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  1. Article ; Online: The Effects of Monosodium Glutamate on PSMA Radiotracer Uptake in Men with Recurrent Prostate Cancer: A Prospective, Randomized, Double-Blind, Placebo-Controlled Intraindividual Imaging Study.

    Harsini, Sara / Saprunoff, Heather / Alden, Tina / Mohammadi, Behnoud / Wilson, Don / Bénard, François

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 62, Issue 1, Page(s) 81–87

    Abstract: The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer. However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary ... ...

    Abstract The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer. However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary glands and kidneys. This study assessed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivary gland radiation exposure using a PSMA-targeting radiotracer.
    MeSH term(s) Aged ; Antigens, Surface/metabolism ; Biological Transport/drug effects ; Double-Blind Method ; Glutamate Carboxypeptidase II/metabolism ; Humans ; Lysine/analogs & derivatives ; Lysine/metabolism ; Male ; Middle Aged ; Placebos ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/metabolism ; Radioactive Tracers ; Recurrence ; Sodium Glutamate/pharmacology ; Urea/analogs & derivatives ; Urea/metabolism
    Chemical Substances 2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid ; Antigens, Surface ; Placebos ; Radioactive Tracers ; Urea (8W8T17847W) ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21) ; Lysine (K3Z4F929H6) ; Sodium Glutamate (W81N5U6R6U)
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.246983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  2. Article ; Online: Metformin Discontinuation prior to FDG PET/CT: A Randomized Controlled Study to Compare 24- and 48-hour Bowel Activity.

    Hamidizadeh, Ramin / Eftekhari, Arash / Wiley, E Ashley / Wilson, Don / Alden, Tina / Bénard, François

    Radiology

    2018  Volume 289, Issue 2, Page(s) 418–425

    Abstract: Purpose To investigate the relationship of 24- and 48-hour metformin discontinuation to bowel uptake of fluorine 18 fluorodeoxyglucose (FDG) on PET/CT scans. Materials and Methods Patients with diabetes who were treated with metformin and referred for ... ...

    Abstract Purpose To investigate the relationship of 24- and 48-hour metformin discontinuation to bowel uptake of fluorine 18 fluorodeoxyglucose (FDG) on PET/CT scans. Materials and Methods Patients with diabetes who were treated with metformin and referred for FDG PET/CT were randomized to three equal groups based on duration of metformin discontinuation: 24 hours, 48 hours, and no discontinuation (control group). Two interpreters blinded to the study groups assessed FDG uptake in multiple segments of small and large bowel qualitatively and semiquantitatively by using maximum standardized uptake values (SUVs
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Humans ; Hypoglycemic Agents ; Intestines/diagnostic imaging ; Intestines/physiology ; Male ; Metformin ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Prospective Studies ; Radiopharmaceuticals/pharmacokinetics ; Single-Blind Method ; Time Factors
    Chemical Substances Hypoglycemic Agents ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2018-08-14
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018180078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Technologist Approach to Global Dose Optimization.

    Costa, Pedro Fragoso / Testanera, Giorgio / Camoni, Luca / Terwinghe, Christelle / Bailey, Elizabeth A / Bolus, Norman E / Alden, Tina M

    Journal of nuclear medicine technology

    2018  Volume 47, Issue 1, Page(s) 75–82

    Abstract: Nuclear medicine technologists are specialized health professionals who cover a wide range of tasks from clinical routine (including image acquisition and processing, radiopharmaceutical dispensing and administration, patient care, and radioprotection ... ...

    Abstract Nuclear medicine technologists are specialized health professionals who cover a wide range of tasks from clinical routine (including image acquisition and processing, radiopharmaceutical dispensing and administration, patient care, and radioprotection tasks) to leading clinical research in the field of nuclear medicine. As a fundamental concern in all radiation sciences applied to medicine, protection of individuals against the harmful effects of ionizing radiation must be constantly revised and applied by the professionals involved in medical exposures. The acknowledgment that nuclear medicine technologists play a prominent role in patient management and several procedural steps, both in diagnostic and in therapeutic nuclear medicine applications, carries the duty to be trained and knowledgeable on the topic of radiation protection and dose optimization. An overview on selected topics related to dose optimization is presented in this article, reflecting the similarities and particularities of dose reduction-related principles, initiatives, and practicalities from a global perspective.
    MeSH term(s) Heart/diagnostic imaging ; Humans ; Nuclear Medicine ; Positron Emission Tomography Computed Tomography ; Radiation Dosage ; Single Photon Emission Computed Tomography Computed Tomography ; Technology, Radiologic
    Language English
    Publishing date 2018-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    DOI 10.2967/jnmt.118.218131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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