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  1. Article ; Online: Use of ivermectin and factors associated with the prevention and/or treatment of COVID-19

    David Guillen-Carbajal / Luz Campos-Loza / J. Smith Torres-Roman / Jose Salvador-Carrillo / Jorge Osada / Alejandra Zevallos

    F1000Research, Vol

    a cross-sectional online survey in the province of Chincha, Peru [version 3; peer review: 2 approved]

    2024  Volume 12

    Abstract: Background Peru has reported one of the highest mortality rates from COVID-19 worldwide. The Chincha province has been one of the most affected regions in Peru and the leading promoter of the use of ivermectin for the treatment of COVID-19. Therefore, ... ...

    Abstract Background Peru has reported one of the highest mortality rates from COVID-19 worldwide. The Chincha province has been one of the most affected regions in Peru and the leading promoter of the use of ivermectin for the treatment of COVID-19. Therefore, our study aimed to evaluate the frequency of use and factors associated with the use of ivermectin for COVID-19 in Chincha. Methods A cross-sectional study was conducted during the second wave of COVID-19 in Peru. For statistical analyses, frequencies and percentages were reported. Prevalence ratios (PR) with a 95% confidence interval (CI), and a p-value of 0.05 were used to determine statistical significance. SPSS version 22 (IBM Corp) program was used for the analyses. Results A total of 432 participants were included in the study. A total of 67.6% (n = 292) of the participants used ivermectin during the COVID-19 pandemic. Of these, 20.20% (n=59) of the people used ivermectin for prophylactic purposes only, while 41.79% (n=122) used it as treatment for COVID-19 only, and 38.01% (n=111) used it for both reasons. The consumption of ivermectin was associated with being 50 years or older (PR:1.27, 95% CI:1.04–1.54), having a technical education level (PR:1.16, 95% CI:1.01–1.34), having had symptoms of COVID-19 with negative/no diagnosis (PR: 1.28, 95% CI: 1.07–1.53) or positive diagnosis (PR:1.38, 95% CI:1.18–1.61), or having had contact with infected people (PR:1.45, 95% CI:1.06–1.98). Conclusions Most people in Chincha used ivermectin during the second wave of the COVID-19 pandemic. The main factors associated with the use of ivermectin for the prevention/treatment of COVID-19 were age ≥50 years, having a technical education level, having had symptoms with negative/no diagnosis or positive diagnosis, and contact with people infected with SARS-CoV-2.
    Keywords Ivermectin ; COVID-19 ; Treatment and Prevention ; Peru ; eng ; Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Use of ivermectin and factors associated with the prevention and/or treatment of COVID-19

    David Guillen-Carbajal / Luz Campos-Loza / J. Smith Torres-Roman / Jose Salvador-Carrillo / Jorge Osada / Alejandra Zevallos

    F1000Research, Vol

    a cross-sectional online survey in the province of Chincha, Peru [version 2; peer review: 2 approved]

    2023  Volume 12

    Abstract: Background: Peru has reported one of the highest mortality rates by COVID-19 worldwide. The Chincha province has been one of the most affected regions in Peru and the leading promoter of the use of ivermectin for the treatment of COVID-19. Therefore, our ...

    Abstract Background: Peru has reported one of the highest mortality rates by COVID-19 worldwide. The Chincha province has been one of the most affected regions in Peru and the leading promoter of the use of ivermectin for the treatment of COVID-19. Therefore, our study aimed to evaluate the frequency of use and factors associated with the use of ivermectin for COVID-19 in Chincha. Methods: A cross-sectional study was conducted during the second wave of COVID-19 in Peru. For statistical analyses, frequencies and percentages were reported. Prevalence ratios (PR) with a 95% confidence interval (CI), and a p-value of 0.05 were used to determine statistical significance. The SPSS version 22 (IBM Corp) program was used for the analyses. Results: A total of 432 participants were included in the study; of these, 67.6% (n = 292) used ivermectin during the COVID-19 pandemic, with 20.20% (n=59) using ivermectin only for prophylactic purposes, while 41.79% (n=122) used it only as treatment for COVID-19. The consumption of ivermectin was associated with age ≥ 50 years (PR:1.27, 95% CI:1.04–1.54), technical education level (PR:1.16, 95% CI:1.01–1.34), symptoms of COVID-19 with negative/no diagnosis (PR: 1.28, 95% CI: 1.07–1.53), positive diagnosis (PR:1.38, 95% CI:1.18–1.61), and positive contact with infected people (PR:1.45, 95% CI:1.06–1.98). Conclusions: Most people in Chincha used ivermectin during the second wave of the COVID-19 pandemic. The main factors associated with the use of ivermectin for the prevention/treatment of COVID-19 were age ≥50 years, having a technical education level, having had symptoms with negative/no diagnosis or positive diagnosis, and contact with people infected with SARS-CoV-2.
    Keywords Ivermectin ; COVID-19 ; Treatment and Prevention ; Peru ; eng ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Case Report

    Yasser Ciro Sullcahuaman Allende / Julio Cesar Mendoza Fernández / Melissa Sindy Peláez Chomba / Guillermo Raúl Vásquez Gómez / Vicente Leandro Cruzate Cabrejos / Nelson David Purizaca Rosillo / Alejandra Zevallos

    F1000Research, Vol

    A prenatal diagnosis of osteogenesis imperfecta in a patient with a novel pathogenic variant in COL1A2 [version 3; peer review: 2 approved]

    2023  Volume 12

    Abstract: Osteogenesis imperfecta is considered a rare genetic condition which is characterized by bone fragility. In 85% of cases, it is caused by mutations in COL1A1 and COL1A2 genes which are essential to produce type I collagen. We report the case of a female ... ...

    Abstract Osteogenesis imperfecta is considered a rare genetic condition which is characterized by bone fragility. In 85% of cases, it is caused by mutations in COL1A1 and COL1A2 genes which are essential to produce type I collagen. We report the case of a female neonate delivered to a 27-year-old women at San Bartolomé Teaching Hospital with a family history of clavicle fracture. A prenatal control with ultrasound was performed to the mother at 29 weeks. A fetus with altered morphology and multiple fractures was found. Therefore, a prenatal diagnosis of osteogenesis imperfecta was performed. The neonate was born with a respiratory distress syndrome and an acyanotic congenital heart disease. Therefore, she remained in NICU until her death. We highlight the importance of prenatal diagnosis, genetic counseling and a multidisciplinary evaluation in this type of pathologies and report a new probably pathogenic variant in the COL1A2 gene detected by exomic sequencing in amniotic fluid.
    Keywords Osteogenesis imperfecta ; newborn ; prenatal diagnosis ; eng ; Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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