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Article ; Online: Glucocorticoids, COVID-19 and Cryptococcosis.

Dos Santos, Wanessa Maria / Rogerio, Alexandre Paula

Anti-inflammatory & anti-allergy agents in medicinal chemistry

2023 Volume 22, Issue 2, Page(s) 67–70

Abstract: Cryptococcus neoformans and C. gattii pneumonitis could persist asymptomatically for indefinite periods, resolve, or progress to symptomatic dissemination, mainly in immunocompromised individuals (e.g., treated with corticosteroids). The symptoms of ... ...

Abstract	Cryptococcus neoformans and C. gattii pneumonitis could persist asymptomatically for indefinite periods, resolve, or progress to symptomatic dissemination, mainly in immunocompromised individuals (e.g., treated with corticosteroids). The symptoms of COVID-19 may range from a self-limiting illness with general symptoms, such as fever, to more severe complications, such as pneumonitis. The glucocorticoids emerged as potential for treatment of COVID-19, mainly those patients who required ventilator therapy. However, although treatment with glucocorticoids has shown benefits in patients with COVID-19, they can be dangerous due to increased risk of coinfections and superinfections caused by opportunistic pathogens such as Cryptococcus ssp. Some patients with severe COVID-19 pneumonia treated with glucocorticoids developed cryptococcal infection and died. Therefore, immunomodulatory therapy could increase the susceptibility to acute infection or reactivation of Cryptococcus ssp in COVID-19 patients, and this could be complicated once pulmonary cryptococcosis has symptoms similar to COVID-19 becomes difficult to distinguish between the two disease states and treatment.
MeSH term(s)	Humans ; Glucocorticoids/therapeutic use ; COVID-19 ; Cryptococcosis/diagnosis ; Cryptococcosis/drug therapy ; Cryptococcus neoformans ; Cryptococcus gattii/physiology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2023-09-13
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2227189-2
ISSN	1875-614X ; 1871-5230
ISSN (online)	1875-614X
ISSN	1871-5230
DOI	10.2174/1871523022666230912142540
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Article ; Online: Influência da rigidez do solo e de parâmetros geométricos no desempenho mecânico de blocos sobre estacas

Vitor Lourensato Leoni / Mauro Alexandre Paula de Sousa / André Luis Christoforo

Revista Principia, Vol 60, Iss 2, Pp 407-

2023 Volume 433

Abstract: Os sistemas de fundação profunda, muito utilizados para transmitir as cargas provenientes da superestrutura para o solo, são usualmente constituídos por estacas e por um bloco de coroamento, que solidariza e transmite os esforços dos pilares para as ... ...

Abstract	Os sistemas de fundação profunda, muito utilizados para transmitir as cargas provenientes da superestrutura para o solo, são usualmente constituídos por estacas e por um bloco de coroamento, que solidariza e transmite os esforços dos pilares para as estacas. Este trabalho realizou uma análise de sensibilidade de parâmetros, com o objetivo de verificar qual a influência desses parâmetros nos recalques e tensões no topo e na base do bloco. A análise considerou dois blocos quadrados de quatro e nove estacas, nos quais foram avaliados os seguintes parâmetros: altura do bloco, tipo de solo, e quantidade e comprimento das estacas. Os resultados colhidos das simulações foram os deslocamentos no topo e na base dos blocos e das estacas, bem como as tensões normais que surgiram nesses elementos. Foram adotadas medidas de altura do bloco acima e abaixo do critério de bloco rígido, e as estacas utilizadas foram de seção quadrada com 40 cm de lado. A análise estatística dos resultados mostrou que o tipo de solo foi o parâmetro que mais afetou os recalques dos blocos, seguido pelo comprimento e pelo número de estacas. A altura do bloco praticamente não teve influência nos deslocamentos obtidos.
Keywords	análise de sensibilidade ; blocos sobre estacas ; método dos elementos finitos ; recalques ; rigidez de fundação ; Technology (General) ; T1-995 ; Science ; Q ; Science (General) ; Q1-390
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Instituto Federal de Educação, Ciência e Tecnologia da Paraíba
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Editorial: Model systems to study the mechanisms of neural development and disease.

Sumru Bayin, N / Alexandre, Paula / Haldipur, Parthiv

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 1006888

Language	English
Publishing date	2022-08-31
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.1006888
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Article ; Online: Delta-Notch Signaling: The Long and The Short of a Neuron's Influence on Progenitor Fates.

Moore, Rachel / Alexandre, Paula

Journal of developmental biology

2020 Volume 8, Issue 2

Abstract: Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial ... ...

Abstract	Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the mantle layer at the basal surface. This review will discuss the existing evidence that supports a role for neurons, from early stages of differentiation, in promoting progenitor cell fates in the vertebrates CNS, maintaining tissue homeostasis and regulating spatiotemporal patterning of neuronal differentiation through Delta-Notch signalling.
Language	English
Publishing date	2020-03-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720870-9
ISSN	2221-3759 ; 2221-3759
ISSN (online)	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb8020008
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Article: Delta-Notch Signaling: The Long and the Short of a Neuron’s Influence on Progenitor Fates

Moore, Rachel / Alexandre, Paula

Journal of developmental biology. 2020 Mar. 26, v. 8, no. 2

2020

Abstract	Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the mantle layer at the basal surface. This review will discuss the existing evidence that supports a role for neurons, from early stages of differentiation, in promoting progenitor cell fates in the vertebrates CNS, maintaining tissue homeostasis and regulating spatiotemporal patterning of neuronal differentiation through Delta-Notch signalling.
Keywords	central nervous system ; embryogenesis ; homeostasis ; neuroglia ; neurons ; stem cells
Language	English
Dates of publication	2020-0326
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720870-9
ISSN	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb8020008
Database	NAL-Catalogue (AGRICOLA)

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Article: Protrusion-Mediated Signaling Regulates Patterning of the Developing Nervous System.

Moore, Rachel E / Clarke, Jon / Alexandre, Paula

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 579073

Abstract: During brain development, the tissue pattern and specification are the foundation of neuronal circuit formation. Contact-mediated lateral inhibition is well known to play an important role in determining cell fate decisions in the nervous system by ... ...

Abstract	During brain development, the tissue pattern and specification are the foundation of neuronal circuit formation. Contact-mediated lateral inhibition is well known to play an important role in determining cell fate decisions in the nervous system by either regulating tissue boundary formation or the classical salt-and-pepper pattern of differentiation that results from direct neighboring cell contacts. In many systems, however, such as the
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.579073
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Article ; Online: Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells.

Souza, Henrique Ismarsi / Pereira, Aline Beatriz Mahler / Oliveira, Jhony Robison / Silva, Paulo Roberto / Teixeira, David Nascimento Silva / Silva-Vergara, Mario Leon / Rogério, Alexandre Paula

Inflammation

2022 Volume 45, Issue 3, Page(s) 1269–1280

Abstract: Cryptococcosis (caused, for example, by Cryptococcus neoformans) and allergic asthma (caused, for example, by Dermatophagoides pteronyssinus) target the respiratory tract (the lung and bronchial epithelium). C. neoformans and D. pteronyssinus can coexist ...

Abstract	Cryptococcosis (caused, for example, by Cryptococcus neoformans) and allergic asthma (caused, for example, by Dermatophagoides pteronyssinus) target the respiratory tract (the lung and bronchial epithelium). C. neoformans and D. pteronyssinus can coexist in the same indoor environment, and exposure to both can cause alterations in the local airway inflammatory milieu and exacerbation of airway inflammatory diseases. Here, we evaluated the effects of the association between C. neoformans and D. pteronyssinus in the modulation of airway inflammatory responses in an in vitro experimental model using human bronchial epithelial cells. BEAS-2B cells were cultivated and stimulated with D. pteronyssinus (10 μg/mL) and/or C. neoformans (MOI 100) for 24 h. No cytotoxic effect was observed in cells stimulated by C. neoformans and/or D. pteronyssinus. The production of IL-8, IL-6, and/or CCL2, but not IL-10, as well as the activation of NF-kB, STAT3, STAT6, and/or ERK1/2 were increased in cells stimulated by C. neoformans or D. pteronyssinus compared to controls. C. neoformans in association with D. pteronyssinus inhibited the CCL2‑ERK1/2 signaling pathway in cells treated with both pathogens compared to cells stimulated by D. pteronyssinus alone. In addition, their association induced an additive effect on the IL-6/STAT3 signaling pathway in cells compared to cells stimulated with D. pteronyssinus or C. neoformans only. D. pteronyssinus increased the internalization and growth of C. neoformans in BEAS-2B cells. D. pteronyssinus in association with C. neoformans promoted pro- and anti-inflammatory responses, which can modulate cryptococcal infection and asthmaticus status.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Bronchi ; Chemokine CCL2/metabolism ; Cryptococcosis/metabolism ; Cryptococcus neoformans/metabolism ; Dermatophagoides pteronyssinus/metabolism ; Down-Regulation ; Epithelial Cells/metabolism ; Humans ; Interleukin-6/metabolism ; MAP Kinase Signaling System ; STAT3 Transcription Factor/metabolism
Chemical Substances	Anti-Inflammatory Agents ; CCL2 protein, human ; Chemokine CCL2 ; Interleukin-6 ; STAT3 Transcription Factor ; STAT3 protein, human
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-021-01619-4
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Zs.A 1401: Show issues

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Article: Anti-inflammatory actions of aspirin-triggered resolvin D1 (AT-RvD1) in bronchial epithelial cells stimulated by cigarette smoke extract.

de Oliveira, Jhony Robson / Pereira, Aline Beatriz Mahler / de Souza, Henrique Ismarsi / Dos Santos, Wanessa Maria / de Assunção, Thaís Sorares Farnesi / de Vito, Fernanda Bernadelli / de Souza, Helio Moraes / da Silva, Paulo Roberto / da Silva, Marcos Vinicius / Junior, Virmondes Rodrigues / Rogerio, Alexandre Paula

Prostaglandins & other lipid mediators

2024 Volume 172, Page(s) 106833

Abstract: Smoking causes several diseases such as chronic obstructive pulmonary disease (COPD). Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and demonstrates anti-inflammatory and pro-resolution effects ...

Abstract	Smoking causes several diseases such as chronic obstructive pulmonary disease (COPD). Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and demonstrates anti-inflammatory and pro-resolution effects in several inflammatory experimental models including in the airways. Here we evaluated the role of AT-RvD1 (100 nM) in bronchial epithelial cells (BEAS-2B) stimulated by cigarette smoke extract (CSE; 1%; 1 cigarette) for 24 h. CSE induced the productions of IL-1β, TNF-α, IL-10, IL-4 and IFN-γ as well as the activations of NF-κB and STAT3 and the expression of ALX/FPR2 receptor. AT-RvD1 reduced the IL-1β and TNF-α production and increased the production of IFN-γ. These effects were reversed BOC2, an antagonist of ALX/FPR2 receptor for AT-RvD1. The production of IL-4 and IL-10 were not altered by AT-RvD1. In addition, AT-RvD1 reduced the phosphorylation of NF-κB and STAT3 when compared to CSE-stimulated BEAS-2B cells. No alteration of ALX/FPR2 expression was observed by AT-RvD1 when compared to CSE group. In the human monocytic leukemia cell line, the relative number of copies of IL-1β and IL-4 was significantly higher in CSE + AT-RvD1 group compared CSE group, however, the expression of M1 cytokine was more pronounced than M2 profile. AT-RvD1 could be an important target for the reduction of inflammation in the airways associated with smoking.
MeSH term(s)	Humans ; Docosahexaenoic Acids/pharmacology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Bronchi/drug effects ; Bronchi/cytology ; Bronchi/metabolism ; Aspirin/pharmacology ; Anti-Inflammatory Agents/pharmacology ; NF-kappa B/metabolism ; STAT3 Transcription Factor/metabolism ; Cell Line ; Smoke/adverse effects ; Cytokines/metabolism ; Nicotiana ; Receptors, Lipoxin/metabolism
Chemical Substances	resolvin D1 ; Docosahexaenoic Acids (25167-62-8) ; Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents ; NF-kappa B ; STAT3 Transcription Factor ; Smoke ; Cytokines ; Receptors, Lipoxin
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1426962-4
ISSN	2212-196X ; 1098-8823 ; 0090-6980
ISSN (online)	2212-196X
ISSN	1098-8823 ; 0090-6980
DOI	10.1016/j.prostaglandins.2024.106833
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Zs.A 815: Show issues

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Article ; Online: Anti-inflammatory actions of aspirin-triggered resolvin D1 (AT-RvD1) in bronchial epithelial cells infected with Cryptococcus neoformans.

Salerno, Bruno Sada / Pereira, Aline Beatriz Mahler / de Souza, Henrique Ismarsi / Silva-Vergara, Mario Leon / Levy, Bruce David / Rogerio, Alexandre Paula

Inflammopharmacology

2021 Volume 29, Issue 5, Page(s) 1603–1612

Abstract: Background: The interaction of Cryptococcus neoformans with airway epithelial cells is crucial for the establishment of cryptococcosis. Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and ... ...

Abstract	Background: The interaction of Cryptococcus neoformans with airway epithelial cells is crucial for the establishment of cryptococcosis. Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and demonstrates anti-inflammatory and pro-resolution effects in several inflammatory experimental models including in the airways. Method: Here, we evaluated the effects of AT-RvD1 (1, 10 or 100 nM) on human bronchial epithelial cells (BEAS-2B) stimulated with C. neoformans (1, 10 or 100 multiplicities of infection; MOI). Results: After 24 h, C. neoformans (all MOI) demonstrated no cytotoxic effects and increased IL-8 production on BEAS-2B cells when compared to controls. In addition, C. neoformans (MOI 100) increased the concentration of IL-6, but not of IL-10. AT-RvD1 (100 nM) significantly reduced the concentration of IL-8 and IL-6 and increased IL-10 production in C. neoformans-stimulated BEAS-2B cells. C. neoformans increased the phosphorylation of NF-κB and ERK1/2, and ALX/FPR2 expression. AT-RvD1 reduced the activation of NF-kB without altering the ERK1/2 and ALX/FPR2 expression. The anti-inflammatory effects of AT-RvD1 were dependent on the ALX/FPR2, once its antagonist (BOC2) reversed its anti-inflammatory effects. No alteration on the fungal burden as well as interactions with BEAS-2B cells was observed by AT-RvD1. Conclusion: AT-RvD1 demonstrated significant anti-inflammatory effects in bronchial epithelial cells infected with C. neoformans without affecting the development of C. neoformans infection in the airways. Trial registration: Not applicable.
MeSH term(s)	Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Bronchi/cytology ; Bronchi/microbiology ; Bronchi/pathology ; Cell Line ; Cryptococcosis/drug therapy ; Cryptococcosis/pathology ; Cryptococcus neoformans/isolation & purification ; Docosahexaenoic Acids/administration & dosage ; Docosahexaenoic Acids/pharmacology ; Dose-Response Relationship, Drug ; Epithelial Cells/drug effects ; Epithelial Cells/microbiology ; Epithelial Cells/pathology ; Humans ; Inflammation/drug therapy ; Inflammation/microbiology
Chemical Substances	Anti-Inflammatory Agents ; resolvin D1 ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2021-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-021-00855-2
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Zs.A 3274: Show issues

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Article ; Online: Spatial distribution and characterization of non-apical progenitors in the zebrafish embryo central nervous system.

McIntosh, Rebecca / Norris, Joseph / Clarke, Jon D / Alexandre, Paula

Open biology

2017 Volume 7, Issue 2

Abstract: Studies of non-apical progenitors (NAPs) have been largely limited to the developing mammalian cortex. They are postulated to generate the increase in neuron numbers that underlie mammalian brain expansion. Recently, NAPs have also been reported in the ... ...

Abstract	Studies of non-apical progenitors (NAPs) have been largely limited to the developing mammalian cortex. They are postulated to generate the increase in neuron numbers that underlie mammalian brain expansion. Recently, NAPs have also been reported in the retina and central nervous system of non-mammalian species; in the latter, however, they remain poorly characterized. Here, we characterize NAP location along the zebrafish central nervous system during embryonic development, and determine their cellular and molecular characteristics and renewal capacity. We identified a small population of NAPs in the spinal cord, hindbrain and telencephalon of zebrafish embryos. Live-imaging analysis revealed at least two types of mitotic behaviour in the telencephalon: one NAP subtype retains the apical attachment during division, while another divides in a subapical position disconnected from the apical surface. All NAPs observed in spinal cord lost apical contact prior to mitoses. These NAPs express HuC and produce two neurons from a single division. Manipulation of Notch activity reveals that neurons and NAPs in the spinal cord use similar regulatory mechanisms. This work suggests that the majority of spinal NAPs in zebrafish share characteristics with basal progenitors in mammalian brains.
Language	English
Publishing date	2017-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2630944-0
ISSN	2046-2441 ; 2046-2441
ISSN (online)	2046-2441
ISSN	2046-2441
DOI	10.1098/rsob.160312
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