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  1. Article ; Online: The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles

    Roxana Ghiulai / Alexandra Mioc / Roxana Racoviceanu / Marius Mioc / Andreea Milan / Alexandra Prodea / Alexandra Semenescu / Cristina Dehelean / Lucian Barbu Tudoran / Ștefana Avram / Cristina Trandafirescu / Codruța Șoica

    Pharmaceuticals, Vol 15, Iss 1362, p

    A Mechanistic In Vitro Approach

    2022  Volume 1362

    Abstract: Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in the field of drug formulation development. ... ...

    Abstract Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in the field of drug formulation development. Gold nanoparticles (GNP) are easily tunable carriers for active phytocompounds like pentacyclic triterpenes. These formulations can boost the bioavailability of a lipophilic structure and, in some instances, can also enhance its therapeutic efficacy. In our work, we proposed a biological in vitro assessment of betulinic acid (BA)-functionalized GNP. BA-GNP were obtained by grafting BA onto previously synthesized citrate-capped GNP through the use of cysteamine as a linker. The nanoformulation was tested in HaCaT human keratinocytes and RPMI-7951 human melanoma cells, revealing selective cytotoxic properties and stronger antiproliferative effects compared to free BA. Further examinations revealed a pro-apoptotic effect, as evidenced by morphological changes in melanoma cells and supported by western blot data showing the downregulation of anti-apoptotic Bcl-2 expression coupled with the upregulation of pro-apoptotic Bax. GNP also significantly inhibited mitochondrial respiration, confirming its mitochondrial-targeted activity.
    Keywords betulinic acid ; gold nanoparticles ; melanoma ; apoptosis ; mitochondria ; protein expression ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 500
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications

    Elena-Alina Moacă / Vlad Socoliuc / Dana Stoian / Claudia Watz / Daniela Flondor / Cornelia Păcurariu / Robert Ianoș / Cristiana Iulia Rus / Lucian Barbu-Tudoran / Alexandra Semenescu / Cristian Sarău / Adelina Chevereșan / Cristina Adriana Dehelean

    Magnetochemistry, Vol 8, Iss 145, p

    2022  Volume 145

    Abstract: Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood ( Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for ... ...

    Abstract Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood ( Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, both at room temperature (25 °C) and at 80 °C, and with two formulations of the precipitation agent. Both the quality and stability of the synthesized magnetic iron oxide nanoparticles were physiochemically characterized: phase composition (X-ray powder diffraction (XRD)), thermal behavior (thermogravimetry (TG) and differential scanning calorimetry (DSC)), electron microscopy (scanning (SEM) and transmission (TEM)), and magnetic properties (DC and HF-AC). The magnetic investigation of the as-obtained magnetic iron oxide nanoparticles revealed that the synthesis at 80 °C using a mixture of NaOH and NH 3 (aq) increases their diameter and implicitly enhances their specific absorption rate (SAR), a mandatory parameter for practical applications in hyperthermia.
    Keywords specific absorption rate ; magnetic nanoparticles ; green synthesis ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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