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  1. Article ; Online: To Be, or Not To Be … a Biomarker? A Question to the FDA.

    Alam, Uazman

    Clinical therapeutics

    2021  Volume 43, Issue 9, Page(s) 1438–1440

    MeSH term(s) Biomarkers ; Drug Approval ; Humans ; United States ; United States Food and Drug Administration
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2021.08.010
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    Zs.A 1435: Show issues Location:
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    Zs.MO 404: Show issues

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  2. Article: Diabetic Neuropathy Collection: Treatment of Diabetic Neuropathy.

    Alam, Uazman

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2020  Volume 11, Issue 4, Page(s) 765–772

    Abstract: Video: Treatment of Diabetic Neuropathy podcast recording (MP4 61908 kb). ...

    Abstract Video: Treatment of Diabetic Neuropathy podcast recording (MP4 61908 kb).
    Language English
    Publishing date 2020-03-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-020-00784-3
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  3. Article: Diabetic Neuropathy Collection: Introduction to Diabetic Neuropathy.

    Alam, Uazman

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2020  Volume 11, Issue 4, Page(s) 755–760

    Abstract: Introduction to Diabetic Neuropathy podcast recording (MP4 55526 kb). ...

    Abstract Introduction to Diabetic Neuropathy podcast recording (MP4 55526 kb).
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-020-00773-6
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  4. Article ; Online: Human genetic evidence supports Fibroblast Growth Factor 21 (FGF21) as a novel therapeutic target for gout.

    Zhao, Sizheng Steven / Cuthbertson, Daniel J / Alam, Uazman

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae210
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    Zs.MO 497: Show issues

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  5. Article ; Online: Cardiovascular and renal benefit of sodium-glucose co-transporter type 2 inhibitors in patients with Type 2 Diabetes.

    Man Lam, Steven Ho / Alam, Uazman / Lip, Gregory Yoke Hong

    The American journal of cardiology

    2024  

    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.05.001
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  6. Article ; Online: Obesity pharmacotherapy in older adults: a narrative review of evidence.

    Henney, Alex E / Wilding, John P H / Alam, Uazman / Cuthbertson, Daniel J

    International journal of obesity (2005)

    2024  

    Abstract: The prevalence of obesity in older adults (people aged >60 years) is increasing in line with the demographic shift in global populations. Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and ... ...

    Abstract The prevalence of obesity in older adults (people aged >60 years) is increasing in line with the demographic shift in global populations. Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the 'obesity paradox'. Obesity in the elderly contributes to various obesity-related complications from cardiometabolic disease and cancer, to functional decline, worsening cognition, and quality of life, that will have already suffered an age-related decline. Lifestyle interventions remain the cornerstone of obesity management in older adults, with emphasis on resistance training for muscle strength and bone mineral density preservation. However, in older adults with obesity refractory to lifestyle strategies, pharmacotherapy, using anti-obesity medicines (AOMs), can be a useful adjunct. Recent evidence suggests that intentional weight loss in older adults with overweight and obesity is effective and safe, hence a diminishing reluctance to use AOMs in this more vulnerable population. Despite nine AOMs being currently approved for the treatment of obesity, limited clinical trial evidence in older adults predominantly focuses on incretin therapy with glucagon-like peptide-1 receptor agonists (liraglutide, semaglutide, and tirzepatide). AOMs enhance weight loss and reduce cardiometabolic events, while maintaining muscle mass. Future randomised controlled trials should specifically evaluate the effectiveness of novel AOMs for long-term weight management in older adults with obesity, carefully considering the impact on body composition and functional ability, as well as health economics.
    Language English
    Publishing date 2024-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-024-01529-z
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  7. Article ; Online: Thyroid disease in pregnancy.

    Yap, Yew Wen / Onyekwelu, Emeka / Alam, Uazman

    Clinical medicine (London, England)

    2023  Volume 23, Issue 2, Page(s) 125–128

    Abstract: Pregnancy is accompanied by metabolic changes associated with the thyroid gland. It is therefore important to understand the underlying physiological alterations and the management of patients with thyroid disorders in pregnancy. This review focuses on ... ...

    Abstract Pregnancy is accompanied by metabolic changes associated with the thyroid gland. It is therefore important to understand the underlying physiological alterations and the management of patients with thyroid disorders in pregnancy. This review focuses on the physiology and the management of hyperthyroidism, hypothyroidism and thyroid nodules in the context of pregnancy.
    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Complications/therapy ; Thyroid Diseases/complications ; Thyroid Diseases/diagnosis ; Thyroid Diseases/therapy ; Hyperthyroidism/complications ; Hyperthyroidism/diagnosis ; Hyperthyroidism/therapy ; Hypothyroidism/complications ; Hypothyroidism/diagnosis
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2023-0018
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    Zs.A 5439: Show issues Location:
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  8. Article ; Online: Disentangling the relationship between depression and chronic widespread pain: A Mendelian randomisation study.

    Zhao, Sizheng Steven / Holmes, Michael V / Alam, Uazman

    Seminars in arthritis and rheumatism

    2023  Volume 60, Page(s) 152188

    Abstract: Objective: Depression and chronic widespread pain (CWP) frequently coexist, but whether depression is an independent causal risk factor for CWP, and/or vice versa, remains unclear. We investigated the bidirectional causal relationship between depression ...

    Abstract Objective: Depression and chronic widespread pain (CWP) frequently coexist, but whether depression is an independent causal risk factor for CWP, and/or vice versa, remains unclear. We investigated the bidirectional causal relationship between depression and CWP.
    Methods: We performed a two-sample Mendelian randomisation (MR) study to estimate the causal relationship between genetically predicted depression (170,756 cases, 329,443 controls) and risk of CWP (6,914 cases, 242,929 controls), and the effect of CWP on depression susceptibility, using large population-level genetic data. We used a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE), which allows for sample overlap, in addition to traditional MR and sensitivity analyses.
    Results: For each doubling in odds of genetic liability to depression, the risk of chronic widespread pain was increased (OR 1.004, 95% credible interval 1.003-1.005; p = 7.3 × 10
    Conclusions: This study provides evidence in support of a bidirectional causal relationship between depression and increased risk of chronic widespread pain, whilst overcoming the major limitations of previous epidemiological studies. Interventions for depression may be an effective strategy to prevent or reduce the burden of chronic widespread pain and vice versa.
    MeSH term(s) Humans ; Depression/genetics ; Chronic Pain/epidemiology ; Chronic Pain/genetics ; Risk Factors ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152188
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    Zs.A 790: Show issues Location:
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  9. Article ; Online: Ultra-processed food and non-communicable diseases in the United Kingdom: A narrative review and thematic synthesis of literature.

    Henney, Alex E / Gillespie, Conor S / Alam, Uazman / Hydes, Theresa J / Boyland, Emma / Cuthbertson, Daniel J

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2024  Volume 25, Issue 4, Page(s) e13682

    Abstract: The social and economic constructs of the United Kingdom (UK) provide a fertile food environment for the dramatic expansion in the ultra-processed food (UPF) market, driving increased UPF consumption. This has coincided with the significant increase in ... ...

    Abstract The social and economic constructs of the United Kingdom (UK) provide a fertile food environment for the dramatic expansion in the ultra-processed food (UPF) market, driving increased UPF consumption. This has coincided with the significant increase in the incidence and prevalence of non-communicable diseases (NCDs) such as obesity, type 2 diabetes, cardiovascular disease, and cancer, with an inherent impact on morbidity and mortality. Our review aims to assess the current epidemiological and public health trends in the United Kingdom, specifically examining consumption of UPFs and subsequent development of NCDs, summarizing existing meta-analytical and experimental approaches. First, we address important socioeconomic and psychosocial domains that may contribute to increased availability and consumption of UPF. Additionally, we explore the putative mechanistic basis for the association between UPFs and NCDs: partly attributable to their energy density, the macro- and micronutrient composition (including high refined carbohydrate, saturated, and trans fats composition, in addition to low fiber and protein content), and artificially engineered additives and other compounds that adversely affect health in inadequately researched pathophysiological pathways. This review highlights the importance of promoting minimally processed diets to both clinical and political decision makers.
    MeSH term(s) Humans ; Food, Processed ; Noncommunicable Diseases/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Food Handling ; Fast Foods ; Diet ; United Kingdom/epidemiology
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13682
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    Zs.A 5908: Show issues Location:
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  10. Article: Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management.

    Preston, Frank G / Riley, David R / Azmi, Shazli / Alam, Uazman

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 1595–1612

    Abstract: Painful diabetic peripheral neuropathy (PDPN) is present in nearly a quarter of people with diabetes. It is estimated to affect over 100 million people worldwide. PDPN is associated with impaired daily functioning, depression, sleep disturbance, ... ...

    Abstract Painful diabetic peripheral neuropathy (PDPN) is present in nearly a quarter of people with diabetes. It is estimated to affect over 100 million people worldwide. PDPN is associated with impaired daily functioning, depression, sleep disturbance, financial instability, and a decreased quality of life. Despite its high prevalence and significant health burden, it remains an underdiagnosed and undertreated condition. PDPN is a complex pain phenomenon with the experience of pain associated with and exacerbated by poor sleep and low mood. A holistic approach to patient-centred care alongside the pharmacological therapy is required to maximise benefit. A key treatment challenge is managing patient expectation, as a good outcome from treatment is defined as a reduction in pain of 30-50%, with a complete pain-free outcome being rare. The future for the treatment of PDPN holds promise, despite a 20-year void in the licensing of new analgesic agents for neuropathic pain. There are over 50 new molecular entities reaching clinical development and several demonstrating benefit in early-stage clinical trials. We review the current approaches to its diagnosis, the tools, and questionnaires available to clinicians, international guidance on PDPN management, and existing pharmacological and non-pharmacological treatment options. We synthesise evidence and the guidance from the American Association of Clinical Endocrinology, American Academy of Neurology, American Diabetes Association, Diabetes Canada, German Diabetes Association, and the International Diabetes Federation into a practical guide to the treatment of PDPN and highlight the need for future research into mechanistic-based treatments in order to prioritise the development of personalised medicine.
    Language English
    Publishing date 2023-06-02
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S370050
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