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  1. Article ; Online: Robot-Assisted Treatment of Symptomatic Lymphocele Postradical Prostatectomy and Lymphadenectomy in the Era or Robotic Surgery:

    Di Gianfrancesco, Luca / Alessandro, Crestani / Paolo, Corsi / Davide, De Marchi / Eugenio, Miglioranza / Angelo, Porreca

    Technology in cancer research & treatment

    2023  Volume 22, Page(s) 15330338221145248

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Male ; Humans ; Robotic Surgical Procedures/adverse effects ; Robotics ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/complications ; Pelvis/surgery ; Lymph Node Excision/adverse effects ; Lymphocele/etiology ; Lymphocele/surgery ; Prostatectomy/adverse effects
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146365-7
    ISSN 1533-0338 ; 1533-0346
    ISSN (online) 1533-0338
    ISSN 1533-0346
    DOI 10.1177/15330338221145248
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  2. Article ; Online: The Role of Checkpoint Inhibitor Expression Directly on Exfoliated Cells from Bladder Cancer

    Luca Di Gianfrancesco / Alessandro Crestani / Antonio Amodeo / Paolo Corsi / Davide De Marchi / Eugenio Miglioranza / Giuliana Lista / Francesca Simonetti / Gian Maria Busetto / Martina Maggi / Francesco Pierconti / Maurizio Martini / Isabella Monia Montagner / Debora Tormen / Antonio Scapinello / Filippo Marino / Angelo Porreca

    Diagnostics, Vol 13, Iss 3119, p

    A Narrative Review

    2023  Volume 3119

    Abstract: Bladder cancer (BCa) is a common type of cancer that affects the urinary bladder. The early detection and management of BCa is critical for successful treatment and patient outcomes. In recent years, researchers have been exploring the use of biomarkers ... ...

    Abstract Bladder cancer (BCa) is a common type of cancer that affects the urinary bladder. The early detection and management of BCa is critical for successful treatment and patient outcomes. In recent years, researchers have been exploring the use of biomarkers as a non-invasive and effective tool for the detection and monitoring of BCa. One such biomarker is programmed death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells and plays a crucial role in the evasion of the immune system. Studies have shown that the PD-L1 expression is higher in BCa tumors than in healthy bladder tissue. Additionally, PD-L1 expression might even be detected in urine samples in BCa patients, in addition to the examination of a histological sample. The technique is being standardized and optimized. We reported how BCa patients had higher urinary PD-L1 levels than controls by considering BCa tumors expressing PD-L1 in the tissue specimen. The expression of PD-L1 in urinary BCa cells might represent both a diagnostic and a prognostic tool, with the perspective that the PD-L1 expression of exfoliate urinary cells might reveal and anticipate eventual BCa recurrence or progression. Further prospective and longitudinal studies are needed to assess the expression of PD-L1 as a biomarker for the monitoring of BCa patients. The use of PD-L1 as a biomarker for the detection and monitoring of BCa has the potential to significantly improve patient outcomes by allowing for earlier detection and more effective management of the disease.
    Keywords bladder cancer ; PD-L1 ; urinary biomarker ; diagnostic tool ; prognostic tool ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Antegrade scrotal sclerotherapy of internal spermatic veins for varicocele treatment

    Alessandro Crestani / Gianluca Giannarini / Mattia Calandriello / Marta Rossanese / Mariangela Mancini / Giacomo Novara / Vincenzo Ficarra

    Asian Journal of Andrology, Vol 18, Iss 2, Pp 292-

    technique, complications, and results

    2016  Volume 295

    Abstract: Varicocele repair is mainly indicated in young adult patients with clinical palpable varicocele and abnormal semen parameters. Varicocele treatment is associated with a significant improvement in sperm concentration, motility, morphology, and pregnancy ... ...

    Abstract Varicocele repair is mainly indicated in young adult patients with clinical palpable varicocele and abnormal semen parameters. Varicocele treatment is associated with a significant improvement in sperm concentration, motility, morphology, and pregnancy rate. Antegrade scrotal sclerotherapy (ASS) represented one of the main alternatives to the traditional inguinal or suprainguinal surgical ligation. This article reviews the use of ASS for varicocele treatment. We provide a brief overview of the history of the procedure and present our methods used in ASS. In addition, we review complication and success of ASS, including our own retrospective data of treating 674 patients over the last 17 years. Herein, we analyzed step by step the ASS technique and described our results with an original modified technique with a long follow-up. Between December 1997 and December 2014, we performed 674 ASS. Mean operative time was 14 min (range 9 to 50 min). No significant intraoperative complications were reported. Within 90 days from the procedure, postoperative complications were recorded in overall 49 (7.2%) patients. No major complications were recorded. A persistent/recurrent varicocele was detected in 40 (5.9%) cases. In 32/40 (80%) cases, patients showed preoperative grade III varicoceles. In patients with a low sperm number before surgery, sperm count improved from 13 × 10 6 to 21 × 10 6 ml−1 (P < 0.001). The median value of the percentage of progressive motile forms at 1 h improved from 25% to 45% (P < 0.001). Percentage of normal forms increased from 17% before surgery to 35% 1 year after the procedure (P < 0.001). In the subgroup of the 168 infertile patients, 52 (31%) fathered offspring at a 12-month-minimum follow-up. Therefore, ASS is an effective minimal invasive treatment for varicocele with low recurrence/persistence rate.
    Keywords antegrade scrotal sclerotherapy; male infertility; outcomes; varicocele ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Medknow Publications and Media Pvt Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Anesthesiologic Effects of Transperitoneal Versus Extraperitoneal Approach During Robot-Assisted Radical Prostatectomy

    Fabrizio Dal Moro / Alessandro Crestani / Claudio Valotto / Andrea Guttilla / Rodolfo Soncin / Angelo Mangano / Filiberto Zattoni

    International Brazilian Journal of Urology, Vol 41, Iss 3, Pp 466-

    Results of a Prospective Randomized Study

    2015  Volume 472

    Abstract: ... ABSTRACT ... Objectives: To compare the effects of CO 2 insufflation on hemodynamics and oxygen levels and on acid-base level during Robot-Assisted Radical Prostatectomy (RARP) with transperitoneal (TP) versus extra-peritoneal (EP) accesses. ... ...

    Abstract ABSTRACT <sec> Objectives: To compare the effects of CO 2 insufflation on hemodynamics and oxygen levels and on acid-base level during Robot-Assisted Radical Prostatectomy (RARP) with transperitoneal (TP) versus extra-peritoneal (EP) accesses. </sec><sec> Materials and Methods: Sixty-two patients were randomly assigned to TP (32) and EP (30) to RARP. Pre-operation data were collected for all patients. Hemodynamic, respiratory and blood acid-base parameters were measured at the moment of induction of anesthesia (T0), after starting CO 2 insuffation (T1), and at 60 (T2) and 120 minutes (T3) after insufflation. In all cases, the abdominal pressure was set at 15 mmHg. Complications were reported according to the Clavien-Dindo classification. Student's two–t-test, with a significance level set at p<0.05, was used to compare categorical values between groups. The Mann-Whitney U-test was used to compare the median values of two nonparametric continuous variables. </sec><sec> Results: The demographic characteristics of the patients in both groups were statistically comparable. Analysis of intra-operative anesthesiologic parameters showed that partial CO 2 pressure during EP was significantly higher than during TP, with a consequent decrease in arterial pH. Other parameters analysed were similar in the two groups. Postoperative complications were comparable between groups. The most important limitations of this study were the small size of the patient groups and the impossibility of maintaining standard abdominal pressure throughout the operational phases, despite attempts to regulate it. </sec><sec> Conclusions: This prospective randomized study demonstrates that, from the anesthesiologic viewpoint, during RARP the TP approach is preferable to EP, because of lower CO 2 reabsorption and risk of acidosis. </sec>
    Keywords Prostatectomy ; Robotic Surgical Procedures ; Laparoscopy ; Anesthesiology ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Urologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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