LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article ; Online: Identification of acute respiratory distress syndrome subphenotypes de novo using routine clinical data

Fernando G Zampieri / Ary Serpa Neto / Alexandre Biasi Cavalcanti / Abhijit Duggal / Rachel Kast / Emily Van Ark / Lucas Bulgarelli / Matthew T Siuba / Jeff Osborn / Diego Ariel Rey / Israel Maia / Denise M Paisani / Ligia N Laranjeira / Rodrigo Octávio Deliberato

BMJ Open, Vol 12, Iss

a retrospective analysis of ARDS clinical trials

2022 Volume 1

Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Early administration of fibrinogen concentrate in patients with polytrauma with thromboelastometry suggestive of hypofibrinogenemia

Lucas Siqueira de Lucena / Roseny dos Reis Rodrigues / Maria José Carvalho Carmona / Francisco José Diniz Noronha / Heleno de Paiva Oliveira / Natalia Martins Lima / Rodrigo Brandão Pinheiro / Wallace Andrino da Silva / Alexandre Biasi Cavalcanti

Clinics, Vol

A randomized feasibility trial

2021 Volume 76

Abstract: OBJECTIVE: To evaluate the clinical effects of early administration of fibrinogen concentrate in patients with severe trauma and hypofibrinogenemia. METHODS: We conducted an open randomized feasibility trial between December 2015 and January 2017 in ... ...

Abstract	OBJECTIVE: To evaluate the clinical effects of early administration of fibrinogen concentrate in patients with severe trauma and hypofibrinogenemia. METHODS: We conducted an open randomized feasibility trial between December 2015 and January 2017 in patients with severe trauma admitted to the emergency department of a large trauma center. Patients presented with hypotension, tachycardia, and FIBTEM findings suggestive of hypofibrinogenemia. The intervention group received fibrinogen concentrate (50 mg/kg), and the control group did not receive early fibrinogen replacement. The primary outcome was feasibility assessed as the proportion of patients receiving the allocated treatment within 60 min after randomization. The secondary outcomes were transfusion requirements and other exploratory outcomes. Randomization was performed using sequentially numbered and sealed opaque envelopes. ClinicalTrials.gov: NCT02864875. RESULTS: Thirty-two patients were randomized (16 in each group). All patients received the allocated treatment within 60 min after randomization (100%, 95% confidence interval, 86.7%-100%). The median length of intensive care unit stay was shorter in the intervention group (8 days, interquartile range [IQR] 5.75-10.0 vs. 11 days, IQR 8.5-16.0; p=0.02). There was no difference between the groups in other clinical outcomes. No adverse effects related to treatment were recorded in either group. CONCLUSION: Early fibrinogen replacement with fibrinogen concentrate was feasible. Larger trials are required to properly evaluate clinical outcomes.
Keywords	Multiple Trauma ; Coagulopathy ; Fibrinogen ; Thromboelastometry ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier España
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery

Erica Aranha Suzumura / Rodrigo Antonini Ribeiro / Leticia Kawano-Dourado / Pedro Gabriel de Barros e Silva / Claudia Oliveira / Mabel Fernandes Figueiró / Alexandre Biasi Cavalcanti / Renato D. Lopes / Otavio Berwanger

Systematic Reviews, Vol 6, Iss 1, Pp 1-

protocol for a systematic review, meta-analysis, and trial sequential analysis

2017 Volume 8

Abstract: Abstract Background Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This review aims to assess the ...

Abstract	Abstract Background Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This review aims to assess the effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery. Methods We will search MEDLINE/PubMed, EMBASE, LILACS, CENTRAL, Web of Science, and CINAHL for randomized controlled trials assessing the effects of perioperative statin use in adults undergoing non-cardiac surgery and reporting cardiovascular complications. For patients already using statins for hyperlipidemia, a preoperative loading dose of statin is required in the experimental group. We will place no language or publication restriction on our search. Teams of two reviewers will independently assess eligibility and risk of bias, and will extract data from the included trials. Our primary outcome is a combination of cardiovascular mortality or non-fatal myocardial infarction. We will also assess the following outcomes: individual components of the primary outcome, all-cause mortality, total myocardial infarction, elevated troponin in the first seven postoperative days, total stroke, total venous thromboembolism, postoperative atrial fibrillation, elevation of creatine phosphokinase or liver enzymes, and rates of myalgia or rhabdomyolysis. We will conduct meta-analyses using random-effects model and will use trial sequential analysis to establish monitoring boundaries to limit global type I error due to repetitive testing for our primary outcome. We will rate the quality of evidence using the GRADE system. Discussion The results of this systematic review may help to inform clinical practice and also the design of future large-scale randomized trials. Systematic review registration PROSPERO CRD42016035987
Keywords	Systematic review ; Meta-analysis ; Randomized ; Statin ; Perioperative period ; Surgical procedures ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: TELE-critical Care verSus usual Care On ICU PErformance (TELESCOPE)

Regis Goulart Rosa / Luciano Cesar Pontes Azevedo / Adriano José Pereira / Otavio Berwanger / Ary Serpa Neto / Otavio T Ranzani / Alexandre Biasi Cavalcanti / Thiago D Correa / Danilo Teixeira Noritomi / Leonardo Jose Rolim Ferraz / Maura C dos Santos / Eduardo Cordioli / Renata Albaladejo / Lubia Caus de Morais / Guilherme Schettino / Rodrigo Santos Biondi / Jorge IF Salluh / Otavio Tavares Ranzani / Maura Santos /

Fernando Gatti / Jorge Salluh / Leonardo JR Ferraz / Lúbia Caus / Luciano Azevedo / Maura Cristina Santos / Rodrigo Biondi / Thiago Domingos Correa

BMJ Open, Vol 11, Iss

protocol for a cluster-randomised clinical trial on adult general ICUs in Brazil

2021 Volume 6

Abstract: Introduction Daily multidisciplinary rounds (DMRs) consist of systematic patient-centred discussions aiming to establish joint therapeutic goals for the next 24 hours of intensive care unit (ICU) care. The aim of the present study protocol is to evaluate ...

Abstract	Introduction Daily multidisciplinary rounds (DMRs) consist of systematic patient-centred discussions aiming to establish joint therapeutic goals for the next 24 hours of intensive care unit (ICU) care. The aim of the present study protocol is to evaluate whether an intervention consisting of guided DMRs, supported by a remote specialist and audit/feedback on care performance will reduce ICU length of stay compared with a control group.Methods and analysis A multicentre, controlled, cluster-randomised superiority trial including 30 ICUs in Brazil (15 intervention and 15 control), from August 2019 to June 2021. In a parallel assignment, ICUs are randomised to a complex-intervention composed by daily rounds carried out through Tele-ICU by a remote ICU physician; development of local quality indicators dashboards coupled with monthly meetings with local leadership; and dissemination of evidence-based clinical protocols versus usual care. Primary outcome is ICU length of stay. Secondary outcomes include classification of the unit according to the profiles defined by the standardised resource use and the standardised mortality rate, hospital mortality, incidence of healthcare-associated infections, ventilator-free days at 28 days, patient-days receiving oral or enteral feeding, patient-days under light sedation or alert and calm, rate of patients under normoxaemia. All adult patients admitted after the beginning of the study in each participant ICU will be enrolled. Inclusion criteria (clusters): public Brazilian ICUs with a minimum of 8 ICU beds interested/committed to participating in the study. Exclusion criteria (clusters): units with fully established DMRs by an intensivist, specialised or step-down units.Ethics and dissemination The study protocol was approved by the institutional review board (IRB) of the coordinator centre, and by IRBs of each enrolled hospital/ICU. Statistical analysis protocol is being prepared for submission before the end of patient’s enrolment. Results will be disseminated through ...
Keywords	Medicine ; R
Subject code	650
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Como avaliar criticamente um ensaio clínico de alocação aleatória em terapia intensiva How to assess intensive care randomized trials

Anna Maria Buehler / Alexandre Biasi Cavalcanti / Erica Aranha Suzumura / Mariana Teixeira Carballo / Otávio Berwanger

Revista Brasileira de Terapia Intensiva, Vol 21, Iss 2, Pp 219-

2009 Volume 225

Abstract: Ensaios clínicos aleatorizados são investigações científicas consideradas padrão-ouro para avaliar intervenções terapêuticas. Ensaios clínicos aleatorizados podem examinar e avaliar a segurança e eficácia de novas drogas ou procedimentos terapêuticos ou ... ...

Abstract	Ensaios clínicos aleatorizados são investigações científicas consideradas padrão-ouro para avaliar intervenções terapêuticas. Ensaios clínicos aleatorizados podem examinar e avaliar a segurança e eficácia de novas drogas ou procedimentos terapêuticos ou comparar os efeitos entre duas ou mais drogas ou qualquer outra intervenção. Nesse artigo apresentamos as características essenciais e fatores que podem introduzir viés nesses estudos. Em seguida, apresentamos critérios para avaliação crítica de artigos reportando os resultados de ensaios clínicos aleatorizados e mostramos como interpretar e aplicá-los à prática clínica. Randomized controlled trials are scientific investigations considered as the gold-standard to evaluate therapeutic interventions. Randomized controlled trials may examine the safety and efficacy of new drugs and therapeutic procedures or compare the effects of two or more drugs or any other intervention. In this article, we present the essential features of these studies, as well as, factors which may bias randomized controlled trials. We also present criteria to critically appraise articles reporting randomized controlled trials, explain how to interpret the results and how to apply them to clinical practice.
Keywords	Avaliação ; Ensaios clínicos controlados aleatórios como assunto ; Medicina baseada em evidências ; Unidades de terapia intensiva ; Evaluation ; Randomized controlled trials as topic ; Evidence-based medicine ; Intensive care units ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	Associação de Medicina Intensiva Brasileira
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Assessment of nursing perceptions of three insulin protocols for blood glucose control in critically ill patients

Thiago Domingos Corrêa / Francisca Pereira de Almeida / Alexandre Biasi Cavalcanti / Adriano José Pereira / Eliézer Silva

Einstein (São Paulo), Vol 10, Iss 3, Pp 347-

2012 Volume 353

Abstract: Objective: To evaluate nurses’ perception regarding three differentblood glucose control protocols for critically ill patients. Methods:As part of a randomized trial comparing three blood glucose controlprotocols in critically ill patients (Computer- ... ...

Abstract	Objective: To evaluate nurses’ perception regarding three differentblood glucose control protocols for critically ill patients. Methods:As part of a randomized trial comparing three blood glucose controlprotocols in critically ill patients (Computer-Assisted Insulin Protocol, Leuven Protocol, and conventional treatment), all nurses participating in the study were asked to fill in a questionnaire to assess their perceptions of efficacy, complexity, feasibility, and safety (as to the occurrence of hypoglycemic episodes), an to indicate which protocol they would like to see adopted as the standard one in the Intensive Care Unit they worked. Results: Sixty nurses answered the questionnaires. Computer-Assisted Insulin Protocol was considered the most efficient protocol to maintain blood glucose levels within the target range by 58% of the nurses, compared to 22% for Leuven Protocol (p<0.001) and 40% for conventional treatment (p=0.04). Computer-Assisted Insulin Protocol was considered easier to use than Leuven Protocol (p<0.001) and as easy as conventional treatment (p=0.78). Out of the nurses, 37% considered Computer-Assisted Insulin Protocol more feasible than Leuven Protocol and conventional treatment. A total of 51% of nurses chose Leuven Protocol as the protocol more often associated with hypoglycemia, while 27% chose Computer-Assisted Insulin Protocol and 8% conventional treatment. Finally, 56% of the nurses selected Computer-Assisted Insulin Protocol as the protocol they would like to see adopted as the standard one in the Intensive Care Unit they were based, as compared to 22% that selected Leuven Protocol and 15% that selected conventional treatment. Conclusion: Computer-Assisted Insulin Protocol was considered more efficacious, easier to use and safer than Leuven Protocol by nurses. The complexity and feasibility of Computer-Assisted Insulin Protocol were considered similar to conventional treatment. Most nurses chose of Computer-Assisted Insulin Protocol as the protocol they would like to see adopted ...
Keywords	Blood glucose/metabolism ; Insulin ; Hyperglycemia ; Hypoglycemia ; Metabolism ; Medicine ; R
Subject code	303
Language	English
Publishing date	2012-09-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals

Beatriz Arns / Crepin Aziz Jose Oluwafoumi Agani / Guilhermo Prates Sesin / Jaqueline Driemeyer C. Horvath / Débora Vacaro Fogazzi / Fernanda Kelly Romeiro Silva / Lauren Sezera Costa / Adriano Jose Pereira / Antônio Paulo Nassar Junior / Bruno Tomazini / Camila Dietrich / Viviane Cordeiro Veiga / Daniela G.M. Catarino / Maysa Yukari Cheno / Alexandre Biasi Cavalcanti / Bianca Ramos Ferronatto / Bil Randerson Bassetti / Caio Cesar Ferreira Fernandes / Caroline Deutschendorf /

Cintia Magalhães Carvalho Grion / Claudia Fernanda de Lacerda Vidal / Cláudio Dornas de Oliveira / Eliana Bernadete Caser / Emerson Boschi / Everton Macêdo Silva / Felipe Dal Pizzol / Hugo Correa de Andrade Urbano / Iany Silva / Israel Silva Maia / Leila Rezegue de Moraes Rego / Luana Pontes Oliveira / Maria Brandão Tavares / Marianna Deway Andrade Dracoulakis / Marina Peres Bainy / Nicole Alberti Golin / Pablo Oscar Tomba / Pedro Martins Pereira Kurtz / Rafael Botelho Foernges / Rejane Martins Prestes / Rodrigo Morel Vieira de Melo / Rodrigo Reghini Da Silva / Tatiana Gozzi Pancev Toledo / Valéria Paes Lima / Vanildes de Fátima Fernandes / Wilson José Lovato / Alexandre Prehn Zavascki

Antimicrobial Stewardship & Healthcare Epidemiology, Vol

A countrywide cross-sectional study – CORRIGENDUM

2023 Volume 3

Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Inaccuracy of Venous Point-of-Care Glucose Measurements in Critically Ill Patients

Adriano José Pereira / Thiago Domingos Corrêa / Francisca Pereira de Almeida / Rodrigo Octávio Deliberato / Michelle dos Santos Lobato / Nelson Akamine / Eliézer Silva / Alexandre Biasi Cavalcanti

PLoS ONE, Vol 10, Iss 6, p e

A Cross-Sectional Study.

2015 Volume 0129568

Abstract: Current guidelines and consensus recommend arterial and venous samples as equally acceptable for blood glucose assessment in point-of-care devices, but there is limited evidence to support this recommendation. We evaluated the accuracy of two devices for ...

Abstract	Current guidelines and consensus recommend arterial and venous samples as equally acceptable for blood glucose assessment in point-of-care devices, but there is limited evidence to support this recommendation. We evaluated the accuracy of two devices for bedside point-of-care blood glucose measurements using arterial, fingerstick and catheter venous blood samples in ICU patients, and assessed which factors could impair their accuracy.145 patients from a 41-bed adult mixed-ICU, in a tertiary care hospital were prospectively enrolled. Fingerstick, central venous (catheter) and arterial blood (indwelling catheter) samples were simultaneously collected, once per patient. Arterial measurements obtained with Precision PCx, and arterial, fingerstick and venous measurements obtained with Accu-chek Advantage II were compared to arterial central lab measurements. Agreement between point-of-care and laboratory measurements were evaluated with Bland-Altman, and multiple linear regression models were used to investigate interference of associated factors.Mean difference between Accu-chek arterial samples versus central lab was 10.7 mg/dL (95% LA -21.3 to 42.7 mg/dL), and between Precision PCx versus central lab was 18.6 mg/dL (95% LA -12.6 to 49.5 mg/dL). Accu-chek fingerstick versus central lab arterial samples presented a similar bias (10.0 mg/dL) but a wider 95% LA (-31.8 to 51.8 mg/dL). Agreement between venous samples with arterial central lab was the poorest (mean bias 15.1 mg/dL; 95% LA -51.7 to 81.9). Hyperglycemia, low hematocrit, and acidosis were associated with larger differences between arterial and venous blood measurements with the two glucometers and central lab. Vasopressor administration was associated with increased error for fingerstick measurements.Sampling from central venous catheters should not be used for glycemic control in ICU patients. In addition, reliability of the two evaluated glucometers was insufficient. Error with Accu-chek Advantage II increases mostly with central venous samples. ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Cochrane meta-analysis

Diogo Diniz Gomes Bugano / Alexandre Biasi Cavalcanti / Anderson Roman Goncalves / Claudia Salvini de Almeida / Eliézer Silva

Einstein (São Paulo), Vol 9, Iss 3, Pp 265-

teicoplanin versus vancomycin for proven or suspected infection

2011 Volume 282

Abstract: Objective: To compare efficacy and safety of vancomycin versusteicoplanin in patients with proven or suspected infection.Methods: Data Sources: Cochrane Renal Group’s SpecializedRegister, CENTRAL, MEDLINE, EMBASE, nephrology textbooksand review articles. ...

Abstract	Objective: To compare efficacy and safety of vancomycin versusteicoplanin in patients with proven or suspected infection.Methods: Data Sources: Cochrane Renal Group’s SpecializedRegister, CENTRAL, MEDLINE, EMBASE, nephrology textbooksand review articles. Inclusion criteria: Randomized controlled trialsin any language comparing teicoplanin to vancomycin for patientswith proven or suspected infection. Data extraction: Two authorsindependently evaluated methodological quality and extracted data.Study investigators were contacted for unpublished information. Arandom effect model was used to estimate the pooled risk ratio (RR)with 95% confidence interval (CI). Results: A total of 24 studies (2,610patients) were included. The drugs had similar rates of clinical cure(RR: 1.03; 95%CI: 0.98-1.08), microbiological cure (RR: 0.98; 95%CI:0.93-1.03) and mortality (RR: 1.02; 95%CI: 0.79-1.30). Teicoplaninhad lower rates of skin rash (RR: 0.57; 95%CI: 0.35-0.92), red mansyndrome (RR: 0.21; 95%CI: 0.08-0.59) and total adverse events (RR:0.73; 95%CI: 0.53-1.00). Teicoplanin reduced the risk of nephrotoxicity(RR: 0.66; 95%CI: 0.48-0.90). This effect was consistent for patientsreceiving aminoglycosides (RR: 0.51; 95%CI: 0.30-0.88) or havingvancomycin doses corrected by serum levels (RR: 0.22; 95%CI:0.10-0.52). There were no cases of acute kidney injury needingdialysis. Limitations: Studies lacked a standardized definition fornephrotoxicity. Conclusions: Teicoplanin and vancomycin are equallyeffective; however the incidence of nephrotoxicity and other adverseevents was lower with teicoplanin. It may be reasonable to considerteicoplanin for patients at higher risk for acute kidney injury.
Keywords	Anti-bacterial agents/adverse effects ; Anti-bacterial agents/therapeutic use ; Teicoplanin/adverse effects ; Teicoplanin/ therapeutic use ; Vancomycin/adverse effects ; Vancomycin/ therapeutic use ; Kidney/drug effects ; Drug eruptions/etiology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Cochrane meta-analysis

Diogo Diniz Gomes Bugano / Alexandre Biasi Cavalcanti / Anderson Roman Goncalves / Claudia Salvini de Almeida / Eliézer Silva

Einstein (São Paulo), Vol 9, Iss 3, Pp 265-

teicoplanin versus vancomycin for proven or suspected infection

2011 Volume 282

Abstract: ABSTRACT Objective: To compare efficacy and safety of vancomycin versus teicoplanin in patients with proven or suspected infection. Methods: Data Sources: Cochrane Renal Group's Specialized Register, CENTRAL, MEDLINE, EMBASE, nephrology textbooks and ... ...

Abstract	ABSTRACT Objective: To compare efficacy and safety of vancomycin versus teicoplanin in patients with proven or suspected infection. Methods: Data Sources: Cochrane Renal Group's Specialized Register, CENTRAL, MEDLINE, EMBASE, nephrology textbooks and review articles. Inclusion criteria: Randomized controlled trials in any language comparing teicoplanin to vancomycin for patients with proven or suspected infection. Data extraction: Two authors independently evaluated methodological quality and extracted data. Study investigators were contacted for unpublished information. A random effect model was used to estimate the pooled risk ratio (RR) with 95% confidence interval (CI). Results: A total of 24 studies (2,610 patients) were included. The drugs had similar rates of clinical cure (RR: 1.03; 95%CI: 0.98-1.08), microbiological cure (RR: 0.98; 95%CI: 0.93-1.03) and mortality (RR: 1.02; 95%CI: 0.79-1.30). Teicoplanin had lower rates of skin rash (RR: 0.57; 95%CI: 0.35-0.92), red man syndrome (RR: 0.21; 95%CI: 0.08-0.59) and total adverse events (RR: 0.73; 95%CI: 0.53-1.00). Teicoplanin reduced the risk of nephrotoxicity (RR: 0.66; 95%CI: 0.48-0.90). This effect was consistent for patients receiving aminoglycosides (RR: 0.51; 95%CI: 0.30-0.88) or having vancomycin doses corrected by serum levels (RR: 0.22; 95%CI: 0.10-0.52). There were no cases of acute kidney injury needing dialysis. Limitations: Studies lacked a standardized definition for nephrotoxicity. Conclusions: Teicoplanin and vancomycin are equally effective; however the incidence of nephrotoxicity and other adverse events was lower with teicoplanin. It may be reasonable to consider teicoplanin for patients at higher risk for acute kidney injury.
Keywords	Anti-bacterial agents/adverse effects ; Anti-bacterial agents/therapeutic use ; Teicoplanin/adverse effects ; Teicoplanin/therapeutic use ; Vancomycin/adverse effects ; Vancomycin/therapeutic use ; Kidney/drug effects ; Drug eruptions/etiology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	Instituto Israelita de Ensino e Pesquisa Albert Einstein
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED