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  1. Article ; Online: Late Worsening of COVID-19 Pneumonia

    Mauro Betelli / Fabio De Stefano / Alberto Tedeschi

    European Journal of Case Reports in Internal Medicine (2020)

    Successful Treatment with Ruxolitinib and Steroid

    2020  

    Abstract: We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with ... ...

    Abstract We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with rapid improvement of respiratory failure; 1 month after the second discharge, maintaining low-dose oral prednisone, lung consolidations were significantly reduced on control CT.
    Keywords covid-19 ; ruxolitinib ; janus kinase inhibitors ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Chronic urticaria

    Riccardo Asero / Alberto Tedeschi / Angelo Valerio Marzano / Massimo Cugno

    F1000Research, Vol

    a focus on pathogenesis [version 1; referees: 3 approved]

    2017  Volume 6

    Abstract: Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality ... ...

    Abstract Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality of life and sometimes represent a challenge for doctors as well. The causes of chronic urticaria are still poorly defined, although there is growing evidence that different biologic systems including immunity, inflammation, and coagulation may take part in the pathomechanism eventually leading to mast cell and basophil degranulation and hence to wheal formation. This review will discuss the main findings that are (slowly) shedding light on the pathogenesis of this disorder.
    Keywords Immunopharmacology & Hematologic Pharmacology ; Innate Immunity ; Leukocyte Signaling & Gene Expression ; Urticaria ; Vasculitis & Connective Tissue Disease ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2017-07-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Enhanced tissue factor expression by blood eosinophils from patients with hypereosinophilia

    Massimo Cugno / Angelo V Marzano / Maurizio Lorini / Vincenzo Carbonelli / Alberto Tedeschi

    PLoS ONE, Vol 9, Iss 11, p e

    a possible link with thrombosis.

    2014  Volume 111862

    Abstract: Thrombotic risk is increased in eosinophil-mediated disorders, and several hypotheses have been proposed to link eosinophilia and thrombosis. In particular, eosinophils have been described as source of tissue factor (TF), the main initiator of blood ... ...

    Abstract Thrombotic risk is increased in eosinophil-mediated disorders, and several hypotheses have been proposed to link eosinophilia and thrombosis. In particular, eosinophils have been described as source of tissue factor (TF), the main initiator of blood coagulation; however, this aspect is still controversial. This study was aimed to evaluate whether TF expression varies in eosinophils isolated from normal subjects and patients with different hypereosinophilic conditions. Eosinophils were immunologically purified from peripheral blood samples of 9 patients with different hypereosinophilic conditions and 9 normal subjects. Western blot analysis and real-time polymerase chain reaction (RT-PCR) were performed to test eosinophil TF expression. For comparison, TF expression was evaluated in monocytes from blood donors and in human endothelial (ECV304) and fibroblast (IMR90) cell lines. Western blot analysis revealed a major band of 47,000 corresponding to native TF in homogenates of purified eosinophils with a higher intensity in the 9 patients than in the 9 controls (p<0.0001). According to RT-PCR cycle threshold (Ct), TF gene expression was higher in eosinophils from patients than in those from controls, median (range) 35.10 (19.45-36.50) vs 37.17 (35.33-37.87) (p = 0.002), and was particularly abundant in one patient with idiopathic hypereosinophilic syndrome and ischemic heart attacks (Ct: 19.45). TF gene expression was moderate in monocytes, Ct: 31.32 (29.82-33.49) and abundant in endothelial cells, Ct: 28.70 (27.79-29.57) and fibroblasts, Ct: 22.77 (19.22-25.05). Our results indicate that human blood eosinophils contain variable amounts of TF. The higher TF expression in patients with hypereosinophilic disorders may contribute to increase the thrombotic risk.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 616
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: JAK Inhibition with Ruxolitinib in Patients with COVID-19 and Severe Pneumonia

    Alessandro Maria Vannucchi / Andrea Mortara / Andrea D’Alessio / Mara Morelli / Alberto Tedeschi / Moreno Benedetto Festuccia / Antonella D’Arminio Monforte / Enrico Capochiani / Carmine Selleri / Federico Simonetti / Annalisa Saracino / Davide Rapezzi / Maria Rita Badagliacca / Katia Falasca / Alfredo Molteni / Roberto Palazzolo / Giuliano Schettino / Monica Bocchia / Mauro Turrini /
    Paolo A. Ascierto / Mike Zuurman / Carole Paley / Paola Coco / Giuseppe Saglio

    Journal of Clinical Medicine, Vol 10, Iss 3752, p

    Multicenter Clinical Experience from a Compassionate Use Program in Italy

    2021  Volume 3752

    Abstract: Jak inhibitors are potent anti-inflammatory drugs that have the potential to dampen the hyperactive inflammatory response associated with severe COVID-19. We reviewed the clinical outcomes of 218 patients with COVID-19 hospitalized for severe pneumonia ... ...

    Abstract Jak inhibitors are potent anti-inflammatory drugs that have the potential to dampen the hyperactive inflammatory response associated with severe COVID-19. We reviewed the clinical outcomes of 218 patients with COVID-19 hospitalized for severe pneumonia and treated with ruxolitinib through a compassionate use program. Data on the duration of treatment; outcomes at 4, 7, 14, and 28 days; oxygen support requirements; clinical status; and laboratory parameters were retrospectively collected. Overall, according to the physician evaluation, 66.5% of patients showed improvement at follow-up; of these, 83.5% showed improvement by day 7. Oxygen support status also showed improvement, and by day 7, 21.6% of patients were on ambient air, compared with 1.4% at baseline, which increased to 48.2% by day 28. Significant decreases in C-reactive protein and increases in the lymphocyte total count were already observed by day 4, which seemed to correlate with a positive outcome. At the end of the observation period, 87.2% of patients were alive. No unexpected safety findings were observed, and grade 3/4 adverse events were reported in 6.9% of patients.
    Keywords COVID-19 ; pneumonia ; ruxolitinib ; SARS-CoV-2 ; hyperactive inflammatory response ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Activation of Blood Coagulation in Two Prototypic Autoimmune Skin Diseases

    Massimo Cugno / Alberto Tedeschi / Alessandro Borghi / Paolo Bucciarelli / Riccardo Asero / Luigia Venegoni / Samantha Griffini / Elena Grovetti / Emilio Berti / Angelo Valerio Marzano

    PLoS ONE, Vol 10, Iss 6, p e

    A Possible Link with Thrombotic Risk.

    2015  Volume 0129456

    Abstract: Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation ( ... ...

    Abstract Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P<0.0001). Tissue factor positivity was evident in skin biopsies of both disorders with higher intensity in bullous pemphigoid. F1+2 and D-dimer, during remission, were markedly reduced in both disorders. These findings support the involvement of coagulation activation in the pathophysiology of both diseases. The strong systemic activation of coagulation in bullous pemphigoid may contribute to increase the thrombotic risk and provides the rationale for clinical trials on anticoagulant treatments in this disease.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Water Dynamics at the Root of Metamorphosis in Living Organisms

    Emilio Del Giudice / Paola Rosa Spinetti / Alberto Tedeschi

    Water

    Issue (3)

    Abstract: Liquid water has been recognized long ago to be the matrix of many processes, including life and also rock dynamics. Interactions among biomolecules occur very differently in a non-aqueous system and are unable to produce life. This ability to make ... ...

    Abstract Liquid water has been recognized long ago to be the matrix of many processes, including life and also rock dynamics. Interactions among biomolecules occur very differently in a non-aqueous system and are unable to produce life. This ability to make living processes possible implies a very peculiar structure of liquid water. According to modern Quantum Field Theory (QFT), a complementary principle (in the sense of Niels Bohr) holds between the number N of field quanta (including the matter field whose quanta are just the atoms/molecules) and the phase Ф. This means that when we focus on the atomic structure of matter it loses its coherence properties and, vice versa, when we examine the phase dynamics of the system its atomic structure becomes undefined. Superfluid liquid Helium is the first example of this peculiar quantum dynamics. In the present paper we show how consideration of the phase dynamics of liquid water makes the understanding of its peculiar role in the onset of self-organization in living organisms and in ecosystems possible.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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