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  1. Article ; Online: Strain specific differences in vitamin D3 response: impact on gut homeostasis.

    Schreiber, Laura / Ghimire, Sakhila / Hiergeist, Andreas / Renner, Kathrin / Althammer, Michael / Babl, Nathalie / Peuker, Alice / Schoenhammer, Gabriele / Hippe, Katrin / Gessner, Andre / Albrecht, Christin / Pielmeier, Fransziska / Büttner-Herold, Maike / Bruns, Heiko / Hoffmann, Petra / Herr, Wolfgang / Holler, Ernst / Peter, Katrin / Kreutz, Marina /
    Matos, Carina

    Frontiers in immunology

    2024  Volume 15, Page(s) 1347835

    Abstract: Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, ... ...

    Abstract Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, we analyzed the impact of different vitamin D3- containing diets on C57BL/6 and BALB/c mice, with a particular focus on gut homeostasis and also investigated effects on immune cells
    MeSH term(s) Mice ; Animals ; Cholecalciferol/pharmacology ; Mice, Inbred C57BL ; Intestine, Small ; Epithelial Cells ; Diet
    Chemical Substances Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1347835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease.

    Dittmar, David J / Pielmeier, Franziska / Strieder, Nicholas / Fischer, Alexander / Herbst, Michael / Stanewsky, Hanna / Wenzl, Niklas / Röseler, Eveline / Eder, Rüdiger / Gebhard, Claudia / Schwarzfischer-Pfeilschifter, Lucia / Albrecht, Christin / Herr, Wolfgang / Edinger, Matthias / Hoffmann, Petra / Rehli, Michael

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3224

    Abstract: The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro ... ...

    Abstract The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro expanded donor regulatory T cells upon migration to target organs. Employing comprehensive gene expression and repertoire profiling, we show that they retain their suppressive function and plasticity after transfer. Upon entering non-lymphoid tissues, donor regulatory T cells acquire organ-specific gene expression profiles resembling tissue-resident cells and activate hallmark suppressive and cytotoxic pathways, most evidently in the colon, when co-transplanted with graft-versus-host disease-inducing conventional T cells. Dominant T cell receptor clonotypes overlap between organs and across recipients and their relative abundance correlates with protection efficacy. Thus, this study reveals donor regulatory T cell selection and adaptation mechanisms in target organs and highlights protective features of Treg to guide the development of improved graft-versus-host disease prevention strategies.
    MeSH term(s) Mice ; Animals ; T-Lymphocytes, Regulatory/transplantation ; Transplantation, Homologous ; Bone Marrow Transplantation ; Graft vs Host Disease/prevention & control ; Mice, Inbred C57BL
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47575-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Analyse des oralen Mikrobioms stammzelltransplantierter Patienten im Verlauf

    Albrecht, Christin [Verfasser] / Borkhardt, Arndt [Akademischer Betreuer] / Kobbe, Guido [Gutachter]

    2019  

    Author's details Christin Albrecht ; Gutachter: Guido Kobbe ; Betreuer: Arndt Borkhardt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania.

    Moock, Joern / Albrecht, Christin / Friedrich, Nele / Völzke, Henry / Nauck, Matthias / Koltowska-Haggström, Maria / Kohlmann, Thomas / Wallaschofski, Henri

    European journal of endocrinology

    2009  Volume 160, Issue 1, Page(s) 17–24

    Abstract: Objective: To analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with ... ...

    Abstract Objective: To analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated.
    Design: HRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (n=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique.
    Results: In KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2+/-6.8 (8.7+/-6.8) in women (men) and in the general population sample 4.5+/-5.3 (4.3+/-5.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (P<0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was -1.1+/-1.4 (-0.8+/-1.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed.
    Conclusions: This study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.
    MeSH term(s) Adult ; Cohort Studies ; Cross-Sectional Studies ; Female ; Germany ; Hormone Replacement Therapy/methods ; Human Growth Hormone/administration & dosage ; Human Growth Hormone/deficiency ; Humans ; Hypopituitarism/drug therapy ; Hypopituitarism/metabolism ; Hypopituitarism/psychology ; Insulin-Like Growth Factor I/metabolism ; Male ; Middle Aged ; Quality of Life
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-08-0738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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