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Book ; Online ; E-Book: Transition Metal-containing Dendrimers in Biomedicine: Current Trends

Abd-El-Aziz, Alaa S. / Youssef, Amal M. / Abd-El-Aziz, Ahmad

(ISSN)

2023

Abstract: There has been increasing research into designing transition metal-containing dendrimers as innovative materials, especially in the field of biomedicine and pharmaceutical science. They have applications in biosensors and drug-delivery systems, and are ... ...

Series title	ISSN
Abstract	There has been increasing research into designing transition metal-containing dendrimers as innovative materials, especially in the field of biomedicine and pharmaceutical science. They have applications in biosensors and drug-delivery systems, and are now one of the leading classes in the design of therapeutics for drug-resistant diseases. This book introduces readers to a number of classes of metal-containing dendrimers, before moving onto their design and synthesis. Their applications in biomedicine are then discussed, before highlighting future research targets in this growing field. It emphasises the synthetic strategies to design transition metal-containing dendrimers, and discusses the type of laboratory work used to examine these types of dendrimers in the fields of medicine and pharmacology.
Keywords	BIOCHEMISTRY ; SCIENCE
Subject code	610.28
Language	English
Size	1 online resource (388 p.)
Edition	1st ed.
Publisher	Lightning Source Inc. (Tier 2)
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-83767-144-3 ; 1-83767-145-1 ; 1-83916-944-3 ; 978-1-83767-144-1 ; 978-1-83767-145-8 ; 978-1-83916-944-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells.

Tulbah, Alaa S

Journal of Taibah University Medical Sciences

2023 Volume 18, Issue 5, Page(s) 1076–1086

Abstract: Objectives: Lung cancer is a leading cause of mortality worldwide. In lung cancer treatment, nebulized solid lipid nanoparticles may be a viable drug delivery method, helping the drug reach sites of action, and improving its inhalation efficiency and ... ...

Abstract	Objectives: Lung cancer is a leading cause of mortality worldwide. In lung cancer treatment, nebulized solid lipid nanoparticles may be a viable drug delivery method, helping the drug reach sites of action, and improving its inhalation efficiency and pulmonary deposition. This research focused on evaluating the effectiveness of solid lipid nanoparticles of favipiravir (Fav-SLNps) in facilitating drug delivery to sites of action in lung cancer treatment. Methods: The hot-evaporation method was used to formulate Fav-SLNps. The in vitro cell viability, anti-cancer effects, and cellular uptake activity were evaluated in A549 human lung adenocarcinoma cells treated with the Fav-SLNp formulation. Results: The Fav-SLNps were formulated successfully. Importantly, Fav-SLNps at a concentration of 322.6 μg/ml were found to be safe and non-toxic toward A549 cells in vitro. The formulation had potential anti-proliferative properties via increasing the proportions of cells in G2/M and G0/G1 phases to 1.20 and 1.13 times those in untreated cells. Additionally, Fav-SLNp treatment significantly induced necrosis in A549 cells. Furthermore, the use of SLNps in the Fav formulation resulted in a macrophage drug uptake 1.23 times that of the free drug. Conclusion: Our results confirmed the internalization and anti-cancer activity of the Fav-SLNp formulation in the A549 lung cancer cell line. Our findings suggest that Fav-SLNps could potentially be used as lung cancer treatment to facilitate drug delivery to sites of action in the lungs.
Language	English
Publishing date	2023-03-10
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2817396-X
ISSN	1658-3612 ; 1658-3612
ISSN (online)	1658-3612
ISSN	1658-3612
DOI	10.1016/j.jtumed.2023.02.014
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Article: Molecular Typing of

Hamzah, Alaa S

Journal of pharmacy & bioallied sciences

2023 Volume 15, Issue Suppl 2, Page(s) S871–S874

Abstract: Aim: Serratia marcescens genes fumC, icd, and mdh were molecularly typed in various groups of 200 clinical samples.: Results: According to the findings, 38 (19%) of the isolates are Serratia marcescens. All these bacterial isolates had their DNA ... ...

Abstract	Aim: Serratia marcescens genes fumC, icd, and mdh were molecularly typed in various groups of 200 clinical samples. Results: According to the findings, 38 (19%) of the isolates are Serratia marcescens. All these bacterial isolates had their DNA extracted. Then, using particular primers, the genes fumC, icd, and mdh are detected and amplified. These genes were sequenced, and the results were aligned with NCBI sequences. Using the Geneious version 9 software, gene sequences were analyzed. Sequencing of these genes revealed variant regions when compared to global isolates in NCBI. Energy levels in bacterial cells may be impacted by TCA cycle enzyme variant sequence genes. Conclusion: The bacterial sequences from Iraq that were listed in NCBI with an accession number were LC735551 is a gene bank. (Gene Bank: LC735550, 1 Iraqi 40 fumC gene. One Iraq 41 icd gene; gene accession number: LC735549.42 mdh gene in Iraq.).
Language	English
Publishing date	2023-07-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_93_23
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Article ; Online: Inhaled Atorvastatin Nanoparticles for Lung Cancer.

Tulbah, Alaa S

Current drug delivery

2022 Volume 19, Issue 10, Page(s) 1073–1082

Abstract: Objective: Lung cancer is one of the main causes of mortality globally. This research paper aims a the development of inhaled nanotechnology for lung cancer to deliver an atorvastatin calcium compound, for lung cancer, capable of reaching the tumor site ...

Abstract	Objective: Lung cancer is one of the main causes of mortality globally. This research paper aims a the development of inhaled nanotechnology for lung cancer to deliver an atorvastatin calcium compound, for lung cancer, capable of reaching the tumor site directly via inhalation. Methods: Atorvastatin calcium micellar nanoparticles (ATO-NPs) encapsulated with Pluronic F-127 and polyvinyl alcohol (PVA) were manufactured utilizing the solvent and anti-solvent precipitation technique. The physicochemical features of the formulation were evaluated in terms of their physicochemical characteristics using Fourier transform infrared spectroscopy, differential scanning calorimetry, and dynamic light scattering. Additionally, the Andersen Cascade impactor was used at 15 L/minutes to assist in the aerosols performances of the formulation. The ATO-NPs formula's cell viability was tested in vitro using the A549 non-small cell lung cancer cell type. Results: Transmission electron microscopy was utilized to determine the ATO-NPs particle morphology, demonstrating a spherical shape with a smooth surface. The fine particle fraction of the aerosol produced was 62.70 ± 1.18%. This finding suggests that atorvastatin micellar nanoparticles are suitable for medication administration by inhalation with a wide particle size dispersion. Moreover, it was found in vitro that concentrations of up to 21 μg/mL of the atorvastatin nanoparticles were safe and non-toxic in the cell model. Conclusion: This study found that atorvastatin micellar nanoparticles for inhalation could potentially be used for lung cancer treatment.
MeSH term(s)	Administration, Inhalation ; Atorvastatin ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Nanoparticles/chemistry ; Particle Size ; Respiratory Aerosols and Droplets
Chemical Substances	Atorvastatin (A0JWA85V8F)
Language	English
Publishing date	2022-04-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/1567201819666220426091500
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Article ; Online: The Mediating Role of Organizational Commitment between Organizational Culture and Job Performance in the Telecommunication Sector

Alaa S. Jameel

مجلة بحوث الإدارة والاقتصاد, Vol 4, Iss

2022 Volume 1

Abstract: This study investigates the impact of organizational culture on job performance and finds the mediating role of organizational commitment among telecommunication employees. The study analysed 476 valid questionnaires collected from the employees in three ...

Abstract	This study investigates the impact of organizational culture on job performance and finds the mediating role of organizational commitment among telecommunication employees. The study analysed 476 valid questionnaires collected from the employees in three telecommunication companies located in Erbil, Iraq. However, the data was analysed by Smart-PLS. The results indicated the direct impact of organizational culture on job performance showed a positive and significant impact. besides, the mediating role of organizational commitment can enhance and increase the impact of organizational culture on job performance among employees in the telecommunication sector. Furthermore, individuals in the workplace will exhibit different behaviours due to the deployment of culture-based strategies for behaviour development. Therefore, job performance will increase if individuals and the workplace culture are in sync.
Keywords	Organizational Commitment ; Organizational Culture ; Job Performance ; Telecommunication ; Social Sciences ; H ; Commerce ; HF1-6182
Subject code	650
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Ziane Achour University of Djelfa
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells

Alaa S. Tulbah, Ph.D.

Journal of Taibah University Medical Sciences, Vol 18, Iss 5, Pp 1076-

2023 Volume 1086

Abstract: المخلص: أهداف البحث: يعد سرطان الرئة أحد الأسباب الرئيسية للوفيات في جميع أنحاء العالم. وجد لعلاج فعال علىسرطان الرئة ، قد تكون الجسيمات النانوية الدهنية الصلبة تعتبر الطريقة الفعالة لإيصال الدواء لأن الدواء يمكن أن يصل إلى موقع التأثير ويحسن كفاءة ... ...

Abstract	المخلص: أهداف البحث: يعد سرطان الرئة أحد الأسباب الرئيسية للوفيات في جميع أنحاء العالم. وجد لعلاج فعال علىسرطان الرئة ، قد تكون الجسيمات النانوية الدهنية الصلبة تعتبر الطريقة الفعالة لإيصال الدواء لأن الدواء يمكن أن يصل إلى موقع التأثير ويحسن كفاءة الاستنشاق والترسيب الرئوي. هذه الورقة البحثية تركز على تقييم الجسيمات النانوية الدهنية الصلبة من علاج الفافيبيرافير من حيث قياس مدى فعاليتة على سرطان الرئة من خلال مساعدة الدواء في الوصول إلى موقع التأثير. طرق البحث: تم استخدام طريقة التبخير الساخن لتطويرالتركيبة النانوية الدوائية من علاج الفافيبيرافير. تم تقييم قابلية بقاء الخلايا المختبرية، ومضادات السرطان ونشاط الامتصاص الخلوي لتركيبة فافيبيرافير على خلايا سرطانية الغدة الرئوية البشرية أ-549. النتائج: تمت تطوير التركيبة الدوائية من علاج الفافيبيرافير بنجاح. الأهم من ذلك، لوحظ أن تركيبة الفافيبيرافير آمنة وغير سامة في المختبر على خلايا أ-549 بتركيز 322.6 ميكروغرام / مل. كان للتركيبة تأثير مذهل فيما يتعلق بالخصائص المضادة للتكاثر من خلال زيادة طور ج2 / م و ج0 / ج1 من مجموعة الخلايا بمقدار 1.20 و 1.13 مرة، على التوالي ، مقارنة با الخلايا غير المعالجة. بالإضافة إلى ذلك، ساعد العلاج باستخدام فافيبيرافير بشكل كبير في حدوث مرحلة النخر في خلايا أ-549. علاوة على ذلك، فإن استخدام تركيبة فافيبيرافير عزز امتصاص الدواء في الضامة بنسبة 1.23 مرة ، مقارنة بالتركيبة الخالية من المادة الفعالة. الاستنتاجات: أكدت نتائج البحث أن للتركيبة النانونية من علاج الفافيبيرافير تأثير فعال على خلايا السرطان الرئوية- أ-549. و يشير هذا إلى أنه يمكن استخدام تركيبة الفافيبيرافير كعلاج لسرطان الرئة اللوصول إلى موقع التأثير في الرئتين. Abstract: Objectives: Lung cancer is a leading cause of mortality worldwide. In lung cancer treatment, nebulized solid lipid nanoparticles may be a viable drug delivery method, helping the drug reach sites of action, and improving its inhalation efficiency and pulmonary deposition. This research focused on evaluating the effectiveness of solid lipid nanoparticles of favipiravir (Fav-SLNps) in facilitating drug delivery to sites of action in lung cancer treatment. Methods: The hot-evaporation method was used to formulate ...
Keywords	A549 cells ; Cell cycle distribution ; Cytotoxicity ; Favipiravir ; Nanoparticles ; Necrosis ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation.

Kassab, Asmaa E / Gedawy, Ehab M / Sayed, Alaa S

International journal of biological macromolecules

2024 Volume 265, Issue Pt 2, Page(s) 131018

Abstract: As a "silent threat," Alzheimer's disease (AD) is quickly rising to the top of the list of costly and troublesome diseases facing humanity. It is growing to be one of the most troublesome and expensive conditions, with annual health care costs higher ... ...

Abstract	As a "silent threat," Alzheimer's disease (AD) is quickly rising to the top of the list of costly and troublesome diseases facing humanity. It is growing to be one of the most troublesome and expensive conditions, with annual health care costs higher than those of cancer and comparable to those of cardiovascular disorders. One of the main pathogenic characteristics of AD is the deficiency of the neurotransmitter acetylcholine (ACh) which plays a vital role in memory, learning, and attention. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) play a crucial role in hydrolyzing ACh. Consequently, a frequent therapy approach for AD is the suppression of AChE and BChE to improve cholinergic neurotransmission and reduce cognitive symptoms. The accumulation of amyloid plaques (Aβ) is a primary factor contributing to neurodegenerative diseases, particularly AD. Glycogen synthase kinase-3β (GSK3-β) is regarded as a pivotal player in the pathophysiology of AD since dysregulation of this kinase affects all major hallmarks of the disease, such as tau phosphorylation, Aβ aggregation, memory, neurogenesis, and synaptic function. One of the most challenging and risky issues in modern medicinal chemistry is the urgent and ongoing need for the study and development of effective therapeutic candidates for the treatment of AD. A significant class of heterocyclic molecules that can target the complex and multifactorial pathogenesis of AD are fused thiophene derivatives. The goal of the current review is to demonstrate the advancements made in fused thiophene derivatives' anti-AD activity. It also covers their mechanisms of action and studies of the structure-activity relationships in addition to the compilation of significant synthetic routes for fused thiophene derivatives with anti-AD potential. This review is intended to stimulate new ideas in the search for more rationale designs of derivatives based on fused thiophene, hoping to be more potent in treating AD.
MeSH term(s)	Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Butyrylcholinesterase ; Acetylcholinesterase ; Glycogen Synthase Kinase 3/therapeutic use ; Monoamine Oxidase ; Acetylcholine ; Amyloid beta-Peptides ; Glycogen Synthase Kinase 3 beta
Chemical Substances	Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Monoamine Oxidase (EC 1.4.3.4) ; Acetylcholine (N9YNS0M02X) ; Amyloid beta-Peptides ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131018
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Article: Trichloroacetic Acid 15% Peel Alone versus in Combination with Microneedling in Patients with Acanthosis Nigricans.

Khashaba, Shrook A / Alaa, Salma / Eldeeb, Fatma

The Journal of clinical and aesthetic dermatology

2024 Volume 17, Issue 4, Page(s) 28–32

Abstract: Background: Acanthosis nigricans is a common hyperpigmentation disorder with a profound aesthetic impact. The primary concern of most patients is the cosmetic improvement, that is way there is a continuous search for the most effective cosmetic ... ...

Abstract	Background: Acanthosis nigricans is a common hyperpigmentation disorder with a profound aesthetic impact. The primary concern of most patients is the cosmetic improvement, that is way there is a continuous search for the most effective cosmetic therapeutic option. Methods: 40 acanthosis nigricans patients were included, lesions are split into equal halves; right side treated with TCA 15% peel and left side was treated with microneedling followed by TCA 15% peel, both sides were treated monthly for three months. Response to treatment was assessed by acanthosis nigricans grade improvement along with the percentage of improvement in texture and pigmentation individually. Results: There was statistically significant improvement in acanthosis nigricans grade after treatment in both sides. The combination side showed more improvement in terms of texture and pigmentation. Conclusion: Both TCA 15% alone or combined with microneedling were effective in improving acanthosis nigricans with superior results in combination modality.
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2571623-2
ISSN	1941-2789
ISSN	1941-2789
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Article ; Online: Introducing an innovative immobilized optode based on PVC-ETH-5294 matrix for environmentally friendly sensing of lead ions

Reem F. Alshehri / Alaa S. Amin / Eman R. Darwish

Talanta Open, Vol 9, Iss , Pp 100285- (2024)

2024

Abstract: A novel selective membrane optode was prepared to determine of ultra-trace amounts of lead. This state-of-the-art optode amalgamates a bespoke ionophore, 4-(thiazol-2-yldiazenyl)benzene-1,3-diol (TDBD), with ETH-5294, assuming the role of a ... ...

Abstract	A novel selective membrane optode was prepared to determine of ultra-trace amounts of lead. This state-of-the-art optode amalgamates a bespoke ionophore, 4-(thiazol-2-yldiazenyl)benzene-1,3-diol (TDBD), with ETH-5294, assuming the role of a chromoionophore. This potent composition converges with sodium tetraphenylborate (NaTPB) and dioctyl phthalate (DOP), harmoniously enclosed within a matrix of poly(vinyl chloride) (PVC). The influence of various parameters on the preparation of the optode and the determination of Pb2+ was investigated and optimized. Evidently, the optode unfurls an expansive linear dynamic expanse, spanning an astonishing range from 6.0 × 10−9 to 8 × 10−5 M. Remarkably, it retains an astonishingly low degree of detection and quantification, registering at 1.75 and 5.85 × 10−9 M, respectively. The response time of the optode was 4.0 min. The optodes versatility extends its embrace towards rejuvenation, permitting multiple rounds of service via 0.2 M HNO3 solutions. The effect of potential interference ions on the Pb2+ determination was illustrated. The results showed that the prepared optode was very selective to lead ions so that it had no significant response to common ions such as Mg2+, Mn2+, Cd2+, Ni2+, Fe2+, Fe3+, Hg2+, Cu2+, and Co2+. The optode was applied successfully to determine of Pb2+ indifferent food, biological and environmental samples and result obtained is comparable to atomic absorption spectrometry method.
Keywords	Selective membrane optode ; Lead determination ; Ionophore ; ETH-5294 ; Colorimetry ; Environmental analysis ; Analytical chemistry ; QD71-142
Subject code	540
Language	English
Publishing date	2024-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: The potential of Atorvastatin for chronic lung diseases therapy.

Tulbah, Alaa S

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2020 Volume 28, Issue 11, Page(s) 1353–1363

Abstract: Atorvastatin (ATO) is of the statin class and is used as an orally administered lipid-lowering drug. ATO is a reversible synthetic competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase thus leading to a reduction in cholesterol ... ...

Abstract	Atorvastatin (ATO) is of the statin class and is used as an orally administered lipid-lowering drug. ATO is a reversible synthetic competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase thus leading to a reduction in cholesterol synthesis. It has recently been demonstrated that ATO has different pharmacological actions, which are unrelated to its lipid-lowering effects and has the ability to treat chronic airway diseases. This paper reviews the potential of ATO as an anti-inflammatory, antioxidant, and anti-proliferative agent after oral or inhaled administration. This paper discusses the advantages and disadvantages of using ATO under conditions associated with those found in the airways. This treatment could potentially be used to support the formulating of ATO as an inhaler for the treatment of chronic respiratory diseases.
Language	English
Publishing date	2020-09-12
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2020.08.025
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