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  1. AU="Alberto Macchi"
  2. AU="Messer, Kassandra L"
  3. AU="Pietro Costantini"
  4. AU="Viknaswaran, N L"
  5. AU="Luo, Huixin"
  6. AU="Li, Gordon"
  7. AU=Bauchner Howard
  8. AU=Markiewski Maciej M

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  1. Artikel ; Online: Nasal Cytology

    Cristiano Caruso / Rossana Giancaspro / Giuseppe Guida / Alberto Macchi / Massimo Landi / Enrico Heffler / Matteo Gelardi

    Frontiers in Allergy, Vol

    A Easy Diagnostic Tool in Precision Medicine for Inflammation in Epithelial Barrier Damage in the Nose. A Perspective Mini Review

    2022  Band 3

    Abstract: Nasal cytology is a diagnostic tool that can be used in precision rhinology medicine. Particularly in non-allergic rhinitis and chronic rhinosinusitis forms it can be useful to evaluate biomarkers of both surgical or biological therapy and especially in ... ...

    Abstract Nasal cytology is a diagnostic tool that can be used in precision rhinology medicine. Particularly in non-allergic rhinitis and chronic rhinosinusitis forms it can be useful to evaluate biomarkers of both surgical or biological therapy and especially in the follow-up it must be used to predict the prognostic index of recurrence of nasal polyposis. All inflammatory cytokines are also linked to the presence of cells such as eosinophils and mastcells and nasal cytology is a non-invasive and repeatable method to assess the situation in real life.
    Schlagwörter nasal cytology ; biomarker ; precision medicine ; NARES ; non-allergic rhinitis ; chronic rhinosinusitis ; Immunologic diseases. Allergy ; RC581-607
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way

    Sergio Strizzi / Letizia Bernardo / Pasqualina D’Ursi / Chiara Urbinati / Andrea Bianco / Fiona Limanaqi / Andrea Manconi / Maria Milanesi / Alberto Macchi / Dario Di Silvestre / Adalberto Cavalleri / Giovanni Pareschi / Marco Rusnati / Mario Clerici / PierLuigi Mauri / Mara Biasin

    Pharmacological Research, Vol 194, Iss , Pp 106862- (2023)

    A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein

    2023  

    Abstract: The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive ... ...

    Abstract The characterization of modifications of microbial proteins is of primary importance to dissect pathogen lifecycle mechanisms and could be useful in identifying therapeutic targets. Attempts to solve this issue yielded only partial and non-exhaustive results. We developed a multidisciplinary approach by coupling in vitro infection assay, mass spectrometry (MS), protein 3D modelling, and surface plasma resonance (SPR). As a proof of concept, the effect of low UV-C (273 nm) irradiation on SARS-CoV-2 spike (S) protein was investigated. Following UV-C exposure, MS analysis identified, among other modifications, the disruption of a disulphide bond within the conserved S2 subunit of S protein. Computational analyses revealed that this bond breakage associates with an allosteric effect resulting in the generation of a closed conformation with a reduced ability to bind the ACE2 receptor. The UV-C-induced reduced affinity of S protein for ACE2 was further confirmed by SPR analyses and in vitro infection assays. This comprehensive approach pinpoints the S2 domain of S protein as a potential therapeutic target to prevent SARS-CoV-2 infection. Notably, this workflow could be used to screen a wide variety of microbial protein domains, resulting in a precise molecular fingerprint and providing new insights to adequately address future epidemics.
    Schlagwörter UV light ; Spike protein ; Proteomics ; Structural biology ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2023-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: UV and violet light can Neutralize SARS-CoV-2 Infectivity

    Mara Biasin / Sergio Strizzi / Andrea Bianco / Alberto Macchi / Olga Utyro / Giovanni Pareschi / Alessia Loffreda / Adalberto Cavalleri / Manuela Lualdi / Daria Trabattoni / Carlo Tacchetti / Davide Mazza / Mario Clerici

    Journal of Photochemistry and Photobiology, Vol 10, Iss , Pp 100107- (2022)

    2022  

    Abstract: We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose ... ...

    Abstract We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 104 times less efficient than UV-C light. Moreover, by qPCR (quantitative Polymerase chain reaction) and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV-A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season.
    Schlagwörter UV light ; Virus replication ; FISH ; Disinfection ; Infectivity ; Action spectrum ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 535
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Elsevier
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  4. Artikel ; Online: Solar ultraviolet light collector for germicidal irradiation on the moon

    Matteo Lombini / Laura Schreiber / Roberto Albertini / Elisa Maria Alessi / Primo Attinà / Andrea Bianco / Enrico Cascone / Maria Eugenia Colucci / Fausto Cortecchia / Vincenzo De Caprio / Emiliano Diolaiti / Mauro Fiorini / Luigi Lessio / Alberto Macchi / Giuseppe Malaguti / Giuseppe Mongelluzzo / Giovanni Pareschi / Maria G. Pelizzo / Cesira Pasquarella

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 16

    Abstract: Abstract Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonisation in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne ... ...

    Abstract Abstract Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonisation in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne biological contaminants represent a relevant problem in space missions. A possible way to perform pathogens’ inactivation is by employing the shortest wavelength range of Solar ultraviolet radiation, the so-called germicidal range. On Earth, it is totally absorbed by the atmosphere and does not reach the surface. In space, such Ultraviolet solar component is present and effective germicidal irradiation for airborne pathogens’ inactivation can be achieved inside habitable outposts through a combination of highly reflective internal coating and optimised geometry of the air ducts. The Solar Ultraviolet Light Collector for Germicidal Irradiation on the Moon is a project whose aim is to collect Ultraviolet solar radiation and use it as a source to disinfect the re-circulating air of the human outposts. The most favourable positions where to place these collectors are over the peaks at the Moon’s poles, which have the peculiarity of being exposed to solar radiation most of the time. On August 2022, NASA communicated to have identified 13 candidate landing regions near the lunar South Pole for Artemis missions. Another advantage of the Moon is its low inclination to the ecliptic, which maintains the Sun’s apparent altitude inside a reduced angular range. For this reason, Ultraviolet solar radiation can be collected through a simplified Sun’s tracking collector or even a static collector and used to disinfect the recycled air. Fluid-dynamic and optical simulations have been performed to support the proposed idea. The expected inactivation rates for some airborne pathogens, either common or found on the International Space Station, are reported and compared with the proposed device efficiency. The results show that it is possible to use Ultraviolet solar radiation directly for ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia

    Luca Carmignani / Giorgio Bozzini / Alberto Macchi / Serena Maruccia / Stefano Picozzi / Stefano Casellato

    Asian Journal of Andrology, Vol 17, Iss 5, Pp 802-

    2015  Band 806

    Abstract: Treatment of patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) may affect the quality of sexual function and ejaculation. The effect of new surgical procedures, which are currently available to treat BPH, ... ...

    Abstract Treatment of patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) may affect the quality of sexual function and ejaculation. The effect of new surgical procedures, which are currently available to treat BPH, on erection and ejaculation, has been poorly studied. This study aimed to assess the effect of thulium laser enucleation of the prostate (ThuLEP) on sexual function and retrograde ejaculation in patients with LUTS secondary to BPH. We performed a prospective study in 110 consecutive patients who had undergone ThuLEP to analyze changes in sexual function and urinary symptoms. To evaluate changes in erection and ejaculation, and the effect of urinary symptoms on the quality of life (QoL), five validated questionnaires were used: the ICIQ-MLUTSsex, MSHQ-EjD, International Index of Erectile Function 5, International Prognostic Scoring System (IPSS) questionnaire, and QoL index of the intraclass correlation coefficients. Patients also underwent IPSS and flowmetry to assess the outcome of flow. Patients were evaluated before surgery and 3-6 months after ThuLEP, whereas those with previous abdominal surgery were excluded. The patients′ mean age was 67.83 years. Postoperative urinary symptoms improved after surgery. No significant differences in erectile function before and after surgery were observed. As compared with other techniques described in the literature, the percentage of patients with conserved ejaculation increased by 52.7% after ThuLEP. ThuLEP positively affects urinary symptoms and their effect on the QoL of patients as assessed by questionnaire scores. While endoscopic management of BPH (e.g. transurethral resection of the prostate) causes retrograde ejaculation in most patients, those who undergo ThuLEP have conserved ejaculation and erectile function.
    Schlagwörter antegrade ejaculation; benign prostatic hyperplasia; sexual function; thulium laser enucleation of the prostate ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: The Role of Carbon Dioxide Laser Therapy in Penile Kaposi’s Sarcoma

    Tullio Torelli / Biagio Paolini / Mario Achille Catanzaro / Nicola Nicolai / Maurizio Colecchia / Davide Biasoni / Alberto Macchi / Silvia Stagni / Antonio Tesone / Roberto Salvioni

    Clinical Management Issues, Vol 13, Iss

    A Case Series of Three HIV-Negative HHV-8-Positive Patients

    2019  Band 1

    Abstract: Kaposi’s sarcoma (KS) is a rare tumor of vascular origin. It is quite common in HIV patients. It is rarely located on the glans penis, especially in HIV-negative patients (just some tens in the literature). Owing to the rarity of the disease, both the ... ...

    Abstract Kaposi’s sarcoma (KS) is a rare tumor of vascular origin. It is quite common in HIV patients. It is rarely located on the glans penis, especially in HIV-negative patients (just some tens in the literature). Owing to the rarity of the disease, both the real impact on survival and the most suitable therapy are not known. However, in this 3-patient case series, carbon dioxide laser therapy was effective both for local control and survival. In fact, two late relapses but no disease-related death were recorded. Probably, KS in HIV-negative patients is a slowly progressive disease, not so aggressive as in HIV-positive patients. Laser therapy is easy, fast, and cheap, and may treat the disease radically. If these data are confirmed by further studies, in the foreseeable future, laser therapy may become the gold standard for treating HIV-negative patients affected by penile KS.
    Schlagwörter Penile Neoplasms ; Laser Therapy ; Sarcoma ; Kaposi ; Herpesvirus 8 ; Human ; Infection ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag SEEd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Allergic and nonallergic rhinitis in children

    Maria Cristina Provero / Alberto Macchi / Sara Antognazza / Maddalena Marinoni / Luigi Nespoli

    Open Journal of Pediatrics, Vol 03, Iss 02, Pp 133-

    The role of nasal cytology

    2013  Band 138

    Abstract: Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis. Over the past few years nasal cytology has been rarely used in pediatrics, nevertheless ...

    Abstract Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis. Over the past few years nasal cytology has been rarely used in pediatrics, nevertheless its clinical and scientific applications seem to be very promising. The advantages of this technique are different: the ease of performance, the noninvasiveness allowing repetition and the low cost. We evaluated 100 children, from 2 to 15 years old, referred to our outpatient service for allergic children for suspected allergic rhinitis (AR). After skin prick test (SPT) or Radio Allergo Sorbent Test (RAST), 59/100 subjects were classified as affected by AR, while 8 children refused to be tested. According to ARIA guidelines, the 59 children with AR (4 - 15 years old) were divided in 56 with persistent AR and 3 with an intermittent form. Nine out of 59 children with AR had a significant number of neutrophils and eosinophils at the nasal cytology, documenting the presence of “minimal persistent inflammation”. Eleven out of 59 AR patients showed a positive swab for bacteria. Children with nonallergic rhinitis (NAR) were 33/100 (2 - 15 years old). After nasal cytology, 17/33 children were classified as NARES (nonallergic rhinitis with eosinophils), including one X-linked agammaglobulinemia (XLA) child, 1/33 as NARESMA (nonallergic rhinitis with eosinophils and mast cell) and another 1/33 as NARMA (nonallergic rhinitis with mast cell). In conclusion, nasal cytology allowed us to correctly classify children with NAR and to better assess the condition of children with AR.
    Schlagwörter Allergic Rhinitis ; Children ; Nasal Cytology ; Nonallergic Rhinitis ; X-Linked Agammaglobulinemia ; Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2013-06-01T00:00:00Z
    Verlag Scientific Research Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic

    Cinzia Cecchetto / Antonella Di Pizio / Federica Genovese / Orietta Calcinoni / Alberto Macchi / Andreas Dunkel / Kathrin Ohla / Sara Spinelli / Michael C. Farruggia / Paule V. Joseph / Anna Menini / Elena Cantone / Caterina Dinnella / Maria Paola Cecchini / Anna D’Errico / Carla Mucignat-Caretta / Valentina Parma / Michele Dibattista

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Abstract Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 ...

    Abstract Abstract Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 pandemic started, we now know much more about smell, taste, and chemesthesis loss associated with COVID-19. However, the temporal dynamics and characteristics of recovery are still unknown. Here, capitalizing on data from the Global Consortium for Chemosensory Research (GCCR) crowdsourced survey, we assessed chemosensory abilities after the resolution of respiratory symptoms in participants diagnosed with COVID-19 during the first wave of the pandemic in Italy. This analysis led to the identification of two patterns of chemosensory recovery, partial and substantial, which were found to be associated with differential age, degrees of chemosensory loss, and regional patterns. Uncovering the self-reported phenomenology of recovery from smell, taste, and chemesthetic disorders is the first, yet essential step, to provide healthcare professionals with the tools to take purposeful and targeted action to address chemosensory disorders and their severe discomfort.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps

    Eugenio De Corso / Carlotta Pipolo / Elena Cantone / Giancarlo Ottaviano / Stefania Gallo / Frank Rikki Mauritz Canevari / Alberto Macchi / Giulia Monti / Carlo Cavaliere / Ignazio La Mantia / Sara Torretta / Francesco Bussu / Emanuele Scarano / Paolo Petrone / Angelo Ghidini / Daniela Lucidi / Massimiliano Garzaro / Matteo Trimarchi / Veronica Seccia /
    Giulio Cesare Passali / Daria Salsi / Domenico Cuda / Ernesto Pasquini / Luca Malvezzi / Stefano Settimi / Gaetano Paludetti / Jacopo Galli

    Journal of Personalized Medicine, Vol 12, Iss 897, p

    Identification of Unmet Clinical Needs

    2022  Band 897

    Abstract: Background : Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in Italy to ... ...

    Abstract Background : Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in Italy to capture current trends in the use of topical and systemic corticosteroids in patients with CRSwNP. Methods : A survey was set up on Survey Monkey ® . Each author distributed the link to the survey in an ad hoc manner and a total of 437 participants filled out the survey. Results : Mometasone furoate (79.3%) was the most frequently prescribed, administered daily by 61.9% of participants; the remaining preferred to discontinue treatment for brief periods to reduce side effects or to modulate the therapy in mild cases. The majority believe that a short cycle of systemic steroids should be prescribed for re-exacerbation of symptoms and that the number of cycles in the previous year should be evaluated to define control of the disease even if international guidelines do not provide clear indications on this topic. A certain degree of divergence emerged from responses regarding how long and the maximal dose of systemic steroids which place patients at high risk for adverse events. Finally, systemic corticosteroids seem to offer only temporary benefit on recovery of smell without guaranteeing long-term control even if the patient is adherent to topical corticosteroids. Conclusions : Our results highlight the need for clear guidelines on oral steroids, which could help supporting the use of a precision medicine approach, including indications for new biological agents.
    Schlagwörter chronic rhinosinusitis ; with nasal polyps ; corticosteroids ; survey ; management ; unmet needs ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Open Comparative, Randomized Controlled Clinical Study of a New Immunostimulating Bacterial Lysate in the Prophylaxis of Upper Respiratory Tract Infections

    Alberto, Macchi / Laura, Vecchia Della

    Arzneimittelforschung

    2005  Band 55, Heft 05, Seite(n) 276–281

    Abstract: One hundred and fourteen patients with a medical history of recurrent upper respiratory tract infections (at least four episodes in the year preceding this open comparative study) were randomly assigned to three groups of 38 patients each. The first ... ...

    Abstract One hundred and fourteen patients with a medical history of recurrent upper respiratory tract infections (at least four episodes in the year preceding this open comparative study) were randomly assigned to three groups of 38 patients each. The first group received, by sublingual route, Ismigen, a new immunostimulating lysate (Polivalent Mechanical Bacterial Lysate, PMBL) obtained by mechanical lysis of 48 billion bacteria commonly responsible for upper respiratory tract infections; the second group received an oral immunostimulating lysate (CLBL) obtained by chemical lysis of 36 billion bacteria. A third group served as control and did not receive any immunostimulating treatment (Control NT). One tablet a day of PMBL was given to the first group for the first ten days during three consecutive months; the patients of the second group received one capsule a day of CLBL with the same treatment schedule. At the end of the treatment period the patients of the 3 groups were followed up for 3 months. The primary end point was the number of acute upper respiratory tract infections (URTIs) that occurred during the three months of treatment and three months of follow-up. Secondary endpoints were: the number of patients free from disease, the duration of infectious episodes, the number of working days lost because of disease, the need for a concomitant antibiotic treatment, and the safety of the two treatments. During the treatment period the mean number (±SD) of URTIs per patient was 0.34 (0.48) in the PMBL group, 1.0 (0.83) and 1.23 (0.77) in the CLBL and Control NT groups, respectively. Results of PMBL treatment were significantly better (p < 0.05) than the results in the other two groups; CLBL was not significantly different from the control group. In the three months of follow-up, the mean number (±SD) of URTIs per patient was: 0.42 (0.55) in the PMBL group, 0.92 (0.67) in the CLBL group, and 1.55 (0.88) in the Control NT group. The PMBL group was significantly better than the other two (p < 0.05). During the 6-month study, significantly more patients of the PMBL group remained free from respiratory infections in comparison to the other two groups. As regards other secondary end points (duration of infectious episodes and number of working days lost), the mean values of the PMBL group were statistically significantly lower than those of the other two groups, in both the treatment and follow-up periods. No PMBL treated patient needed concomitant administration of an antibiotic, while 9 patients of the CLBL group received such treatment (p < 0.05). No patient reported adverse events.
    Schlagwörter Bacterial lysate, polivalent mechanical ; Immunostimulant ; Ismigen®, clinical trial, upper respiratory tract infections ; Upper respiratory tract infections, prevention, recurrent
    Sprache Englisch
    Erscheinungsdatum 2005-05-01
    Verlag Editio Cantor Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 502081-5
    ISSN 1616-7066 ; 0004-4172
    ISSN (online) 1616-7066
    ISSN 0004-4172
    DOI 10.1055/s-0031-1296857
    Datenquelle Thieme Verlag

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