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  1. Article: Adipokines as predictive factor of cardiac function in pediatric patients with chronic kidney disease.

    Villasis-Keever, Miguel Angel / Zurita-Cruz, Jessie Nallely / Zepeda-Martinez, Claudia / Alegria-Torres, Gabriela / Serret-Montoya, Juana / Estrada-Loza, Maria de Jesus / Hernández-Hernández, Beatriz Carolina / Alonso-Flores, Sara / Zavala-Serret, Monica

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1120445

    Abstract: Background: Adipokines are associated with cardiovascular disease; in chronic kidney disease (CKD) patients adipokines could be useful prognostic factors.: Objectives: To explore whether leptin and adiponectin in kidney replacement therapy (KRT) ... ...

    Abstract Background: Adipokines are associated with cardiovascular disease; in chronic kidney disease (CKD) patients adipokines could be useful prognostic factors.
    Objectives: To explore whether leptin and adiponectin in kidney replacement therapy (KRT) children could have a role on their cardiac function, in the long-term.
    Design: Prospective cohort study was performed with pediatric KRT patients, aged 8 to 17 years who were undergoing hemodialysis or peritoneal dialysis. At enrollment, lipid profile, adipokines (leptin, leptin receptor, free leptin, and adiponectin), anthropometric measurements and cardiological evaluation were determined. At two-year follow-up, a new cardiological evaluation was performed.
    Results: We included 56 patients, with a median age of 12.5 years. In the first cardiological evaluation, median LVEF was 70.0% (IQR 61%, 76%), 20 patients (35.7%) had some cardiovascular condition, and 10 (17.8%) altered LVEF. At 24-month follow-up, the median LVEF was 70.5% (IQR 65.1%, 77%), while the delta-LVEF values was 3% (IQR -6.5%, 7%). Delta-LVEF were correlated with baseline adipokines serum levels, and the only positive correlation found was with free leptin (r=0.303, p=0.025). In multivariate analysis, levels of free leptin (Coef. 0.12, p<0.036) and leptin (coef. 1.72, p=0.049), as well as baseline LVEF (Coef. -0.65, p<0.001) were associated with delta-LVEF.
    Conclusions: Free leptin, leptin and LVEF at the beginning of follow-up were associated with the LVEF decrease at the 24-month follow-up in KRT children.
    MeSH term(s) Humans ; Child ; Adipokines ; Leptin ; Adiponectin ; Prospective Studies ; Renal Insufficiency, Chronic/therapy ; Cardiovascular Diseases/diagnosis
    Chemical Substances Adipokines ; Leptin ; Adiponectin
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1120445
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  2. Article ; Online: Utilidad de una estrategia nutricional sobre la dislipidemia en pacientes pediátricos con enfermedad renal crónica terminal.

    Villasis-Keever, Miguel Ángel / Zurita-Cruz, Jessie Nallely / Barradas-Vázquez, Aly Sugei / Barbosa-Cortés, Lourdes / Zepeda-Martínez, Claudia Del Carmen / Alegría-Torres, Gabriela / González-Estévez, Marianne / Domínguez-Salgado, Juan Manuel

    Nutricion hospitalaria

    2022  Volume 39, Issue 3, Page(s) 530–536

    Abstract: Introduction: Background and objective: in chronic kidney disease (CKD) there are several factors that increase the presence of dyslipidemia. The aim of this study was to identify the usefulness of a nutritional intervention, in children with terminal ... ...

    Title translation Usefulness of a nutritional strategy on dyslipidemia in pediatric patients with terminal chronic kidney disease.
    Abstract Introduction: Background and objective: in chronic kidney disease (CKD) there are several factors that increase the presence of dyslipidemia. The aim of this study was to identify the usefulness of a nutritional intervention, in children with terminal CKD, on dyslipidemia 6 months after intervention start. Materials and methods: a quasi-experiment study (before and after) was performed. End-stage CKD patients on peritoneal dialysis and hemodialysis were included. Each child underwent a determination somatometry, and lipid profile at the beginning and at 6 months of follow-up. A nutritional guide was made with food traffic lights, turning the food that should be consumed in the least amount possible in red. In addition to including life-size food using educational models. To compare the quantitative variables before and after the intervention, the variables were transformed to their logarithm and a paired Student's t-test was applied. Results: a total of 41 patients were analyzed. After the intervention, the parameters in the lipid profile were modified; meanwhile HDL concentrations increased (41.0 mg/dL vs 44.4 mg/dL, p = 0.048), triglyceride concentrations decreased (227.1 mg/dL vs 185.9 mg/dL, p = 0.007), and these changes persist even after excluding patients who were under lipid-lowering treatment (195 mg/dL vs 171.6, p = 0.049). Regarding the state of dyslipidemia, hypertriglyceridemia decreased, without reaching significance (80.5 % vs 62.5 %, p = 0.073). Conclusions: the nutritional intervention improved HDL and triglyceride concentrations 6 months afterwards in children with terminal CKD.
    MeSH term(s) Child ; Dyslipidemias/therapy ; Humans ; Kidney Failure, Chronic/therapy ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Triglycerides
    Chemical Substances Triglycerides
    Language Spanish
    Publishing date 2022-02-28
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1481223-x
    ISSN 1699-5198 ; 0212-1611
    ISSN (online) 1699-5198
    ISSN 0212-1611
    DOI 10.20960/nh.03921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5078: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The leptin/adiponectin ratio as prognostic marker for dyslipidemia during 1 year of follow-up in pediatric patients receiving kidney replacement therapy.

    Villasís-Keever, Miguel Ángel / Zurita-Cruz, Jessie Nallely / Serret-Montoya, Juana / Barbosa-Cortés, Lourdes / Zepeda-Martínez, Claudia Del Carmen / Alegría-Torres, Gabriela / Barradas-Vázquez, Aly Sugei / Alonso-Flores, Sara / Hernández-Hernández, Carolina / Manuel-Apolinar, Leticia / Damasio-Santana, Leticia / Domínguez-Salgado, Juan Manuel

    Nutricion hospitalaria

    2022  Volume 39, Issue 5, Page(s) 977–987

    Abstract: Introduction: Background: leptin and adiponectin are associated with cardiovascular disease in chronic kidney disease (CKD) patients and could be useful prognostic factors. Objectives. to explore the usefulness of the leptin/adiponectin ratio (LAR) to ... ...

    Title translation Índice leptina/adiponectina como indicador pronóstico de dislipidemia durante 1 año de seguimiento en pacientes pediátricos que reciben terapia de reemplazo renal.
    Abstract Introduction: Background: leptin and adiponectin are associated with cardiovascular disease in chronic kidney disease (CKD) patients and could be useful prognostic factors. Objectives. to explore the usefulness of the leptin/adiponectin ratio (LAR) to predict the presence or worsening of dyslipidemia during 1 year of follow-up in children receiving kidney replacement therapy (KRT). Material and methods: a prospective cohort study was performed. Pediatric KRT patients aged between 8 and 17 years who were undergoing hemodialysis or peritoneal dialysis were included. At enrollment, the lipid profile, adiponectin and leptin levels, and somatometric measurements, including body fat percentage, were determined. At the one-year follow-up, the lipid profile was reassessed. Results: of the 70 patients included, the median age was 13 years, and there was no sex predominance (52.8 % males). At the end of follow-up, the patients were divided into three groups: those without dyslipidemia (WOD), those who developed or experienced worsening of their dyslipidemia (DWD) and those with persistent dyslipidemia (PD). A LAR > 0.85 (OR, 16.7) and body fat percentage (OR, 1.46) were associated with an increased risk of PD and DWD at 12 months, independently of urea level, BMI Z-score, benzafibrate treatment, CKD progression time, and replacement treatment. Conclusions: a LAR > 0.85 and fat body percentage at the beginning of follow-up were strongly associated with the presence, persistence or worsening of dyslipidemia at the 12-month follow-up in children with KRT.
    MeSH term(s) Adiponectin ; Adolescent ; Child ; Dyslipidemias ; Female ; Follow-Up Studies ; Humans ; Leptin ; Lipids ; Male ; Peritoneal Dialysis ; Prognosis ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Urea
    Chemical Substances Adiponectin ; Leptin ; Lipids ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-09-12
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1481223-x
    ISSN 1699-5198 ; 0212-1611
    ISSN (online) 1699-5198
    ISSN 0212-1611
    DOI 10.20960/nh.03890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5078: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Leptin receptor and prolactin in pubertal disorders and chronic kidney disease.

    Villasís-Keever, Miguel A / Zurita-Cruz, Jessie N / Serret-Montoya, Juana / Zepeda-Martinez, Claudia Del Carmen / Alegria-Torres, Gabriela / Barradas-Vazquez, Aly S / Hernández-Hernández, Beatriz C / Alonso-Flores, Sara R / Manuel-Apolinar, Leticia / Damasio-Santana, Leticia

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15183

    Abstract: Background: Knowledge of chronic kidney disease (CKD) with pubertal disorders (PD) in adolescent boys is limited as few studies have explored this disorder. This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents ...

    Abstract Background: Knowledge of chronic kidney disease (CKD) with pubertal disorders (PD) in adolescent boys is limited as few studies have explored this disorder. This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents with CKD and their correlation with PD in a 12-month follow-up period.
    Methods: A prospective cohort study was conducted among male adolescents with CKD (stages IV and V). Data regarding the age at puberty onset were collected from the patients' clinical records and through interview. The patients were followed up for 12 months during their pubertal development. At the beginning, routine hormonal profile tests were performed to examine the patients' thyroid profile, prolactin levels, luteinizing hormone, follicle-stimulating hormone, testosterone, leptin, and receptor leptin. The hormonal profiles of patients with and without PD were compared. Comparisons between the groups were performed using the Student t-test and Fisher's exact tests. Logistic regression analysis was also performed.
    Results: Data of 64 patients (26/64 with PD) were analyzed. The median age was 15 years and the median time for CKD evolution was 11 months. No differences between groups were noted in the general or biochemical characteristics of the patients. The hormonal parameters, prolactin levels were higher and the free leptin and free thyroxine levels were lower in patients with PD. Leptin receptor levels of >0.90 ng/mL (risk ratio [RR], 8.6; P = 0.004) and hyperprolactinemia (RR, 21.3; P = 0.049) were the risk factors for PD.
    Conclusions: Leptin receptor levels of >0.90 ng/mL and hyperprolactinemia are associated with the development of PD in male adolescents with CKD.
    MeSH term(s) Adolescent ; Humans ; Male ; Receptors, Leptin ; Prolactin ; Leptin ; Hyperprolactinemia/complications ; Prospective Studies ; Puberty ; Renal Insufficiency, Chronic/complications
    Chemical Substances Receptors, Leptin ; Prolactin (9002-62-4) ; Leptin
    Language English
    Publishing date 2022-11-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15183
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 848: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cardiometabolic Factors in Pediatric Patients with Chronic Diseases.

    Villasís-Keever, Miguel A / Zurita-Cruz, Jessie N / Serret-Montoya, Juana / de Leon-Herrera, Andrea Ponce / Galván-Heredia, Penélope / Zepeda-Martínez, Claudia Del Carmen / Alegría-Torres, Gabriela / Hernández-Hernández, Carolina / Alonso-Flores, Sara / Barbosa-Cortes, Lourdes / Arenas-Aguayo, Luis Antonio

    Archives of medical research

    2021  Volume 52, Issue 5, Page(s) 535–543

    Abstract: Background: The prevalence of chronic diseases (CDs) in the pediatric population has increased due to technological advances that decrease mortality and increase survival.: Aim of the study: To compare the frequency of cardiometabolic factors (CFs) ... ...

    Abstract Background: The prevalence of chronic diseases (CDs) in the pediatric population has increased due to technological advances that decrease mortality and increase survival.
    Aim of the study: To compare the frequency of cardiometabolic factors (CFs) among pediatric patients with CDs with those among children with obesity and overweight without CDs.
    Methods: This study was a cross-sectional study. Pediatric patients from 6-17 years of age were included. A total of 333 patients with CD were studied, and of these patients, 77 had difficult-to-control epilepsy, 183 had chronic kidney disease (CKD), and 73 underwent kidney transplants; in addition, a comparison group was included, consisting of 286 overweight and obese children without any other pathologies. We performed anthropometry, blood pressure, glucose, insulin, and lipid profiling on all of the patients. Statistical analysis was conducted as follows: Chi
    Results: We included 619 patients from 6-17 years old. Patients with CDs had a low frequency of obesity (12.4%) but a high frequency of the remaining CFs. Hypertriglyceridemia (65%), hypoalphalipoproteinemia (49%) and systemic arterial hypertension (46.5%) were the most common CFs, particularly among subjects with CKD and kidney transplantation. When comparing the frequencies of these CFs with those in the obesity/overweight group, hypertriglyceridemia (p <0.05) was more common in patients with CDs.
    Conclusions: In patients with CDs, dyslipidemia, hypertension, and hyperglycemia occur at frequencies that are the same as or higher than those in overweight/obese children, but when the CD patients are overweight/obese, it increases their frequency.
    MeSH term(s) Adolescent ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Child ; Chronic Disease ; Cross-Sectional Studies ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Overweight/complications ; Overweight/epidemiology ; Pediatric Obesity ; Prevalence ; Risk Factors
    Language English
    Publishing date 2021-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2021.01.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1001: Show issues Location:
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  6. Article: Factores de riesgo cardiovascular en niños con síndrome nefrótico primario.

    Alegría-Torres, Gabriela Alejandra / Aguilar-Kitsu, María Alejandra / Estrada-Loza, María Jesús / Villasís-Keever, Miguel Ángel

    Revista medica del Instituto Mexicano del Seguro Social

    2015  Volume 53 Suppl 3, Page(s) S284–93

    Abstract: Background: It has been suggested that patients with nephrotic syndrome (NS) have an increased frequency of cardiovascular risk factors. The aim of this study was to determine the frequency of cardiovascular risk factors in children with primary NS.: ... ...

    Title translation Cardiovascular risk factors in children with primary nephrotic syndrome.
    Abstract Background: It has been suggested that patients with nephrotic syndrome (NS) have an increased frequency of cardiovascular risk factors. The aim of this study was to determine the frequency of cardiovascular risk factors in children with primary NS.
    Methods: Cross-sectional, descriptive and prospective study. Fifty-five patients with primary NS were included. The presence of overweight/obesity, hypertension, dyslipidemias, hyperglycemia, elevated C-reactive protein and carotid intima-media thickness (IMT) was evaluated. The treatment time, the type of treatment and the number of relapses were analyzed. For statistical analysis chi-square and Spearman's rho were used.
    Results: The most frequent cardiovascular risk factor was increased carotid IMT (98.1 %), followed by hypertriglyceridemia (54.4 %) and total cholesterol (40 %). Patients with corticosensitive NS had fewer risk factors compared with patients with steroid-resistant NS. There was also a positive correlation of longer time of evolution and number of relapses with the increase in the number of factors.
    Conclusions: Ninety-eight percent of children with primary NS had at least one cardiovascular risk factor. Certain clinical features, such as steroid-resistant NS, and the time of evolution and treatment, seem to be related to the presence of larger number of risk factors.
    MeSH term(s) Adolescent ; C-Reactive Protein/metabolism ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Carotid Intima-Media Thickness ; Child ; Child, Preschool ; Cross-Sectional Studies ; Dyslipidemias/etiology ; Female ; Humans ; Hyperglycemia/etiology ; Hypertension/etiology ; Infant ; Male ; Nephrotic Syndrome/blood ; Nephrotic Syndrome/complications ; Obesity/etiology ; Overweight/etiology ; Prospective Studies ; Risk Factors
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language Spanish
    Publishing date 2015
    Publishing country Mexico
    Document type Journal Article ; Observational Study
    ZDB-ID 732133-8
    ISSN 0443-5117 ; 0484-7849
    ISSN 0443-5117 ; 0484-7849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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