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Article: Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer.

Chhouri, Houssein / Alexandre, David / Grumolato, Luca

2023 Volume 15, Issue 2

Abstract: Non-small cell lung cancers (NSCLC) harboring activating mutations of the epidermal growth factor receptor (EGFR) are treated with specific tyrosine kinase inhibitors (EGFR-TKIs) of this receptor, resulting in clinically responses that can generally last ...

Abstract	Non-small cell lung cancers (NSCLC) harboring activating mutations of the epidermal growth factor receptor (EGFR) are treated with specific tyrosine kinase inhibitors (EGFR-TKIs) of this receptor, resulting in clinically responses that can generally last several months. Unfortunately, EGFR-targeted therapy also favors the emergence of drug tolerant or resistant cells, ultimately resulting in tumor relapse. Recently, cellular barcoding strategies have arisen as a powerful tool to investigate the clonal evolution of these subpopulations in response to anti-cancer drugs. In this review, we provide an overview of the currently available treatment options for NSCLC, focusing on EGFR targeted therapy, and discuss the common mechanisms of resistance to EGFR-TKIs. We also review the characteristics of drug-tolerant persister (DTP) cells and the mechanistic basis of drug tolerance in EGFR-mutant NSCLC. Lastly, we address how cellular barcoding can be applied to investigate the response and the behavior of DTP cells upon EGFR-TKI treatment.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Hierarchical B-frame Video Coding Using Two-Layer CANF without Motion Coding

Alexandre, David / Hang, Hsueh-Ming / Peng, Wen-Hsiao

2023

Abstract: Typical video compression systems consist of two main modules: motion coding and residual coding. This general architecture is adopted by classical coding schemes (such as international standards H.265 and H.266) and deep learning-based coding schemes. ... ...

Abstract	Typical video compression systems consist of two main modules: motion coding and residual coding. This general architecture is adopted by classical coding schemes (such as international standards H.265 and H.266) and deep learning-based coding schemes. We propose a novel B-frame coding architecture based on two-layer Conditional Augmented Normalization Flows (CANF). It has the striking feature of not transmitting any motion information. Our proposed idea of video compression without motion coding offers a new direction for learned video coding. Our base layer is a low-resolution image compressor that replaces the full-resolution motion compressor. The low-resolution coded image is merged with the warped high-resolution images to generate a high-quality image as a conditioning signal for the enhancement-layer image coding in full resolution. One advantage of this architecture is significantly reduced computational complexity due to eliminating the motion information compressor. In addition, we adopt a skip-mode coding technique to reduce the transmitted latent samples. The rate-distortion performance of our scheme is slightly lower than that of the state-of-the-art learned B-frame coding scheme, B-CANF, but outperforms other learned B-frame coding schemes. However, compared to B-CANF, our scheme saves 45% of multiply-accumulate operations (MACs) for encoding and 27% of MACs for decoding. The code is available at https://nycu-clab.github.io.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
Subject code	003
Publishing date	2023-04-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-term exposure of Allonais inaequalis to a mixture of antibiotics in freshwater and synthetic wastewater matrices: Reproduction, recovery, and swimming responses.

Castro, Gleyson B / Alexandre, David S / Bernegossi, Aline C / Bezerra, Yohanna A F / Fonsêca, Mateus C / Zaiat, Marcelo / Corbi, Juliano J

Water environment research : a research publication of the Water Environment Federation

2024 Volume 96, Issue 3, Page(s) e11007

Abstract: Antibiotics from sulfonamide, fluoroquinolone, and diaminopyrimidine classes are widely used in human and veterinary medicine, and their combined occurrence in the aquatic environment is increasing around the world. In parallel, the understanding of how ... ...

Abstract	Antibiotics from sulfonamide, fluoroquinolone, and diaminopyrimidine classes are widely used in human and veterinary medicine, and their combined occurrence in the aquatic environment is increasing around the world. In parallel, the understanding of how mixtures of these compounds affect non-target species from tropical freshwaters is scarce. Thus, this work aimed to study the long-term reproductive, recovery, and swimming effects of mixtures of 12 antibiotics from three different classes (up to 10 μg L
MeSH term(s)	Humans ; Anti-Bacterial Agents ; Wastewater ; Swimming ; Fluoroquinolones/analysis ; Fluoroquinolones/toxicity ; Sulfanilamide ; Sulfonamides ; Fresh Water ; Reproduction ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis
Chemical Substances	Anti-Bacterial Agents ; Wastewater ; Fluoroquinolones ; Sulfanilamide (21240MF57M) ; Sulfonamides ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1098976-6
ISSN	1554-7531 ; 1047-7624 ; 1061-4303
ISSN (online)	1554-7531
ISSN	1047-7624 ; 1061-4303
DOI	10.1002/wer.11007
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Book ; Online: Learned Video Codec with Enriched Reconstruction for CLIC P-frame Coding

Alexandre, David / Hang, Hsueh-Ming

2020

Abstract: This paper proposes a learning-based video codec, specifically used for Challenge on Learned Image Compression (CLIC, CVPRWorkshop) 2020 P-frame coding. More specifically, we designed a compressor network with Refine-Net for coding residual signals and ... ...

Abstract	This paper proposes a learning-based video codec, specifically used for Challenge on Learned Image Compression (CLIC, CVPRWorkshop) 2020 P-frame coding. More specifically, we designed a compressor network with Refine-Net for coding residual signals and motion vectors. Also, for motion estimation, we introduced a hierarchical, attention-based ME-Net. To verify our design, we conducted an extensive ablation study on our modules and different input formats. Our video codec demonstrates its performance by using the perfect reference frame at the decoder side specified by the CLIC P-frame Challenge. The experimental result shows that our proposed codec is very competitive with the Challenge top performers in terms of quality metrics.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Publishing date	2020-12-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: On the feasibility of the Rayleigh cycle for dynamic soaring trajectories.

Alexandre, David / Marino, Luca / Marta, André / Graziani, Giorgio / Piva, Renzo

PloS one

2020 Volume 15, Issue 3, Page(s) e0229746

Abstract: Dynamic soaring is a flight technique used by albatrosses and other birds to cover large distances without the expenditure of energy, which is extracted from the available wind conditions, as brightly perceived five centuries ago by Leonardo da Vinci. ... ...

Abstract	Dynamic soaring is a flight technique used by albatrosses and other birds to cover large distances without the expenditure of energy, which is extracted from the available wind conditions, as brightly perceived five centuries ago by Leonardo da Vinci. Closed dynamic soaring trajectories use spatial variations of wind speed to travel, in principle, indefinitely over a prescribed area. The application of the concept of closed dynamic soaring trajectories to aerial vehicles, such as UAVs, may provide a solution to improve the endurance in certain missions. The main limitation of dynamic soaring is its dependence on the wind characteristics. More than one century ago, Lord Rayleigh proposed a very simple model, based on the repeated crossing of a step wind profile, presently known as Rayleigh cycle, that provides a clear explanation of the physical phenomenon. The present paper studies the feasibility of closed, single-loop, energy-neutral trajectories for a broad set of wind and vehicle conditions. Through the use of trajectory optimization methods, it was possible to see how the shape of the wind profile, the initial flight conditions and the vehicle constraints influence the required wind strength to perform dynamic soaring trajectories and consequently their feasibility. It was possible to conclude that there are optimal values for the initial airspeed and initial height of the vehicle, that minimize the required wind strength. In addition, it was seen how the structural and aerodynamic constraints of the vehicle affect dynamic soaring at high and low airspeeds respectively. Finally, some new trajectories that can be performed in conditions of excess wind are proposed. The purpose is to maximize the time spent aloft and the path length while maintaining the concept of single-loop, energy-neutral trajectories, making them especially useful for aerial vehicles surveillance applications.
MeSH term(s)	Animals ; Aviation/methods ; Birds/physiology ; Feasibility Studies ; Flight, Animal/physiology ; Models, Theoretical ; Wind ; Wings, Animal/physiology
Language	English
Publishing date	2020-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0229746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Physical modeling of ribosomes along messenger RNA

Carole Chevalier / Jérôme Dorignac / Yahaya Ibrahim / Armelle Choquet / Alexandre David / Julie Ripoll / Eric Rivals / Frédéric Geniet / Nils-Ole Walliser / John Palmeri / Andrea Parmeggiani / Jean-Charles Walter

PLoS Computational Biology, Vol 19, Iss 10, p e

Estimating kinetic parameters from ribosome profiling experiments using a ballistic model.

2023 Volume 1011522

Abstract: Gene expression is the synthesis of proteins from the information encoded on DNA. One of the two main steps of gene expression is the translation of messenger RNA (mRNA) into polypeptide sequences of amino acids. Here, by taking into account mRNA ... ...

Abstract	Gene expression is the synthesis of proteins from the information encoded on DNA. One of the two main steps of gene expression is the translation of messenger RNA (mRNA) into polypeptide sequences of amino acids. Here, by taking into account mRNA degradation, we model the motion of ribosomes along mRNA with a ballistic model where particles advance along a filament without excluded volume interactions. Unidirectional models of transport have previously been used to fit the average density of ribosomes obtained by the experimental ribo-sequencing (Ribo-seq) technique in order to obtain the kinetic rates. The degradation rate is not, however, accounted for and experimental data from different experiments are needed to have enough parameters for the fit. Here, we propose an entirely novel experimental setup and theoretical framework consisting in splitting the mRNAs into categories depending on the number of ribosomes from one to four. We solve analytically the ballistic model for a fixed number of ribosomes per mRNA, study the different regimes of degradation, and propose a criterion for the quality of the inverse fit. The proposed method provides a high sensitivity to the mRNA degradation rate. The additional equations coming from using the monosome (single ribosome) and polysome (arbitrary number) ribo-seq profiles enable us to determine all the kinetic rates in terms of the experimentally accessible mRNA degradation rate.
Keywords	Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arteriovenous fistula after radial catheterization with cardiopulmonary repercussions.

de Oliveira, Alexandre Faraco / Ribeiro, Alexandre David / Ávila, Marcio Costa Silveira

Jornal vascular brasileiro

2019 Volume 18, Page(s) e20180086

Abstract: This article describes the case of an 86-year-old coronary disease patient who underwent cardiac catheterization via a left radial access. Around 16 months after the procedure, he presented with dyspnea, unrelated to effort, but associated with nocturnal ...

Abstract	This article describes the case of an 86-year-old coronary disease patient who underwent cardiac catheterization via a left radial access. Around 16 months after the procedure, he presented with dyspnea, unrelated to effort, but associated with nocturnal hypoxia. There was a palpable thrill in the left wrist and he was diagnosed with a radiocephalic arteriovenous fistula in the left wrist. A duplex scan revealed an abnormal wave pattern and increased diastolic velocity compatible with arteriovenous fistula. The fistula was repaired surgically and the patient exhibited improvement in clinical and laboratory parameters after the procedure. Radial access is increasingly being used for cardiac catheterization, primarily because it is associated with fewer and less harmful complications than femoral access. However, complications such as arteriovenous fistula occur and can be particularly harmful in octogenarian patients.
Language	English
Publishing date	2019-01-30
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2571403-X
ISSN	1677-7301 ; 1677-5449
ISSN (online)	1677-7301
ISSN	1677-5449
DOI	10.1590/1677-5449.008618
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Article ; Online: Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

Anand K. Singh / Akilu Abdullahi / Matthias Soller / Alexandre David / Saverio Brogna

Biology Open, Vol 8, Iss

2019 Volume 12

Abstract: The distribution of assembled, and potentially translating, ribosomes within cells can be visualised in Drosophila by using Bimolecular Fluorescence Complementation (BiFC) to monitor the interaction between tagged pairs of 40S and 60S ribosomal proteins ( ...

Abstract	The distribution of assembled, and potentially translating, ribosomes within cells can be visualised in Drosophila by using Bimolecular Fluorescence Complementation (BiFC) to monitor the interaction between tagged pairs of 40S and 60S ribosomal proteins (RPs) that are close neighbours across inter-subunit junctions in the assembled 80S ribosome. Here we describe transgenes expressing two novel RP pairs tagged with Venus-based BiFC fragments that considerably increase the sensitivity of this technique we termed Ribo-BiFC. This improved method should provide a convenient way of monitoring the local distribution of ribosomes in most Drosophila cells and we suggest that it could be implemented in other organisms. We visualised 80S ribosomes in different neurons, particularly photoreceptors in the larva, pupa and adult brain. Assembled ribosomes are most abundant in the various neuronal cell bodies, but they are also present along the full length of axons. They are concentrated in growth cones of developing photoreceptors and are apparent at the terminals of mature larval photoreceptors targeting the larval optical neuropil. Surprisingly, there is relatively less puromycin incorporation in the distal portion of axons in the larval optic stalk, suggesting that some of the ribosomes that have initiated translation may not be engaged in elongation in growing axons. This article has an associated First Person interview with the first author of the paper.
Keywords	bifc ; 80s ; ribosomes ; neurons ; axons ; drosophila ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	The Company of Biologists
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyses in Mice

Duriez, Philibert / Nilsson, Ida A. K. / Le Thuc, Ophelia / Alexandre, David / Chartrel, Nicolas / Rovere, Carole / Chauveau, Christophe / Gorwood, Philip / Tolle, Virginie / Viltart, Odile

Nutrients. 2021 Aug. 13, v. 13, no. 8

2021

Abstract: Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, a significant part of patients experience ... ...

Abstract	Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, a significant part of patients experience relapses. In this translational study, we combined clinical and preclinical approaches. We describe preliminary data about the effect of weight gain on the symptomatology of patients suffering from acute AN (n = 225) and partially recovered (n = 41). We measured more precisely physical activity with continuous cardiac monitoring in a sub-group (n = 68). Using a mouse model, we investigated whether a long-term food restriction followed by nutritional recovery associated or not with physical activity may differentially impact peripheral and central homeostatic regulation. We assessed the plasma concentration of acyl ghrelin, desacyl ghrelin and leptin and the mRNA expression of hypothalamic neuropeptides and their receptors. Our data show an effect of undernutrition history on the level of physical activity in AN. The preclinical model supports an important role of physical activity in the recovery process and points out the leptin system as one factor that can drive a reliable restoration of metabolic variables through the hypothalamic regulation of neuropeptides involved in feeding behavior.
Keywords	anorexia nervosa ; gene expression ; ghrelin ; humans ; hypothalamic regulation ; leptin ; low calorie diet ; malnutrition ; mice ; neuropeptides ; physical activity ; weight gain
Language	English
Dates of publication	2021-0813
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13082786
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Auditoria fiscal previdenciária em ambiente SAP

Alexandre David Viva

Revista Organizações em Contexto, Vol 2, Iss 4, Pp 215-

2006 Volume 221

Abstract: Este trabalho busca identificar meios para efetuar auditoria fiscal nos bancos de dados do SAP - o mais adotado ERP da atualidade (Bae e Ashcroft, 2004, 1 e 5; Khan, 2005, 5). Pretende-se concentrar no método de acesso às tabelas SAP, um dos cinco ... ...

Abstract	Este trabalho busca identificar meios para efetuar auditoria fiscal nos bancos de dados do SAP - o mais adotado ERP da atualidade (Bae e Ashcroft, 2004, 1 e 5; Khan, 2005, 5). Pretende-se concentrar no método de acesso às tabelas SAP, um dos cinco métodos de acesso aos bancos de dados de ERP (Neil Raden, 2004, 10). Em um primeiro momento, é necessário o levantamento, por empresa, de uma listagem dos cabeçalhos das tabelas com as quais ela trabalha, em bancos de dados que já alcançam os terabytes (SAP, SAP NetWeaver: 50). Como o SAP é um programa multilíngüe e multiempresarial, suas tabelas são criptografadas, isto é, os nomes das tabelas e de duas colunas não guardam a menor relação com os dados que elas registram (Saphir, 2004, 1). Em um segundo momento, então, por meio do ACL, a listagem de cabeçalhos de tabelas obtida é filtrada. As tabelas que interessam ao Fisco são solicitadas à empresa de uma forma mais precisa, de modo a não sobrecarregar nem a empresa nem do Fisco. Em um terceiro momento, ainda com auxílio do ACL, as tabelas especificadas são analisadas (Primeiros Passos, 2003, 3).
Keywords	Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H ; DOAJ:Business and Management ; DOAJ:Business and Economics
Language	Portuguese
Publishing date	2006-12-01T00:00:00Z
Publisher	Universidade Metodista de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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