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  1. Article ; Online: SIRT7 and p53 interaction in embryonic development and tumorigenesis

    Berta N. Vazquez / Irene Fernández-Duran / Yurdiana Hernandez / Shahriar Tarighi / Joshua K. Thackray / Maria Espinosa-Alcantud / Poonam Kumari / Alessandro Ianni / Lionel Cesaire / Thomas Braun / Manel Esteller / Jay Tischfield / Alejandro Vaquero / Lourdes Serrano

    Frontiers in Cell and Developmental Biology, Vol

    2024  Volume 11

    Abstract: p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic, ...

    Abstract p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic, oxidative, and genotoxic stress. In the recent years, mammalian Sirtuin 7 (SIRT7) has emerged as a pivotal regulator of p53, fine-tuning its activity in a context dependent manner. SIRT7 is frequently overexpressed in human cancer, yet its precise role in tumorigenesis and whether it involves p53 regulation is insufficiently understood. Depletion of SIRT7 in mice results in impaired embryo development and premature aging. While p53 activity has been suggested to contribute to tissue specific dysfunction in adult Sirt7−/− mice, whether this also applies during development is currently unknown. By generating SIRT7 and p53 double-knockout mice, here we show that the demise of SIRT7-deficient embryos is not the result of p53 activity. Notably, although SIRT7 is commonly considered an oncogene, SIRT7 haploinsufficiency increases tumorigenesis in p53 knockout mice. Remarkably, in specific human tumors harboring p53 mutation, we identified that SIRT7 low expression correlates with poor patient prognosis. Transcriptomic analysis unveils a previously unrecognized interplay between SIRT7 and p53 in epithelial-to-mesenchymal transition (EMT) and extracellular matrix regulation with major implications for our understanding of embryonic development and tumor progression.
    Keywords p53 ; SIRTUIN ; Sirt7 ; embryonic development ; tumor suppressor ; gene expression ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin

    Jessica González / Laia Bosch-Presegué / Anna Marazuela-Duque / Anna Guitart-Solanes / María Espinosa-Alcantud / Agustín F. Fernandez / Jeremy P. Brown / Juan Ausió / Berta N. Vazquez / Prim B. Singh / Mario F. Fraga / Alejandro Vaquero

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH ... ...

    Abstract Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. Among the less understood components of PCH is the histone H2A variant H2A.Z, whose role in the organization and maintenance of PCH is poorly defined. Here we show that there is a complex interplay between H2A.Z and HP1 isoforms in PCH. While the loss of HP1α results in the accumulation of H2A.Z.1 in PCH, which is associated with a significant decrease in its mobile fraction, H2A.Z.1 binds preferentially to HP1β in these regions. Of note, H2A.Z.1 downregulation results in increased heterochromatinization and instability of PCH, reflected by accumulation of the major epigenetic hallmarks of heterochromatin in these regions and increased frequency of chromosome aberrations related to centromeric/pericentromeric defects. Our studies support a role for H2A.Z in genome stability and unveil a key role of H2A.Z in the regulation of heterochromatin-specific epigenetic modifications through a complex interplay with the HP1 isoforms.
    Keywords HP1α,β,γ ; heterochromatin ; H2A.Z ; epigenetics ; genome stability ; H3K9me3 ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A view on the role of epigenetics in the biology of malaria parasites.

    Alfred Cortés / Valerie M Crowley / Alejandro Vaquero / Till S Voss

    PLoS Pathogens, Vol 8, Iss 12, p e

    2012  Volume 1002943

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Costos de cumplimiento de inocuidad de empacadoras exportadoras de limón Persa en Veracruz, México

    Jorge Aguilar Ávila / Alejandro Vaquero Vera / Gustavo Almaguer Vargas / Juan Antonio Leos Rodríguez / Belem Avendaño Ruiz

    Investigación y Ciencia de la Universidad Autónoma de Aguascalientes, Iss 57, Pp 40-

    2013  Volume 48

    Abstract: The aim of this work was to estimate the compliancecosts at “Persa” lemon packing from two regions ofVeracruz to implement an innocuousness program,to define the problems they face during a GoodManufacturing Practices (GMP) certificationprogram and the ... ...

    Abstract The aim of this work was to estimate the compliancecosts at “Persa” lemon packing from two regions ofVeracruz to implement an innocuousness program,to define the problems they face during a GoodManufacturing Practices (GMP) certificationprogram and the benefits they notice by fulfilling it.The information was collected by the applicationof a questionnaire to the packinghouses at thearea of interest. Certified companies perceivefood safety as an opportunity to gain marketsand displace those packing that do not satisfyGMP adoption for international market. The mainchallenge to get the certification is low financialresources availability, so high costs for amenities.The implementation of a food safety programand its costs are considered as a non-tariff actionthat may affect exportations from non-certifiedpacking.
    Keywords cost analysis ; recurrent cost ; non-recurring cost ; relating to compliance costs index. ; Science (General) ; Q1-390 ; Science ; Q ; DOAJ:Science (General) ; DOAJ:Science General
    Language Spanish
    Publishing date 2013-04-01T00:00:00Z
    Publisher Universidad Autónoma de Aguascalientes
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

    Laia Bosch-Presegué / Helena Raurell-Vila / Joshua K. Thackray / Jessica González / Carmen Casal / Noriko Kane-Goldsmith / Miguel Vizoso / Jeremy P. Brown / Antonio Gómez / Juan Ausió / Timo Zimmermann / Manel Esteller / Gunnar Schotta / Prim B. Singh / Lourdes Serrano / Alejandro Vaquero

    Cell Reports, Vol 21, Iss 8, Pp 2048-

    2017  Volume 2057

    Abstract: HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α−/−, Hp1β−/−, and Hp1γ−/− MEFs show ... ...

    Abstract HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α−/−, Hp1β−/−, and Hp1γ−/− MEFs show that HP1 proteins have both redundant and unique functions within pericentric heterochromatin (PCH) and also act globally throughout the genome. HP1α confines H4K20me3 and H3K27me3 to regions within PCH, while its absence results in a global hyper-compaction of chromatin associated with a specific pattern of mitotic defects. In contrast, HP1β is functionally associated with Suv4-20h2 and H4K20me3, and its loss induces global chromatin decompaction and an abnormal enrichment of CTCF in PCH and other genomic regions. Our work provides insight into the roles of HP1 proteins in heterochromatin structure and genome stability.
    Keywords heterochromatin ; HP1α ; HP1β ; HP1γ ; Suv420h2 ; H4K20me3 ; genome organization ; genome stability ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2017-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

    Irene Santos-Barriopedro / Laia Bosch-Presegué / Anna Marazuela-Duque / Carolina de la Torre / Carlota Colomer / Berta N. Vazquez / Thomas Fuhrmann / Bárbara Martínez-Pastor / Wenfu Lu / Thomas Braun / Eva Bober / Thomas Jenuwein / Lourdes Serrano / Manel Esteller / Zhenbang Chen / Silvia Barceló-Batllori / Raúl Mostoslavsky / Lluis Espinosa / Alejandro Vaquero

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB ... ...

    Abstract Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB pathway.
    Keywords Science ; Q
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

    Irene Santos-Barriopedro / Laia Bosch-Presegué / Anna Marazuela-Duque / Carolina de la Torre / Carlota Colomer / Berta N. Vazquez / Thomas Fuhrmann / Bárbara Martínez-Pastor / Wenfu Lu / Thomas Braun / Eva Bober / Thomas Jenuwein / Lourdes Serrano / Manel Esteller / Zhenbang Chen / Silvia Barceló-Batllori / Raúl Mostoslavsky / Lluis Espinosa / Alejandro Vaquero

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB ... ...

    Abstract Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κB pathway.
    Keywords Science ; Q
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

    Virginia C. Rodríguez-Cortez / Paloma Martínez-Redondo / Francesc Català-Moll / Javier Rodríguez-Ubreva / Antonio Garcia-Gomez / Ganesh Poorani-Subramani / Laura Ciudad / Henar Hernando / Arantxa Pérez-García / Carlos Company / José M. Urquiza / Almudena R. Ramiro / Javier M. Di Noia / Alejandro Vaquero / Esteban Ballestar

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Volume 13

    Abstract: Abstract Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes ... ...

    Abstract Abstract Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regulation. AID is mutated in hyper-IgM type 2 (HIGM2) syndrome. Here, we investigated the potential role of AID in the acquisition of epigenetic changes. We discovered that AID binding to the IgH locus promotes an increase in H4K20me3. In 293F cells, we demonstrate interaction between co-transfected AID and the three SUV4-20 histone H4K20 methyltransferases, and that SUV4-20H1.2, bound to the IgH switch (S) mu site, is replaced by SUV4-20H2 upon AID binding. Analysis of HIGM2 mutants shows that the AID truncated form W68X is impaired to interact with SUV4-20H1.2 and SUV4-20H2 and is unable to bind and target H4K20me3 to the Smu site. We finally show in mouse primary B cells undergoing class-switch recombination (CSR) that AID deficiency associates with decreased H4K20me3 levels at the Smu site. Our results provide a novel link between SUV4-20 enzymes and CSR and offer a new aspect of the interplay between AID and histone modifications in setting the epigenetic status of CSR sites.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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