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Article ; Online: PDGFR‐β and kidney fibrosis

Alberto Ortiz

EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)

2020

Abstract: Chronic kidney disease (CKD) is one of the fastest growing global causes of death, estimated to rank among the top five by 2040 (Foreman et al, 2018). This illustrates current pitfalls in diagnosis and management of CKD. Advanced CKD requires renal ... ...

Abstract	Chronic kidney disease (CKD) is one of the fastest growing global causes of death, estimated to rank among the top five by 2040 (Foreman et al, 2018). This illustrates current pitfalls in diagnosis and management of CKD. Advanced CKD requires renal function replacement by dialysis or transplantation. However, earlier CKD stages, even when renal function is still normal, are already associated with an increased risk of premature death (Perez‐Gomez et al, 2019). Thus, novel approaches to diagnose and treat CKD are needed. The histopathological hallmark of CKD is kidney fibrosis, which is closely associated with local inflammation and loss of kidney parenchymal cells. Thus, kidney fibrosis is an attractive process to develop tests allowing an earlier diagnosis of CKD and represents a potential therapeutic target to slow CKD progression or promote regression.
Keywords	Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identificación y tratamiento oportuno exitoso de hipertermia maligna

Alexander García Castañeda / Carlos Alberto Ortiz / Mario Villaveces

Revista Chilena de Anestesia, Vol 52, Iss 4, Pp 422-

2023 Volume 425

Keywords	hipertermia maligna ; succinilcolina ; dantroleno ; Medicine ; R ; Anesthesiology ; RD78.3-87.3
Language	Spanish
Publishing date	2023-07-01T00:00:00Z
Publisher	Editorial Iku
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluación de Desempeño como Factor Estratégico para Rendimiento Académico del Docente Universitario

Luís Alberto Ortiz López

Revista Scientific, Vol 5, Iss

2020 Volume 15

Abstract: El sector universitario debe estar a la vanguardia de los desafíos y cambios que se producen en una sociedad globalizada, tener perspectiva hacia dónde dirigir sus acciones y planear hacia el futuro, el cual le permita razonar en detalle su misión, ... ...

Abstract	El sector universitario debe estar a la vanguardia de los desafíos y cambios que se producen en una sociedad globalizada, tener perspectiva hacia dónde dirigir sus acciones y planear hacia el futuro, el cual le permita razonar en detalle su misión, visión, metas, estrategias y actividades que se requieren para cumplir con los objetivos deseados, al mismo tiempo se debe enfrentar los diferentes retos que se producen cotidianamente en los ambientes de enseñanza y aprendizaje. De modo tal, que este ensayo, pretende hacer una reflexión con respecto al beneficio que produce la evaluación de desempeño en el trabajador y las ventajas que tiene para los supervisores universitarios sobre el aprovechamiento de las posibilidades materiales y humanas que conlleva a facilitar y agrupar aún más a todos los funcionarios en torno a las metas establecidas en el sector universitario. De allí que, que la evaluación de desempeño mediante el factor estratégico viene a representar un mecanismo efectivo a la organización universitaria porque permite precisar los roles y responsabilidades de cada uno de los docentes y así poder obtener un mayor impacto y efectos positivos en el rendimiento académico de sus funciones en beneficio de la sociedad.
Keywords	evaluación del docente ; estrategias educativas ; rendimiento académico ; Social Sciences ; H
Language	Spanish
Publishing date	2020-02-01T00:00:00Z
Publisher	Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potencial Use of Near Infrared Spectroscopy (NIRS) to Categorise Chorizo Sausages from Iberian Pigs According to Several Quality Standards

Alberto Ortiz / Lucía León / Rebeca Contador / David Tejerina

Applied Sciences, Vol 11, Iss 11379, p

2021 Volume 11379

Abstract: The ability of Near Infrared Spectroscopy (NIRS) to classify pre-sliced Iberian chorizo modified atmosphere packaged (MAP) according to the animal material used in their production ( Black , Red , White ) in their production in accordance with the ... ...

Abstract	The ability of Near Infrared Spectroscopy (NIRS) to classify pre-sliced Iberian chorizo modified atmosphere packaged (MAP) according to the animal material used in their production ( Black , Red , White ) in their production in accordance with the official trade categories (which includes the handling system and the different inter-racial crossbreeds) without opening the package was assayed. Furthermore, various spectra pre-treatments and supervised classification chemometric tools; Partial least square-discriminant analysis (PLS-DA), soft independent modelling of class analogies (SIMCA) and linear discriminant analysis (LDA), were assessed. The highest sensitivity values in both calibration and external validation were achieved with SIMCA followed by PLS-DA approaches, while LDA had more provided values among sensitivity and specificity and between the different commercial categories in both sample sets, thus yielding the highest discriminant ability. These results could be a resource to support the traceability and authentication control of individual pre-sliced MAP Iberian chorizo according to the commercial category of the raw material in a non-destructive way.
Keywords	PLS-DA ; SIMCA ; LDA ; unopened package ; modified atmosphere packaging ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Agricultural Potential of a Region with Semi-Dry, Warm and Temperate Subhumid Climate Diversity through Agroecological Zoning

Edgar Vladimir Gutiérrez Castorena / Gustavo Andrés Ramírez Gómez / Carlos Alberto Ortíz Solorio

Sustainability, Vol 15, Iss 9491, p

2023 Volume 9491

Abstract: The sustainability of the natural resources used in agricultural production is essential to meet the future food needs of the population. It is necessary to understand the characteristics of climate and soil changes through agroclimatic zoning models, ... ...

Abstract	The sustainability of the natural resources used in agricultural production is essential to meet the future food needs of the population. It is necessary to understand the characteristics of climate and soil changes through agroclimatic zoning models, even with non-existent or limited climatic and edaphic databases, to avoid a decline in production. The objective of the study was to determine the accuracy of the Global Agroecological Zoning (GAEZ), ECOCROP and Papadakis models for major cereals, vegetables and fruit trees in the state of Nuevo León, Mexico, using the databases of climatic stations and soil profiles collected by INEGI with random sampling in the field. The model with the best projection was ECOCROP, which predicted 37,609 km 2 of irrigated area for sorghum and 34,796 km 2 for wheat, in addition to identifying by soil characteristics rainfed areas with higher suitability for beans measuring 8470 km 2 and orange measuring 6175 km 2 with zoning predictions based on field information. In conclusion, the thematic maps obtained with ECOCROP had an accuracy greater than 50% for more than half of the crops analyzed, making it the best method for the study area. Therefore, the food production decisions of the producers must be directed towards cereal crops based on the projected area; however, it is necessary to establish an updating program and generate edaphoclimatic databases, updating thematic soil and climate maps with models that support the projections verified in the field.
Keywords	agroecological zones ; northeastern Mexico ; agroclimatic suitability ; spline ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Liraglutide effectiveness in preoperative weight-loss for patients with severe obesity undergoing bariatric-metabolic surgery.

Muñoz, Martha Patricia Sánchez / Blandón, José Daniel Reyes / Gutierrez, Ileana Susana Camba / Mendoza, Carlos Manuel Moreno / Aguiñaga, Ma Soledad Aldana / Orozco, César Alberto Ortiz

Updates in surgery

2024

Abstract: Preoperative management of patients living with severe obesity can be challenging; in this context, the preoperative weight loss may help to obtain better outcomes and less morbidity for bariatric surgery. Therefore, we evaluated the effectiveness of GLP- ...

Abstract	Preoperative management of patients living with severe obesity can be challenging; in this context, the preoperative weight loss may help to obtain better outcomes and less morbidity for bariatric surgery. Therefore, we evaluated the effectiveness of GLP-1 analogue Liraglutide in preoperative weight loss. We performed a single-center, quasi-experimental prospective study. Eligible participants were adults in preoperative management for bariatric-metabolic surgery with body-mass index ≥ 48 kg/m
Language	English
Publishing date	2024-04-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-024-01828-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lyso-Gb3 Increases αvβ3 Integrin Gene Expression in Cultured Human Podocytes in Fabry Nephropathy

Hernán Trimarchi / Alberto Ortiz / Maria Dolores Sánchez-Niño

Journal of Clinical Medicine, Vol 9, Iss 3659, p

2020 Volume 3659

Abstract: Background: Podocyturia in Fabry nephropathy leads to glomerulosclerosis and kidney disease progression. Integrins are involved in podocyte attachment to the glomerular basement membrane. We hypothesized that in Fabry nephropathy, lyso-Gb3 could modulate ...

Abstract	Background: Podocyturia in Fabry nephropathy leads to glomerulosclerosis and kidney disease progression. Integrins are involved in podocyte attachment to the glomerular basement membrane. We hypothesized that in Fabry nephropathy, lyso-Gb3 could modulate αvβ3 expression in podocytes. Together with UPAR, the αvβ3 integrin is a key mechanism involved in podocyte detachment and podocyturia. Methods: In cultured human podocytes stimulated with lyso-Gb3, the mRNA expression of the ITGAV and ITGB3 genes encoding integrins αv and β3, respectively, was analyzed by RT-qPCR. Results: In cultured human podocytes, lyso-Gb3 at concentrations encountered in the serum of Fabry patients increased ITGAV and ITGB3 mRNA levels within 3 to 6 h. This pattern of gene expression is similar to that previously observed for PLAUR (UPAR) gene expression but is in contrast to the delayed (24 h) upregulation of other markers of podocyte stress and mediators of injury, such as CD80, TGFβ1, CD74, Notch1, and HES. Conclusions: Human podocyte stress in response to glycolipid overload in Fabry nephropathy, exemplified by lyso-Gb3, is characterized by an early increase in the expression of components of the αvβ3/UPAR system, which contrasts with the delayed rise in the expression of other mediators of podocyte injury. This suggests that the αvβ3/UPAR system may be a therapeutic target in Fabry nephropathy.
Keywords	Fabry disease ; lyso-Gb3 ; podocyte ; podocyturia ; αvβ3 integrin ; proteinuria ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Indicadores cienciométricos y altmétricos para la identificación de líderes científicos

Emilio Alberto Ortiz Torres / Yoan Israel Viamonte-Garrido

Palabra Clave [La Plata], Vol 10, Iss

2020 Volume 1

Abstract: Hasta el presente, la literatura científica latinoamericana revisada, sobre el liderazgo científico universitario en las ciencias sociales ha ignorado, al menos en aquella publicada en plataformas bibliográficas gratuitas, el uso posible y necesario de ...

Abstract	Hasta el presente, la literatura científica latinoamericana revisada, sobre el liderazgo científico universitario en las ciencias sociales ha ignorado, al menos en aquella publicada en plataformas bibliográficas gratuitas, el uso posible y necesario de indicadores cienciométricos, tradicionales y altmétricos, como parte de una metodología de identificación y evaluación temprana de dicho fenómeno en el contexto específico de las redes académicas iberoamericanas. El objetivo del presente trabajo es proponer una batería de 12 indicadores cienciométricos combinados con los cuales identificar y evaluar tempranamente el liderazgo científico en redes académicas latinoamericanas, empleando como fuentes de datos los perfiles de los investigadores objeto de estudio las plataformas académicas ResearchGate y Google Académico. Los indicadores propuestos fueron aplicados a un universo de 102 miembros de la Red Iberoamericana de Investigación sobre la Calidad de la Formación Doctoral en Ciencias Sociales, los cuales constituyen producto de la selección y la combinación de 6 indicadores cienciométricos tradicionales abordados por los autores en trabajos anteriores junto a otros 6 de tipo altmétricos obtenidos a partir de la producción científica de los investigadores en las plataformas académicas ResearchGate y Google Académico. Como resultado de la presente investigación, 7 miembros de la Red fueron identificados como líderes científicos.
Keywords	Indicadores cienciométricos y altmétricos ; Líderes científicos latinoamericanos ; Redes académicas iberoamericanas ; Indicadores de ResearchGate ; Indicadores de Google Académico ; Bibliography. Library science. Information resources ; Z
Language	Spanish
Publishing date	2020-10-01T00:00:00Z
Publisher	Universidad Nacional de La Plata
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Undiagnosed cardiovascular risk factors in overweight and obese individuals

Patricio Alfredo Vallejo-Valdivieso / Graciela Zambrano-Pincay / Alberto Ortiz

PeerJ, Vol 9, p e

a low income country experience

2021 Volume 10870

Abstract: Background Overweight and obesity are associated with diabetes, hypertension and chronic kidney disease (CKD). However, there is scarce information from lower income countries about undiagnosed obesity-associated conditions. This information is necessary ...

Abstract	Background Overweight and obesity are associated with diabetes, hypertension and chronic kidney disease (CKD). However, there is scarce information from lower income countries about undiagnosed obesity-associated conditions. This information is necessary for healthcare planning and for assessment of Global Burden of Disease. Methods We assessed the prevalence of obesity-associated conditions in 656 overweight (n = 360) and obese (n = 296) adults from inner-city Portoviejo (Ecuador), in descriptive field research, based on an opportunistic and selective sampling strategy. Results Of 316 men and 340 women, 73% met criteria for prehypertension (27%) or hypertension (46%), 50% met criteria for prediabetes (30%) or diabetes (20%), 11% had an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 consistent with chronic kidney disease (CKD) and 5.5% had pathological albuminuria for a total CKD prevalence of 16%. Age-related prevalence data were generated. In all participants, serum total cholesterol and triglycerides were >200 and >150 mg/dl, respectively. Hyperuricemia and microhematuria (<2%) were uncommon. Women were more likely to have low eGFR (18 vs 5%, p 0.000). Diabetes and pathological albuminuria prevalence were higher in obese than in overweight participants (15 vs 12%, p 0.018; and 8 vs 4%, p 0.0199, respectively). Discussion In conclusion, undiagnosed hypertension, diabetes and CKD were more common than expected in overweight and obese persons from Ecuador. Detection rates exceeded official estimates of prevalene of these conditions. Screening the overweight/obese for these conditions, especially at the age ranges at higher risk, may be cost-effective to identify a high number of persons who may benefit from early inexpensive intervention.
Keywords	Obesity ; Overweight ; Global burden of disease ; Diabetes ; Albuminuria ; Chronic kidney disease ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extracellular Vesicles and Acute Kidney Injury

Maja Kosanović / Bojana Milutinovic / Sofija Glamočlija / Ingrid Mena Morlans / Alberto Ortiz / Milica Bozic

International Journal of Molecular Sciences, Vol 23, Iss 3792, p

Potential Therapeutic Avenue for Renal Repair and Regeneration

2022 Volume 3792

Abstract: Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular ...

Abstract	Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular vesicles (EVs) are nanoparticles secreted by various cell types in both physiological and pathological conditions. EVs can arise from distinct parts of the kidney and can mediate intercellular communication between various cell types along the nephron. Besides their potential as diagnostic tools, EVs have been proposed as powerful new tools for regenerative medicine and have been broadly studied as therapeutic mediators in different models of experimental AKI. In this review, we present an overview of the basic features and biological relevance of EVs, with an emphasis on their functional role in cell-to-cell communication in the kidney. We explore versatile roles of EVs in crucial pathophysiological mechanisms contributing to AKI and give a detailed description of the renoprotective effects of EVs from different origins in AKI. Finally, we explain known mechanisms of action of EVs in AKI and provide an outlook on the potential clinical translation of EVs in the setting of AKI.
Keywords	extracellular vesicles ; exosomes ; microvesicles ; cellular communication ; acute kidney injury ; therapeutic agents ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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