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  1. Article ; Online: Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from

    Ashrafi, Sania / Alam, Safaet / Emon, Nazim Uddin / Ahsan, Monira

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 18

    Abstract: Plants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states. ...

    Abstract Plants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states.
    MeSH term(s) Alkaloids ; Anti-Bacterial Agents/chemistry ; Antioxidants/pharmacology ; Guaiacol ; Indoles ; Phenols/pharmacology ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Rutaceae/chemistry ; Stigmasterol
    Chemical Substances Alkaloids ; Anti-Bacterial Agents ; Antioxidants ; Indoles ; Phenols ; Phytochemicals ; Plant Extracts ; Guaiacol (6JKA7MAH9C) ; Stigmasterol (99WUK5D0Y8)
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27185972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article: Chemico-pharmacological evaluation of the methanolic leaf extract of

    Shahriar, Saimon / Shermin, Samia Akter / Hasnat, Hasin / Hossain, Faisal / Han, Aixia / Geng, Peiwu / Alam, Safaet / Mamun, Abdullah Al

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1347069

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1347069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chemico-Biological Profiling of

    Ashrafi, Sania / Alam, Safaet / Islam, Ariful / Emon, Nazim Uddin / Islam, Quazi Sufia / Ahsan, Monira

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 2293415

    Abstract: ... Blumea ... ...

    Abstract Blumea lacera
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/2293415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  4. Article ; Online: Prospective Asian plants with corroborated antiviral potentials: Position standing in recent years.

    Ashrafi, Sania / Rahman, Mamunur / Ahmed, Pollob / Alam, Safaet / Hossain, Md Abid

    Beni-Suef University journal of basic and applied sciences

    2022  Volume 11, Issue 1, Page(s) 47

    Abstract: Viral diseases are extremely widespread infections caused by viruses. Amongst numerous other illnesses, viral infections have challenged human existence severely. Over the history of mankind, new viruses have emerged and presented us with new tests. The ... ...

    Abstract Viral diseases are extremely widespread infections caused by viruses. Amongst numerous other illnesses, viral infections have challenged human existence severely. Over the history of mankind, new viruses have emerged and presented us with new tests. The range of viral infections varies from familiar infectious diseases such as the common cold, flu, and warts to severe ailments such as AIDS, Ebola, and COVID-19. The world has been racing to find an effective cure for the newly evolving viruses. Toxic effects, non-selectivity, drug resistance, and high price are the most common complications of conventional treatment procedures. Nature is a marvelous source of phytoconstituents with incredible varieties of biological activities. By tradition, medicinal plants have been utilized for the treatment of countless infectious diseases worldwide, some of which contain a broad spectrum of activities. Modern drug discovery and development techniques offer highly efficient separation techniques, inauguration of vector-based schemes where the original infectious virus is cloned to the non-infectious one for antiviral screening targets. The objective of the review was to gather available data on 20 both cultivated and native plants of Asia giving antiviral activities and provide comprehensive information on the phytochemical analysis of the plants and potential antiviral compounds isolated from these plants.
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2768279-1
    ISSN 2314-8543 ; 2314-8535 ; 2314-8543
    ISSN (online) 2314-8543
    ISSN 2314-8535 ; 2314-8543
    DOI 10.1186/s43088-022-00218-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The outbreak of Delta Plus variant: The notorious and novel strain of SARS-CoV-2.

    Richi, Fahmida Tasnim / Alam, Safaet / Ahmed, Firoj / Al-Hossain, A S M Monjur

    Clinical epidemiology and global health

    2022  Volume 14, Page(s) 100974

    Language English
    Publishing date 2022-02-05
    Publishing country India
    Document type Journal Article
    ISSN 2452-0918
    ISSN 2452-0918
    DOI 10.1016/j.cegh.2022.100974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Isolation of bioactive phytochemicals from

    Rakhi, Sharmin Ahmed / Hara, Yasumasa / Islam, Md Saiful / Manome, Teruhisa / Alam, Safaet / Emon, Nazim Uddin / Al-Mansur, Muhammad Abdullah / Kuddus, Md Ruhul / Sarkar, Md Raihan / Ishibashi, Masami / Ahmed, Firoj

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25049

    Abstract: ... Crinum ... ...

    Abstract Crinum asiaticum
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Phyto-pharmacological evaluation and characterization of the methanolic extract of the

    Shompa, Suriya Akter / Hasnat, Hasin / Riti, Saima Jahan / Islam, Md Mirazul / Nur, Farjahan / Alam, Safaet / Shao, Chuxiao / Wang, Shuanghu / Geng, Peiwu / Mamun, Abdullah Al

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1359815

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1359815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Flavonoids: A treasure house of prospective pharmacological potentials.

    Hasnat, Hasin / Shompa, Suriya Akter / Islam, Md Mirazul / Alam, Safaet / Richi, Fahmida Tasnim / Emon, Nazim Uddin / Ashrafi, Sania / Ahmed, Nazim Uddin / Chowdhury, Md Nafees Rahman / Fatema, Nour / Hossain, Md Sakhawat / Ghosh, Avoy / Ahmed, Firoj

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27533

    Abstract: Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these ... ...

    Abstract Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids. These flavonoids appear to have promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, according to evidence from
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antibody-Drug Conjugates: A Review on the Epitome of Targeted Anti- Cancer Therapy.

    Hasan, Mahmudul / Alam, Safaet / Poddar, Saikat Kumar

    Current clinical pharmacology

    2018  Volume 13, Issue 4, Page(s) 236–251

    Abstract: Cancer is one of the deadly diseases which is characterized by unchecked cell division or abnormal cell growth due to the incapability of cell cycle arrest. As the treatment for this is to kill the cancerous cells, the main challenge for scientists is to ...

    Abstract Cancer is one of the deadly diseases which is characterized by unchecked cell division or abnormal cell growth due to the incapability of cell cycle arrest. As the treatment for this is to kill the cancerous cells, the main challenge for scientists is to direct the cell killing to cancerous cells while leaving the normal cells unharmed. Antibody-Drug Conjugates (ADC) are one such targeted anti-cancer therapy. It is an effective drug delivery system that utilizes the targeting action of antibody along with cell death by potent cytotoxic agent, linked up with one another by a linker molecule and thus helps to reduce toxicity to non-target cells, ensure broad therapeutic window and overcome multi-drug resistance. Multiple parameters like total antibody (conjugated and unconjugated antibody), conjugated antibody, conjugated drug, unconjugated antibody and unconjugated (free) drug are needed to be analyzed to find out the behavior as well as safety and efficacy of ADCs. With 2 FDA approved drugs (Kadcylca and Adcetris) and more than 40 drugs undergoing clinical trial, this field has gained pace in recent years. Some challenges still persist in this field like reducing immunogenic response to antibodies, ensuring the ADC homogeneity and antibody-drug ratio, selection of appropriate targets, successful conjugation of drug to antibody, securing the stability of linkers in systemic circulation as well as improvement of oral bioavailability. With the advent of stable linkers, cytotoxic drugs having higher potency and better conjugation capability with the linker and antibodies having high specificity, these ADCs can overcome the limitations of cancer treatment. This review focuses on the criteria for proper construction of ADC, conjugation techniques, the target choices, the underlying mechanism of action and pharmacokinetic considerations associated with ADC.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Drug Delivery Systems/methods ; Humans ; Immunoconjugates/administration & dosage ; Immunoconjugates/chemistry ; Immunoconjugates/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism
    Chemical Substances Antineoplastic Agents ; Immunoconjugates
    Language English
    Publishing date 2018-08-02
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2250809-0
    ISSN 2212-3938 ; 1574-8847
    ISSN (online) 2212-3938
    ISSN 1574-8847
    DOI 10.2174/1574884712666180802095521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6392: Show issues Location:
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  10. Article: Chemical, Pharmacological and Computerized Molecular Analysis of Stem’s Extracts of Bauhinia scandens L. Provide Insights into the Management of Diarrheal and Microbial Infections

    Islam, Md Minarul / Alam, Rashedul / Chung, Hea-Jong / Emon, Nazim Uddin / Fazlul Kabir, Mohammad / Rudra, Sajib / Alam, Safaet / Ullah, Ahsan / Hong, Seong-Tshool / Aktar Sayeed, Mohammed

    Nutrients. 2022 Jan. 09, v. 14, no. 2

    2022  

    Abstract: Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine ...

    Abstract Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in silico study was also implemented to elucidate the binding affinity and drug capability of the selected phytochemicals. In vivo anti diarrheal activity was investigated in mice models. In vitro, antibacterial and antifungal properties of MEBS against several pathogenic strains were evaluated using the disc diffusion method. In addition, in silico study has been employed using Discovery studio 2020, UCFS Chimera, PyRx autodock vina, and online tools. In the anti-diarrheal investigation, MEBS showed a significant dose-dependent inhibition rate in all three methods. The antibacterial and antifungal screening showed a remarkable zone of inhibition, of the diameter 14–26 mm and 12–28 mm, by MEBS. The present study revealed that MEBS has remarkable anti-diarrheal potential and is highly effective in wide-spectrum bacterial and fungal strains. Moreover, the in silico study validated the results of biological screenings. To conclude, MEBS is presumed to be a good source in treating diarrhea, bacterial and fungal infections.
    Keywords Bauhinia ; asthma ; cholera ; computer simulation ; diabetes ; diarrhea ; dose response ; drugs ; fungi ; medicine ; phytochemicals
    Language English
    Dates of publication 2022-0109
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020265
    Database NAL-Catalogue (AGRICOLA)

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