattering (SAXS), particle diameters, and z-potential were measured to assess the physicochemical properties of the formulations. A dialysis release technique was used to evaluate medication release from petrolatum-LC formulations. In vitro testing was performed to determine the potential to enhance skin penetration. The biocompatibility of the produced formulations was further tested using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and single-cell gel electrophoresis. According to the results, the novel petrolatum-LC formulations are biocompatible and effective in forming hexosomes. PABA skin penetration was significantly enhanced by the new petrolatum-LC formulations. According to this study, petroleum-LC formulations are more efficient than commercial petrolatum in terms of skin permeability improvement and PABA skin concentration.
    MeSH term(s) Administration, Cutaneous ; Liquid Crystals ; Petrolatum/chemistry ; Petrolatum/metabolism ; Scattering, Small Angle ; Skin/metabolism ; Skin Absorption ; X-Ray Diffraction
    Chemical Substances Petrolatum (8009-03-8)
    Language English
    Publishing date 2022-02-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess21344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Improvement of the Ocular Bioavailability of Econazole Nitrate upon Complexation with Cyclodextrins.

    Abd El-Gawad, Abd El-Gawad Helmy / Soliman, Osama A / El-Dahan, Marwa S / Al-Zuhairy, Saeed A S

    AAPS PharmSciTech

    2017  Volume 18, Issue 5, Page(s) 1795–1809

    Abstract: Econazole nitrate (EC) is an active, imidazole antifungal agent. However, low aqueous solubility and dissolution rate of EC has discouraged its usage for the treatment of ophthalmic fungal infection. In this study, inclusion complexes of EC with ... ...

    Abstract Econazole nitrate (EC) is an active, imidazole antifungal agent. However, low aqueous solubility and dissolution rate of EC has discouraged its usage for the treatment of ophthalmic fungal infection. In this study, inclusion complexes of EC with cyclodextrins were prepared to enhance its solubility, dissolution, and ocular bioavailability. To achieve this goal, EC was complexed with β-CyD/HP-β-CyD using kneading, co-precipitation, and freeze-drying techniques. Phase-solubility studies were performed to investigate the complexes in the liquid form. Additionally, the complexes in the solid form were characterized with Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and transmission electron microscopy (TEM). Furthermore, different eye drops containing EC-CyD complexes were prepared using different polymers and then characterized regarding their drug contents, pH, viscosity, mucoadhesive strength, and in vitro release characteristics. The results showed that stable EC-CyD complexes were formed in 1:1 molar ratio as designated by B
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ISSN 1530-9932
    ISSN (online) 1530-9932
    DOI 10.1208/s12249-016-0609-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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