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  1. Article ; Online: Unknowledgment of the brain death concept among African immigrants resident in Spain. Multivariant analysis of related factors.

    Ríos, Antonio / Carrillo, Joaquín / López-Navas, Ana Isabel / Ayala-García, Marco Antonio / Alconchel, Felipe / Ramírez, Pablo

    Nefrologia

    2024  Volume 44, Issue 1, Page(s) 100–102

    MeSH term(s) Humans ; Spain ; Brain Death ; Surveys and Questionnaires ; Tissue and Organ Procurement ; Emigrants and Immigrants
    Language English
    Publishing date 2024-02-20
    Publishing country Spain
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hemorrhagic Cholecystitis.

    López, Víctor / Alconchel, Felipe

    Radiology

    2018  Volume 289, Issue 2, Page(s) 316

    MeSH term(s) Aged, 80 and over ; Cholecystitis/complications ; Cholecystitis/diagnostic imaging ; Cholecystitis/surgery ; Gallbladder/diagnostic imaging ; Gallbladder/surgery ; Hemorrhage/complications ; Hemorrhage/diagnostic imaging ; Hemorrhage/surgery ; Humans ; Imaging, Three-Dimensional ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018181161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unresectable GIST liver metastases and liver transplantation: A review and theoretical basis for a new indication.

    Fernández, Juan Ángel / Alconchel, Felipe / Gómez, Beatriz / Martínez, Jerónimo / Ramírez, Pablo

    International journal of surgery (London, England)

    2021  Volume 94, Page(s) 106126

    Abstract: Background: Liver metastases from gastrointestinal stromal tumors (GIST) can be found synchronously to a primary tumor and in the medium/long term after resection of a high-risk GIST. In these cases, treatment with tyrosine kinase inhibitors like ... ...

    Abstract Background: Liver metastases from gastrointestinal stromal tumors (GIST) can be found synchronously to a primary tumor and in the medium/long term after resection of a high-risk GIST. In these cases, treatment with tyrosine kinase inhibitors like imatinib has provided good results, but drug resistance is common after two years of treatment. Liver resection of potentially resectable metastases can improve the results of medical treatment. In cases of unresectability, the role of liver transplantation (LT) has not been well-studied.
    Materials and methods: A review of the literature was undertaken from January 1995 to December 2020 following the PRISMA and AMSTAR guidelines.
    Results: Fifteen cases were identified. In eight cases, the LT was carried out before 2002. Mutational status was only studied in seven cases. LT was performed in 12 cases with a deceased donor and in three cases with a living donor. After a mean follow-up of 52.4 months, overall survival was 86.6% with disease-free survival of 53.3% CONCLUSION: LT in the management of unresectable GIST metastases has rarely been performed. Although its application has a solid theoretical basis, its use understood as a radical extension of a standard resection can only be recommended within prospective studies by groups with considerable experience in both GIST and transplantation care.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Imatinib Mesylate/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Transplantation ; Prospective Studies
    Chemical Substances Antineoplastic Agents ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2021.106126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Audiovisual Creation in Educational Proposals on Organ Donation: Attitude Towards Organ Donation and Transplantation of Secondary School Teachers.

    Almela-Baeza, Javier / Febrero, Beatriz / Alconchel, Felipe / Bonache-Ibáñez, Adrián / Ramírez, Pablo

    Transplantation proceedings

    2021  Volume 54, Issue 1, Page(s) 7–10

    Abstract: Background: Audiovisual creation allows teachers and students to become consumers and producers of information, creating collaborative environments. In the field of organ donation and transplantation (ODT), most of the educational proposals analyzed to ... ...

    Abstract Background: Audiovisual creation allows teachers and students to become consumers and producers of information, creating collaborative environments. In the field of organ donation and transplantation (ODT), most of the educational proposals analyzed to date consist of presentations. The teacher does not usually have a decisive role in this type of methodologies, in addition to not having the appropriate training to be able to participate actively.
    Objectives: To analyze the change in teachers' attitudes towards ODT after participating in an educational proposal based on the creation of short films.
    Methods: Teachers of secondary education in ten schools in southeastern Spain. The proposal consisted in the creation of short films based on topics related to ODT by the students. A validated ODT attitude form was administered to teachers at the beginning of the proposal and at the end of the proposal. A descriptive analysis was carried out together with McNemar test was used to compare the pre and post test results of the teacher. P < .05 was considered statiscally significant.
    Results: The favorable attitude towards organ donation at death increased after the proposal (64% vs 88%; P = .008). Favorable attitude towards organ donation from a relative also improved (52% vs 76%; P = .008), as did favorable attitude towards living kidney donation (52% vs 88%; P < .001), living liver donation (36% vs 85%; P = .008) and xenotransplantation (45% vs 82%; P < .001).
    Conclusions: The teachers improves after an educational proposal based on the creation of short films related to ODT.
    MeSH term(s) Attitude ; Health Knowledge, Attitudes, Practice ; Humans ; Organ Transplantation ; Schools ; Spain ; Surveys and Questionnaires ; Tissue and Organ Procurement
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.09.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Film Creation for Education on Concepts Related to Religion, Immigration, and Legislation in the Field of Organ Donation and Transplantation.

    Almela-Baeza, Javier / Febrero, Beatriz / Alconchel, Felipe / Pérez-Manzano, Antonio / Ramírez, Pablo

    Transplantation proceedings

    2021  Volume 54, Issue 1, Page(s) 11–14

    Abstract: Background: In education, we can use cinema to create methodologies that develop the critical thinking to acquire knowledge in a collaborative way. Favorable attitudes toward organ donation and transplantation (ODT) is low in adolescents. Working on ... ...

    Abstract Background: In education, we can use cinema to create methodologies that develop the critical thinking to acquire knowledge in a collaborative way. Favorable attitudes toward organ donation and transplantation (ODT) is low in adolescents. Working on topics related to ODT, such as religion, immigration, and the law, can help to improve students' knowledge and endear them toward ODT with innovative educational methodologies.
    Objectives: This study aims to analyze the change in knowledge about religion, immigration, and legislation on ODT after an educational proposal based on film creation.
    Methods: In this study, 16-year-old students participated in an educational proposal based on ODT education through filmmaking. A total of 543 students participated in the experimental group, and 320 participated in the control group. A validated ODT knowledge form was administered to both groups. Statistical analysis was carried out with SPSS version 21.0 package (SPSS, Inc, Chicago, IL, USA). A descriptive analysis and χ
    Results: The study had a 72% participation rate in the experimental group. After receiving the educational proposal, the students presented a greater knowledge with respect to the control group in all aspects: the position of the different religions in relation to organ donation, knowledge of the rights and obligations of immigrants in relation to the ODT, and knowledge of the law of presumed consent in ODT CONCLUSIONS: Working in the classroom on psychosocial aspects such as religion, immigration, and legislation through filmmaking can favorably influence the adolescent's awareness of organ donation.
    MeSH term(s) Adolescent ; Emigration and Immigration ; Health Knowledge, Attitudes, Practice ; Humans ; Motion Pictures ; Organ Transplantation ; Religion ; Surveys and Questionnaires ; Tissue and Organ Procurement
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: African Immigrants Living in Spain: Awareness Toward Organ Donation and the Need for Specific Awareness Campaigns.

    Ríos, Antonio / Carrillo, Joaquín / López-Navas, Ana Isabel / Ayala-García, Marco Antonio / Alconchel, Felipe / Iniesta-Sepúlveda, Marina / Ramírez, Pablo

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue 2, Page(s) 199–208

    Abstract: Objectives: The African population is an important, growing population group in Spain. Our objective was to determine attitudes toward organ donation among the African population living in Spain and to determine factors influencing attitudes.: ... ...

    Abstract Objectives: The African population is an important, growing population group in Spain. Our objective was to determine attitudes toward organ donation among the African population living in Spain and to determine factors influencing attitudes.
    Materials and methods: A population sample was taken of Africans residing in Spain, stratified by age and sex (n = 4145). Attitude was assessed using a validated questionnaire, which was self-administered and completed anonymously. Descriptive statistics, the chi-squared test, ttest, and logistic regression analysis were used for data analyses.
    Results: The questionnaire completion rate was 87% (n = 3618). Attitudes toward donation of one's own organs was favorable in 31% of respondents (n = 1112). Among the remaining respondents, attitude was unfavorable in 40% (n = 1458) and undecided in 29% (n = 1037). Multivariate analysis showed the following variables as being associated with attitude: (1) age (P < .001), (2) having descendents (P < .001), (3) education level (P < .001), (4) belief of respondent that he or she may need a transplant in the future (P = .001), (5) knowledge ofthe concept of brain death (P < .001), (6) attitude toward donation of a family member's organ (P < .001), (7) having spoken with one's family about donation and transplant (P < .001), (8) opinion of one's partner toward organ donation (P < .001), (9) respondent's religion (P < .001), (10) knowledge of the view of one's religion toward organ donation and transplant (P < .001), and (10) fear of possible mutilation of the body after donation (P < .001).
    Conclusions: Attitudes toward donation of an individual's organs after death were negative among Africans living in Spain and may be related to psychosocial factors. This group should have priority for receiving organ donation awareness campaigns in Spain.
    MeSH term(s) Emigrants and Immigrants ; Female ; Humans ; Living Donors/psychology ; Organ Transplantation ; Spain/epidemiology ; Surveys and Questionnaires ; Tissue and Organ Procurement ; Treatment Outcome
    Language English
    Publishing date 2022-03-14
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2021.0480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stab wound of the spinal cord from in front with no neurologic deficit.

    Alconchel, Felipe / Navarro Baño, Antonio / Gómez Pérez, Beatriz / Ramírez Romero, Pablo

    Cirugia espanola

    2019  Volume 98, Issue 8, Page(s) 487

    Title translation Sección medular cervical sin repercusión neurológica por herida anterior con arma blanca.
    MeSH term(s) Follow-Up Studies ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Postoperative Period ; Spinal Cord/pathology ; Spinal Cord/surgery ; Spinal Cord Injuries/diagnostic imaging ; Spinal Cord Injuries/physiopathology ; Tomography, X-Ray Computed/methods ; Treatment Outcome ; Vertebral Body/injuries ; Wounds, Stab/complications
    Language Spanish
    Publishing date 2019-10-31
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2019.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cell-specific Extracellular Vesicles and Their miRNA Cargo Released Into the Organ Preservation Solution During Cold Ischemia Storage as Biomarkers for Liver Transplant Outcomes.

    Vidal-Correoso, Daniel / Mateo, Sandra V / Muñoz-Morales, Ana M / Lucas-Ruiz, Fernando / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / Sánchez-Redondo, Sara / Santos, Vanesa / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José Antonio / Ramírez, Pablo / Pelegrín, Pablo / Peinado, Héctor / Baroja-Mazo, Alberto

    Transplantation

    2024  

    Abstract: Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, ... ...

    Abstract Background: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, hepatic artery thrombosis, and biliary issues still impact posttransplant prognosis. Biomarkers, including extracellular vesicles (EVs) and microRNAs (miRNAs), show promise in understanding and monitoring posttransplant events. This study explores the role of EVs and their miRNA cargo in LT, including their potential as diagnostic tools.
    Methods: EVs from intrahepatic end-ischemic organ preservation solution (eiOPS) in 79 donated livers were detected using different techniques (nanosight tracking analysis, transmission electron microscopy, and flow cytometry). EV-derived miRNAs were identified by quantitative real time-polymerase chain reaction. Bioinformatics analysis was performed using the R platform.
    Results: Different-sized and origin-specific EVs were found in eiOPS, with significantly higher concentrations in DCD compared with donation after brain death organs. Additionally, several EV-associated miRNAs, including let-7d-5p, miR-28-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, and miR-429, were overexpressed in DCD-derived eiOPS. These miRNAs also exhibited differential expression patterns in liver tissue biopsies. Pathway analysis revealed enrichment in signaling pathways involved in extracellular matrix organization and various cellular processes. Moreover, specific EVs and miRNAs correlated with clinical outcomes, including survival and early allograft dysfunction. A predictive model combining biomarkers and clinical variables showed promise in acute rejection detection after LT.
    Conclusions: These findings provide new insights into the use of EVs and miRNAs as biomarkers and their possible influence on posttransplantation outcomes, potentially contributing to improved diagnostic approaches and personalized treatment strategies in LT.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000005008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Proceedings of the 28th Annual Congress of the International Liver Transplantation Society.

    Shaji Mathew, Johns / Shingina, Alexandra / Khan, Mohammad Qasim / Wilson, Elizabeth / Syn, Nicholas / Rammohan, Ashwin / Alconchel, Felipe / Hakeem, Abdul Rahman / Shankar, Sadhana / Patel, Dhupal / Keskin, Onur / Liu, Jiang / Nasralla, David / Mazzola, Alessandra / Patel, Madhukar S / Tanaka, Tomohiro / Victor, David / Yoon, Uzung / Yoon, Young-In /
    Vinaixa, Carmen / Kirchner, Varvara / De Martin, Eleonora / Ghobrial, R Mark / Chadha, Ryan

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  Volume 30, Issue 5, Page(s) 544–554

    Abstract: The 2023 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestine Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE) held in Rotterdam, the Netherlands, ... ...

    Abstract The 2023 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestine Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE) held in Rotterdam, the Netherlands, marked a significant recovery milestone for the liver transplant community after COVID-19. With 1159 participants and a surge in abstract submissions, the event focused on "Liver Disorders and Transplantation: Innovations and Evolving Indications." This conference report provides a comprehensive overview of the key themes discussed during the event, encompassing Hepatology, Anesthesia and Critical Care, Acute Liver Failure, Infectious Disease, Immunosuppression, Pediatric Liver Transplantation, Living Donor Liver Transplantation, Transplant Oncology, Surgical Approaches, and Machine Perfusion. The congress provided a platform for extensive discussions on a wide range of topics, reflecting the continuous advancements and collaborative efforts within the liver transplant community.
    MeSH term(s) Humans ; Child ; Liver Transplantation/adverse effects ; Living Donors ; Immunosuppression Therapy ; Liver Neoplasms
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation.

    Villalba-López, Francisco / García-Bernal, David / Mateo, Sandra V / Vidal-Correoso, Daniel / Jover-Aguilar, Marta / Alconchel, Felipe / Martínez-Alarcón, Laura / López-López, Víctor / Ríos-Zambudio, Antonio / Cascales, Pedro / Pons, José A / Ramírez, Pablo / Pelegrín, Pablo / Baroja-Mazo, Alberto

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 167, Page(s) 115529

    Abstract: DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of ... ...

    Abstract DAMPs (danger-associated molecular patterns) are self-molecules of the organism that appear after damage. The endothelium plays several roles in organ rejection, such as presenting alloantigens to T cells and contributing to the development of inflammation and thrombosis. This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVECs. Moreover, eiOPS increased the membrane expression of ICAM-1and HLA-DR, which facilitated leukocyte migration toward a chemokine gradient. Furthermore, eiOPS demonstrated its chemoattractant ability. This activation was mediated by free mitochondria. Defibrotide was found to partially inhibit the eiOPS-mediated activation. Moreover, the eiOPS-mediated activation of endothelial cells (ECs) correlated with early allograft dysfunction in liver transplant patients. Our finding provide support for the hypothesis that mitochondria released during cold ischemia could trigger EC activation, leading to complications in graft outcomes. Therefore, the analysis and quantification of free mitochondria in the eiOPS samples obtained after CIS could provide a predictive value for monitoring the progression of transplantation. Moreover, defibrotide emerges as a promising therapeutic agent to mitigate the damage induced by ischemia in donated organs.
    Language English
    Publishing date 2023-09-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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