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  1. Article: Comparative Transcriptome Analysis of

    Santamaria, Rebeca M / Estrada, Karel / López, María E / Rojas, Edith / Martínez, Grecia / Alcalá, Yazmín / Rojas, Carmen / Álvarez, Jesús Antonio / Lira, José J / Santamaria, Tomás V / Sánchez-Flores, Alejandro / Figueroa, Julio V

    Vaccines

    2024  Volume 12, Issue 3

    Abstract: Bovine babesiosis, caused by the ... ...

    Abstract Bovine babesiosis, caused by the protozoan
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12030309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Higher bioavailability of doxycycline in broiler chickens with a novel in-feed pharmaceutical formulation.

    Gutiérrez, Lilia / Zermeño, Juan / Alcalá, Yazmín / Sumano, Héctor

    Poultry science

    2017  Volume 96, Issue 8, Page(s) 2662–2669

    Abstract: Bioavailability of a new, long-acting (LA) pharmaceutical preparation for administering doxycycline as in-feed medication to broiler chickens was compared to the standard in-feed administration of doxycycline. A commercial poultry house harboring Ross- ... ...

    Abstract Bioavailability of a new, long-acting (LA) pharmaceutical preparation for administering doxycycline as in-feed medication to broiler chickens was compared to the standard in-feed administration of doxycycline. A commercial poultry house harboring Ross-308 broiler chickens, weighing 450 g, was divided into 7 sections as follows: doxy-FOLA group (n = 6,000 chickens divided into 3 replicates) medicated with 10% doxycyline, long-acting pellets at a dose of 400 g of doxycycline HCl/ton of food, resulting in a calculated dose of 48 mg/kg for 5 d; doxy-ref group (n = 6,000, divided into 3 replicates) medicated as for doxy-FOLA, but using a 20% commercial preparation of doxycycline. A third group of 300 broiler chickens (divided into 3 replicates), received a single IV dose of 48 mg/kg from a 2.4% solution of doxycycline HCl under ketamine anesthesia. Blood samples were obtained at designated times, serum was harvested, and doxycycline concentrations determined by high-performance liquid chromatography (HPLC). Bioavailability values were 156% and 227% on d 1 and 5 for doxy-FOLA and 13% and 23% for doxy-ref, on the same days. Mean residence time (MRT) and elimination half-life (T½β) were statistically different (P < 0.05) in doxy-FOLA group as compared to doxy-ref group (MRT: 26 h and 5.2 h; and T½β: 18 h vs 3 h, on the first day for doxy-FOLA and doxy-ref, respectively). Based on 3 levels of bacterial sensitivity of E. coli derived from a small survey carried out (i.e., 1.0, 2.0, and 4.0 μg/mL) and considering pharmacokinetic/pharmacodynamic (PK/PD) ratios required for this time-dependent antibacterial drug, it is possible to postulate that doxy-FOLA outstrips the reference preparation maintaining higher and more prolonged serum concentrations of doxycycline and consequently complying better with PK/PD ratios regarded as optimal for this drug. The advantages of using doxy-FOLA in poultry medicine include a more comprehensive use of the active principle, which in turn should have a better impact on bacterial diseases. Yet, a longer withdrawal time is anticipated based on an almost 4-fold increment in the MRT value.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacokinetics ; Biological Availability ; Chickens/metabolism ; Doxycycline/pharmacokinetics ; Drug Compounding/veterinary ; Escherichia coli/physiology ; Escherichia coli Infections/prevention & control ; Escherichia coli Infections/veterinary ; Female ; Male ; Poultry Diseases/prevention & control ; Random Allocation
    Chemical Substances Anti-Bacterial Agents ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2017-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.3382/ps/pex036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: In vivo anticoccidial activity of quinfamide in broilers: a preliminary report

    Aquino, Itzcoatl / Alcalá, Yazmin / Gutiérrez, Lilia / Tapia, Graciela / Jung, Helgi / Sumano, Héctor

    Italian journal of animal science. 2016 Oct. 1, v. 15, no. 4

    2016  

    Abstract: The aim of this trial was to evaluate the anticoccidial efficacy of quinfamide in broilers. Three different treatments were implemented over a 49-day period as follows: quinfamide; quinfamide plus carbopol and decoquinate, all prepared as small pellets ... ...

    Abstract The aim of this trial was to evaluate the anticoccidial efficacy of quinfamide in broilers. Three different treatments were implemented over a 49-day period as follows: quinfamide; quinfamide plus carbopol and decoquinate, all prepared as small pellets and mixed with feed at a final dose of either active principle of 30 ppm. Parameters measured were: weight gain, number of oocysts shedding per gram of litter and degree of gross lesions caused by coccidia. Body weight gain was statistically greater for quinfamide and quinfamide-carbopol groups in comparison to other groups. However, only the quinfamide-carbopol group showed similar efficacy in the occyst counts as compared to the decoquinate group. Statistically significant differences were observed when intestinal lesions score were compared and the less affected group was quinfamide-carbopol. Based on these results, it is concluded that quinfamide possesses a low anticoccidial efficacy. However, this is noticeably improved when it is prepared as pellets with carbopol. The adhesion of carbopol to intestinal mucosa may influence residence time of quinfamide in the gastrointestinal tract, thus enhancing efficacy.
    Keywords adhesion ; body weight changes ; coccidiostats ; decoquinate ; digestive tract ; intestinal mucosa ; oocysts ; weight gain
    Language English
    Dates of publication 2016-1001
    Size p. 689-695.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-light
    ZDB-ID 2408994-1
    ISSN 1828-051X ; 1594-4077
    ISSN (online) 1828-051X
    ISSN 1594-4077
    DOI 10.1080/1828051X.2016.1229585
    Database NAL-Catalogue (AGRICOLA)

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