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  1. Article ; Online: Early Onset of Tardive Dyskinesia in an Antipsychotic-Naive Patient Treated With Low-Dose Cariprazine.

    Tsamakis, Konstantinos / Pantazidi, Maria / Alevyzakis, Evangelos / Tsiptsios, Dimitrios / Mueller, Christoph / Smyrnis, Nikolaos / Rizos, Emmanouil N

    Journal of clinical psychopharmacology

    2024  Volume 44, Issue 2, Page(s) 189–191

    MeSH term(s) Humans ; Antipsychotic Agents/adverse effects ; Tardive Dyskinesia/chemically induced ; Piperazines/therapeutic use ; Dyskinesia, Drug-Induced/etiology
    Chemical Substances Antipsychotic Agents ; cariprazine (F6RJL8B278) ; Piperazines
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1664: Show issues Location:
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  2. Article: Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis.

    Tsamakis, Konstantinos / Galinaki, Sofia / Alevyzakis, Evangelos / Hortis, Ioannis / Tsiptsios, Dimitrios / Kollintza, Evangelia / Kympouropoulos, Stylianos / Triantafyllou, Konstantinos / Smyrnis, Nikolaos / Rizos, Emmanouil

    Microorganisms

    2022  Volume 10, Issue 6

    Abstract: There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut- ... ...

    Abstract There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut-brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.
    Language English
    Publishing date 2022-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis

    Tsamakis, Konstantinos / Galinaki, Sofia / Alevyzakis, Evangelos / Hortis, Ioannis / Tsiptsios, Dimitrios / Kollintza, Evangelia / Kympouropoulos, Stylianos / Triantafyllou, Konstantinos / Smyrnis, Nikolaos / Rizos, Emmanouil

    Microorganisms. 2022 May 29, v. 10, no. 6

    2022  

    Abstract: There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut– ... ...

    Abstract There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.
    Keywords autism ; bipolar disorder ; cognition ; humans ; intestinal microorganisms ; microbiome ; pathogenesis ; prognosis ; schizophrenia
    Language English
    Dates of publication 2022-0529
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061121
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: COVID-19 and post-traumatic stress disorder: The perfect 'storm' for mental health (Review).

    Giannopoulou, Ioanna / Galinaki, Sofia / Kollintza, Evangelia / Adamaki, Maria / Kympouropoulos, Stylianos / Alevyzakis, Evangelos / Tsamakis, Konstantinos / Tsangaris, Iraklis / Spandidos, Demetrios A / Siafakas, Nikolaos / Zoumpourlis, Vassilios / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2021  Volume 22, Issue 4, Page(s) 1162

    Abstract: Since its outbreak, in December, 2019, in the Chinese city of Wuhan, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into an ongoing global pandemic. Due to the novel antigenic ... ...

    Abstract Since its outbreak, in December, 2019, in the Chinese city of Wuhan, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into an ongoing global pandemic. Due to the novel antigenic properties of this virus, the world population could not develop immunity effectively and this led to the subsequent spread of COVID-19. This caused an unprecedented emergency situation with significant negative effects on health and well-being both on an individual and societal level. Apart from health, economic and social consequences, the impact of this pandemic on mental health is increasingly being reported in the scientific literature. The present review aimed to provide a comprehensive discussion of the possible neurological and neuropsychiatric manifestations of SARS-CoV-2, together with the related underlying molecular pathways. In addition, the present review focused on populations which are at a higher risk of developing psychiatric disturbances due to the COVID-19 pandemic and discussed possible routes of clinical management and therapeutics to minimize the burden associated with psychiatric disorders. Moreover, research findings exploring the prevalence of COVID-19-related post-traumatic stress disorder (PTSD) symptoms across vulnerable groups, including children, adolescents and COVID-19 survivors are presented, with particular emphasis on those with severe disease who required hospitalization and/or intensive care unit admission. Based on the available literature, the identification of potential determinants associated with PTSD across the different populations is underlined. Lessons learnt from the pandemics across the globe together with the ongoing research on COVID-19 and its impact on mental health, highlight the utmost importance for evidence-based, proactive and targeted interventions in high-risk groups aiming to mitigate the risks and manage vulnerabilities.
    Language English
    Publishing date 2021-08-11
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.10596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association of antipsychotic use with raised eosinophil count.

    Tsamakis, Konstantinos / Mueller, Christoph / Hortis, Ioannis / Kallergi, Maria / Tolos, Ioannis / Alevyzakis, Evangelos / Siafakas, Nikolaos / Ouranidis, Andreas / Tsiptsios, Dimitrios / Kympouropoulos, Stylianos / Spandidos, Demetrios A / Smyrnis, Nikolaos / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2021  Volume 21, Issue 5, Page(s) 513

    Abstract: The current study aimed to assess the possibility of an association between first and second generation antipsychotic medication and raised eosinophil count. A total of 22 in-patients at the psychiatric unit of the University General Hospital 'Attikon', ... ...

    Abstract The current study aimed to assess the possibility of an association between first and second generation antipsychotic medication and raised eosinophil count. A total of 22 in-patients at the psychiatric unit of the University General Hospital 'Attikon', a tertiary hospital, were included in the present study. Patients had received antipsychotic monotherapy and did not have any co-morbidities or require additional treatments. Patients were monitored weekly and their eosinophil count was assessed. One-way ANOVA and summary measures analysis were applied to study the effect of time and medication type on the absolute eosinophil concentration (or relative percentage) for each patient. The differences in mean eosinophil concentrations or relative percentage by patient and time were also assessed. An increase in the absolute concentration and the relative percentage of eosinophils over time was observed in patients receiving Olanzapine, Haloperidol and Aripiprazole. However, there was no difference between individual medications. In conclusion, antipsychotics may be associated with increased eosinophil count over time; however, larger studies involving more patients and a longer follow-up are required to reach a definitive conclusion.
    Language English
    Publishing date 2021-03-19
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.9944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risperidone-induced acute eosinophilic pneumonia.

    Rizos, Emmanouil / Tsigkaropoulou, Evdoxia / Lambrou, Panagiota / Kanakaki, Maria / Chaniotou, Aikaterini / Alevyzakis, Evangelos / Liappas, Ioannis

    In vivo (Athens, Greece)

    2013  Volume 27, Issue 5, Page(s) 651–653

    Abstract: Background: Acute eosinophilic pneumonia (AEP) is a severe syndrome which can be induced for many reasons, including drugs. AEP has rarely been associated with first-generation antipsychotics and never been reported after use of second-generation ... ...

    Abstract Background: Acute eosinophilic pneumonia (AEP) is a severe syndrome which can be induced for many reasons, including drugs. AEP has rarely been associated with first-generation antipsychotics and never been reported after use of second-generation antipsychotics, such as risperidone.
    Case report: We report a case of a 64-year-old man with a medical history of alchoholism and paranoid symptoms, treated with risperidone at low doses. Following risperidone medication, he presented with respiratory distress. Bronchoalveolar lavage (BAL) specimen was indicated of AEP. All evidence indicated risperidone as the most probable causal factor. The syndrome rapidly resolved after discontinuation of the drug.
    Discussion: Pathophysiological mechanisms implicated in the development of AEP in our patient seem to be associated with eotaxin and serotonin eosinophilic-specific chemoattracting action, through the serotoninergic action of risperidone.
    Conclusion: To our knowledge, this is the first case report of a clinical adverse reaction of AEP from an atypical antipsychotic agent (risperidone).
    MeSH term(s) Acute Disease ; Antipsychotic Agents/adverse effects ; Humans ; Male ; Middle Aged ; Pulmonary Eosinophilia/chemically induced ; Pulmonary Eosinophilia/diagnosis ; Risperidone/adverse effects
    Chemical Substances Antipsychotic Agents ; Risperidone (L6UH7ZF8HC)
    Language English
    Publishing date 2013-09
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Acute Necrotizing Pancreatitis Following Olanzapine Treatment and 759C/T Polymorphism of HTR2C Gene: A Case Report.

    Rizos, Emmanouil / Tournikioti, Kalliopi / Alevyzakis, Evangelos / Peppa, Melpomeni / Papazaxos, Konstantinos / Zorbas, Georgios / Michopoulos, Ioannis / Liappas, Ioannis / Papageorgiou, Charalampos / Douzenis, Athanasios

    In vivo (Athens, Greece)

    2015  Volume 29, Issue 5, Page(s) 529–531

    Abstract: Acute pancreatitis can be attributed to numerous potential causes, such as alcohol abuse, chololithiasis, infection, lesions, tumors, hypercalcemia, hyperlipidemia, and medications. Among psychotropic medications, the use of some atypical antipsychotics, ...

    Abstract Acute pancreatitis can be attributed to numerous potential causes, such as alcohol abuse, chololithiasis, infection, lesions, tumors, hypercalcemia, hyperlipidemia, and medications. Among psychotropic medications, the use of some atypical antipsychotics, such as clozapine, olanzapine, quetiapine and risperidone, has been implicated in the development of acute pancreatitis, although the underlying mechanism has not been clarified. We describe the case of a young man with no other major medical problems, alcohol abuse or predisposing factors, who developed acute necrotizing pancreatitis following olanzapine administration, possibly through severe elevation of serum triglycerides. A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome.
    MeSH term(s) Alleles ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Drug Substitution ; Haplotypes ; Humans ; Male ; Pancreatitis, Acute Necrotizing/diagnosis ; Pancreatitis, Acute Necrotizing/etiology ; Polymorphism, Single Nucleotide ; Receptor, Serotonin, 5-HT2C/genetics ; Schizophrenia/complications ; Schizophrenia/drug therapy ; Treatment Outcome ; Young Adult
    Chemical Substances Antipsychotic Agents ; Receptor, Serotonin, 5-HT2C ; Benzodiazepines (12794-10-4) ; olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2015-09
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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