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Article: Using English medium instruction to teach a general course in a College of Business and Management.

Oraif, Iman / Alrashed, Mohammed

2022 Volume 13, Page(s) 984869

Abstract: Even though learning can be complex when using a language other than one's mother tongue, the English-medium communicative approach has been widely adopted in Saudi universities over recent years. Many universities in Saudi Arabia are teaching their ... ...

Abstract	Even though learning can be complex when using a language other than one's mother tongue, the English-medium communicative approach has been widely adopted in Saudi universities over recent years. Many universities in Saudi Arabia are teaching their courses through the medium of English rather than Arabic, as was previously the case. This also applies to the social and natural sciences. Moreover, instructors are trying to avoid using any Arabic in class, given that English has become the
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.984869
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Article ; Online: The relationship between malocclusion and oral health-related quality of life among adolescents: a systematic literature review and meta-analysis.

Alrashed, Muath / Alqerban, Ali

European journal of orthodontics

2020 Volume 43, Issue 2, Page(s) 173–183

Abstract: Background: Malocclusion is a deviation from an anatomical norm that occurs in various populations. Evidence shows that it has physical and psychological implications as well as an influence on the patient's oral health-related quality of life (OHRQoL). ...

Abstract	Background: Malocclusion is a deviation from an anatomical norm that occurs in various populations. Evidence shows that it has physical and psychological implications as well as an influence on the patient's oral health-related quality of life (OHRQoL). Self-perception of oral health plays an important role in the understanding of malocclusion's influence on the quality of life. Malocclusion has been reported to impair a patient's function, appearance, interpersonal relationships and psychological well-being. Objectives: The aim of this study was to investigate whether adolescents aged between 11 and 18 years with malocclusion are at increased risk for having a high level of OHRQoL compared with those without malocclusion. Search methods: The Ovid Medline, Embase and Scopus databases were used to identify studies measuring the association between malocclusion and HRQoL. Selection criteria: Only cross-sectional studies were included, and the following inclusion criteria were used: subjects were systemically healthy; data were available for untreated malocclusion and OHRQoL; malocclusion was measured by Dental Aesthetic Index and Index of Orthodontic Treatment Needs; OHRQoL was assessed by Child Perception Questionnaire, Child Oral Health Impact Profile and Child Oral Health Impact Profile; and the paper was published in English. Data collection and analysis: Data were extracted by two independent reviewers. The Appraisal tool for Cross-Sectional Studies (AXIS) was used to establish the risk of bias, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence quality assessment tool was used to assess the impact of malocclusion on adolescents across studies. Results: The initial search yielded 530 papers. Eleven cross-sectional studies were included in the meta-analyses, and all data describing the relationship between malocclusion and OHRQoL were gathered via a structured questionnaire. Our results showed that malocclusion is linked to decreased OHRQoL in children and adolescents aged between 11 and 18 years in continuously analysed studies. However, in dichotomously analysed studies, it was shown that young people without malocclusion are linked to decreased OHRQoL. Conclusions: Adolescents with severe levels of malocclusion might have among the worst levels of OHRQoL. The effects of malocclusion on OHRQoL were influenced by the age of the adolescents as well as by their culture and environment. Registration: PROSPERO (CRD42020178657).
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Humans ; Malocclusion ; Oral Health ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	423731-6
ISSN	1460-2210 ; 0141-5387
ISSN (online)	1460-2210
ISSN	0141-5387
DOI	10.1093/ejo/cjaa051
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Article ; Online: Age estimation based on Willems method versus country specific model in Saudi Arabia children and adolescents.

Alqerban, Ali / Alrashed, Muath / Alaskar, Ziyad / Alqahtani, Khalid

BMC oral health

2021 Volume 21, Issue 1, Page(s) 341

Abstract: Background: The aims of this study were to create a method for estimation of dental age in Saudi children and adolescents based on the Willems model developed using the Belgian Caucasian (BC) reference data and to compare the ability of the two models ... ...

Abstract	Background: The aims of this study were to create a method for estimation of dental age in Saudi children and adolescents based on the Willems model developed using the Belgian Caucasian (BC) reference data and to compare the ability of the two models to predict age in Saudi children. Methods: Development of the seven lower left permanent mandibular teeth was staged in 1146 panoramic radiographs from healthy Saudi children (605 male, 541 female) without missing permanent teeth and without all permanent teeth fully developed (except third molars). The data were used to validate the Willems BC model and to construct a Saudi Arabian-specific (Willems SA) model. The mean error, mean absolute error, and root mean square error obtained from both validations were compared to quantify the variance in errors in the sample. Results: The overall mean error for the Willems SA method was 0.023 years (standard deviation, ± 0.55), indicating no systematic underestimation or overestimation of age. For girls, the error using the Willems SA method was significantly lower but still negligible at 0.06 years. A small but statistically significant difference in total mean absolute error (11 days) was found between the Willems BC and Willems SA models when the data were compared independent of sex. The overall mean absolute error for girls was slightly lower for the Willems BC method than for the Willems SA method (1.33 years vs. 1.37 years). Conclusions: The difference in ability to predict dental age between the Willems BC and Willems SA methods is very small, indicating that the data from the BC population can be used as a reference in the Saudi population.
MeSH term(s)	Adolescent ; Age Determination by Teeth ; Belgium ; Child ; Female ; Humans ; Male ; Molar, Third ; Radiography, Panoramic ; Saudi Arabia ; Tooth
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-021-01707-9
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Article: An Extremely Rare and Aggressive Case of Undifferentiated Carcinoma With Osteoclast-Like Giant Cells of the Pancreas Presenting as a Paraneoplastic Syndrome: A Case Report and Literature Review.

AlAli, Mohammed N / Alothman, Ghada I / Essa, Mohamed S / Alrashed, Muath / Amer, Sadiq M / ALMuqrin, Farah / Albdah, Abdullah M / Alamri, Ossama

Cureus

2024 Volume 16, Issue 1, Page(s) e51996

Abstract: Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is a rare tumor type of pancreatic cancer. Paraneoplastic syndromes, an idiopathic inflammatory myositis characterized by various skin manifestations (such as dermatomyositis (DM)), ... ...

Abstract	Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is a rare tumor type of pancreatic cancer. Paraneoplastic syndromes, an idiopathic inflammatory myositis characterized by various skin manifestations (such as dermatomyositis (DM)), cannot be attributed to the primary tumor itself. Here, we report an unusual case of UC-OGC presenting as a paraneoplastic syndrome, the first reported from Saudi Arabia and the Arabian Gulf states. A 49-year-old Eritrean woman with known DM was referred to our hospital with a left-sided pleural effusion. Computed tomography of the abdomen revealed a large necrotic splenic mass (~17 × 12.9 × 18.2 cm). The patient underwent exploratory laparotomy with en bloc resection of the mass (splenectomy, distal pancreatectomy, and partial excision of the left hemidiaphragm). Following a histopathological examination of the mass, UG-OGC of the pancreas, presenting as a paraneoplastic syndrome, was diagnosed. To our knowledge, this case is the first to present a paraneoplastic syndrome associated with UC-OGC. The identification of an exceedingly rare tumor presenting atypically as a paraneoplastic syndrome shows the importance of conducting comprehensive examinations of patients with malignancies, emphasizing the need for more reports of similar cases.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51996
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Article ; Online: Quantification of Methylisothiazolinone and Methylchloroisothiazolinone Preservatives by High-Performance Liquid Chromatography.

Alanazi, Samyah / Tabassum, Hajera / Abudawood, Manal / Alrashoudi, Reem / Alrashed, May / Alsheikh, Yazeed A / Alkaff, Salma / Alghamdi, Manal / Alenzi, Naif

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Isothiazolinone preservatives (methylisothiazolinone (MIT) and methylchloroisothiazolinone (CMIT) are commonly used in cosmetics, industrial and household products. However, these isothiazolinone derivatives are known to cause allergic contact dermatitis. ...

Abstract	Isothiazolinone preservatives (methylisothiazolinone (MIT) and methylchloroisothiazolinone (CMIT) are commonly used in cosmetics, industrial and household products. However, these isothiazolinone derivatives are known to cause allergic contact dermatitis. Hence, a sensitive, accurate, and reliable method for the detection of these compounds is thus warranted. The study aims to analyze concentrations of MIT and CMIT by high performance liquid chromatography. The analytical method used for quantification of MIT and CMIT in cosmetic products (leave-on-baby wet wipes) complies with the validation acceptance criteria (international standards ISO 5725, EU25 European Union for cosmetic regulations). MIT and CMIT were extracted and analyzed in leave-on baby wet-wipes collected from different stores in Riyadh city. Extraction was performed by ultrasonication of the samples, solid-phase extraction, and liquid-liquid extraction. Ten (10) µL of the sample was injected into the HPLC system and samples were analyzed with a mixture of acetic acid and methanol (80:20
MeSH term(s)	Humans ; Chromatography, High Pressure Liquid/methods ; Cosmetics/chemistry ; Thiazoles/chemistry ; Preservatives, Pharmaceutical/chemistry ; Dermatitis, Allergic Contact
Chemical Substances	5-chloro-2-methyl-4-isothiazolin-3-one (DEL7T5QRPN) ; 2-methyl-4-isothiazolin-3-one (229D0E1QFA) ; Cosmetics ; Thiazoles ; Preservatives, Pharmaceutical
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041760
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Article: Healthcare Providers' knowledge, attitudes and practice in relation to drug hypersensitivity reactions at King Abdulaziz Medical City in Riyadh.

Alrashed, Mohammed / Alanazi, Ahmed A / Bin Saleh, Khalid / Alanazi, Faisal / Alanazi, Ahmed S / Mashraqi, Sumayyah / Mahdali, Madhawi / Alshammari, Abdullah / Alnuhait, Mohammed A / Alzahrani, Mohammed / Alqahtani, Tariq

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2024 Volume 32, Issue 5, Page(s) 102042

Abstract: Background: Drug hypersensitivity reactions (DHRs) are immune-mediated responses triggered by exposure to a drug. DHRs are responsible for serious adverse drug reactions (ADRs) and are considered the fifth leading cause of death. This study aims to ... ...

Abstract	Background: Drug hypersensitivity reactions (DHRs) are immune-mediated responses triggered by exposure to a drug. DHRs are responsible for serious adverse drug reactions (ADRs) and are considered the fifth leading cause of death. This study aims to assess and evaluate the knowledge, practice, and attitudes of healthcare providers (HCPs) towards DHRs. Methods: A cross-sectional survey was conducted at King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. Healthcare providers, including pharmacists, physicians, and nurses, were recruited using a convenience sampling method to complete the survey. The survey comprised three domains: knowledge (14 items), attitudes (5 items), and practices (6 items), utilizing a standardized self-administered questionnaire. Results: The survey was completed by 373 healthcare providers. The respondents were predominantly female (72.1 %) with a mean age of 33.8 ± 7.8 years. Of the respondents, 64 % were nurses, 25 % pharmacists, and 11.3 % physicians. Educational levels varied, with 53 % holding a bachelor's degree, 22 % an associate degree, and 25 % a master's degree or higher. The median knowledge score was 48. Female healthcare providers, those with advanced levels of education, and physicians had higher knowledge scores compared to male and nurse participants (p < 0.05). One-third of the respondents (33 %) were satisfied with their knowledge of DHRs, and 42 % believed HCPs should receive more advanced training in DHR management. Less than a quarter of HCPs reported inquiring about patients' histories of hypersensitivity reactions. Conclusions: The study revealed that healthcare workers had a relatively low level of knowledge about drug hypersensitivity reactions and lacked a consensus on DHR management. While displaying a positive attitude towards DHRs, they often did not translate this attitude into consistent clinical practice.
Language	English
Publishing date	2024-03-19
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2024.102042
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Article: A huge benign gastric schwannomas presented with upper and lower gastrointestinal bleeding: a case report and literature review.

AlAli, Mohammed N / AlDayel, Aya K / Alshammari, Afraj T / Essa, Mohamed S / AlAmodi, Maha / Alrashed, Muath / Amer, Sadiq M / Meaigel, Mohammed A / AlTahan, Talal M / Ahmad, Khalid S

Journal of surgical case reports

2024 Volume 2024, Issue 4, Page(s) rjae267

Abstract: Gastric schwannomas (GS) are rare mesenchymal tumors from Schwann cells in the gastrointestinal (GI) tract, representing 2-6% of such tumors. We report a 52-year-old woman who experienced abdominal pain, hematemesis, and melena, initially suspected of ... ...

Abstract	Gastric schwannomas (GS) are rare mesenchymal tumors from Schwann cells in the gastrointestinal (GI) tract, representing 2-6% of such tumors. We report a 52-year-old woman who experienced abdominal pain, hematemesis, and melena, initially suspected of having a GI stromal tumor through ultrasound and computed tomography abdomen. Despite no active bleeding found during an upper endoscopy, she underwent a successful open subtotal gastrectomy, with histopathology confirming GS. The diagnosis of GS, which may mimic other GI conditions, relies heavily on imaging and histopathological analysis due to its nonspecific symptomatology, including the potential for both upper and lower GI bleeding. This case underscores the diagnostic challenges of GS and highlights surgical resection as the preferred treatment, generally leading to a favorable prognosis.
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjae267
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Article ; Online: Calcium Channel Blocker Toxicity

Alshaya OA / Alhamed A / Althewaibi S / Fetyani L / Alshehri S / Alnashmi F / Alharbi S / Alrashed M / Alqifari SF / Alshaya AI

Journal of Multidisciplinary Healthcare, Vol Volume 15, Pp 1851-

A Practical Approach

2022 Volume 1862

Abstract: Omar A Alshaya,1– 3 Arwa Alhamed,3,4 Sara Althewaibi,1 Lolwa Fetyani,1 Shaden Alshehri,1 Fai Alnashmi,1 Shmeylan Alharbi,1– 3 Mohammed Alrashed,1– 3,5 Saleh F Alqifari,6 Abdulrahman I Alshaya1– 3 1Department of Pharmacy Practice, College of Pharmacy, ... ...

Abstract	Omar A Alshaya,1– 3 Arwa Alhamed,3,4 Sara Althewaibi,1 Lolwa Fetyani,1 Shaden Alshehri,1 Fai Alnashmi,1 Shmeylan Alharbi,1– 3 Mohammed Alrashed,1– 3,5 Saleh F Alqifari,6 Abdulrahman I Alshaya1– 3 1Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Department of Pharmaceutical Care, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; 3King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; 4College of Nursing, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 5Pharmacy Department, Northwest Medical Center, Tucson, AZ, USA; 6Department of Pharmacy Practice, College of Pharmacy, University of Tabuk, Tabuk, Saudi ArabiaCorrespondence: Omar A Alshaya, Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 3660, Riyadh, 11481, Saudi Arabia, Email omaraalshaya@gmail.comAbstract: Calcium channel blockers (CCBs) are widely prescribed medications for various clinical indications in adults and children. They are available in both immediate and long-acting formulations and are generally classified into dihydropyridines and nondihydropyridines, with nondihydropyridines having more cardioselectivity. CCB toxicity is common given the widespread use which leads to serious adverse clinical outcomes, especially in children. Severe CCB toxicities may present with life-threatening bradycardia, hypotension, hyperglycemia, and renal insufficiency. Dihydropyridine toxicity, however, may present with reflex tachycardia instead of bradycardia. Initial patient evaluation and assessment are crucial to identify the severity of CCB toxicity and design the best management strategy. There are different strategies to overcome CCB toxicity that requires precise dosing and close monitoring in various patient populations. These strategies may include large volumes of IV fluids, calcium salts, high insulin euglycemia therapy (HIET), and ...
Keywords	calcium channel blockers ; drug overdose ; poisoning ; emergency medicine ; toxicity ; Medicine (General) ; R5-920
Subject code	590
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Selenium Nanoparticles by Moderating Oxidative Stress Promote Differentiation of Mesenchymal Stem Cells to Osteoblasts.

Fatima, Sabiha / Alfrayh, Rawan / Alrashed, May / Alsobaie, Sarah / Ahmad, Rehan / Mahmood, Amer

International journal of nanomedicine

2021 Volume 16, Page(s) 331–343

Abstract: Purpose: Redox homeostasis plays an important role in the osteogenic differentiation of human mesenchymal stem cells (hMSCs) for bone engineering. Oxidative stress (OS) is believed to induce osteoporosis by changing bone homeostasis. Selenium ... ...

Abstract	Purpose: Redox homeostasis plays an important role in the osteogenic differentiation of human mesenchymal stem cells (hMSCs) for bone engineering. Oxidative stress (OS) is believed to induce osteoporosis by changing bone homeostasis. Selenium nanoparticles (SeNPs), an antioxidant with pleiotropic pharmacological activity, prevent bone loss. However, the molecular mechanism underlying the osteogenic activity during hMSC-SeNP interaction is unclear. Methods: This study assessed the effects of different concentrations (25, 50, 100, and 300 ng/mL) of SeNPs on the cell viability and differentiation ability of human embryonic stem cell-derived hMSCs. In addition, we analyzed OS markers and their effect on mitogen-activated protein kinase (MAPK) and Forkhead box O3 (FOXO3) during osteogenesis. Results: SeNPs increased the cell viability of hMSCs and induced their differentiation toward an osteogenic over an adipogenic lineage by enhancing osteogenic transcription and mineralization, while inhibiting Nile red staining and adipogenic gene expression. By preventing excessive reactive oxygen species accumulation, SeNPs increased antioxidant levels in hMSCs undergoing osteogenesis compared to untreated cells. In addition, SeNPs significantly upregulated the gene and protein expression of phosphorylated c-Jun N-terminal kinase (JNK) and FOXO3a, with no significant change in the expression levels of extracellular signal-related kinase (ERK) and p38 MAPK. Conclusion: The results approved that low concentrations of SeNPs might enhance the cell viability and osteogenic potential of hMSCs by moderating OS. Increased JNK and FOXO3a expression shows that SeNPs might enhance osteogenesis via activation of the JNK/FOXO3 pathway. In addition, SeNP co-supplementation might prevent bone loss by enhancing osteogenesis and, thus, can be an effective candidate for treating osteoporosis through cell-based therapy.
MeSH term(s)	Adipogenesis/drug effects ; Cell Differentiation/drug effects ; Cells, Cultured ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System/drug effects ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Nanoparticles ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteogenesis/drug effects ; Oxidative Stress/drug effects ; Selenium/chemistry ; Selenium/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Selenium (H6241UJ22B)
Language	English
Publishing date	2021-01-13
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S285233
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Article: A Rare Case and Presentation of Traumatic Penetrating Aortic Arch Injury: A Case Report and Literature Review.

AlAli, Mohammed N / Essa, Mohamed S / Alasheikh, Muath / Alrashed, Muath / Albdah, Abdullah M / Arrowaili, Arief

Cureus

2022 Volume 14, Issue 11, Page(s) e31069

Abstract: A penetrating injury to the thoracic aorta is an extremely rare, life-threatening condition, with a high overall mortality rate. The incidence of a penetrating injury to the aortic arch is unknown because the majority of patients die before receiving ... ...

Abstract	A penetrating injury to the thoracic aorta is an extremely rare, life-threatening condition, with a high overall mortality rate. The incidence of a penetrating injury to the aortic arch is unknown because the majority of patients die before receiving adequate treatment due to excessive bleeding. Through a literature review, 23 cases of favorable outcomes were found. We report the first case from the Arab Gulf states. We present the extremely rare case of a 23-year-old male who presented to the emergency department with stable hemodynamics after being stabbed in the left supraclavicular region. The investigation revealed that he suffered from aortic arch transection and contrast extravasation. The patient was rushed to the operating room, where a primary repair was performed through a median sternotomy approach. The patient was discharged on the 14th postoperative day without complications. Penetrating chest trauma (aortic arch injury) is uncommon, and it is typically fatal at the scene or time of injury, even in patients who arrive at the emergency department alive or while undergoing surgery. CT aortography should be performed on patients with normal vital signs but abnormal clinical findings suggestive of a vascular injury. For injuries of types II to IV without concomitant injuries, immediate surgical repair is recommended. Aortic arch penetrating injuries continue to be extremely lethal. Emergency surgical repair remains the standard of care and is associated with high morbidity and mortality rates. However, managing such uncommon injuries remains a formidable challenge. We encourage additional studies.
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.31069
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