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  1. AU="AlHarfoush, Enmar"
  2. AU="Savill, Edward"
  3. AU="Pavel P. Polyakov"
  4. AU="Robert Haennel"
  5. AU="Robert W. Crawford"
  6. AU="Figueroa, Andres V"
  7. AU="Racca, C."
  8. AU="Slavu, Diana-Maria"
  9. AU="Talbert, Emily"
  10. AU=Abdelnour Loay H
  11. AU=Meisburger Steve P.
  12. AU="Silveira, Fernando A. O."
  13. AU="Toru Nabika"
  14. AU="Vojkovic, Marina"
  15. AU="Gaier, Eric D"
  16. AU="Chandler Crews"
  17. AU="Comte, Marie-Hélène"
  18. AU="Cohen, Or"
  19. AU="Abdellatifi, Mohamed"
  20. AU="Luebbe, Elizabeth"
  21. AU="Emidio, Adriana"
  22. AU=Masmejan Sophie
  23. AU="Samantha Ridley"
  24. AU="Moghaddam-Alvandi, Arash"
  25. AU="Khanolkar, Amey R."
  26. AU="Vasquez Martinez, Rodolfo"
  27. AU="Morgan, E"

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  1. Artikel ; Online: Adenosine kinase: An epigenetic modulator in development and disease.

    Murugan, Madhuvika / Fedele, Denise / Millner, David / Alharfoush, Enmar / Vegunta, Geetasravya / Boison, Detlev

    Neurochemistry international

    2021  Band 147, Seite(n) 105054

    Abstract: Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5'-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). The two isoforms ...

    Abstract Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5'-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). The two isoforms are developmentally regulated and are differentially expressed in distinct subcellular compartments with ADK-L localized in the nucleus and ADK-S localized in the cytoplasm. The nuclear localization of ADK-L and its biochemical link to the transmethylation pathway suggest a specific role for gene regulation via epigenetic mechanisms. Recent evidence reveals an adenosine receptor-independent role of ADK in determining the global methylation status of DNA and thereby contributing to epigenomic regulation. Here we summarize recent progress in understanding the biochemical interactions between adenosine metabolism by ADK-L and epigenetic modifications linked to transmethylation reactions. This review will provide a comprehensive overview of ADK-associated changes in DNA methylation in developmental, as well as in pathological conditions including brain injury, epilepsy, vascular diseases, cancer, and diabetes. Challenges in investigating the epigenetic role of ADK for therapeutic gains are briefly discussed.
    Mesh-Begriff(e) Adenosine Kinase/genetics ; Adenosine Kinase/metabolism ; Animals ; Brain Injuries/metabolism ; DNA Methylation/genetics ; DNA Methylation/physiology ; Epigenesis, Genetic/genetics ; Epilepsy/genetics ; Epilepsy/metabolism ; Gene Expression Regulation/genetics ; Gene Expression Regulation/physiology ; Humans
    Chemische Substanzen Adenosine Kinase (EC 2.7.1.20)
    Sprache Englisch
    Erscheinungsdatum 2021-05-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2021.105054
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Developmental Role of Adenosine Kinase in the Cerebellum.

    Gebril, Hoda / Wahba, Amir / Zhou, Xiaofeng / Lai, Tho / Alharfoush, Enmar / DiCicco-Bloom, Emanuel / Boison, Detlev

    eNeuro

    2021  Band 8, Heft 3

    Abstract: Adenosine acts as a neuromodulator and metabolic regulator of the brain through receptor dependent and independent mechanisms. In the brain, adenosine is tightly controlled through its metabolic enzyme adenosine kinase (ADK), which exists in a ... ...

    Abstract Adenosine acts as a neuromodulator and metabolic regulator of the brain through receptor dependent and independent mechanisms. In the brain, adenosine is tightly controlled through its metabolic enzyme adenosine kinase (ADK), which exists in a cytoplasmic (ADK-S) and nuclear (ADK-L) isoform. We recently discovered that ADK-L contributes to adult hippocampal neurogenesis regulation. Although the cerebellum (CB) is a highly plastic brain area with a delayed developmental trajectory, little is known about the role of ADK. Here, we investigated the developmental profile of ADK expression in C57BL/6 mice CB and assessed its role in developmental and proliferative processes. We found high levels of ADK-L during cerebellar development, which was maintained into adulthood. This pattern contrasts with that of the cerebrum, in which ADK-L expression is gradually downregulated postnatally and largely restricted to astrocytes in adulthood. Supporting a functional role in cell proliferation, we found that the ADK inhibitor 5-iodotubericine (5-ITU) reduced DNA synthesis of granular neuron precursors in a concentration-dependent manner
    Mesh-Begriff(e) Adenosine Kinase/genetics ; Adenosine Kinase/metabolism ; Animals ; Astrocytes/metabolism ; Cerebellum/metabolism ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism
    Chemische Substanzen Adenosine Kinase (EC 2.7.1.20)
    Sprache Englisch
    Erscheinungsdatum 2021-06-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0011-21.2021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Resection of a posterior fossa arteriovenous malformation complicated by leaked Onyx: a case report and review of literature.

    Solli, Elena / Jumah, Fareed / Narayan, Vinayak / Quinoa, Travis / Xiong, Zhenggang / Gupta, Gaurav / Alharfoush, Enmar / Nanda, Anil

    Acta neurochirurgica

    2020  Band 162, Heft 4, Seite(n) 923–928

    Abstract: Extravasation of Onyx is a rare complication during embolization of arteriovenous malformations (AVM). We present a case of embolization that was complicated by leakage of Onyx into the cerebellum which was later encountered during surgical excision of ... ...

    Abstract Extravasation of Onyx is a rare complication during embolization of arteriovenous malformations (AVM). We present a case of embolization that was complicated by leakage of Onyx into the cerebellum which was later encountered during surgical excision of the AVM. Our goal is to report this rare event and to outline successful treatment of this complication. The patient's records were reviewed for medical history, laboratory and radiologic workup, and outpatient clinical follow-up. A 62-year-old female presented with Hunt Hess grade 2 and modified Fisher grade 2 subarachnoid hemorrhage (SAH) secondary to ruptured left posterior inferior cerebellar artery (PICA) aneurysm associated with a superior cerebellar vermian AVM. Following endovascular intervention, the aneurysm was completely embolized; however, only 75% of the AVM could be safely obliterated. Extravasation of Onyx from the ruptured aneurysm was noted on her initial angiogram. Elective suboccipital craniectomy was subsequently planned for resection of the residual AVM where the extravasated Onyx posed an operative nuisance during resection. Post-op angiogram confirmed complete resection of the AVM, as well as the bulk of the extravasated Onyx. Patient did well post-operatively, remaining neurologically intact throughout her hospital course. Although infrequently reported in the literature, Onyx extravasation is a potential complication that neurosurgeons should be ready to face. Adherence of Onyx to surrounding parenchyma could hinder optimal surgical resection of AVM and increase complications. Therefore, careful surgical dissection should be performed with special care to delicate neurovasculature. In this case, complete resection of the AVM and Onyx mass was safely achieved.
    Mesh-Begriff(e) Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/surgery ; Aneurysm, Ruptured/therapy ; Craniotomy/adverse effects ; Craniotomy/methods ; Dissection/adverse effects ; Dissection/methods ; Elective Surgical Procedures/adverse effects ; Elective Surgical Procedures/methods ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Female ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/surgery ; Intracranial Arteriovenous Malformations/therapy ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery
    Sprache Englisch
    Erscheinungsdatum 2020-01-30
    Erscheinungsland Austria
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-019-04199-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Role of Adenosine in Epilepsy and Seizures.

    Tescarollo, Fabio C / Rombo, Diogo M / DeLiberto, Lindsay K / Fedele, Denise E / Alharfoush, Enmar / Tomé, Ângelo R / Cunha, Rodrigo A / Sebastião, Ana M / Boison, Detlev

    Journal of caffeine and adenosine research

    2020  Band 10, Heft 2, Seite(n) 45–60

    Abstract: Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, ... ...

    Abstract Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain into an epileptic brain (epileptogenesis). It is involved in the control of abnormal synaptic plasticity and neurodegeneration and plays a major role in the expression of comorbid symptoms and complications of epilepsy, such as sudden unexpected death in epilepsy (SUDEP). Given the important role of adenosine in epilepsy, therapeutic strategies are in development with the goal to utilize adenosine augmentation not only for the suppression of seizures but also for disease modification and epilepsy prevention, as well as strategies to block adenosine A
    Sprache Englisch
    Erscheinungsdatum 2020-06-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2928613-X
    ISSN 2573-3400 ; 2573-3397
    ISSN (online) 2573-3400
    ISSN 2573-3397
    DOI 10.1089/caff.2019.0022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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