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  1. Book ; Thesis: The role of tumor derived circulating cell-free RNA as a potential biomarker in melanoma

    Albrecht, Lea Jessica / Rösch, Alexander Oliver

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Lea Jessica Albrecht. Gutachter/in: 1. Herr Univ.-Prof. Dr. med. A. Rösch, 2. Frau Univ.-Prof. Dr. med. K. Fleischhauer
    Language English
    Size 108 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2022
    HBZ-ID HT021471280
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 510 order for loan Magazin

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  2. Book ; Thesis: Gen-Polymorphismen (SNPS) in Zellzyklus-regulierenden und Apoptose-induzierenden Genen (p21 und DR4) als prädisponierende Faktoren für das Urothelkarzinom

    Seidl, Alexander Oliver

    Untersuchung von jungen Patienten mit Harnblasenkarzinom

    2006  

    Author's details vorgelegt von Alexander Oliver Seidl
    Subject code 616.994
    Language German
    Size 67 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 2007
    HBZ-ID HT015310244
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 D 1131 order for loan Magazin

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  3. Book ; Thesis: Morphologische und morphometrische Befunde bei molekulargenetisch differenzierten hereditären Neuropathien

    Tiebe, Alexander Oliver

    2005  

    Author's details vorgelegt von Alexander Oliver Tiebe
    Language German
    Size 43 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2005
    HBZ-ID HT015682537
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 E 1240 order for loan Magazin

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  4. Book ; Thesis: Melatoninbedingte Wachstumsänderungen von HELA-Zellen im niederfrequenten Magnetfeld

    Ast, Alexander Oliver

    1999  

    Author's details vorgelegt von Alexander Oliver Ast
    Language German
    Size 66 Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Witten, Herdecke, Univ., Diss., 1999
    HBZ-ID HT013123038
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 MB 1484 order for loan Magazin

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  5. Article ; Online: Application of Mass Cytometry Platforms to Solid Organ Transplantation.

    Zhang, Wenming / Sen, Ayantika / Pena, Josselyn K / Reitsma, Andrea / Alexander, Oliver C / Tajima, Tetsuya / Martinez, Olivia M / Krams, Sheri M

    Transplantation

    2024  

    Abstract: Transplantation serves as the cornerstone of treatment for patients with end-stage organ disease. The prevalence of complications, such as allograft rejection, infection, and malignancies, underscores the need to dissect the complex interactions of the ... ...

    Abstract Transplantation serves as the cornerstone of treatment for patients with end-stage organ disease. The prevalence of complications, such as allograft rejection, infection, and malignancies, underscores the need to dissect the complex interactions of the immune system at the single-cell level. In this review, we discuss studies using mass cytometry or cytometry by time-of-flight, a cutting-edge technology enabling the characterization of immune populations and cell-to-cell interactions in granular detail. We review the application of mass cytometry in human and experimental animal studies in the context of transplantation, uncovering invaluable contributions of the tool to understanding rejection and other transplant-related complications. We discuss recent innovations that have the potential to streamline and standardize mass cytometry workflows for application to multisite clinical trials. Additionally, we introduce imaging mass cytometry, a technique that couples the power of mass cytometry with spatial context, thereby mapping cellular interactions within tissue microenvironments. The synergistic integration of mass cytometry and imaging mass cytometry data with other omics data sets and high-dimensional data platforms to further define immune dynamics is discussed. In conclusion, mass cytometry technologies, when integrated with other tools and data, shed light on the intricate landscape of the immune response in transplantation. This approach holds significant potential for enhancing patient outcomes by advancing our understanding and facilitating the development of new diagnostics and therapeutics.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  6. Book ; Thesis: Entwicklung eines coracoclaviculären Hakens zur operativen Behandlung der Schultereckgelenksprengung und sein kritischer Vergleich mit anderen operativen Verfahren

    Zach, Alexander

    2001  

    Author's details vorgelegt von Alexander Zach
    Language German
    Size 131 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2001
    HBZ-ID HT013354901
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 3128 order for loan Magazin

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  7. Article ; Online: Histological Tracking into the Third Dimension: Evolution of Early Tumorigenesis in VHL Kidney.

    Mubarak, Mayyan / Al-Gharaibeh, Nayef / Sommaruga, Samuel / Li, Jie / Vortmeyer, Alexander Oliver

    Journal of kidney cancer and VHL

    2021  Volume 8, Issue 3, Page(s) 5–14

    Abstract: Using a novel three-dimensional (3D) approach, we tracked histological changes to elucidate the earliest stages of renal clear cell neoplasia in normal kidney tissue of patients with von Hippel-Lindau (VHL) disease. Tissue blocks of interest were ... ...

    Abstract Using a novel three-dimensional (3D) approach, we tracked histological changes to elucidate the earliest stages of renal clear cell neoplasia in normal kidney tissue of patients with von Hippel-Lindau (VHL) disease. Tissue blocks of interest were procured, serially sectioned, and 3D reconstruction of the entirety of pathologic events was performed. The results reveal an abundance of foci with aberrant clear cell proliferation that initially develop along the tubular lining, but have the potential to aggregate within individual tubules. This stage is followed by the extension of clear cell aggregates beyond the tubular basement membrane, which allows for the recruitment of angiogenesis derived from interstitial vasculature. The results suggest that the most frequent pathologic event in VHL kidneys is the presence of isolated or aggregated clear cells within the tubular epithelium, potentially developing further into a protracted process of neoplasia. The abundance of independent pathologic events in VHL kidneys confirms developmental mechanisms to precede tumor initiation. To our knowledge, this is the first report demonstrating that tracking of histologic changes in the 3rd dimension enables the confirmation of the sequence of events from the earliest pathologic change in the VHL kidney to the neoplastic stage. This approach is not only useful for visualization and quantification of pathologic changes but also for targeted sampling allowing selective analysis of the earliest stages of clear cell carcinogenesis.
    Language English
    Publishing date 2021-09-10
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2803342-5
    ISSN 2203-5826 ; 2203-5826
    ISSN (online) 2203-5826
    ISSN 2203-5826
    DOI 10.15586/jkcvhl.v8i3.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Interaction of an intense few-cycle infrared laser pulse with an ultrathin transparent liquid sheet.

    Ferchaud, Clément / Jarosch, Sebastian / Avni, Timur / Alexander, Oliver / Barnard, Jonathan C T / Larsen, Esben W / Matthews, Mary R / Marangos, Jonathan P

    Optics express

    2022  Volume 30, Issue 19, Page(s) 34684–34692

    Abstract: We experimentally study the interaction between intense infrared few-cycle laser pulses and an ultrathin (∼2 µm) flat liquid sheet of isopropanol running in vacuum. We observe a rapid decline in transmission above a critical peak intensity of 50 TW/ ... ...

    Abstract We experimentally study the interaction between intense infrared few-cycle laser pulses and an ultrathin (∼2 µm) flat liquid sheet of isopropanol running in vacuum. We observe a rapid decline in transmission above a critical peak intensity of 50 TW/cm
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.457470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficient prediction of attosecond two-colour pulses from an X-ray free-electron laser with machine learning.

    Alaa El-Din, Karim K / Alexander, Oliver G / Frasinski, Leszek J / Mintert, Florian / Guo, Zhaoheng / Duris, Joseph / Zhang, Zhen / Cesar, David B / Franz, Paris / Driver, Taran / Walter, Peter / Cryan, James P / Marinelli, Agostino / Marangos, Jon P / Mukherjee, Rick

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7267

    Abstract: X-ray free-electron lasers are sources of coherent, high-intensity X-rays with numerous applications in ultra-fast measurements and dynamic structural imaging. Due to the stochastic nature of the self-amplified spontaneous emission process and the ... ...

    Abstract X-ray free-electron lasers are sources of coherent, high-intensity X-rays with numerous applications in ultra-fast measurements and dynamic structural imaging. Due to the stochastic nature of the self-amplified spontaneous emission process and the difficulty in controlling injection of electrons, output pulses exhibit significant noise and limited temporal coherence. Standard measurement techniques used for characterizing two-coloured X-ray pulses are challenging, as they are either invasive or diagnostically expensive. In this work, we employ machine learning methods such as neural networks and decision trees to predict the central photon energies of pairs of attosecond fundamental and second harmonic pulses using parameters that are easily recorded at the high-repetition rate of a single shot. Using real experimental data, we apply a detailed feature analysis on the input parameters while optimizing the training time of the machine learning methods. Our predictive models are able to make predictions of central photon energy for one of the pulses without measuring the other pulse, thereby leveraging the use of the spectrometer without having to extend its detection window. We anticipate applications in X-ray spectroscopy using XFELs, such as in time-resolved X-ray absorption and photoemission spectroscopy, where improved measurement of input spectra will lead to better experimental outcomes.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56782-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Time-resolved pump-probe spectroscopy with spectral domain ghost imaging.

    Li, Siqi / Driver, Taran / Alexander, Oliver / Cooper, Bridgette / Garratt, Douglas / Marinelli, Agostino / Cryan, James P / Marangos, Jonathan P

    Faraday discussions

    2021  Volume 228, Page(s) 488–501

    Abstract: An atomic-level picture of molecular and bulk processes, such as chemical bonding and charge transfer, necessitates an understanding of the dynamical evolution of these systems. On the ultrafast timescales associated with nuclear and electronic motion, ... ...

    Abstract An atomic-level picture of molecular and bulk processes, such as chemical bonding and charge transfer, necessitates an understanding of the dynamical evolution of these systems. On the ultrafast timescales associated with nuclear and electronic motion, the temporal behaviour of a system is often interrogated in a 'pump-probe' scheme. Here, an initial 'pump' pulse triggers dynamics through photoexcitation, and after a carefully controlled delay a 'probe' pulse initiates projection of the instantaneous state of the evolving system onto an informative measurable quantity, such as electron binding energy. In this paper, we apply spectral ghost imaging to a pump-probe time-resolved experiment at an X-ray free-electron laser (XFEL) facility, where the observable is spectral absorption in the X-ray regime. By exploiting the correlation present in the shot-to-shot fluctuations in the incoming X-ray pulses and measured electron kinetic energies, we show that spectral ghost imaging can be applied to time-resolved pump-probe measurements. In the experiment presented, interpretation of the measurement is simplified because spectral ghost imaging separates the overlapping contributions to the photoelectron spectrum from the pump and probe pulse.
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article
    ISSN 1364-5498
    ISSN (online) 1364-5498
    DOI 10.1039/d0fd00122h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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