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  1. Article: The culture of gut explants: A model to study the mucosal response

    Russo, Ilaria / Alessandro Puzziello / Carolina Ciacci / Chiara Del Giorno / Cristina Bucci / Fabiana Zingone / Paola Iovino / Pio Zeppa

    Journal of Immunological Methods. 2016 Nov., v. 438

    2016  

    Abstract: Various experimental model designs have been used to analyze the inflammatory pathways in human gastrointestinal illnesses. Traditionally, analytical techniques and animal models are popular experimental tools to study the inflammation process of ... ...

    Abstract Various experimental model designs have been used to analyze the inflammatory pathways in human gastrointestinal illnesses. Traditionally, analytical techniques and animal models are popular experimental tools to study the inflammation process of intestinal diseases. However, the comparison of results between animal and human models is difficult for the inconsistency of outcomes. Although there are different animal models for studying the intestinal diseases, none of them fully represents the physiological and environmental conditions typical of the human species. Also, there is currently a concerted effort to decrease the experimental use of animals. On the converse, experimental protocols using the culture of gut mucosa had become popular with the advent of endoscopy which allows explanting multiple fragments from the intestine. The peculiar characteristic of this model is the ability to preserve in vitro the features that we found in vivo, thus also the response to various stimuli that differs from person to person.The aim of the present paper is to provide a review of some of the possible uses of the organ intestinal mucosa culture.
    Keywords analytical methods ; animal models ; digestive system diseases ; endoscopy ; environmental factors ; explants ; humans ; inflammation ; intestinal mucosa
    Language English
    Dates of publication 2016-11
    Size p. 1-10.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2016.07.004
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 795: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules

    Marotta, Vincenzo / Alessandro Puzziello / Annamaria Colao / Antongiulio Faggiano / Claudio Gambardella / Domenico La Sala / Francesco Barbato / Giacomo Russo / Giovanni Docimo / Lucia Grumetto / Maria Grazia Chiofalo / Marica Grasso / Raffaella D'Anna / Stefania Masone

    Chemosphere. 2019 Mar., v. 218

    2019  

    Abstract: Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of ... ...

    Abstract Pollutants represent potential threats to the human health, being ubiquitous in the environment and exerting toxicity even at low doses. This study aims at investigating the role of fifteen multiclass organic pollutants, assumed as markers of environmental pollution, most of which exerting endocrine-disrupting activity, in thyroid cancer development. The increasing incidence of differentiated thyroid cancer (DTC) may be related to the rising production and environmental dissemination of pollutants.Fifty-five patients, twenty-seven with diagnosis of benign thyroid nodules and twenty-eight suffering from differentiated thyroid cancer, were enrolled and the concentration levels of seven bisphenols, two phthalates (i.e. di(2-ethylhexyl) phthalate (DEHP) and its main metabolite, mono-(2-ethyl-hexyl) phthalate) (MEHP)), two chlorobenzenes, (1,4-dichlorobenzene and 1,2,4,5-tetrachlorobenzene), and 3 phenol derivatives (2-chlorophenol, 4- nonylphenol, and triclosan) were determined in their serum by using a validated analytical method based on high performance liquid chromatography with ultraviolet tandem fluorescence detection.A significant relationship was found between malignancy and the detection in the serum of both bisphenol AF and DEHP. Indeed, their presence confers a more than fourteen times higher risk of developing differentiated thyroid cancer. Relationship between these two pollutants and the risk of malignancy was dose-independent and not mediated by higher thyroid stimulating hormone levels. Even if a conclusive evidence cannot still be drawn and larger prospective studies are needed, the exposure to low doses of environmental endocrine-disrupting contaminants can be considered consistent with the development of thyroid cancer.
    Keywords 2-chlorophenol ; blood serum ; carcinogenesis ; fluorescence ; high performance liquid chromatography ; human health ; humans ; metabolites ; nonylphenols ; patients ; phenol ; phthalates ; pollutants ; pollution ; prospective studies ; risk ; thyroid neoplasms ; thyrotropin ; toxicity ; triclosan
    Language English
    Dates of publication 2019-03
    Size p. 885-894.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2018.11.084
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Surgery in COVID-19 patients

    Federico Coccolini / Gennaro Perrone / Massimo Chiarugi / Francesco Di Marzo / Luca Ansaloni / Ildo Scandroglio / Pierluigi Marini / Mauro Zago / Paolo De Paolis / Francesco Forfori / Ferdinando Agresta / Alessandro Puzziello / Domenico D’Ugo / Elena Bignami / Valentina Bellini / Pietro Vitali / Flavia Petrini / Barbara Pifferi / Francesco Corradi /
    Antonio Tarasconi / Vittoria Pattonieri / Elena Bonati / Luigi Tritapepe / Vanni Agnoletti / Davide Corbella / Massimo Sartelli / Fausto Catena

    World Journal of Emergency Surgery, Vol 15, Iss 1, Pp 1-

    operational directives

    2020  Volume 7

    Abstract: Abstract The current COVID-19 pandemic underlines the importance of a mindful utilization of financial and human resources. Preserving resources and manpower is paramount in healthcare. It is important to ensure the ability of surgeons and specialized ... ...

    Abstract Abstract The current COVID-19 pandemic underlines the importance of a mindful utilization of financial and human resources. Preserving resources and manpower is paramount in healthcare. It is important to ensure the ability of surgeons and specialized professionals to function through the pandemic. A conscious effort should be made to minimize infection in this sector. A high mortality rate within this group would be detrimental. This manuscript is the result of a collaboration between the major Italian surgical and anesthesiologic societies: ACOI, SIC, SICUT, SICO, SICG, SIFIPAC, SICE, and SIAARTI. We aim to describe recommended clinical pathways for COVID-19-positive patients requiring acute non-deferrable surgical care. All hospitals should organize dedicated protocols and workforce training as part of the effort to face the current pandemic.
    Keywords Coronavirus ; COVID-19 ; Epidemic ; Pandemic ; Mass casualties ; Management ; Surgery ; RD1-811 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Acute cholecystitis during COVID-19 pandemic

    Fabio Cesare Campanile / Mauro Podda / Alberto Arezzo / Emanuele Botteri / Alberto Sartori / Mario Guerrieri / Elisa Cassinotti / Irnerio Muttillo / Marcello Pisano / Riccardo Brachet Contul / Giancarlo D’Ambrosio / Diego Cuccurullo / Carlo Bergamini / Marco Ettore Allaix / Valerio Caracino / Wanda Luisa Petz / Marco Milone / Gianfranco Silecchia / Gabriele Anania /
    Antonino Agrusa / Salomone Di Saverio / Salvatore Casarano / Caterina Cicala / Piero Narilli / Sara Federici / Massimo Carlini / Alessandro Paganini / Paolo Pietro Bianchi / Adelona Salaj / Andrea Mazzari / Roberto Luca Meniconi / Alessandro Puzziello / Giovanni Terrosu / Belinda De Simone / Federico Coccolini / Fausto Catena / Ferdinando Agresta

    World Journal of Emergency Surgery, Vol 15, Iss 1, Pp 1-

    a multisocietary position statement

    2020  Volume 5

    Abstract: Abstract Following the spread of the infection from the new SARS-CoV2 coronavirus in March 2020, several surgical societies have released their recommendations to manage the implications of the COVID-19 pandemic for the daily clinical practice. The ... ...

    Abstract Abstract Following the spread of the infection from the new SARS-CoV2 coronavirus in March 2020, several surgical societies have released their recommendations to manage the implications of the COVID-19 pandemic for the daily clinical practice. The recommendations on emergency surgery have fueled a debate among surgeons on an international level. We maintain that laparoscopic cholecystectomy remains the treatment of choice for acute cholecystitis, even in the COVID-19 era. Moreover, since laparoscopic cholecystectomy is not more likely to spread the COVID-19 infection than open cholecystectomy, it must be organized in such a way as to be carried out safely even in the present situation, to guarantee the patient with the best outcomes that minimally invasive surgery has shown to have.
    Keywords Acute cholecystitis ; Emergency surgery ; COVID-19 pandemic ; New coronavirus ; Position statement ; Surgery ; RD1-811 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A pandemic recap

    Federico Coccolini / Enrico Cicuttin / Camilla Cremonini / Dario Tartaglia / Bruno Viaggi / Akira Kuriyama / Edoardo Picetti / Chad Ball / Fikri Abu-Zidan / Marco Ceresoli / Bruno Turri / Sumita Jain / Carlo Palombo / Xavier Guirao / Gabriel Rodrigues / Mahir Gachabayov / Fernando Machado / Lostoridis Eftychios / Souha S. Kanj /
    Isidoro Di Carlo / Salomone Di Saverio / Vladimir Khokha / Andrew Kirkpatrick / Damien Massalou / Francesco Forfori / Francesco Corradi / Samir Delibegovic / Gustavo M. Machain Vega / Massimo Fantoni / Demetrios Demetriades / Garima Kapoor / Yoram Kluger / Shamshul Ansari / Ron Maier / Ari Leppaniemi / Timothy Hardcastle / Andras Vereczkei / Evika Karamagioli / Emmanouil Pikoulis / Mauro Pistello / Boris E. Sakakushev / Pradeep H. Navsaria / Rita Galeiras / Ali I. Yahya / Aleksei V. Osipov / Evgeni Dimitrov / Krstina Doklestić / Michele Pisano / Paolo Malacarne / Paolo Carcoforo / Maria Grazia Sibilla / Igor A. Kryvoruchko / Luigi Bonavina / Jae Il Kim / Vishal G. Shelat / Jacek Czepiel / Emilio Maseda / Sanjay Marwah / Mircea Chirica / Giandomenico Biancofiore / Mauro Podda / Lorenzo Cobianchi / Luca Ansaloni / Paola Fugazzola / Charalampos Seretis / Carlos Augusto Gomez / Fabio Tumietto / Manu Malbrain / Martin Reichert / Goran Augustin / Bruno Amato / Alessandro Puzziello / Andreas Hecker / Angelo Gemignani / Arda Isik / Alessandro Cucchetti / Mirco Nacoti / Doron Kopelman / Cristian Mesina / Wagih Ghannam / Offir Ben-Ishay / Sameer Dhingra / Raul Coimbra / Ernest E. Moore / Yunfeng Cui / Martha A. Quiodettis / Miklosh Bala / Mario Testini / Jose Diaz / Massimo Girardis / Walter L. Biffl / Matthias Hecker / Ibrahima Sall / Ugo Boggi / Gabriele Materazzi / Lorenzo Ghiadoni / Junichi Matsumoto / Wietse P. Zuidema / Rao Ivatury / Mushira A. Enani / Andrey Litvin / Majdi N. Al-Hasan / Zaza Demetrashvili / Oussama Baraket / Carlos A. Ordoñez / Ionut Negoi / Ronald Kiguba / Ziad A. Memish / Mutasim M. Elmangory / Matti Tolonen / Korey Das / Julival Ribeiro / Donal B. O’Connor / Boun Kim Tan / Harry Van Goor / Suman Baral / Belinda De Simone / Davide Corbella / Pietro Brambillasca / Michelangelo Scaglione / Fulvio Basolo / Nicola De’Angelis / Cino Bendinelli / Dieter Weber / Leonardo Pagani / Cinzia Monti / Gianluca Baiocchi / Massimo Chiarugi / Fausto Catena / Massimo Sartelli

    World Journal of Emergency Surgery, Vol 16, Iss 1, Pp 1-

    lessons we have learned

    2021  Volume 8

    Abstract: Abstract On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white ...

    Abstract Abstract On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.
    Keywords Pandemia ; International ; Thoughts ; Reflection ; Ethics ; Biology ; Surgery ; RD1-811 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Subject code 360
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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