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  1. AU="Albizu, Constanza Lopez"
  2. AU="Antonova, Anastasiia"
  3. AU=Crowther L. M.
  4. AU=Zhan Xiping
  5. AU="Xuhui Bao"
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  1. Artikel ; Online: Increased Natural Killer (NK)-cell cytotoxicity and Trypanosoma cruzi-specific memory B cells in subjects with discordant serology for Chagas disease.

    Elias, María J / Cesar, Gonzalo / Caputo, María B / De Rissio, Ana M / Alvarez, María G / Lococo, Bruno / Natale, María A / Albizu, Constanza López / Podhorzer, Ariel / Parodi, Cecilia / Albareda, María C / Laucella, Susana A

    Biochimica et biophysica acta. Molecular basis of disease

    2024  , Seite(n) 167237

    Abstract: The presence of memory T cell specific for Trypanosoma cruzi in subjects with discordant serology for Chagas disease supports a cleared infection in these subjects. Using high-dimensional flow cytometry, ELISPOT assays and quantitative PCR, antibody- ... ...

    Abstract The presence of memory T cell specific for Trypanosoma cruzi in subjects with discordant serology for Chagas disease supports a cleared infection in these subjects. Using high-dimensional flow cytometry, ELISPOT assays and quantitative PCR, antibody-secreting cells and memory B cells specific for T. cruzi, total B-cell phenotypes, innate immune responses and parasite DNA were evaluated in serodiscordant, seropositive and seronegative subjects for T. cruzi infection. T. cruzi-specific memory B cells but no antibody-secreting cells specific for T. cruzi, increased proportion of nonclassical monocytes and increased levels of polyfunctional NK cells were found in serodiscordant compared with seropositive subjects. None of the serodiscordant subjects evaluated showed detectable parasite DNA, most of them did not show cardiac abnormalities and a group of them had had confirmed positive serology for Chagas disease. The unique immune profiles in serodiscordant subjects support that T. cruzi infection was cleared or profoundly controlled in these subjects.
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2024.167237
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Molecular Characterization of

    Fernandez, Marisa Liliana / Albizu, Constanza Lopez / Nicita, Diego / Besuschio, Susana / Giomi, Cinthia / Biondi, María Laura / Leguizamón, María Susana / Garcia, Julian / Corti, Marcelo / Schijman, Alejandro / Burgos, Juan Miguel

    Open forum infectious diseases

    2023  Band 10, Heft 8, Seite(n) ofad357

    Abstract: ... We ... ...

    Abstract We characterize
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad357
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Prospective multicenter evaluation of real time PCR Kit prototype for early diagnosis of congenital Chagas disease.

    Benatar, Alejandro Francisco / Danesi, Emmaría / Besuschio, Susana Alicia / Bortolotti, Santiago / Cafferata, María Luisa / Ramirez, Juan Carlos / Albizu, Constanza Lopez / Scollo, Karenina / Baleani, María / Lara, Laura / Agolti, Gustavo / Seu, Sandra / Adamo, Elsa / Lucero, Raúl Horacio / Irazu, Lucía / Rodriguez, Marcelo / Poeylaut-Palena, Andrés / Longhi, Silvia Andrea / Esteva, Mónica /
    Althabe, Fernando / Rojkin, Federico / Bua, Jacqueline / Sosa-Estani, Sergio / Schijman, Alejandro Gabriel

    EBioMedicine

    2021  Band 69, Seite(n) 103450

    Abstract: Background: Current algorithm for Congenital Chagas Disease (cCD) diagnosis is unsatisfactory due to low sensitivity of the parasitological methods. Moreover, loss to follow-up precludes final serodiagnosis after nine months of life in many cases. A ... ...

    Abstract Background: Current algorithm for Congenital Chagas Disease (cCD) diagnosis is unsatisfactory due to low sensitivity of the parasitological methods. Moreover, loss to follow-up precludes final serodiagnosis after nine months of life in many cases. A duplex TaqMan qPCR kit for Trypanosoma cruzi DNA amplification was prospectively evaluated in umbilical cord (UCB) and peripheral venous blood (PVB) of infants born to CD mothers at endemic and non-endemic sites of Argentina.
    Methods: We enrolled and followed-up 370 infants; qPCR was compared to gold-standard cCD diagnosis following studies of diagnostic accuracy guidelines.
    Findings: Fourteen infants (3·78%) had cCD. The qPCR sensitivity and specificity were higher in PVB (72·73%, 99·15% respectively) than in UCB (66·67%, 96·3%). Positive and negative predictive values were 80 and 98·73% and 50 and 98·11% for PVB and UCB, respectively. The Areas under the Curve (AUC) of ROC analysis for qPCR and micromethod (MM) were 0·81 and 0·67 in UCB and 0·86 and 0·68 in PVB, respectively. Parasitic loads ranged from 37·5 to 23,709 parasite equivalents/mL. Discrete typing Unit Tc V was identified in five cCD patients and in six other cCD cases no distinction among Tc II, Tc V or Tc VI was achieved.
    Interpretation: This first prospective field study demonstrated that qPCR was more sensitive than MM for early cCD detection and more accurate in PVB than in UCB. Its use, as an auxiliary diagnostic tool to MM will provide more accurate records on cCD incidence.
    Funding: FITS SALUD 001-CHAGAS (FONARSEC, MINCyT, Argentina) to the Public-Private Consortium (INGEBI-CONICET, INP-ANLIS MALBRAN and Wiener Laboratories); ERANET-LAC-HD 328 to AGS and PICT 2015-0074 (FONCYT, MinCyT) to AGS and FA.
    Mesh-Begriff(e) Adult ; Chagas Disease/congenital ; Chagas Disease/diagnosis ; Early Diagnosis ; Female ; Humans ; Infant, Newborn ; Male ; Reagent Kits, Diagnostic/standards ; Real-Time Polymerase Chain Reaction/methods ; Real-Time Polymerase Chain Reaction/standards ; Sensitivity and Specificity
    Chemische Substanzen Reagent Kits, Diagnostic
    Sprache Englisch
    Erscheinungsdatum 2021-06-26
    Erscheinungsland Netherlands
    Dokumenttyp Evaluation Study ; Journal Article ; Multicenter Study
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103450
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients.

    Álvarez, María Gabriela / Hernández, Yolanda / Bertocchi, Graciela / Fernández, Marisa / Lococo, Bruno / Ramírez, Juan Carlos / Cura, Carolina / Albizu, Constanza Lopez / Schijman, Alejandro / Abril, Marcelo / Sosa-Estani, Sergio / Viotti, Rodolfo

    Antimicrobial agents and chemotherapy

    2016  Band 60, Heft 2, Seite(n) 833–837

    Abstract: There is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas ... ...

    Abstract There is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas disease patients. A pilot study with intermittent doses of benznidazole at 5 mg/kg/day in two daily doses every 5 days for a total of 60 days was designed. The main criterion of response was the comparison of quantitative PCR (qPCR) findings prior to and 1 week after the end of treatment. The safety profile was assessed by the rate of suspensions and severity of adverse effects. Twenty patients were analyzed for safety, while qPCR was tested for 17 of them. The average age was 43 ± 7.9 years; 55% were female. Sixty-five percent of treated subjects showed detectable qPCR results prior to treatment of 1.45 (0.63 to 2.81) and 2.1 (1.18 to 2.78) parasitic equivalents per milliliter of blood (par.eq/ml) for kinetoplastic DNA (kDNA) qPCR and nuclear repetitive sequence satellite DNA (SatDNA) qPCR, respectively. One patient showed detectable PCR at the end of treatment (1/17), corresponding to 6% treatment failure, compared with 11/17 (65%) patients pretreatment (P = 0.01). Adverse effects were present in 10/20 (50%) patients, but in only one case was treatment suspended. Eight patients showed mild adverse effects, whereas moderate reactions with increased liver enzymes were observed in two patients. The main accomplishment of this pilot study is the promising low rate of treatment suspension. Intermittent administration of benznidazole emerges a new potential therapeutic scheme, the efficacy of which should be confirmed by long-term assessment posttreatment.
    Mesh-Begriff(e) Adult ; Chagas Disease/drug therapy ; Chronic Disease ; DNA, Kinetoplast/blood ; DNA, Satellite/blood ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Liver/enzymology ; Male ; Middle Aged ; Nitroimidazoles/administration & dosage ; Nitroimidazoles/adverse effects ; Nitroimidazoles/therapeutic use ; Pilot Projects ; Polymerase Chain Reaction ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/adverse effects ; Trypanocidal Agents/therapeutic use ; Trypanosoma cruzi/drug effects
    Chemische Substanzen DNA, Kinetoplast ; DNA, Satellite ; Nitroimidazoles ; Trypanocidal Agents ; benzonidazole (YC42NRJ1ZD)
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00745-15
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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