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  1. AU="Aldrich, J Matthew"
  2. AU="Williams, Kristopher"
  3. AU="Calvet, Loreley"
  4. AU="Rui Pinto"
  5. AU="Feret, Geoff"
  6. AU="Sherrill-Mix, Scott"
  7. AU="Eleanor Eaton"
  8. AU="Latour, Corine H M"
  9. AU="Radetic, Mark"
  10. AU="James Jensen"
  11. AU="McFalls, Jeanne"
  12. AU="Sylvain Sebert"

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  1. Artikel ; Online: Acute Respiratory Distress Syndrome: Ventilator Management and Rescue Therapies.

    Coleman, Melissa H / Aldrich, J Matthew

    Critical care clinics

    2021  Band 37, Heft 4, Seite(n) 851–866

    Abstract: This review describes the management of mechanical ventilation in patients with acute respiratory distress syndrome, including in those with coronavirus disease 2019. Low tidal volume ventilation with a moderate to high positive end-expiratory pressure ... ...

    Abstract This review describes the management of mechanical ventilation in patients with acute respiratory distress syndrome, including in those with coronavirus disease 2019. Low tidal volume ventilation with a moderate to high positive end-expiratory pressure remains the foundation of an evidence-based approach. We consider strategies for setting positive end-expiratory pressure levels, the use of recruitment maneuvers, and the potential role of driving pressure. Rescue therapies including prone positioning and extracorporeal membrane oxygenation are also discussed.
    Mesh-Begriff(e) COVID-19 ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Ventilators, Mechanical
    Sprache Englisch
    Erscheinungsdatum 2021-05-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2021.05.008
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  2. Artikel ; Online: Overview of the Medical Management of the Critically Ill Patient.

    Martinez, Rebecca H / Liu, Kathleen D / Aldrich, J Matthew

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Band 17, Heft 12, Seite(n) 1805–1813

    Abstract: The medical management of the critically ill patient focuses predominantly on treatment of the underlying condition ( ...

    Abstract The medical management of the critically ill patient focuses predominantly on treatment of the underlying condition (
    Mesh-Begriff(e) Humans ; Critical Illness ; Critical Care ; Intensive Care Units ; Patient Care Bundles
    Sprache Englisch
    Erscheinungsdatum 2022-11-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.07130622
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  3. Artikel ; Online: Treatment for severe acute respiratory distress syndrome from COVID-19.

    Matthay, Michael A / Aldrich, J Matthew / Gotts, Jeffrey E

    The Lancet. Respiratory medicine

    2020  Band 8, Heft 5, Seite(n) 433–434

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Communicable Diseases, Emerging ; Coronavirus Infections ; Disease Outbreaks ; Extracorporeal Membrane Oxygenation ; Humans ; Pandemics ; Pneumonia, Viral ; Respiratory Distress Syndrome ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30127-2
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  4. Artikel ; Online: Revisiting the Role of Health Care Proxies in Reproductive Choice.

    Narayana, Sirisha / Gaw, Stephanie L / Aldrich, J Matthew / Guterman, Elan L

    Obstetrics and gynecology

    2020  Band 137, Heft 1, Seite(n) 170–172

    Abstract: In an effort to protect patients' reproductive rights, many states prohibit health care proxies from serving as surrogate decision makers for pregnancy termination in patients who lack capacity. We explore the case of a 24-year-old developmentally ... ...

    Abstract In an effort to protect patients' reproductive rights, many states prohibit health care proxies from serving as surrogate decision makers for pregnancy termination in patients who lack capacity. We explore the case of a 24-year-old developmentally delayed woman with intractable seizures and complex psychosocial needs who was found to be pregnant. Her older sister was her health care proxy and declared that an abortion would be in her best interest, medically and socially; the patient herself lacked capacity to make this decision. Legally, her sister's judgment alone was insufficient to move forward with the procedure. Here we describe our multidisciplinary medical, ethical, and legal review of this case and how, despite agreeing with the patient's sister, legal barriers hindered our ability to obtain an abortion for this patient. Her situation illustrates the unintended consequences of our current approach to surrogate decision making in pregnancy termination. It highlights the need to reconsider the role of health care proxies in reproductive-choice decisions and emphasizes the value of a holistic evaluation of patients' social circumstances.
    Mesh-Begriff(e) Abortion, Therapeutic/legislation & jurisprudence ; Abortion, Therapeutic/psychology ; Developmental Disabilities/psychology ; Female ; Humans ; Mental Competency/legislation & jurisprudence ; Pregnancy ; Pregnancy Complications/psychology ; Proxy/legislation & jurisprudence ; Rape ; Reproductive Rights/legislation & jurisprudence ; Seizures/psychology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-12-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004196
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Treatment for severe acute respiratory distress syndrome from COVID-19.

    Matthay, Michael A / Aldrich, J Matthew / Gotts, Jeffrey E

    The Lancet. Respiratory medicine, vol 8, iss 5

    2020  

    Schlagwörter Humans ; Communicable Diseases ; Emerging ; Pneumonia ; Viral ; Coronavirus Infections ; Respiratory Distress Syndrome ; Adult ; Extracorporeal Membrane Oxygenation ; Disease Outbreaks ; Pandemics ; Betacoronavirus ; Clinical Sciences ; Public Health and Health Services ; Other Medical and Health Sciences ; covid19
    Erscheinungsdatum 2020-05-01
    Verlag eScholarship, University of California
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Treatment for severe acute respiratory distress syndrome from COVID-19

    Matthay, Michael A / Aldrich, J Matthew / Gotts, Jeffrey E

    The Lancet Respiratory Medicine

    2020  Band 8, Heft 5, Seite(n) 433–434

    Schlagwörter Pulmonary and Respiratory Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/s2213-2600(20)30127-2
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  8. Artikel ; Online: Dynamic Risk Prediction for Hospital-Acquired Pressure Injury in Adult Critical Care Patients.

    Shui, Amy M / Kim, Phillip / Aribindi, Vamsi / Huang, Chiung-Yu / Kim, Mi-Ok / Rangarajan, Sachin / Schorger, Kaelan / Aldrich, J Matthew / Lee, Hanmin

    Critical care explorations

    2021  Band 3, Heft 11, Seite(n) e0580

    Abstract: Accurately measuring the risk of pressure injury remains the most important step for effective prevention and intervention. Time-dependent risk factors for pressure injury development in the adult intensive care unit setting are not well understood.: ... ...

    Abstract Accurately measuring the risk of pressure injury remains the most important step for effective prevention and intervention. Time-dependent risk factors for pressure injury development in the adult intensive care unit setting are not well understood.
    Objectives: To develop and validate a dynamic risk prediction model to estimate the risk of developing a hospital-acquired pressure injury among adult ICU patients.
    Design: ICU admission data were split into training and validation sets. With death as a competing event, both static and dynamic Fine-Gray models were developed to predict hospital-acquired pressure injury development less than 24, 72, and 168 hours postadmission. Model performance was evaluated using Wolbers' concordance index, Brier score, net reclassification improvement, and integrated discrimination improvement.
    Setting and participants: We performed a retrospective cohort study of ICU patients in a tertiary care hospital located in San Francisco, CA, from November 2013 to August 2017.
    Main outcomes and measures: Data were extracted from electronic medical records of 18,019 ICU patients (age ≥ 18 yr; 21,220 encounters). Record of hospital-acquired pressure injury data was captured in our institution's incident reporting system. The information is periodically reviewed by our wound care team. Presence of hospital-acquired pressure injury during an encounter and hospital-acquired pressure injury diagnosis date were provided.
    Results: The dynamic model predicting hospital-acquired pressure injury more than 24 hours postadmission, including predictors age, body mass index, lactate serum, Braden scale score, and use of vasopressor and antifungal medications, had adequate discrimination ability within 6 days from time of prediction (
    Conclusions and relevance: A dynamic risk prediction model predicting hospital-acquired pressure injury development less than 24 hours postadmission in ICU patients for up to 7 days postadmission was developed and validated using a large dataset of clinical variables readily available in the electronic medical record.
    Sprache Englisch
    Erscheinungsdatum 2021-11-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000580
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  9. Artikel ; Online: Risk Factors for Hospital-Acquired Pressure Injury in Adult Critical Care Patients.

    Kim, Phillip / Aribindi, Vamsi K / Shui, Amy M / Deshpande, Sharvari S / Rangarajan, Sachin / Schorger, Kaelan / Aldrich, J Matthew / Lee, Hanmin

    American journal of critical care : an official publication, American Association of Critical-Care Nurses

    2021  Band 31, Heft 1, Seite(n) 42–50

    Abstract: Background: Accurately measuring the risk of pressure injury remains the most important step for effective prevention and intervention. Relative contributions of risk factors for the incidence of pressure injury in adult critical care patients are not ... ...

    Abstract Background: Accurately measuring the risk of pressure injury remains the most important step for effective prevention and intervention. Relative contributions of risk factors for the incidence of pressure injury in adult critical care patients are not well understood.
    Objective: To develop and validate a model to identify risk factors associated with hospital-acquired pressure injuries among adult critical care patients.
    Methods: This retrospective cohort study included 23 806 adult patients (28 480 encounters) with an intensive care unit stay at an academic quaternary care center. Patient encounters were randomly split (7:3) into training and validation sets. The training set was used to develop a multivariable logistic regression model using the least absolute shrinkage and selection operator method. The model's performance was evaluated with the validation set.
    Results: Independent risk factors identified by logistic regression were length of hospital stay, preexisting diabetes, preexisting renal failure, maximum arterial carbon dioxide pressure, minimum arterial oxygen pressure, hypotension, gastrointestinal bleeding, cellulitis, and minimum Braden Scale score of 14 or less. On validation, the model differentiated between patients with and without pressure injury, with area under the receiver operating characteristic curve of 0.85, and performed better than a model with Braden Scale score alone (P < .001).
    Conclusions: A model that identified risk factors for hospital-acquired pressure injury among adult critical care patients was developed and validated using a large data set of clinical variables. This model may aid in selecting high-risk patients for focused interventions to prevent formation of hospital-acquired pressure injuries.
    Mesh-Begriff(e) Adult ; Critical Care ; Hospitals ; Humans ; Intensive Care Units ; Pressure Ulcer/epidemiology ; Pressure Ulcer/etiology ; Pressure Ulcer/prevention & control ; Retrospective Studies ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2021-12-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1130987-8
    ISSN 1937-710X ; 1062-3264
    ISSN (online) 1937-710X
    ISSN 1062-3264
    DOI 10.4037/ajcc2022657
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  10. Artikel ; Online: Outcomes and risk factors for delayed-onset postoperative respiratory failure: a multi-center case-control study by the University of California Critical Care Research Collaborative (UC

    Stocking, Jacqueline C / Drake, Christiana / Aldrich, J Matthew / Ong, Michael K / Amin, Alpesh / Marmor, Rebecca A / Godat, Laura / Cannesson, Maxime / Gropper, Michael A / Romano, Patrick S / Sandrock, Christian / Bime, Christian / Abraham, Ivo / Utter, Garth H

    BMC anesthesiology

    2022  Band 22, Heft 1, Seite(n) 146

    Abstract: Background: Few interventions are known to reduce the incidence of respiratory failure that occurs following elective surgery (postoperative respiratory failure; PRF). We previously reported risk factors associated with PRF that occurs within the first ... ...

    Abstract Background: Few interventions are known to reduce the incidence of respiratory failure that occurs following elective surgery (postoperative respiratory failure; PRF). We previously reported risk factors associated with PRF that occurs within the first 5 days after elective surgery (early PRF; E-PRF); however, PRF that occurs six or more days after elective surgery (late PRF; L-PRF) likely represents a different entity. We hypothesized that L-PRF would be associated with worse outcomes and different risk factors than E-PRF.
    Methods: This was a retrospective matched case-control study of 59,073 consecutive adult patients admitted for elective non-cardiac and non-pulmonary surgical procedures at one of five University of California academic medical centers between October 2012 and September 2015. We identified patients with L-PRF, confirmed by surgeon and intensivist subject matter expert review, and matched them 1:1 to patients who did not develop PRF (No-PRF) based on hospital, age, and surgical procedure. We then analyzed risk factors and outcomes associated with L-PRF compared to E-PRF and No-PRF.
    Results: Among 95 patients with L-PRF, 50.5% were female, 71.6% white, 27.4% Hispanic, and 53.7% Medicare recipients; the median age was 63 years (IQR 56, 70). Compared to 95 matched patients with No-PRF and 319 patients who developed E-PRF, L-PRF was associated with higher morbidity and mortality, longer hospital and intensive care unit length of stay, and increased costs. Compared to No-PRF, factors associated with L-PRF included: preexisiting neurologic disease (OR 4.36, 95% CI 1.81-10.46), anesthesia duration per hour (OR 1.22, 95% CI 1.04-1.44), and maximum intraoperative peak inspiratory pressure per cm H
    Conclusions: We identified that pre-existing neurologic disease, longer duration of anesthesia, and greater maximum intraoperative peak inspiratory pressures were associated with respiratory failure that developed six or more days after elective surgery in adult patients (L-PRF). Interventions targeting these factors may be worthy of future evaluation.
    Mesh-Begriff(e) Adult ; Aged ; Case-Control Studies ; Critical Care ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Length of Stay ; Male ; Medicare ; Middle Aged ; Postoperative Complications/etiology ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/etiology ; Retrospective Studies ; Risk Factors ; United States
    Sprache Englisch
    Erscheinungsdatum 2022-05-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-022-01681-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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