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  1. AU="Alelayan, Hasan"
  2. AU="Geerling, Elizabeth C"
  3. AU="Khan, Sabiya Samim"
  4. AU="Caldwell, Maeve"
  5. AU=Yan Nao
  6. AU="Hiva Kabgani"
  7. AU="Toporcerová, Silva"
  8. AU="Felici, Angelina"
  9. AU="Bai, Bingyao"
  10. AU="Woodhead, Jon D"
  11. AU="Wojnarowicz, Mark W"
  12. AU="Cox, Rebecca Jane"
  13. AU="Huang, Bijun"
  14. AU="Marriage, Keith"
  15. AU=Ren Ziyuan
  16. AU="Tae-Houn Kim"
  17. AU="Mias-Lucquin, Dominique"
  18. AU="Karagiannidis, Artemios G"
  19. AU="Alice H Reis"
  20. AU="Malik, Shahbaz A"
  21. AU=Mittal Rajat AU=Mittal Rajat
  22. AU="Seguin, Rebecca A"
  23. AU="Tinbergen, Jan"
  24. AU="Rodrigues-Díez, Raquel"
  25. AU="Yang, Haihao"

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  1. Artikel ; Online: Can performance status mediate the relationship between therapy-related symptoms and health-related quality of life in children with cancer? A mediation model.

    Alelayan, Hasan / Zhao, Yuxuan / Lin, Kai / Meng, Jiangnan / Huang, Haiying / Liao, Xiaoyan

    European journal of oncology nursing : the official journal of European Oncology Nursing Society

    2024  Band 68, Seite(n) 102513

    Abstract: Purpose: Understanding the interplay among health-related quality of life (HRQoL), therapy-related symptoms, and performance status can offer insights into potential strategies to enhance HRQoL for pediatric cancer patients. This study aimed to examine ... ...

    Abstract Purpose: Understanding the interplay among health-related quality of life (HRQoL), therapy-related symptoms, and performance status can offer insights into potential strategies to enhance HRQoL for pediatric cancer patients. This study aimed to examine the mediating effect of performance status on the relationship between symptom burden and HRQoL in children and adolescents with cancer.
    Method: A cross-sectional study was conducted. Participants were recruited from two tertiary hospitals located in Guangzhou, China. HRQoL, therapy-related symptoms, and performance status were assessed using the DISAKIDS Chronic Generic Measure (DCGM-37), Therapy-Related Symptom Checklist for Children (TRSC-C), and Lansky Play Performance Scale (LPPS), respectively.
    Results: A total of 287 children with cancer (aged 11.08 ± 2.34 years) were included. The DCGM-37 scores were 59.70 ± 9.64. Emotion (56.45 ± 14.56) and physical limitations (58.59 ± 15.38) were the most affected domains. The number of symptoms experienced was 12.49 ± 5.95. The DCGM-37 demonstrated strong negative correlations with the TRSC-C (r = -0.60, P < 0.001) and number of symptoms (r = -0.62, P < 0.001), but mild-to-moderate negative correlations (r -0.16∼ -0.42, P < 0.05) with individual symptoms. The TRSC-C demonstrated an indirect effect on the DCGM-37 via the LPPS (Bootstrap-corrected standardized β = -0.05, 95 % CI -0.10∼ -0.01; SE = 0.02). Additional analysis showed that tripping/falling (OR = 4.02, 95 % CI 2.02-7.98; P < 0.001) and sore mouth (OR = 2.38, 95 % CI 1.56-3.64; P < 0.001) were associated factors for presenting poor performance status in children undergoing acute chemotherapy.
    Conclusions: The accumulated symptom burden, rather than individual symptoms, weighs heavily on the HRQoL. Performance status partially mediated the relationship between symptom burdens and HRQoL among these patients.
    Mesh-Begriff(e) Child ; Adolescent ; Humans ; Quality of Life ; Cross-Sectional Studies ; Neoplasms/therapy ; Emotions ; Checklist ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2024-01-28
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 2017117-1
    ISSN 1532-2122 ; 1462-3889
    ISSN (online) 1532-2122
    ISSN 1462-3889
    DOI 10.1016/j.ejon.2024.102513
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Translation and linguistic validation of the DISABKIDS chronic generic module into simplified Chinese (DCGM-37) for use among children with cancer.

    Alelayan, Hasan / Liang, Lizhu / Ye, Rui / Aldosari, Nasser / Liao, Xiaoyan

    Journal for specialists in pediatric nursing : JSPN

    2022  Band 27, Heft 3, Seite(n) e12374

    Abstract: Purpose: To develop a simplified Chinese version of the DISABKIDS chronic generic module-37 (DCGM-37), and to test the translated measures in children with cancer by employing a cognitive interviewing technique.: Design and methods: The English ... ...

    Abstract Purpose: To develop a simplified Chinese version of the DISABKIDS chronic generic module-37 (DCGM-37), and to test the translated measures in children with cancer by employing a cognitive interviewing technique.
    Design and methods: The English version of DCGM-37 was translated forward and backward into simplified Chinese by bilingual translators, following the guidelines from its copyright holders, which also involved a cultural adaptation component. Twelve Chinese children aged 8-18 years and eight parents were cognitively interviewed.
    Results: The findings support the relevance, comprehensibility, and efficacy of the Chinese version. Consideration was given, and improvements were made, to the language, cultural concerns, and content, which improved functionality and increased validation. The patients/caregivers understood the instructions, questions, and answer choices. Some revisions, however, were made to address patient/caregiver feedback obtained through cognitive interviews. Conceptually and semantically, the simplified Chinese version of the DCGM-37 version was identical to the original. Conclusions The simplified Chinese version of the DCGM-37 was semantically and conceptually equivalent to the English version. Chinese children aged 8 to 18 years were able to comprehend this instrument.
    Conclusions: The simplified Chinese version of the DCGM-37 was semantically and conceptually equivalent to the English version. Chinese children aged 8 to 18 years were able to comprehend this instrument and express their experiences and feelings about their life.
    Practice implications: The simplified Chinese version of the DCGM-37 was translated, and cross-cultural adaptation and validation were performed. Chinese children found the tool easy to use and were able to express their experiences and feelings about their health-related quality of life.
    Mesh-Begriff(e) Child ; China ; Humans ; Language ; Linguistics ; Neoplasms ; Psychometrics ; Quality of Life/psychology ; Reproducibility of Results ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2022-04-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2082595-X
    ISSN 1744-6155 ; 1539-0136 ; 1088-145X
    ISSN (online) 1744-6155
    ISSN 1539-0136 ; 1088-145X
    DOI 10.1111/jspn.12374
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Psychometric validation of the simplified Chinese version of the therapy-related symptom checklist in children with cancer.

    Alelayan, Hasan / Huang, Haiying / Yang, Yiling / Chen, Yingying / Liao, Xiaoyan

    Journal of pediatric nursing

    2022  Band 64, Seite(n) e32–e39

    Abstract: Purpose: To validate a simplified Chinese version of the therapy-related symptom checklist for children (TRSC-C) in children with cancer.: Methods: Reliability was assessed by internal consistency and test-retest coefficients. Dimensionality and ... ...

    Abstract Purpose: To validate a simplified Chinese version of the therapy-related symptom checklist for children (TRSC-C) in children with cancer.
    Methods: Reliability was assessed by internal consistency and test-retest coefficients. Dimensionality and construct validity were clarified using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Pearson's correlation coefficient was calculated between the TRSC-C and the PedsQL 3.0 cancer model (PedsQL 3.0) and the Lansky Play Performance Scale (LPPS) to test concurrent validity. A Student's t-test was used to compare the scores of the simplified Chinese version of the TRSC-C subscales by gender, age groups, and functional status to test sensitivity of the TRSC-C.
    Results: A sample of 170 children with cancer was recruited (11.27 ± 2.31 years). Cronbach's alpha (0.89) and interclass correlation coefficient (0.98) were acceptable. Seven factors with eigenvalues >1 explained 56.86% of the total variances. CFA demonstrated an acceptable model (CFI = 0.93, RMSE = 0.04). Concurrent validity was supported by moderate to high correlations between the TRSC-C and both the PedsQL 3.0 (r = -0.71) and LPPS (r = -0.43). The TRSC-C scores significantly differed by age groups and functional status (effect size 0.40-0.93), indicating adequate sensitivity.
    Conclusion: The simplified Chinese version of the TRSC-C demonstrated acceptable reliability, validity, and sensitivity to support its use in clinical practice and future studies.
    Mesh-Begriff(e) Checklist ; Child ; China ; Humans ; Neoplasms/diagnosis ; Neoplasms/therapy ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2022.01.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Translation and cross-cultural adaptation of the National Health Service Sustainability Model to the Chinese healthcare context.

    Lai, Jie / Maher, Lynne / Li, Chaixiu / Zhou, Chunlan / Alelayan, Hasan / Fu, Jiaqi / Wu, Yanni

    BMC nursing

    2023  Band 22, Heft 1, Seite(n) 124

    Abstract: Background: International attention is being paid to the issue of making evidence sustainable after implementation. Developing an identification model is essential to promote and monitor the sustainability of evidence implementation. However, this model ...

    Abstract Background: International attention is being paid to the issue of making evidence sustainable after implementation. Developing an identification model is essential to promote and monitor the sustainability of evidence implementation. However, this model is not available in Chinese. This study aims to translate the National Health Service Sustainability Model into Chinese and to verify whether the model is adapted to the Chinese healthcare environment.
    Methods: This study follows the translation and validation guidelines developed by Sousa and Rojjanasrirat. The translations include forward and backward translations and their comparison. Expert reviews were used to validate the content validity of the Chinese version of the National Health Service sustainability model. Cognitive interviews were used to assess the validity of the language in the Chinese setting.
    Results: The translation was conducted by a bilingual research team and took 12 months. Expert reviews were undertaken with eight experts, and cognitive interviews with six participants. The content validity of the model is excellent, but at least 20% of the experts still felt that items one, three, five and nine needed refinements. In the cognitive interviews, most items, instructions and response options were well understood by the participants responsible for the evidence-based practice project. However, some language issues were still identified in items one, three, four, five, seven, nine, and ten. Participants reported that the sustainability results of the model assessment were consistent with their previous judgments of the items. Based on the expert review and interview results, items one, three, four, five, seven, nine and ten require further refinement. In summary, seven of the ten items have been amended.
    Conclusions: This study provides insight into how the National Health Service sustainability model can be used in the Chinese healthcare setting and paves the way for future large-scale psychometric testing.
    Sprache Englisch
    Erscheinungsdatum 2023-04-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-023-01293-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Assessing health-related quality of life in Chinese children and adolescents with cancer: validation of the DISABKIDS chronic generic module (DCGM-37).

    Alelayan, Hasan / Liang, Lizhu / Ye, Rui / Meng, Jiangnan / Liao, Xiaoyan

    BMC cancer

    2021  Band 21, Heft 1, Seite(n) 204

    Abstract: Background: With increasing cancer incidence and decreasing cancer mortality, there is a growing need for a valid and culturally adapted tool to measure health-related quality of life in children with cancer. This study validated the DISABKIDS Chronic ... ...

    Abstract Background: With increasing cancer incidence and decreasing cancer mortality, there is a growing need for a valid and culturally adapted tool to measure health-related quality of life in children with cancer. This study validated the DISABKIDS Chronic Generic Module (DCGM-37) in Chinese children and adolescents with cancer.
    Methods: The DCGM-37 was translated and adapted for use in China following the guidelines from its copyright holders. In total, 140 children and adolescents with cancer and their guardians were included in this cross-sectional study. Internal consistency and test-retest reliability were evaluated. Convergent validity was examined using Pearson correlation between the DCGM-37 and the PedsQL 4.0 Generic Core Scale. Dimensionality was clarified using exploratory factor analysis. Discriminant validity was evaluated by comparing DCGM-37 scores by sex, age, family income, and clinical characteristics.
    Results: Internal consistency (Cronbach's alpha 0.91) and test-retest reliability were good (intraclass correlation coefficient 0.87, 95% confidence interval 0.73-0.94). Strong correlations between the DCGM-37 and the PedsQL 4.0 (r = 0.83) suggest good convergent validity. Six factors explained 51.94% of the total variance. Children with leukemia scored higher than those with sarcoma in all subscales (effect size ranged from 0.39 to 0.83), especially the "social exclusion" subscales (effect size 0.83). Small to moderate differences (effect size ranged from 0.38 to 0.58) were observed by sex, age, and family income. Neither floor nor ceiling effects were observed.
    Conclusion: The DCGM-37 is reliable and valid for measuring health-related quality of life in Chinese children and adolescents with cancer.
    Mesh-Begriff(e) Activities of Daily Living ; Adolescent ; Child ; China/epidemiology ; Cross-Sectional Studies ; Emotions ; Female ; Humans ; Male ; Neoplasms/epidemiology ; Neoplasms/nursing ; Neoplasms/psychology ; Parents/psychology ; Patients/psychology ; Proxy ; Psychology, Adolescent ; Psychology, Child ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Retrospective Studies ; Self Report ; Social Behavior ; Socioeconomic Factors ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2021-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-021-07910-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The Therapy-Related Symptom Checklist for Children as a Method for Monitoring Symptoms in Chinese Children With Cancer: Linguistic Validation and Cross-Cultural Adaptation.

    Alelayan, Hasan / Wen, Huangliang / Li, Hui / Ge, Jing / Han, Wei / Liao, Xiaoyan

    Pain management nursing : official journal of the American Society of Pain Management Nurses

    2022  Band 23, Heft 6, Seite(n) 855–860

    Abstract: Background: Children with cancer commonly experience severe symptoms. These may be managed by routine monitoring of their occurrence andseverity using a validated tool.: Aim: This study aimed to translate and culturally validate a simplified Chinese ... ...

    Abstract Background: Children with cancer commonly experience severe symptoms. These may be managed by routine monitoring of their occurrence andseverity using a validated tool.
    Aim: This study aimed to translate and culturally validate a simplified Chinese version of the Therapy-Related Symptom Checklist for Children (TRSC-C).
    Design: Qualitative method.
    Participants and setting: We recruited children with cancer from a pediatric department of a tertiary hospital in Guangzhou, China.
    Methods: We used forward and backward translation by bilingual translators and standardized cognitive interviewing for linguistic validation and to check cross-cultural adaptation. A panel of experts assessed content validity.
    Results: Agreement was reached on cultural applicability, suitability for intended purpose, and clarification of the pre-test version. The content validity was good (indices ranged from 0.80-0.90). Fifteen Chinese children with cancer (aged 8-18 years) were included in cognitive interviews. The cognitive debriefing showed that the instrument was easy to understand and appropriate for monitoring symptoms in children with cancer. Some words were adjusted following participants' comments.
    Conclusions: The simplified Chinese version of the TRSC-C was semantically and conceptually equivalent to the original version. Children between 8-18 years old can use this instrument to report symptoms and share their experiences about their disease and treatment.
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2213260-0
    ISSN 1532-8635 ; 1524-9042
    ISSN (online) 1532-8635
    ISSN 1524-9042
    DOI 10.1016/j.pmn.2021.12.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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