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  1. Article ; Online: The Activity of Red Nigerian Propolis and Some of Its Components against

    Alenezi, Samya S / Alenezi, Naif D / Ebiloma, Godwin U / Natto, Manal J / Ungogo, Marzuq A / Igoli, John O / Ferro, Valerie A / Gray, Alexander I / Fearnley, James / Koning, Harry P de / Watson, David G

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 2

    Abstract: Propolis is a resin that is gathered by bees from exudates produced by various plants. Its exact chemical composition depends on the plants available near the hive. Bees use propolis to coat the surfaces of the hive, where it acts as an anti-infective. ... ...

    Abstract Propolis is a resin that is gathered by bees from exudates produced by various plants. Its exact chemical composition depends on the plants available near the hive. Bees use propolis to coat the surfaces of the hive, where it acts as an anti-infective. Regardless of the chemical composition of propolis, it is always anti-protozoal, probably because protozoan parasites, particularly
    MeSH term(s) Humans ; Animals ; Trypanosoma brucei brucei ; Trypanosoma congolense ; Propolis/pharmacology ; Propolis/chemistry ; Anti-Infective Agents ; Nigeria ; Trypanosomiasis, African/drug therapy
    Chemical Substances Propolis (9009-62-5) ; Anti-Infective Agents
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes.

    Alenezi, Samya S / Alenezi, Naif D / Ebiloma, Godwin U / Natto, Manal J / Ungogo, Marzuq A / Igoli, John O / Ferro, Valerie A / Gray, Alexander I / Fearnley, James / de Koning, Harry P / Watson, David G

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 5

    Abstract: Profiling a propolis sample from Papua New Guinea (PNG) using high-resolution mass spectrometry indicated that it contained several triterpenoids. Further fractionation by column chromatography and medium-pressure liquid chromatography (MPLC) followed by ...

    Abstract Profiling a propolis sample from Papua New Guinea (PNG) using high-resolution mass spectrometry indicated that it contained several triterpenoids. Further fractionation by column chromatography and medium-pressure liquid chromatography (MPLC) followed by nuclear magnetic resonance spectroscopy (NMR) identified 12 triterpenoids. Five of these were obtained pure and the others as mixtures of two or three compounds. The compounds identified were: mangiferonic acid, ambonic acid, isomangiferolic acid, ambolic acid, 27-hydroxyisomangiferolic acid, cycloartenol, cycloeucalenol, 24-methylenecycloartenol, 20-hydroxybetulin, betulin, betulinic acid and madecassic acid. The fractions from the propolis and the purified compounds were tested in vitro against
    MeSH term(s) Propolis
    Chemical Substances Propolis (9009-62-5)
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27051622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples.

    Alenezi, Samya S / Natto, Manal J / Igoli, John O / Gray, Alexander I / Fearnley, James / Fearnley, Hugo / de Koning, Harry P / Watson, David G

    International journal for parasitology. Drugs and drug resistance

    2020  Volume 14, Page(s) 201–207

    Abstract: A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were ...

    Abstract A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were characterized based on their spectral and physical data and identified as 6-(1,1-dimethylallyl) pinocembrin and 5-hydroxy-4″,4″-dimethyl-5″-methyl-5″-H-dihydrofuranol [2″,3″,6,7] flavanone. The two compounds, together with the propolis extracts and fractions, were assayed against a standard drug-sensitive strain of T. b. brucei (s427 wild-type), multi-drug resistant-resistant T. b. brucei (B48), drug-sensitive T. congolense (1L300) and a derived diminazene-resistant T. congolense strain (6C3), and for toxicity against U947 human cells and RAW 246.7 murine cells. Activity against T. b. brucei was higher than against T. congolense. Interestingly, the Tanzanian propolis extract was found to be more active than its fractions and purified compounds in these assays, with an IC
    MeSH term(s) Animals ; Antiprotozoal Agents ; Flavanones ; Humans ; Mice ; Propolis ; Trypanocidal Agents ; Trypanosoma ; Trypanosoma brucei brucei
    Chemical Substances Antiprotozoal Agents ; Flavanones ; Trypanocidal Agents ; Propolis (9009-62-5)
    Language English
    Publishing date 2020-10-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2751132-7
    ISSN 2211-3207 ; 2211-3207
    ISSN (online) 2211-3207
    ISSN 2211-3207
    DOI 10.1016/j.ijpddr.2020.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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