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  1. AU="Alberton, Michele D"
  2. AU="Chou, Tsung-Ching"
  3. AU="Mehdizadeh, Rana"
  4. AU="Sue Chen"
  5. AU=Smrcka A V
  6. AU="Costache, Oana"
  7. AU="Jungilligens, Johannes"
  8. AU="Kegel, S"
  9. AU="Frances P. Rodriguez-Rivera"
  10. AU="Viennet, Hervé"
  11. AU="Martínez-Silva, María G"
  12. AU="Christino, Melissa A"
  13. AU="Silva, Larissa L"
  14. AU="Tonks, Michael R."
  15. AU="Korhonen, H"
  16. AU="Mukendi, John T"
  17. AU="Athira S. Raj"
  18. AU="Corbacho, Belen"
  19. AU="Andrei, Adin Cristian" AU="Andrei, Adin Cristian"
  20. AU="Erminia Donnarumma"
  21. AU="Albores-Figueroa, Rosenberg"
  22. AU="Squillace, Lino"
  23. AU="Laufs, Sebastian"
  24. AU="McCanny, Suzette"
  25. AU="McHardy, John Alexander"
  26. AU="Erdal, Ranya"
  27. AU="Li, Long-Xia"
  28. AU="Esapa, Benjamina"

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  1. Artikel: A Bioguided Approach for the Screening of Antibacterial Compounds Isolated From the Hydroalcoholic Extract of the Native Brazilian Bee's Propolis Using Mollicutes as a Model.

    Hochheim, Sabrina / Pacassa Borges, Pamela / Boeder, Ariela Maína / Scharf, Dilamara Riva / Simionatto, Edésio Luiz / Yamanaka, Celina Noriko / Alberton, Michele D / Guedes, Alessandro / de Cordova, Caio Mauricio Mendes

    Frontiers in microbiology

    2020  Band 11, Seite(n) 558

    Abstract: Nature is a vast source of medicinal substances, including propolis, which has been extensively investigated. Propolis is a resinous substance produced by bees from the exudates of plants that they collect and modify in their jaws; it is a rich and ... ...

    Abstract Nature is a vast source of medicinal substances, including propolis, which has been extensively investigated. Propolis is a resinous substance produced by bees from the exudates of plants that they collect and modify in their jaws; it is a rich and complex matrix with secondary metabolites of diverse botanical origins. The objective of this study was to apply an
    Sprache Englisch
    Erscheinungsdatum 2020-04-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00558
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Eugenia brasiliensis leaves extract attenuates visceral and somatic inflammatory pain in mice.

    Simões, Róli R / Kraus, Scheila I / Coelho, Igor S / Dal-Secco, Daniela / Siebert, Diogo A / Micke, Gustavo A / Alberton, Michele D / Santos, Adair R S

    Journal of ethnopharmacology

    2018  Band 217, Seite(n) 178–186

    Abstract: Ethnopharmacological relevance: Eugenia brasiliensis Lam. (Myrtaceae) is a Brazilian tree distributed throughout Atlantic rain forest, since Bahia until Santa Catarina state, and is popularly known as "grumixaba, grumixameira, cumbixaba, ibaporoiti, and ...

    Abstract Ethnopharmacological relevance: Eugenia brasiliensis Lam. (Myrtaceae) is a Brazilian tree distributed throughout Atlantic rain forest, since Bahia until Santa Catarina state, and is popularly known as "grumixaba, grumixameira, cumbixaba, ibaporoiti, and cereja-brasileira". The bark and leaves of Eugenia brasiliensis are used in folk medicine as adstringent, diuretic, energizing, anti-rheumatic and anti-inflammatory. This study aimed at investigating the chemical composition, antinociceptive and anti-inflammatory effect of the hydroalcoholic extract of Eugenia brasiliensis (HEEb).
    Material and methods: Chemical composition of the HEEb was determined by High Performance Liquid Chromatography/ESI-Mass Spectrometry (HPLC-ESI-MS/MS). The antinociceptive and anti-inflammatory effects of HEEb (30-300 mg/kg) was verified in mice after oral administration by intra-gastric gavage (i.g.) 60 min prior to experimentation. It was investigated whether HEEb decreases visceral pain and leukocyte migration induced by an intraperitoneal (i.p.) injection of acetic acid (0.6%). We also evaluated whether HEEb decreases nociceptive behavior induced by formalin (including paw edema and temperature), prostaglandin E
    Results: Seven polyphenols were identified in HEEb by HPLC-ESI-MS/MS analysis. HEEb treatment alleviated nocifensive behavior and leukocyte migration caused by acetic acid. Moreover, HEEb also reduced the inflammatory pain and paw temperature induced by formalin, as well as it decreased nociceptive behavior induced by histamine and compound 48/80. Finally, acute and repeated treatment of animals with HEEb (100 mg/kg, i.g.) markedly reduced the mechanical and thermal (heat) hypersensitivity, besides decrease paw edema and temperature induced by CFA, and this effect was evident until the day 7. Moreover, repeated treatment with HEEb (100 mg/kg, i.g.) significantly reduced the levels of IL-6 and TNF-α in the paw when compared to the CFA group.
    Conclusions: This is the first report showing that HEEb presents antinociceptive and anti-inflammatory effects in the visceral and somatic inflammatory pain in mice, possibly involving the inhibition of histamine receptors and pro-inflammatory cytokines activated pathways. Our results are of interest because they support the use of Eugenia brasiliensis as a potential source of phytomedicine for inflammatory diseases and pain.
    Mesh-Begriff(e) Analgesics/isolation & purification ; Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Eugenia/chemistry ; Female ; Inflammation Mediators/metabolism ; Interleukin-6/metabolism ; Mice ; Nociceptive Pain/chemically induced ; Nociceptive Pain/metabolism ; Nociceptive Pain/prevention & control ; Phytotherapy ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plants, Medicinal ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; Tumor Necrosis Factor-alpha/metabolism ; Visceral Pain/chemically induced ; Visceral Pain/metabolism ; Visceral Pain/prevention & control
    Chemische Substanzen Analgesics ; Anti-Inflammatory Agents ; Inflammation Mediators ; Interleukin-6 ; Plant Extracts ; Tumor Necrosis Factor-alpha ; interleukin-6, mouse
    Sprache Englisch
    Erscheinungsdatum 2018-02-17
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.02.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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