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  1. AU="Albers, Gesa"
  2. AU="Armbrecht, Linda"
  3. AU="Celentano, Angelica"
  4. AU="Vargo, John A"
  5. AU="Zhu, Zhiqiang"
  6. AU="Schreiber, Emil"
  7. AU="Gravel, Jocelyn"
  8. AU="Wall, Patrick"
  9. AU="Crandall, Wallace V"
  10. AU="Lamontagne, Steven J"
  11. AU="Lum, Krystal K"
  12. AU="Peschke, Robert"
  13. AU="Kaliappan, Abinaya"
  14. AU="Ford, Gregory"
  15. AU="Ahmad Kassim, Affifah Saadah"
  16. AU=Scharfenberger Angela
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  20. AU="Flores-Campos, Rocío"
  21. AU="Pandit, Jayvardhan"
  22. AU="Peter M. Visscher"
  23. AU=Martn-Begu Nieves
  24. AU="Kiang, David"
  25. AU="Helal, Shaaban R"
  26. AU=Meltzer H Y
  27. AU="Gambhir, Prakash S"
  28. AU="El-Sayed, Saad A."
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  1. Article ; Online: Itaconate as a key regulator of respiratory disease.

    Michalaki, Christina / Albers, Gesa J / Byrne, Adam J

    Clinical and experimental immunology

    2023  Volume 215, Issue 2, Page(s) 120–125

    Abstract: Macrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to ... ...

    Abstract Macrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review aims to bring together evidence which highlights a role for itaconate in chronic lung diseases (such as asthma and pulmonary fibrosis) and respiratory infections (such as SARS-CoV-2, influenza and Mycobacterium tuberculosis infection). A better understanding of the role of itaconate in lung disease could pave the way for novel therapeutic interventions and improve patient outcomes in respiratory disorders.
    MeSH term(s) Humans ; Succinates/metabolism ; Lung Diseases ; Respiratory Tract Infections ; Asthma
    Chemical Substances itaconic acid (Q4516562YH) ; Succinates
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxad127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glucocorticoid Nanoparticles Show Full Therapeutic Efficacy in a Mouse Model of Acute Lung Injury and Concomitantly Reduce Adverse Effects.

    Albers, Gesa J / Amouret, Agathe / Ciupka, Katrin / Montes-Cobos, Elena / Feldmann, Claus / Reichardt, Holger M

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Glucocorticoids (GCs) are widely used to treat inflammatory disorders such as acute lung injury (ALI). Here, we explored inorganic-organic hybrid nanoparticles (IOH-NPs) as a new delivery vehicle for GCs in a mouse model of ALI. Betamethasone (BMZ) ... ...

    Abstract Glucocorticoids (GCs) are widely used to treat inflammatory disorders such as acute lung injury (ALI). Here, we explored inorganic-organic hybrid nanoparticles (IOH-NPs) as a new delivery vehicle for GCs in a mouse model of ALI. Betamethasone (BMZ) encapsulated into IOH-NPs (BNPs) ameliorated the massive infiltration of neutrophils into the airways with a similar efficacy as the free drug. This was accompanied by a potent inhibition of pulmonary gene expression and secretion of pro-inflammatory mediators, whereas the alveolar-capillary barrier integrity was only restored by BMZ in its traditional form. Experiments with genetically engineered mice identified myeloid cells and alveolar type II (AT II) cells as essential targets of BNPs in ALI therapy, confirming their high cell-type specificity. Consequently, adverse effects were reduced when using IOH-NPs for GC delivery. BNPs did not alter T and B cell numbers in the blood and also prevented the induction of muscle atrophy after three days of treatment. Collectively, our data suggest that IOH-NPs target GCs to myeloid and AT II cells, resulting in full therapeutic efficacy in the treatment of ALI while being associated with reduced adverse effects.
    MeSH term(s) Mice ; Animals ; Glucocorticoids ; Betamethasone ; Lung/metabolism ; Acute Lung Injury/metabolism ; Drug-Related Side Effects and Adverse Reactions ; Nanoparticles ; Lipopolysaccharides
    Chemical Substances Glucocorticoids ; Betamethasone (9842X06Q6M) ; Lipopolysaccharides
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Airway soluble CSF1R predicts progression in patients with idiopathic pulmonary fibrosis.

    Oldham, Justin M / Johnson, Kirk W / Albers, Gesa J / Calamita, Emily / Mah, Jordina / Ghai, Poonam / Hewitt, Richard J / Maher, Toby M / Molyneaux, Philip L / Huang, Michael / Byrne, Adam J

    ERJ open research

    2023  Volume 9, Issue 4

    Abstract: This study provides the first evidence for a role of airway sCSF1R in ... ...

    Abstract This study provides the first evidence for a role of airway sCSF1R in IPF
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00690-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CYFRA 21-1 Predicts Progression in Idiopathic Pulmonary Fibrosis: A Prospective Longitudinal Analysis of the PROFILE Cohort.

    Molyneaux, Philip L / Fahy, William A / Byrne, Adam J / Braybrooke, Rebecca / Saunders, Peter / Toshner, Richard / Albers, Gesa / Chua, Felix / Renzoni, Elisabetta A / Wells, Athol U / Karkera, Yakshitha / Oballa, Eunice / Saini, Gauri / Nicholson, Andrew G / Jenkins, R Gisli / Maher, Toby M

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 12, Page(s) 1440–1448

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Antigens, Neoplasm ; Biomarkers ; Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis ; Keratin-19 ; Prospective Studies
    Chemical Substances Antigens, Neoplasm ; Biomarkers ; Keratin-19 ; antigen CYFRA21.1
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202107-1769OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: DNA Methylome Alterations Are Associated with Airway Macrophage Differentiation and Phenotype during Lung Fibrosis.

    McErlean, Peter / Bell, Christopher G / Hewitt, Richard J / Busharat, Zabreen / Ogger, Patricia P / Ghai, Poonam / Albers, Gesa J / Calamita, Emily / Kingston, Shaun / Molyneaux, Philip L / Beck, Stephan / Lloyd, Clare M / Maher, Toby M / Byrne, Adam J

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 8, Page(s) 954–966

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bronchoalveolar Lavage Fluid/cytology ; Case-Control Studies ; Cell Differentiation/genetics ; DNA Methylation ; Epigenesis, Genetic ; Epigenome ; Female ; Gene Expression Profiling ; Genetic Markers ; Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Male ; Middle Aged ; Phenotype ; Real-Time Polymerase Chain Reaction
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202101-0004OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Itaconate controls the severity of pulmonary fibrosis.

    Ogger, Patricia P / Albers, Gesa J / Hewitt, Richard J / O'Sullivan, Brendan J / Powell, Joseph E / Calamita, Emily / Ghai, Poonam / Walker, Simone A / McErlean, Peter / Saunders, Peter / Kingston, Shaun / Molyneaux, Philip L / Halket, John M / Gray, Robert / Chambers, Daniel C / Maher, Toby M / Lloyd, Clare M / Byrne, Adam J

    Science immunology

    2021  Volume 5, Issue 52

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role during fibrosis is unknown. Here, we reveal that itaconate is an ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role during fibrosis is unknown. Here, we reveal that itaconate is an endogenous antifibrotic factor in the lung. Itaconate levels are reduced in bronchoalveolar lavage, and itaconate-synthesizing cis-aconitate decarboxylase expression (
    MeSH term(s) Administration, Inhalation ; Adoptive Transfer/methods ; Adult ; Aged ; Animals ; Bleomycin/administration & dosage ; Bleomycin/toxicity ; Bronchoalveolar Lavage Fluid/immunology ; Bronchoscopy ; Carboxy-Lyases/metabolism ; Case-Control Studies ; Cells, Cultured ; Disease Models, Animal ; Female ; Fibroblasts ; Healthy Volunteers ; Humans ; Hydro-Lyases/genetics ; Hydro-Lyases/metabolism ; Idiopathic Pulmonary Fibrosis/chemically induced ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/immunology ; Idiopathic Pulmonary Fibrosis/therapy ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/transplantation ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Primary Cell Culture ; Severity of Illness Index ; Succinates/administration & dosage ; Succinates/immunology ; Succinates/metabolism
    Chemical Substances Succinates ; Bleomycin (11056-06-7) ; ACOD1 protein, human (EC 4.1.1.-) ; Carboxy-Lyases (EC 4.1.1.-) ; Hydro-Lyases (EC 4.2.1.-) ; Irg1 protein, mouse (EC 4.2.1.79) ; itaconic acid (Q4516562YH)
    Keywords covid19
    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abc1884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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