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  1. AU="Alalaiwe, Ahmed"
  2. AU="Hofmann, Ariane L"
  3. AU="Morawski, Franciszek"
  4. AU="Huo, Lijun"
  5. AU="Weinheimer, Claudia"
  6. AU="Akbari, Syed Hassan A"
  7. AU="Lutfi H. Alfarsi"
  8. AU="Maria Rosaria Campitiello"
  9. AU="Kazzi, Ziad N"
  10. AU=Jain Somya
  11. AU="Ming, Xiu-Fen"
  12. AU="Gileadi, Opher"
  13. AU="Wang, Zeng-Liang"
  14. AU=Berman Jonathan M
  15. AU="Vivienne Clark"
  16. AU=Sheridan Brian S AU=Sheridan Brian S
  17. AU="Yang, Zuyu"
  18. AU="Suzuki, Tomo"
  19. AU="Horiguchi, Akihiko"
  20. AU="Band, Rebecca"
  21. AU=Pablos Isabel AU=Pablos Isabel
  22. AU="O'Flaherty, Vincent"
  23. AU="Jérémie, Riou"
  24. AU="Ma, Yunshu"
  25. AU="Pu, Junyi"
  26. AU="Benlloch, Sara"
  27. AU="Jay D Evans"
  28. AU=Unger Jean-Pierre
  29. AU="Soday, Lior"
  30. AU="Wan, Xuan"
  31. AU="Camille Fritzell"
  32. AU=Wei Huijun
  33. AU="Levine, Morgan E"
  34. AU="Chen, Yalei"
  35. AU="Rogaeva, Ekaterina" AU="Rogaeva, Ekaterina"
  36. AU="Jain, Ishaan"
  37. AU="Chatelier, Josh"
  38. AU="Passarelli, L."
  39. AU="Marques, R"
  40. AU="Restaino, Valeria"
  41. AU="Wang, Haochen"
  42. AU=Shoib Sheikh
  43. AU=Patel Ishan
  44. AU="Mongioì, Laura M"
  45. AU="Fernández-Pacheco, Borja Camacho"
  46. AU=Waghmare Alpana AU=Waghmare Alpana
  47. AU="Peyre, Marion"
  48. AU=Mulazimoglu L
  49. AU=Roy Satyaki
  50. AU="Li Yuanyuan"
  51. AU=Khan Shehryar
  52. AU=Cole Sarah L
  53. AU="Júnior, Raimundo Nonato Colares Camargo"
  54. AU="Feeney, Judith A"

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  1. Artikel ; Online: Bioconjugated nanometals and cancer therapy: a pharmaceutical perspective.

    Alalaiwe, Ahmed

    Nanomedicine (London, England)

    2021  Band 16, Heft 20, Seite(n) 1791–1811

    Abstract: Conventional cancer chemotherapies are associated with challenges like delivering sub-therapeutic doses to target cells, lack of bioavailability, drug insolubility and nonspecific toxicity to healthy cells. Nanomedicine, an advanced process, can ... ...

    Abstract Conventional cancer chemotherapies are associated with challenges like delivering sub-therapeutic doses to target cells, lack of bioavailability, drug insolubility and nonspecific toxicity to healthy cells. Nanomedicine, an advanced process, can contribute to the development of personalized medicine for diagnosis, therapy and monitoring of cancer. The nanometals enhance drug dissolution and adhesion to targeted tumor surfaces, resulting in rapid onset of effective therapeutic action. Moreover, nanometals can be conjugated with ligands or polymers through a conjugation process, which further leads to enhanced efficiency, target specificity, improved pharmacokinetics and pharmacodynamics of the drug. This review focuses on the applications of conjugated nanometals in cancer therapy, with a special focus on noble and magnetic nanometals.
    Mesh-Begriff(e) Drug Delivery Systems ; Humans ; Nanomedicine ; Neoplasms/drug therapy ; Pharmaceutical Preparations ; Polymers/therapeutic use
    Chemische Substanzen Pharmaceutical Preparations ; Polymers
    Sprache Englisch
    Erscheinungsdatum 2021-07-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2021-0010
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  2. Artikel ; Online: The clinical pharmacokinetics impact of medical nanometals on drug delivery system.

    Alalaiwe, Ahmed

    Nanomedicine : nanotechnology, biology, and medicine

    2019  Band 17, Seite(n) 47–61

    Abstract: Nanometals are widely being used for diagnosis, treatment and monitoring of medical conditions. Majorly, nanometals are used to facilitate the delivery of drug to targeted site, minimize drug's penetration to healthy tissues, increase drug's ... ...

    Abstract Nanometals are widely being used for diagnosis, treatment and monitoring of medical conditions. Majorly, nanometals are used to facilitate the delivery of drug to targeted site, minimize drug's penetration to healthy tissues, increase drug's bioavailability, and inhibit its uptake and elimination from the blood by reticuloendothelial process. Despite several benefits, use of nanoparticles as drug carriers is also associated with many problems including instability in blood during circulation, undesirable biodistribution, and toxicity. Research has shown that modification in physicochemical properties including shape, size, and surface can develop a nanometal with desired properties but devoid of associated problems. This review introduces the clinical impact of important physicochemical properties of nanometals such as surface modification, shape, and size. Further, the review focuses on evidence reporting the impact of these properties on pharmacokinetics of nanometals with focus on gold, silver, and iron oxide due to their wide use in the medical field.
    Mesh-Begriff(e) Animals ; Drug Carriers/analysis ; Drug Carriers/metabolism ; Drug Carriers/pharmacokinetics ; Drug Delivery Systems ; Ferric Compounds/analysis ; Ferric Compounds/metabolism ; Ferric Compounds/pharmacokinetics ; Gold/analysis ; Gold/metabolism ; Gold/pharmacokinetics ; Humans ; Metals/analysis ; Metals/metabolism ; Metals/pharmacokinetics ; Nanostructures/analysis ; Silver/analysis ; Silver/metabolism ; Silver/pharmacokinetics ; Tissue Distribution
    Chemische Substanzen Drug Carriers ; Ferric Compounds ; Metals ; ferric oxide (1K09F3G675) ; Silver (3M4G523W1G) ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2019-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2019.01.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica.

    Alrobaian, Majed / Alalaiwe, Ahmed / Almalki, Ziyad S / Fayed, Mohamed H

    Pharmaceutics

    2023  Band 15, Heft 11

    Abstract: Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and ... ...

    Abstract Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and tableting problems associated with a high-drug-loading canagliflozin (CNG), facilitating high-speed DC tableting. This was accomplished through a single-step dry coating process using hydrophilic nano-sized colloidal silica. A 3
    Sprache Englisch
    Erscheinungsdatum 2023-10-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15112552
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  4. Artikel: Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of Pediatric Pulmonary Hypertension Using Response Surface Methodology.

    Alalaiwe, Ahmed / Alsenaidy, Mohammad A / Almalki, Ziyad S / Fayed, Mohamed H

    Pharmaceutics

    2023  Band 15, Heft 3

    Abstract: The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and ... ...

    Abstract The availability of age-appropriate oral dosage forms for pediatric patients has remained a challenge. Orodispersible mini-tablets (ODMTs) are a promising delivery system for pediatric patients. The purpose of this work was the development and optimization of sildenafil ODMTs as a new dosage form for the treatment of pulmonary hypertension in children using a design-of-experiment (DoE) approach. A two-factor, three levels (3
    Sprache Englisch
    Erscheinungsdatum 2023-03-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030923
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  5. Artikel ; Online: Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect.

    Hsu, Ching-Yun / Liao, Chia-Chih / Lin, Zih-Chan / Alalaiwe, Ahmed / Hwang, Erica / Lin, Tzu-Wei / Fang, Jia-You

    Journal of nanobiotechnology

    2024  Band 22, Heft 1, Seite(n) 50

    Abstract: Obesity is a major risk to human health. Adipogenesis is blocked by α-tocopherol and conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The effectiveness of the bioactive agents is associated with their delivery ... ...

    Abstract Obesity is a major risk to human health. Adipogenesis is blocked by α-tocopherol and conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The effectiveness of the bioactive agents is associated with their delivery method. Herein, we designed CLA-loaded tocol nanostructured lipid carriers (NLCs) for enhancing the anti-adipogenic activity of α-tocopherol and CLA. Adipogenesis inhibition by the nanocarriers was examined using an in vitro adipocyte model and an in vivo rat model fed a high fat diet (HFD). The targeting of the tocol NLCs into adipocytes and adipose tissues were also investigated. A synergistic anti-adipogenesis effect was observed for the combination of free α-tocopherol and CLA. Nanoparticles with different amounts of solid lipid were developed with an average size of 121‒151 nm. The NLCs with the smallest size (121 nm) showed greater adipocyte internalization and differentiation prevention than the larger size. The small-sized NLCs promoted CLA delivery into adipocytes by 5.5-fold as compared to free control. The nanocarriers reduced fat accumulation in adipocytes by counteracting the expression of the adipogenic transcription factors peroxisome proliferator activated receptor (PPAR)γ and CCAAT/enhancer-binding protein (C/EBP)α, and lipogenic enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). Localized administration of CLA-loaded tocol NLCs significantly reduced body weight, total cholesterol, and liver damage indicators in obese rats. The biodistribution study demonstrated that the nanoparticles mainly accumulated in liver and adipose tissues. The NLCs decreased adipocyte hypertrophy and cytokine overexpression in the groin and epididymis to a greater degree than the combination of free α-tocopherol and CLA. In conclusion, the lipid-based nanocarriers were verified to inhibit adipogenesis in an efficient and safe way.
    Mesh-Begriff(e) Male ; Humans ; Rats ; Animals ; Adipogenesis ; Linoleic Acids, Conjugated/pharmacology ; Linoleic Acids, Conjugated/metabolism ; alpha-Tocopherol/metabolism ; alpha-Tocopherol/pharmacology ; Tissue Distribution ; Obesity/metabolism ; Adipocytes/metabolism ; Adipose Tissue/metabolism ; Liver/metabolism ; Tocopherols
    Chemische Substanzen tocol (S2XEE7OB8X) ; Linoleic Acids, Conjugated ; alpha-Tocopherol (H4N855PNZ1) ; Tocopherols (R0ZB2556P8)
    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-024-02316-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Design Space Approach for the Optimization of Green Fluidized Bed Granulation Process in the Granulation of a Poorly Water-Soluble Fenofibrate Using Design of Experiment.

    Fayed, Mohamed H / Alalaiwe, Ahmed / Almalki, Ziyad S / Helal, Doaa A

    Pharmaceutics

    2022  Band 14, Heft 7

    Abstract: In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experiment ( ...

    Abstract In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experiment (DoE) driven QbD approach for the optimization of key process variables of the green fluidized bed granulation (GFBG) process. A 3
    Sprache Englisch
    Erscheinungsdatum 2022-07-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071471
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  7. Artikel ; Online: Small interfering RNA-based nanotherapeutics for treating skin-related diseases.

    Chang, Yen-Tzu / Huang, Tse-Hung / Alalaiwe, Ahmed / Hwang, Erica / Fang, Jia-You

    Expert opinion on drug delivery

    2023  Band 20, Heft 6, Seite(n) 757–772

    Abstract: Introduction: RNA interference (RNAi) has demonstrated great potential in treating skin-related diseases, as small interfering RNA (siRNA) can efficiently silence specific genes. The design of skin delivery systems for siRNA is important to protect the ... ...

    Abstract Introduction: RNA interference (RNAi) has demonstrated great potential in treating skin-related diseases, as small interfering RNA (siRNA) can efficiently silence specific genes. The design of skin delivery systems for siRNA is important to protect the nucleic acid while facilitating both skin targeting and cellular ingestion. Entrapment of siRNA into nanocarriers can accomplish these aims, contributing to improved targeting, controlled release, and increased transfection.
    Areas covered: The siRNA-based nanotherapeutics for treating skin disorders are summarized. First, the mechanisms of RNAi are presented, followed by the introduction of challenges for skin therapy. Then, the different nanoparticle types used for siRNA skin delivery are described. Subsequently, we introduce the mechanisms of how nanoparticles enhance siRNA skin penetration. Finally, the current investigations associated with nanoparticulate siRNA application in skin disease management are reviewed.
    Expert opinion: The potential application of nanotherapeutic RNAi allows for a novel skin application strategy. Further clinical studies are required to confirm the findings in the cell-based or animal experiments. The capability of large-scale production and reproducibility of nanoparticle products are also critical for translation to commercialization. siRNA delivery by nanocarriers should be optimized to attain cutaneous targeting without the risk of toxicity.
    Mesh-Begriff(e) Animals ; RNA, Small Interfering ; Reproducibility of Results ; RNA Interference ; Skin Diseases/drug therapy ; Transfection ; Nanoparticles
    Chemische Substanzen RNA, Small Interfering
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167286-6
    ISSN 1744-7593 ; 1742-5247
    ISSN (online) 1744-7593
    ISSN 1742-5247
    DOI 10.1080/17425247.2023.2206646
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6012: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Artikel ; Online: Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA.

    Nirmal, G R / Lin, Zih-Chan / Chiu, Tai-Sheng / Alalaiwe, Ahmed / Liao, Chia-Chih / Fang, Jia-You

    International journal of biological macromolecules

    2024  Band 268, Heft Pt 1, Seite(n) 131673

    Abstract: Bacterial infections trigger inflammation and impede the closure of skin wounds. The misuse of antibiotics exacerbates skin infections by generating multidrug-resistant bacteria. In this study, we developed chemo-photothermal therapy (chemo-PTT) based on ...

    Abstract Bacterial infections trigger inflammation and impede the closure of skin wounds. The misuse of antibiotics exacerbates skin infections by generating multidrug-resistant bacteria. In this study, we developed chemo-photothermal therapy (chemo-PTT) based on near-infrared (NIR)-irradiated chitosan/gold nanorod (GNR) clusters as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. The nanocomposites exhibited an average size of 223 nm with a surface charge of 36 mV. These plasmonic nanocomposites demonstrated on-demand and rapid hyperthermal action under NIR. The combined effect of positive charge and PTT by NIR-irradiated nanocomposites resulted in a remarkable inhibition rate of 96 % against planktonic MRSA, indicating a synergistic activity compared to chitosan nanoparticles or GNR alone. The nanocomposites easily penetrated the biofilm matrix. The combination of chemical and photothermal treatments by NIR-stimulated clusters significantly damaged the biofilm structure, eradicating MRSA inside the biomass. NIR-irradiated chitosan/GNR clusters increased the skin temperature of mice by 13 °C. The plasmonic nanocomposites induced negligible skin irritation in vivo. In summary, this novel nanosystem demonstrated potent antibacterial effects against planktonic and biofilm MRSA, showcasing the possible efficacy in treating skin infections.
    Mesh-Begriff(e) Chitosan/chemistry ; Chitosan/pharmacology ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Gold/chemistry ; Gold/pharmacology ; Biofilms/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Nanotubes/chemistry ; Animals ; Photothermal Therapy/methods ; Mice ; Plankton/drug effects ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/therapy ; Nanocomposites/chemistry ; Microbial Sensitivity Tests
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131673
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2374: Hefte anzeigen Standort:
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  9. Artikel ; Online: Nanoencapsulation of Tea Catechins for Enhancing Skin Absorption and Therapeutic Efficacy.

    Aljuffali, Ibrahim A / Lin, Chih-Hung / Yang, Shih-Chun / Alalaiwe, Ahmed / Fang, Jia-You

    AAPS PharmSciTech

    2022  Band 23, Heft 6, Seite(n) 187

    Abstract: Tea catechins are a group of flavonoids that show many bioactivities. Catechins have been extensively reported as a potential treatment for skin disorders, including skin cancers, acne, photoaging, cutaneous wounds, scars, alopecia, psoriasis, atopic ... ...

    Abstract Tea catechins are a group of flavonoids that show many bioactivities. Catechins have been extensively reported as a potential treatment for skin disorders, including skin cancers, acne, photoaging, cutaneous wounds, scars, alopecia, psoriasis, atopic dermatitis, and microbial infection. In particular, there has been an increasing interest in the discovery of cosmetic applications using catechins as the active ingredient because of their antioxidant and anti-aging activities. However, active molecules with limited lipophilicity have difficulty penetrating the skin barrier, resulting in low bioavailability. Nevertheless, topical application is a convenient method for delivering catechins into the skin. Nanomedicine offers an opportunity to improve the delivery efficiency of tea catechins and related compounds. The advantages of catechin-loaded nanocarriers for topical application include high catechin loading efficiency, sustained or prolonged release, increased catechin stability, improved bioavailability, and enhanced accumulation or targeting to the nidus. Further, various types of nanoparticles, including liposomes, niosomes, micelles, lipid-based nanoparticles, polymeric nanoparticles, liquid crystalline nanoparticles, and nanocrystals, have been employed for topical catechin delivery. These nanoparticles can improve catechin permeation via close skin contact, increased skin hydration, skin structure disorganization, and follicular uptake. In this review, we describe the catechin skin delivery approaches based on nanomedicine for treating skin disorders. We also provide an in-depth description of how nanoparticles effectively improve the skin absorption of tea catechins and related compounds, such as caffeine. Furthermore, we summarize the possible future applications and the limitations of nanocarriers for topical delivery at the end of this review article.
    Mesh-Begriff(e) Biological Availability ; Catechin ; Skin/metabolism ; Skin Absorption ; Tea/chemistry ; Tea/metabolism
    Chemische Substanzen Tea ; Catechin (8R1V1STN48)
    Sprache Englisch
    Erscheinungsdatum 2022-07-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-022-02344-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils

    Lin, Cheng-Yu / Yu, Huang-Ping / Chang, Yen-Tzu / Lin, Zih-Chan / Alalaiwe, Ahmed / Hwang, Tsong-Long / Fang, Jia-You

    Biomaterials science

    2023  Band 11, Heft 3, Seite(n) 873–893

    Abstract: Psoriasis is a refractory and difficult-to-treat skin disorder. The neutrophil-targeting approach represents a promising option for psoriasis therapy. This study developed and examined NIMP-R14-conjugated immunonanoparticles for specific targeting to ... ...

    Abstract Psoriasis is a refractory and difficult-to-treat skin disorder. The neutrophil-targeting approach represents a promising option for psoriasis therapy. This study developed and examined NIMP-R14-conjugated immunonanoparticles for specific targeting to neutrophils associated with psoriasiform dermatitis. In the process, roflumilast (RFL), as a phosphodiesterase (PDE) 4 inhibitor, was encapsulated in the nanocarriers to assess the anti-inflammatory capability against primary neutrophil activation and murine psoriasiform lesion. The average size and surface charge of the immunonanocarriers were 305 ± 36 nm and -18 ± 6 mV, respectively. The monovalent antibody-conjugated nanoparticles offered precise uptake by both human and mouse neutrophils but failed to exhibit this effect in monocytes and lymphocytes. The intracellular RFL concentration of the immunonanocarriers was five-fold superior to that of the passive counterparts. The immunonanocarriers specifically recognized the neutrophils through the Ly6 antigen with no apparent cytotoxicity. The antibody-conjugated nanoparticles mitigated superoxide anion production and migration of the activated human neutrophils. The
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Anti-Inflammatory Agents/pharmacology ; Dermatitis/pathology ; Disease Models, Animal ; Inflammation/pathology ; Neutrophils ; Psoriasis/drug therapy ; Psoriasis/pathology ; Tissue Distribution ; Antigens, Ly
    Chemische Substanzen Anti-Inflammatory Agents ; Ly6 protein, mouse ; Antigens, Ly
    Sprache Englisch
    Erscheinungsdatum 2023-01-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm01521h
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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