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  1. AU="Alexandra J. Corbett"
  2. AU="Felderman, Howard E"
  3. AU="Chen, Fuxing"
  4. AU="Soekadar, Surjo R"
  5. AU="Pagotto, Sara"
  6. AU="Dominguez, Georgina Cutillas"
  7. AU=Barabutis Nektarios
  8. AU="Rumalla, Kavelin"
  9. AU=Meares Gordon P.
  10. AU="Gawron, Lori M"
  11. AU=Guettari Moez
  12. AU=Ma Xingcong
  13. AU="Greene, Kerrie" AU="Greene, Kerrie"
  14. AU="Adebayo, Abe"
  15. AU=Amoako Yaw Ampem
  16. AU="Khanna, Sakshum"

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  1. Artikel ; Online: Unconventional T Cell Immunity in the Lungs of Young Children with Cystic Fibrosis

    Rebecca McElroy / Ghazal Alipour Talesh / Christopher M. Harpur / Rosemary Carzino / Alexandra J. Corbett / Daniel G. Pellicci / Sarath Ranganathan / Philip Sutton

    Frontiers in Bioscience-Landmark, Vol 27, Iss 5, p

    2022  Band 149

    Abstract: Background: People with Cystic Fibrosis (CF) develop pulmonary inflammation, chronic infection and structural lung damage early in life, with these manifestations being prevalent among preschool children and infants. While early immune events are ... ...

    Abstract Background: People with Cystic Fibrosis (CF) develop pulmonary inflammation, chronic infection and structural lung damage early in life, with these manifestations being prevalent among preschool children and infants. While early immune events are believed to play critical roles in shaping the progression, severity and disease burden later in life, T cells and their subsets are poorly studied in the CF lung, particularly during the formative early stages of disease. Methods: Using flow cytometry, we analyzed Mucosal Associated Invariant T (MAIT) cells, γδ T cells, and Natural Killer T (NKT)-like cells in bronchoalveolar lavage (BAL) samples from seventeen children with CF, aged two to six years old. The effect of age, sex and lung infections on the frequencies of these cells in BAL samples was analysed (grouped data were tested for normality and compared by t-test or Kruskal-Wallis analysis). Results: No difference was noted in the proportions of unconventional T cells related to the sex or age of the children. The frequency of γδ T cells and MAIT cells appeared unchanged by infection status. However, viral infections were associated with a significant increase in the proportion of NKT-like cells. Conclusions: By evaluating T cells in the lungs of children during the early formative stages of CF, this study identified potentially important interactions between these cells and viral pathogens.
    Schlagwörter cystic fibrosis ; unconventional t cells ; mucosal immunity ; host/pathogen ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag IMR Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

    Zhongfang Wang / Xiaoyun Yang / Jiaying Zhong / Yumin Zhou / Zhiqiang Tang / Haibo Zhou / Jun He / Xinyue Mei / Yonghong Tang / Bijia Lin / Zhenjun Chen / James McCluskey / Ji Yang / Alexandra J. Corbett / Pixin Ran

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 8

    Abstract: T cells compose a critical component of the immune response to coronavirus infection with SARS-CoV-2. Here the authors characterise the T cell response to SARS CoV-2 in patients and their close contacts, and show the presence of SARS-CoV-2 specific T ... ...

    Abstract T cells compose a critical component of the immune response to coronavirus infection with SARS-CoV-2. Here the authors characterise the T cell response to SARS CoV-2 in patients and their close contacts, and show the presence of SARS-CoV-2 specific T cells in the absence of detectable virus infection.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

    Amine Toubal / Badr Kiaf / Lucie Beaudoin / Lucie Cagninacci / Moez Rhimi / Blandine Fruchet / Jennifer da Silva / Alexandra J. Corbett / Yannick Simoni / Olivier Lantz / Jamie Rossjohn / James McCluskey / Philippe Lesnik / Emmanuelle Maguin / Agnès Lehuen

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 20

    Abstract: Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting ... ...

    Abstract Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

    Amine Toubal / Badr Kiaf / Lucie Beaudoin / Lucie Cagninacci / Moez Rhimi / Blandine Fruchet / Jennifer da Silva / Alexandra J. Corbett / Yannick Simoni / Olivier Lantz / Jamie Rossjohn / James McCluskey / Philippe Lesnik / Emmanuelle Maguin / Agnès Lehuen

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 20

    Abstract: Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting ... ...

    Abstract Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

    Timothy S.C. Hinks / Emanuele Marchi / Maisha Jabeen / Moshe Olshansky / Ayako Kurioka / Troi J. Pediongco / Bronwyn S. Meehan / Lyudmila Kostenko / Stephen J. Turner / Alexandra J. Corbett / Zhenjun Chen / Paul Klenerman / James McCluskey

    Cell Reports, Vol 28, Iss 12, Pp 3249-3262.e

    2019  Band 5

    Abstract: Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine ...

    Abstract Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine lungs, we define the basic transcriptome of an activated MAIT cell in both species and demonstrate how this profile changes during the resolution of infection and during reinfection. We observe strong similarities between MAIT cells in humans and mice. In both species, activation leads to strong expression of pro-inflammatory cytokines and chemokines as well as a strong tissue repair signature, recently described in murine commensal-specific H2-M3-restricted T cells. Transcriptomes of MAIT cells and H2-M3-specific CD8+ T cells displayed the most similarities to invariant natural killer T (iNKT) cells when activated, but to γδ T cells after the resolution of infection. These data define the requirements for and consequences of MAIT cell activation, revealing a tissue repair phenotype expressed upon MAIT cell activation in both species. : Mucosal-associated invariant T (MAIT) cells are implicated in antibacterial and antiviral immunity. Using RNA sequencing of human MAIT cells stimulated with their cognate ligand and murine MAIT cells stimulated by acute Legionella infection, Hinks et al. report that activation leads to expression of a strong tissue repair signature in both species. Keywords: mucosal-associated invariant T cell, T cell, transcriptome, MHC-related protein 1, activation, lung, human, mouse, riboflavin, tissue repair
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

    Jeffrey Y. W. Mak / Weijun Xu / Robert C. Reid / Alexandra J. Corbett / Bronwyn S. Meehan / Huimeng Wang / Zhenjun Chen / Jamie Rossjohn / James McCluskey / Ligong Liu / David P. Fairlie

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Band 13

    Abstract: MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo. ...

    Abstract MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

    Zhe Zhao / Huimeng Wang / Mai Shi / Tianyuan Zhu / Troi Pediongco / Xin Yi Lim / Bronwyn S. Meehan / Adam G. Nelson / David P. Fairlie / Jeffrey Y. W. Mak / Sidonia B. G. Eckle / Marcela de Lima Moreira / Carolin Tumpach / Michael Bramhall / Cameron G. Williams / Hyun Jae Lee / Ashraful Haque / Maximilien Evrard / Jamie Rossjohn /
    James McCluskey / Alexandra J. Corbett / Zhenjun Chen

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 15

    Abstract: Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and ...

    Abstract Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

    Erin W. Meermeier / Bruno F. Laugel / Andrew K. Sewell / Alexandra J. Corbett / Jamie Rossjohn / James McCluskey / Melanie J. Harriff / Tamera Franks / Marielle C. Gold / David M. Lewinsohn

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Band 12

    Abstract: Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a ... ...

    Abstract Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2016-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function

    Christopher R Shaler / Joshua Choi / Patrick T Rudak / Arash Memarnejadian / Peter A Szabo / Mauro E Tun-Abraham / Jamie Rossjohn / Alexandra J Corbett / James McCluskey / John K McCormick / Olivier Lantz / Roberto Hernandez-Alejandro / S M Mansour Haeryfar

    PLoS Biology, Vol 15, Iss 6, p e

    Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.

    2017  Band 2001930

    Abstract: Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically ... ...

    Abstract Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections. Unlike in mouse models, the mechanisms underlying SAg-associated immunosuppression in humans are ill-defined. In this work, we have identified a population of innate-like T cells, called mucosa-associated invariant T (MAIT) cells, as the most powerful source of pro-inflammatory cytokines after exposure to SAgs. We have utilized primary human peripheral blood and hepatic mononuclear cells, mouse MAIT hybridoma lines, HLA-DR4-transgenic mice, MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rγnull mice to demonstrate for the first time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by staphylococcal enterotoxin B (SEB); ii) the human MAIT cell response to SEB is rapid and far greater in magnitude than that launched by unfractionated conventional T, invariant natural killer T (iNKT) or γδ T cells, and is characterized by production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-2, but not IL-17A; iii) high-affinity MHC class II interaction with SAgs, but not MHC-related protein 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occur in a T cell receptor (TCR) Vβ-specific manner but are largely contributed by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develop a molecular signature consistent with exhaustion and ...
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: MAIT cells protect against pulmonary Legionella longbeachae infection

    Huimeng Wang / Criselle D’Souza / Xin Yi Lim / Lyudmila Kostenko / Troi J. Pediongco / Sidonia B. G. Eckle / Bronwyn S. Meehan / Mai Shi / Nancy Wang / Shihan Li / Ligong Liu / Jeffrey Y. W. Mak / David P. Fairlie / Yoichiro Iwakura / Jennifer M. Gunnersen / Andrew W. Stent / Dale I. Godfrey / Jamie Rossjohn / Glen P. Westall /
    Lars Kjer-Nielsen / Richard A. Strugnell / James McCluskey / Alexandra J. Corbett / Timothy S. C. Hinks / Zhenjun Chen

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 15

    Abstract: Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by ... ...

    Abstract Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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