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  1. AU="Aleksander Zińczuk"
  2. AU="Rowe, Logan M."
  3. AU="Sharma N." AU="Sharma N."
  4. AU=Yuan Shu
  5. AU="Ye Liu"
  6. AU="Bezerra, Antônio Diego M"
  7. AU="HE Xiufeng"
  8. AU=Freeman Hugh J AU=Freeman Hugh J
  9. AU="Choi, John Kim"
  10. AU="Streng, Bianca M M"
  11. AU="Franklin, Renty B"
  12. AU="Tetri, Laura H"
  13. AU="Badve, Sunil V"
  14. AU=Zhang Yinan
  15. AU="Piquero, Nicole Leeper"
  16. AU="Russo, Giorgio Ivan" AU="Russo, Giorgio Ivan"
  17. AU=Pourdowlat Guitti
  18. AU="Frisenda, Riccardo"
  19. AU=Palmucci Stefano

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  1. Artikel ; Online: EASIX, Modified EASIX and Simplified EASIX as an Early Predictor for Intensive Care Unit Admission and Mortality in Severe COVID-19 Patients

    Aleksander Zińczuk / Marta Rorat / Krzysztof Simon / Tomasz Jurek

    Journal of Personalized Medicine, Vol 12, Iss 1022, p

    2022  Band 1022

    Abstract: COVID-19 receives a lot of attention due to its threat to global public health. Research is ongoing to find universal methods to assess the baseline health status of a patient to determine prognosis and management strategies. This study aims to assess ... ...

    Abstract COVID-19 receives a lot of attention due to its threat to global public health. Research is ongoing to find universal methods to assess the baseline health status of a patient to determine prognosis and management strategies. This study aims to assess the predictive potential of the EASIX (Endothelial Activation and Stress Index) and two of its modifications (mEASIX and sEASIX) in terms of the need for admission to the ICU (intensive care unit), the use of IMV (invasive mechanical ventilation) and death due to COVID-19. The medical data of 370 severely ill patients hospitalised in the COVID-19 departments of the Regional Specialist Hospital in Wroclaw (Poland), including the ICU, were analysed retrospectively. The mortality rate in the group studied was 65.7% (243 cases). In the case of all three indices, EASIX, mEASIX and sEASIX, there was a statistically significant correlation between the need for admission to the ICU ( p = 0.026, p = 0.019, p = 0.001, respectively) and the risk of death ( p < 0.001). In terms of the risk of death, the high values of the assessed indices (EASIX ≥ 2.36, mEASIX ≥ 704.03, sEASIX ≥ 3.81) were characterised by low sensitivity (≤40%), high specificity (approximately 90%) and low NPV (negative predictive value) (approximately 40%) with high PPV (positive predictive value) (approximately 80%). Due to the ease of implementation and the low cost of performing basic laboratory tests, the above-mentioned indices can be used as an additional, but not universal tool for the initial assessment of the health condition of patients admitted to the hospital.
    Schlagwörter Endothelial Activation and Stress Index ; SARS-CoV-2 ; endotheliitis ; inflammation ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Analysis of Deaths among HIV-Infected Patients Hospitalized in 2009–2018 in Main Centre of Infectious Disease in Region of Lower Silesia in Poland, Detailing Lesions in the Central Nervous System

    Justyna Janocha-Litwin / Aleksander Zińczuk / Sylwia Serafińska / Anna Szymanek-Pasternak / Krzysztof Simon

    Medicina, Vol 58, Iss 270, p

    2022  Band 270

    Abstract: Background and Objectives : Patients living with HIV (PLWH), especially those diagnosed too late or not receiving treatment with antiretroviral drugs in the stage of advanced immunodeficiency AIDS for various reasons, develop additional opportunistic ... ...

    Abstract Background and Objectives : Patients living with HIV (PLWH), especially those diagnosed too late or not receiving treatment with antiretroviral drugs in the stage of advanced immunodeficiency AIDS for various reasons, develop additional opportunistic infections or AIDS-defining diseases that may contribute directly to the death of these patients. Material and Methods : In this work, we focused on disorders of the central nervous system (CNS) by retrospectively analyzing the symptoms, clinical and autopsy diagnoses of patients diagnosed with HIV infection who died in the provincial specialist hospital in the Lower Silesia region in Poland. Results : The autopsy was performed in 27.4% cases. The cause of death was determined to be HIV-related/AIDS-associated in 78% patients. The most common AIDS-defining CNS diseases in our cohort were toxoplasmosis and cryptococcosis. Conslusions : The presented results of the most common causes of changes in the central nervous system among deceased HIV-infected patients are comparable to the results of studies by other scientists cited in the publication.
    Schlagwörter PLWH ; HIV ; death ; central nervous system ; toxoplasmosis ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19

    Elżbieta Kalicińska / Monika Biernat / Justyna Rybka / Aleksander Zińczuk / Justyna Janocha-Litwin / Marta Rosiek-Biegus / Marta Morawska / Anna Waszczuk-Gajda / Joanna Drozd-Sokołowska / Łukasz Szukalski / Marcin Rymko / Paula Jabłonowska / Krzysztof Simon / Tomasz Wróbel

    Journal of Clinical Medicine, Vol 10, Iss 4373, p

    Multicenter Cohort Study

    2021  Band 4373

    Abstract: COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The ... ...

    Abstract COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients.
    Schlagwörter endothelial dysfunction ; EASIX ; COVID-19 ; hematological cancer ; lactate dehydrogenase ; platelet count ; Medicine ; R
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Immunosuppression as a Hallmark of Critical COVID-19

    Elżbieta Kalicińska / Donata Szymczak / Aleksander Zińczuk / Barbara Adamik / Jakub Smiechowicz / Tomasz Skalec / Danuta Nowicka-Suszko / Monika Biernat / Aleksandra Bogucka-Fedorczuk / Justyna Rybka / Adrian Martuszewski / Waldemar Gozdzik / Krzysztof Simon / Tomasz Wróbel

    Cells, Vol 10, Iss 1293, p

    Prospective Study

    2021  Band 1293

    Abstract: The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on the course of COVID-19, and play a role in the clinical outcome of the disease. Here, we performed a comprehensive analysis of peripheral blood lymphocyte ... ...

    Abstract The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on the course of COVID-19, and play a role in the clinical outcome of the disease. Here, we performed a comprehensive analysis of peripheral blood lymphocyte subpopulations in 82 patients with COVID-19, including 31 patients with a critical course of the disease. In COVID-19 patients who required hospitalization we analyzed T cell subsets, including Treg cells, as well as TCRα/β and γ/δ, NK cells, and B cells, during the first two weeks after admission to hospital due to the SARS-CoV-2 infection, with marked reductions in leukocytes subpopulations, especially in critically ill COVID-19 patients. We showed decreased levels of Th, Ts cells, Treg cells (both naïve and induced), TCRα/β and γ/δ cells, as well as CD16+CD56+NK cells in ICU compared to non-ICU COVID-19 patients. We observed impaired function of T and NK cells in critically ill COVID-19 patients with extremely low levels of secreted cytokines. We found that the IL-2/INFγ ratio was the strongest indicator of a critical course of COVID-19, and was associated with fatal outcomes. Our findings showed markedly impaired innate and adaptive responses in critically ill COVID-19 patients, and suggest that the immunosuppressive state in the case of a critical course of SARS-CoV-2 infection might reflect subsequent clinical deterioration and predict a fatal outcome.
    Schlagwörter immunosuppression ; lymphocyte subsets ; T cells ; regulatory T cells ; NK cells ; TCR γ/δ cells ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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